NPW Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description neuropeptide W|The product of this gene is processed into 23- and 30-amino acid neuropeptides that bind and activate two G-protein coupled receptors in the central nervous system. The neuropeptides have been shown to enhance cortisol secretion from adrenal cells through the adenylate cyclase/protein kinase A signaling cascade. The preproprotein is translated using a non-AUG initiation codon that is inferred from analyses of the mouse ortholog. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 283869)
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Genes

302 genes differentially expressed following the NPW gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
IDI2 isopentenyl-diphosphate delta isomerase 2 2.55504
COL20A1 collagen, type XX, alpha 1 2.55504
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1 2.55504
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase) 2.55504
CD34 CD34 molecule 2.55504
C10ORF67 chromosome 10 open reading frame 67 2.55504
GIPR gastric inhibitory polypeptide receptor 2.55504
POPDC2 popeye domain containing 2 2.55504
CHI3L2 chitinase 3-like 2 2.55504
TMPRSS11F transmembrane protease, serine 11F 2.55504
SCNN1B sodium channel, non voltage gated 1 beta subunit 2.55504
TRAF3IP3 TRAF3 interacting protein 3 2.55504
UBE2U ubiquitin-conjugating enzyme E2U (putative) 2.55504
ZFP57 ZFP57 zinc finger protein 2.55504
FOLR1 folate receptor 1 (adult) 2.55504
SLITRK1 SLIT and NTRK-like family, member 1 2.55504
PLA2G2C phospholipase A2, group IIC 2.55504
TUBA3D tubulin, alpha 3d 2.55504
EIF4E1B eukaryotic translation initiation factor 4E family member 1B 2.55504
TMEM255A transmembrane protein 255A 2.55504
NPY2R neuropeptide Y receptor Y2 2.55504
CPLX4 complexin 4 2.55504
PCDHA7 protocadherin alpha 7 2.53963
VTN vitronectin 2.53963
FOXD1 forkhead box D1 2.53963
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 2.53963
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha 2.53963
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 2.53963
KLHL34 kelch-like family member 34 2.53963
SIX2 SIX homeobox 2 2.53963
AGTR1 angiotensin II receptor, type 1 2.53963
PABPC1L2A poly(A) binding protein, cytoplasmic 1-like 2A 2.53963
ZACN zinc activated ligand-gated ion channel 2.53963
TMPRSS11A transmembrane protease, serine 11A 2.53963
OR52A5 olfactory receptor, family 52, subfamily A, member 5 2.53963
CABP4 calcium binding protein 4 2.53963
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa 2.53963
S100A2 S100 calcium binding protein A2 2.53963
VSX1 visual system homeobox 1 2.53963
PRDM12 PR domain containing 12 2.53963
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.53963
GALR2 galanin receptor 2 2.53963
CPLX3 complexin 3 2.53963
ASGR2 asialoglycoprotein receptor 2 2.53963
TRPV5 transient receptor potential cation channel, subfamily V, member 5 2.53963
NRROS negative regulator of reactive oxygen species 2.53963
ATXN7L2 ataxin 7-like 2 2.53963
IL5RA interleukin 5 receptor, alpha 2.53963
CXORF65 chromosome X open reading frame 65 2.53963
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) 2.53963
SIGLEC5 sialic acid binding Ig-like lectin 5 2.53963
TNIP3 TNFAIP3 interacting protein 3 2.53963
PECAM1 platelet/endothelial cell adhesion molecule 1 2.53963
REN renin 2.53963
BIRC3 baculoviral IAP repeat containing 3 2.53963
GYS2 glycogen synthase 2 (liver) 2.53963
EPCIP exosomal polycystin 1 interacting protein 2.53963
GOLGA6L7 golgin A6 family like 7 2.53963
ELFN2 extracellular leucine-rich repeat and fibronectin type III domain containing 2 2.53963
SAPCD1 suppressor APC domain containing 1 2.53963
GPX6 glutathione peroxidase 6 2.53963
AANAT aralkylamine N-acetyltransferase 2.53963
SPMAP1 sperm microtubule associated protein 1 2.53963
