NPFF Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description neuropeptide FF-amide peptide precursor|FMFRamide-related protein precursor plays a role in the regulation of heart rate and blood pressure and the modulation of morphine-induced antinociception. FMRFAL encodes a preproprotein which is cleaved to form two active peptides with similar function. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 8620)
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Genes

319 genes differentially expressed following the NPFF gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SCNN1D sodium channel, non voltage gated 1 delta subunit 2.95415
DNAAF8 dynein axonemal assembly factor 8 2.95415
RARS2 arginyl-tRNA synthetase 2, mitochondrial 2.95415
TMEM150B transmembrane protein 150B 2.95415
SHBG sex hormone-binding globulin 2.95415
LCN10 lipocalin 10 2.95415
SHISA8 shisa family member 8 2.95415
UTS2R urotensin 2 receptor 2.95415
TBX10 T-box 10 2.95415
UPB1 ureidopropionase, beta 2.95415
DCST1 DC-STAMP domain containing 1 2.95415
UPK3B uroplakin 3B 2.95415
PLCXD3 phosphatidylinositol-specific phospholipase C, X domain containing 3 2.95415
CNR2 cannabinoid receptor 2 (macrophage) 2.95415
GOLGA8N golgin A8 family, member N 2.95415
CD22 CD22 molecule 2.95415
P2RY8 purinergic receptor P2Y, G-protein coupled, 8 2.95415
B3GNT8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 2.95415
THPO thrombopoietin 2.95415
TSGA13 testis specific, 13 2.91819
CELA3A chymotrypsin-like elastase family, member 3A 2.91819
LRIT2 leucine-rich repeat, immunoglobulin-like and transmembrane domains 2 2.91819
RAB44 RAB44, member RAS oncogene family 2.91819
CST9L cystatin 9-like 2.91819
MS4A4E membrane-spanning 4-domains, subfamily A, member 4E 2.91819
ARID3C AT rich interactive domain 3C (BRIGHT-like) 2.91819
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 2.91819
SMARCAD1 SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1 2.91819
ACTL10 actin-like 10 2.91819
SLC22A16 solute carrier family 22 (organic cation/carnitine transporter), member 16 2.91819
SLC6A18 solute carrier family 6 (neutral amino acid transporter), member 18 2.91819
PON1 paraoxonase 1 2.91819
PCDHB1 protocadherin beta 1 2.91819
CRYGN crystallin, gamma N 2.91819
RIMBP3C RIMS binding protein 3C 2.91819
OR1D2 olfactory receptor, family 1, subfamily D, member 2 2.91819
SMIM5 small integral membrane protein 5 2.91819
LOC124900192 uncharacterized LOC124900192 2.91819
TDRD1 tudor domain containing 1 2.91819
B3GALT2 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 2.91819
NCKAP1L NCK-associated protein 1-like 2.91819
ADAMTSL2 ADAMTS-like 2 2.91819
BIRC7 baculoviral IAP repeat containing 7 2.91819
MYCT1 myc target 1 2.91819
ASPA aspartoacylase 2.91819
RSPO1 R-spondin 1 2.91819
SLC15A4 solute carrier family 15 (oligopeptide transporter), member 4 2.91819
ASMT acetylserotonin O-methyltransferase 2.91819
SLC22A13 solute carrier family 22 (organic anion/urate transporter), member 13 2.91819
SKOR2 SKI family transcriptional corepressor 2 2.91819
OR4D9 olfactory receptor, family 4, subfamily D, member 9 2.91819
PCDHA3 protocadherin alpha 3 2.91819
MAGEB1 melanoma antigen family B1 2.91819
GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1 2.91819