LMNTD2 lamin tail domain containing 2 2.53963
TMPRSS7 transmembrane protease, serine 7 2.53963
PHF24 PHD finger protein 24 2.53963
FYB1 FYN binding protein 1 2.53963
MSANTD5 Myb/SANT DNA binding domain containing 5 2.53963
PNMA6F PNMA family member 6F 2.53963
CIMAP1D CIMAP1 family member D 2.53963
H3-7 H3.7 histone (putative) 2.53963
SEPTIN12 septin 12 2.53963
H2BW2 H2B.W histone 2 2.53963
CFAP206 cilia and flagella associated protein 206 2.53963
GARIN1A golgi associated RAB2 interactor 1A 2.53963
CALHM5 calcium homeostasis modulator family member 5 2.53963
BDKRB1 bradykinin receptor B1 2.53963
CMKLR1 chemerin chemokine-like receptor 1 2.53963
ZNF705D zinc finger protein 705D 2.53963
HAPLN2 hyaluronan and proteoglycan link protein 2 2.53963
SCRT1 scratch family zinc finger 1 2.53963
MSX1 msh homeobox 1 2.53963
PTP4A1 protein tyrosine phosphatase type IVA, member 1 2.53963
LIX1 Lix1 homolog (chicken) 2.53963
SCN10A sodium channel, voltage gated, type X alpha subunit 2.53963
CHRD chordin 2.53963
PTGDR2 prostaglandin D2 receptor 2 2.53963
IL6 interleukin 6 2.53963
BHLHA9 basic helix-loop-helix family, member a9 2.53963
SH3TC2 SH3 domain and tetratricopeptide repeats 2 2.53963
GATA6 GATA binding protein 6 2.53963
MBIP MAP3K12 binding inhibitory protein 1 2.53963
PXDC1 PX domain containing 1 2.53963
PNPLA1 patatin-like phospholipase domain containing 1 2.53963
LRRC73 leucine rich repeat containing 73 2.53963
TOE1 target of EGR1, member 1 (nuclear) 2.53963
PIWIL1 piwi-like RNA-mediated gene silencing 1 2.53963
C1QL2 complement component 1, q subcomponent-like 2 2.53963
NKX2-6 NK2 homeobox 6 2.53963
CIDEA cell death-inducing DFFA-like effector a 2.53963
C2CD4B C2 calcium-dependent domain containing 4B 2.53963
PCDHGA1 protocadherin gamma subfamily A, 1 2.53963
NUPR1 nuclear protein, transcriptional regulator, 1 2.53963
SHISA8 shisa family member 8 2.53963
MUC12 mucin 12, cell surface associated 2.53963
VWA3A von Willebrand factor A domain containing 3A 2.53963
THBD thrombomodulin 2.53963
SST somatostatin 2.53963
DRD1 dopamine receptor D1 2.53963
IRGC immunity-related GTPase family, cinema 2.53963
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa 2.53963
EBF4 early B-cell factor 4 2.53963
MYF5 myogenic factor 5 2.53963
ZNF541 zinc finger protein 541 2.53963
RAD51AP2 RAD51 associated protein 2 2.53963
C9ORF64 chromosome 9 open reading frame 64 2.53963
DGCR6 DiGeorge syndrome critical region gene 6 2.53963
WFDC9 WAP four-disulfide core domain 9 2.53963
HKDC1 hexokinase domain containing 1 2.53963
KLK3 kallikrein-related peptidase 3 2.53963
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 2.53963
LY96 lymphocyte antigen 96 2.53963
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 2.53963
OPTC opticin 2.53963
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 2.53963
IL24 interleukin 24 2.53963
NUP107 nucleoporin 107kDa 2.53963
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle) 2.53963
PLA2G5 phospholipase A2, group V 2.53963
CFB complement factor B 2.53963
FAM76A family with sequence similarity 76, member A 2.53963
GPR149 G protein-coupled receptor 149 2.53963
RASA4 RAS p21 protein activator 4 2.53963
CRYBA1 crystallin, beta A1 2.53963
TF transferrin 2.53963
SCNN1D sodium channel, non voltage gated 1 delta subunit 2.53963
SPHKAP SPHK1 interactor, AKAP domain containing 2.53963
PRH2 proline-rich protein HaeIII subfamily 2 2.53963
QRFP pyroglutamylated RFamide peptide 2.53963
CLEC1A C-type lectin domain family 1, member A 2.53963
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 2.53963
NLRP14 NLR family, pyrin domain containing 14 2.53963
SLFN12L schlafen family member 12-like 2.53963
RTP3 receptor (chemosensory) transporter protein 3 2.53963
ANXA9 annexin A9 2.53963
MMP12 matrix metallopeptidase 12 2.53963