CCN3 cellular communication network factor 3 2.91819
MYH1 myosin, heavy chain 1, skeletal muscle, adult 2.91819
RCVRN recoverin 2.91819
RHCG Rh family, C glycoprotein 2.91819
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 2.91819
PLCZ1 phospholipase C, zeta 1 2.91819
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 2.91819
ODAPH odontogenesis associated phosphoprotein 2.91819
GARIN5B golgi associated RAB2 interactor family member 5B 2.91819
REELD1 reeler domain containing 1 2.91819
H4C12 H4 clustered histone 12 2.91819
SMIM31 small integral membrane protein 31 2.91819
MYMK myomaker, myoblast fusion factor 2.91819
EZHIP EZH inhibitory protein 2.91819
PEAK3 PEAK family member 3 2.91819
MUCL3 mucin like 3 2.91819
H2AC1 H2A clustered histone 1 2.91819
ABCC12 ATP-binding cassette, sub-family C (CFTR/MRP), member 12 2.91819
ASB5 ankyrin repeat and SOCS box containing 5 2.91819
MS4A13 membrane-spanning 4-domains, subfamily A, member 13 2.91819
S100P S100 calcium binding protein P 2.91819
APOBEC4 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative) 2.91819
SLC45A2 solute carrier family 45, member 2 2.91819
OVOL3 ovo-like zinc finger 3 2.91819
CLEC20A C-type lectin domain containing 20A 2.91819
NPIPB9 nuclear pore complex interacting protein family, member B9 2.91819
CBLN3 cerebellin 3 precursor 2.91819
UTS2 urotensin 2 2.91819
SASH3 SAM and SH3 domain containing 3 2.91819
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 2.91819
OR7D2 olfactory receptor, family 7, subfamily D, member 2 2.91819
PRDM7 PR domain containing 7 2.91819
BEST3 bestrophin 3 2.91819
PLEK2 pleckstrin 2 2.91819
PGA5 pepsinogen 5, group I (pepsinogen A) 2.91819
PTCHD3 patched domain containing 3 2.91819
SAA2 serum amyloid A2 2.91819
TEKTL1 tektin like 1 2.91819
LUZP4 leucine zipper protein 4 2.91819
CFP complement factor properdin 2.91819
FOXE3 forkhead box E3 2.91819
CCDC27 coiled-coil domain containing 27 2.91819
IL36R interleukin 36 receptor 2.91819
CBX3 chromobox homolog 3 2.91819
C11ORF16 chromosome 11 open reading frame 16 2.91819
BPIFB1 BPI fold containing family B, member 1 2.91819
MAP3K19 mitogen-activated protein kinase kinase kinase 19 2.91819
TAS2R50 taste receptor, type 2, member 50 2.91819
CRYBB3 crystallin, beta B3 2.91819
ARR3 arrestin 3, retinal (X-arrestin) 2.91819
SERPINB11 serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene) 2.91819
CERKL ceramide kinase-like 2.91819
NIM1K NIM1 serine/threonine protein kinase 2.91819
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) 2.91819
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 2.91819
GAL3ST2 galactose-3-O-sulfotransferase 2 2.91819
MBOAT4 membrane bound O-acyltransferase domain containing 4 2.91819
DNTT DNA nucleotidylexotransferase 2.91819
SEC14L3 SEC14-like 3 (S. cerevisiae) 2.91819
DMRTB1 DMRT-like family B with proline-rich C-terminal, 1 2.91819
CCDC177 coiled-coil domain containing 177 2.91819
PDE11A phosphodiesterase 11A 2.91819
TTC24 tetratricopeptide repeat domain 24 2.91819
CXORF58 chromosome X open reading frame 58 2.91819
CXORF49C chromosome X open reading frame 49C 2.91819
KRT39 keratin 39, type I 2.91819
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 2.91819
IDI2 isopentenyl-diphosphate delta isomerase 2 2.91819
HIGD2B HIG1 hypoxia inducible domain family, member 2B 2.91819
F13B coagulation factor XIII, B polypeptide 2.91819
TP63 tumor protein p63 2.91819
SYNGR4 synaptogyrin 4 2.91819
PLA2G12B phospholipase A2, group XIIB 2.91819
FCRL2 Fc receptor-like 2 2.91819
C20ORF144 chromosome 20 open reading frame 144 2.91819
CER1 cerberus 1, DAN family BMP antagonist 2.91819
CMTM5 CKLF-like MARVEL transmembrane domain containing 5 2.91819
ANKRD33 ankyrin repeat domain 33 2.91819
NMUR2 neuromedin U receptor 2 2.91819
SPAG8 sperm associated antigen 8 2.91819
SLX1A SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae) 2.91819
PPY pancreatic polypeptide 2.91819
PLGLB2 plasminogen-like B2 2.91819
CMPK2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial 2.91819
MDFI MyoD family inhibitor 2.91819
PITX2 paired-like homeodomain 2 2.91819
CLCA1 chloride channel accessory 1 2.91819
ERAP2 endoplasmic reticulum aminopeptidase 2 2.91819
ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 2.91819
ACY3 aminoacylase 3 2.91819
GREM1 gremlin 1, DAN family BMP antagonist 2.91819
MYL1 myosin, light chain 1, alkali; skeletal, fast 2.91819
CARD9 caspase recruitment domain family, member 9 2.91819
MMP13 matrix metallopeptidase 13 2.91819
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22 2.91819
ANKRD62 ankyrin repeat domain 62 2.91819
ACTR3C ARP3 actin-related protein 3 homolog C (yeast) 2.91819
ANAPC16 anaphase promoting complex subunit 16 2.90752
SDR39U1 short chain dehydrogenase/reductase family 39U, member 1 2.86424
GRK4 G protein-coupled receptor kinase 4 2.82358
TAPBPL TAP binding protein-like 2.78979
FAM110C family with sequence similarity 110, member C 2.73609
PEX7 peroxisomal biogenesis factor 7 2.65993
WSB1 WD repeat and SOCS box containing 1 2.61111
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5 2.60814
INHBA inhibin, beta A 2.57686
CUL3 cullin 3 2.57246
PXDN peroxidasin 2.54662
DIAPH3 diaphanous-related formin 3 2.51936
POR P450 (cytochrome) oxidoreductase 2.46711
UBL3 ubiquitin-like 3 2.46711
C7orf78 chromosome 7 open reading frame 78 2.46072
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) 2.45095
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 2.43364
NCOA5 nuclear receptor coactivator 5 2.42434
NOXO1 NADPH oxidase organizer 1 2.42171
S100A14 S100 calcium binding protein A14 2.42171
ILF2 interleukin enhancer binding factor 2 2.42171
NSRP1 nuclear speckle splicing regulatory protein 1 2.36074
RAP1GAP2 RAP1 GTPase activating protein 2 2.35932
ZYG11A zyg-11 family member A, cell cycle regulator 2.34103
ASXL1 additional sex combs like transcriptional regulator 1 2.33978
MRPL10 mitochondrial ribosomal protein L10 2.33978
IREB2 iron-responsive element binding protein 2 2.30339
ARHGAP1 Rho GTPase activating protein 1 2.29334
ABTB3 ankyrin repeat and BTB domain containing 3 2.28897
LMTK2 lemur tyrosine kinase 2 2.28897
IRF2BP2 interferon regulatory factor 2 binding protein 2 2.2317
SAMTOR S-adenosylmethionine sensor upstream of mTORC1 2.22129
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4 2.21527
BST1 bone marrow stromal cell antigen 1 2.21478
PIGL phosphatidylinositol glycan anchor biosynthesis, class L 2.21273
DYNLT2B dynein light chain Tctex-type 2B 2.19195