GGN gametogenetin 2.53963
IRX6 iroquois homeobox 6 2.53963
PANO1 proapoptotic nucleolar protein 1 2.53963
APOA1 apolipoprotein A-I 2.53963
TBL2 transducin (beta)-like 2 2.53963
R3HDML R3H domain containing-like 2.53963
GALP galanin-like peptide 2.53963
LDHC lactate dehydrogenase C 2.53963
MEIG1 meiosis/spermiogenesis associated 1 2.53963
TWIST1 twist family bHLH transcription factor 1 2.53963
EN2 engrailed homeobox 2 2.53963
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 2.53963
EMCN endomucin 2.53963
LOC102724877 uncharacterized LOC102724877 2.53963
HES2 hes family bHLH transcription factor 2 2.53963
PPP1R3A protein phosphatase 1, regulatory subunit 3A 2.53963
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 2.53963
AQP1 aquaporin 1 (Colton blood group) 2.53963
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 2.53963
TMEM156 transmembrane protein 156 2.53963
FITM1 fat storage-inducing transmembrane protein 1 2.53963
LRRC38 leucine rich repeat containing 38 2.53963
NAT16 N-acetyltransferase 16 (GCN5-related, putative) 2.53963
TGM3 transglutaminase 3 2.53963
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 2.53963
CALML6 calmodulin-like 6 2.53963
SPNS3 spinster homolog 3 (Drosophila) 2.53963
SREK1 splicing regulatory glutamine/lysine-rich protein 1 2.51472
PDIA4 protein disulfide isomerase family A, member 4 2.44334
PANK4 pantothenate kinase 4 2.43496
APOBEC4 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative) 2.42283
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.42283
ESRP2 epithelial splicing regulatory protein 2 2.42283
VSTM5 V-set and transmembrane domain containing 5 2.39351
TACR1 tachykinin receptor 1 2.37132
CEPT1 choline/ethanolamine phosphotransferase 1 2.34076
SARS1 seryl-tRNA synthetase 1 2.3407
AKAP8 A kinase (PRKA) anchor protein 8 2.3407
MAST1 microtubule associated serine/threonine kinase 1 2.31351
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase 2.27556
CHMP3 charged multivesicular body protein 3 2.26285
DEF6 differentially expressed in FDCP 6 homolog (mouse) 2.25003
FCN3 ficolin (collagen/fibrinogen domain containing) 3 2.24701
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 2.24701
DEGS2 delta(4)-desaturase, sphingolipid 2 2.23588
AK2 adenylate kinase 2 2.22678
TSPAN6 tetraspanin 6 2.20095
MYH14 myosin, heavy chain 14, non-muscle 2.16145
MOV10 Mov10 RISC complex RNA helicase 2.13582
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) 2.13323
SUCLG1 succinate-CoA ligase, alpha subunit 2.12695
GPR107 G protein-coupled receptor 107 2.12665
C19ORF33 chromosome 19 open reading frame 33 2.12665
CWC22 CWC22 spliceosome-associated protein 2.12116
ACP6 acid phosphatase 6, lysophosphatidic 2.10703
RPH3AL rabphilin 3A-like (without C2 domains) 2.06659
ERGIC2 ERGIC and golgi 2 2.06659
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein 2.05897
PHF10 PHD finger protein 10 2.05897
NDUFA9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa 2.05765
CRHR2 corticotropin releasing hormone receptor 2 2.04819
FCHO2 FCH domain only 2 2.04819
GALM galactose mutarotase (aldose 1-epimerase) 2.03741

decreased expression

Symbol Name Standardized Value
VWA5B1 von Willebrand factor A domain containing 5B1 -2.55504
IKZF3 IKAROS family zinc finger 3 (Aiolos) -2.55504
DNAAF3 dynein, axonemal, assembly factor 3 -2.55504
MYO3B myosin IIIB -2.53963
ALS2CL ALS2 C-terminal like -2.53963
RABEPK Rab9 effector protein with kelch motifs -2.53963
OR2A12 olfactory receptor, family 2, subfamily A, member 12 -2.53963
SH2D3A SH2 domain containing 3A -2.53963
WDR41 WD repeat domain 41 -2.53963
ZCCHC3 zinc finger, CCHC domain containing 3 -2.53963
RND2 Rho family GTPase 2 -2.53963
SNCG synuclein, gamma (breast cancer-specific protein 1) -2.53963
HPSE heparanase -2.53963
FOXI3 forkhead box I3 -2.53963