RTF2 replication termination factor 2 2.18365
SOCS5 suppressor of cytokine signaling 5 2.17193
STX16 syntaxin 16 2.17047
BMPR1A bone morphogenetic protein receptor, type IA 2.15313
DELE1 DAP3 binding cell death enhancer 1 2.15035
GPR27 G protein-coupled receptor 27 2.14196
TEX264 testis expressed 264 2.1375
METTL27 methyltransferase like 27 2.11874
INVS inversin 2.11874
ZNF429 zinc finger protein 429 2.10257
LARS1 leucyl-tRNA synthetase 1 2.09537
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein) 2.08546
DIRAS1 DIRAS family, GTP-binding RAS-like 1 2.08546
PDIA5 protein disulfide isomerase family A, member 5 2.07926
GTF3A general transcription factor IIIA 2.07728
LRGUK leucine-rich repeats and guanylate kinase domain containing 2.02903
ATG101 autophagy related 101 2.02877
MX2 MX dynamin-like GTPase 2 2.02877
PGLS 6-phosphogluconolactonase 2.02877
IVD isovaleryl-CoA dehydrogenase 2.00528

decreased expression

Symbol Name Standardized Value
ALDH1L1 aldehyde dehydrogenase 1 family, member L1 -2.95415
CMKLR2 chemerin chemokine-like receptor 2 -2.95415
TMEM184A transmembrane protein 184A -2.95415
ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide -2.95415
PAX8 paired box 8 -2.91819
DRP2 dystrophin related protein 2 -2.91819
SPINK13 serine peptidase inhibitor, Kazal type 13 (putative) -2.91819
GALR3 galanin receptor 3 -2.91819
PRR22 proline rich 22 -2.91819
ADAM20 ADAM metallopeptidase domain 20 -2.91819
CERCAM cerebral endothelial cell adhesion molecule -2.91819
ZNF471 zinc finger protein 471 -2.91819
SH2D7 SH2 domain containing 7 -2.91819
ZBTB42 zinc finger and BTB domain containing 42 -2.91819
DIS3L DIS3 like exosome 3'-5' exoribonuclease -2.91819
LOC124906010 uncharacterized LOC124906010 -2.91819
FYB2 FYN binding protein 2 -2.91819
NSG2 neuronal vesicle trafficking associated 2 -2.91819
CATSPERT catsper channel auxiliary subunit tau -2.91819
COX8C cytochrome c oxidase subunit VIIIC -2.91819
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 -2.91819
SIX3 SIX homeobox 3 -2.91819
RASL10A RAS-like, family 10, member A -2.91819
SLC46A3 solute carrier family 46, member 3 -2.91819
MUC6 mucin 6, oligomeric mucus/gel-forming -2.91819
SEMG1 semenogelin I -2.91819
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated) -2.91819
DAW1 dynein assembly factor with WDR repeat domains 1 -2.91819
PCDH12 protocadherin 12 -2.91819
PHACTR3 phosphatase and actin regulator 3 -2.91819
PHYKPL 5-phosphohydroxy-L-lysine phospho-lyase -2.88828
PTGES prostaglandin E synthase -2.86989
RGMA repulsive guidance molecule family member a -2.69054
SIGLEC10 sialic acid binding Ig-like lectin 10 -2.68139
HNRNPF heterogeneous nuclear ribonucleoprotein F -2.66583
RPL23A ribosomal protein L23a -2.65469
ZSCAN20 zinc finger and SCAN domain containing 20 -2.6494
USP46 ubiquitin specific peptidase 46 -2.6494
GNB4 guanine nucleotide binding protein (G protein), beta polypeptide 4 -2.63691
PPP5C protein phosphatase 5, catalytic subunit -2.61059
PAQR9 progestin and adipoQ receptor family member IX -2.54789
MYLK4 myosin light chain kinase family, member 4 -2.53843
TNRC18 trinucleotide repeat containing 18 -2.49555
SEPTIN6 septin 6 -2.48494
VPS4B vacuolar protein sorting 4 homolog B (S. cerevisiae) -2.47131
AGA-DT AGA divergent transcript -2.46365
SLC9A9 solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9 -2.46365
INAFM1 InaF-motif containing 1 -2.46365
RAI2 retinoic acid induced 2 -2.46365
PTCD3 pentatricopeptide repeat domain 3 -2.45095
ARMCX3 armadillo repeat containing, X-linked 3 -2.44883
PYGM phosphorylase, glycogen, muscle -2.41682
PRB2 proline-rich protein BstNI subfamily 2 -2.41682
TEX11 testis expressed 11 -2.41682
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 -2.41682
ACSS1 acyl-CoA synthetase short-chain family member 1 -2.41682
NOCT nocturnin -2.41564
RABL3 RAB, member of RAS oncogene family-like 3 -2.40719
APELA apelin receptor early endogenous ligand -2.37996
ZMIZ1 zinc finger, MIZ-type containing 1 -2.35196
GSTM3 glutathione S-transferase mu 3 (brain) -2.34808
AGER advanced glycosylation end product-specific receptor -2.34808
LDLRAD3 low density lipoprotein receptor class A domain containing 3 -2.34103
IFT81 intraflagellar transport 81 -2.34103
CYGB cytoglobin -2.3114
CAPNS1 calpain, small subunit 1 -2.28897
PCSK7 proprotein convertase subtilisin/kexin type 7 -2.28897
C3ORF70 chromosome 3 open reading frame 70 -2.22868
RNF152 ring finger protein 152 -2.20431
RPL36A ribosomal protein L36a -2.19465
KCNQ2 potassium channel, voltage gated KQT-like subfamily Q, member 2 -2.18239
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) -2.17631
STK11 serine/threonine kinase 11 -2.17631
TMC6 transmembrane channel-like 6 -2.17193
NSD2 nuclear receptor binding SET domain protein 2 -2.17193
GNG2 guanine nucleotide binding protein (G protein), gamma 2 -2.17193
CHMP3 charged multivesicular body protein 3 -2.17193
SLFN5 schlafen family member 5 -2.16863
CLCC1 chloride channel CLIC-like 1 -2.15555
ANAPC1 anaphase promoting complex subunit 1 -2.1432
SEC11A SEC11 homolog A (S. cerevisiae) -2.14102
RIBC2 RIB43A domain with coiled-coils 2 -2.12913
ARRB1 arrestin, beta 1 -2.12739
FAS Fas cell surface death receptor -2.11765
BRI3 brain protein I3 -2.11579
PEX39 peroxisomal biogenesis factor 39 -2.08999
CLSTN1 calsyntenin 1 -2.08273
CDHR2 cadherin-related family member 2 -2.06654
ECRG4 ECRG4 augurin precursor -2.05719
DHX38 DEAH (Asp-Glu-Ala-His) box polypeptide 38 -2.05719
WFS1 Wolfram syndrome 1 (wolframin) -2.04723
ARF4 ADP-ribosylation factor 4 -2.03256
RHOV ras homolog family member V -2.02877
UGT8 UDP glycosyltransferase 8 -2.02877
SFN stratifin -2.02877
CHAF1B chromatin assembly factor 1, subunit B (p60) -2.02459
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 -2.02179
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal) -2.02179
CD151 CD151 molecule (Raph blood group) -2.02179
DCDC2B doublecortin domain containing 2B -2.02179
C1ORF116 chromosome 1 open reading frame 116 -2.02179
COL8A2 collagen, type VIII, alpha 2 -2.02179
EFCAB13 EF-hand calcium binding domain 13 -2.014
CCAR1 cell division cycle and apoptosis regulator 1 -2.014
COX16 COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) -2.014
CENPO centromere protein O -2.01296
TXN2 thioredoxin 2 -2.01296
PTK2 protein tyrosine kinase 2 -2.00992
C4ORF51 chromosome 4 open reading frame 51 -2.00874
BEND6 BEN domain containing 6 -2.0036
RNF8 ring finger protein 8, E3 ubiquitin protein ligase -2.00147
SLC25A40 solute carrier family 25, member 40 -2.00147