TMEM242 transmembrane protein 242 -2.53963
ZFP3 ZFP3 zinc finger protein -2.53963
SAXO5 stabilizer of axonemal microtubules 5 -2.53963
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -2.53963
SP140L SP140 nuclear body protein-like -2.53963
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast) -2.53963
BSPRY B-box and SPRY domain containing -2.52098
TDRP testis development related protein -2.48257
RPF1 ribosome production factor 1 homolog (S. cerevisiae) -2.46456
HMX2 H6 family homeobox 2 -2.42283
GLUD2 glutamate dehydrogenase 2 -2.42283
CORIN corin, serine peptidase -2.42283
FOXR1 forkhead box R1 -2.42283
ADAM32 ADAM metallopeptidase domain 32 -2.42283
LOC124906010 uncharacterized LOC124906010 -2.42283
CNTN3 contactin 3 (plasmacytoma associated) -2.42283
CFAP52 cilia and flagella associated protein 52 -2.42283
MYOT myotilin -2.42283
FAM178B family with sequence similarity 178, member B -2.42283
VSX2 visual system homeobox 2 -2.42283
TMIE transmembrane inner ear -2.42283
ACOT1 acyl-CoA thioesterase 1 -2.42283
OR2A7 olfactory receptor, family 2, subfamily A, member 7 -2.42283
MS4A12 membrane-spanning 4-domains, subfamily A, member 12 -2.42283
TMEM215 transmembrane protein 215 -2.42283
PSORS1C1 psoriasis susceptibility 1 candidate 1 -2.42283
LGALS12 lectin, galactoside-binding, soluble, 12 -2.42283
IL17REL interleukin 17 receptor E-like -2.42283
UFSP1 UFM1-specific peptidase 1 (non-functional) -2.42283
CCDC158 coiled-coil domain containing 158 -2.42283
CCDC152 coiled-coil domain containing 152 -2.42283
RFX1 regulatory factor X, 1 (influences HLA class II expression) -2.42283
PPP1R14C protein phosphatase 1, regulatory (inhibitor) subunit 14C -2.42283
IL1A interleukin 1, alpha -2.42283
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal -2.42283
PLET1 placenta expressed transcript 1 -2.42283
ADAM29 ADAM metallopeptidase domain 29 -2.42283
CD86 CD86 molecule -2.42283
MB myoglobin -2.42283
KPNA7 karyopherin alpha 7 (importin alpha 8) -2.42283
PCDHGB2 protocadherin gamma subfamily B, 2 -2.42283
MATN3 matrilin 3 -2.42283
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast) -2.38238
FAIM Fas apoptotic inhibitory molecule -2.32593
POU5F1B POU class 5 homeobox 1B -2.27715
ZNF41 zinc finger protein 41 -2.27556
RHBDF1 rhomboid 5 homolog 1 (Drosophila) -2.26314
BOP1 block of proliferation 1 -2.26314
ZNF688 zinc finger protein 688 -2.26314
DOK5 docking protein 5 -2.26285
ALG8 ALG8, alpha-1,3-glucosyltransferase -2.23588
NCOA1 nuclear receptor coactivator 1 -2.21912
CAMKV CaM kinase-like vesicle-associated -2.18847
NDUFC1 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa -2.17865
ZWILCH zwilch kinetochore protein -2.17776
SEPTIN7 septin 7 -2.16603
TSPO translocator protein (18kDa) -2.16234
EIF4A2 eukaryotic translation initiation factor 4A2 -2.15834
SRP72 signal recognition particle 72kDa -2.15374
ACAD9 acyl-CoA dehydrogenase family, member 9 -2.14752
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast) -2.12116
BIN3 bridging integrator 3 -2.10964
CFAP77 cilia and flagella associated protein 77 -2.08457
TOM1 target of myb1 (chicken) -2.07442
TTC27 tetratricopeptide repeat domain 27 -2.06659
ZSCAN20 zinc finger and SCAN domain containing 20 -2.06659
MICALL2 MICAL-like 2 -2.06659
LIN7C lin-7 homolog C (C. elegans) -2.06659
GLRX5 glutaredoxin 5 -2.06659
SEZ6L seizure related 6 homolog (mouse)-like -2.06627
CEP55 centrosomal protein 55kDa -2.06555
CCNE1 cyclin E1 -2.06076
BUD31 BUD31 homolog (S. cerevisiae) -2.05897
RPE ribulose-5-phosphate-3-epimerase -2.05897
TBKBP1 TBK1 binding protein 1 -2.05897
SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa -2.05765
CLTA clathrin, light chain A -2.01751
KIF17 kinesin family member 17 -2.01736
REDIC1 regulator of DNA class I crossover intermediates 1 -2.00926