NR0B1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description nuclear receptor subfamily 0, group B, member 1|This gene encodes a protein that contains a DNA-binding domain. The encoded protein acts as a dominant-negative regulator of transcription which is mediated by the retinoic acid receptor. This protein also functions as an anti-testis gene by acting antagonistically to Sry. Mutations in this gene result in both X-linked congenital adrenal hypoplasia and hypogonadotropic hypogonadism. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 190)
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Genes

294 genes differentially expressed following the NR0B1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CFHR3 complement factor H-related 3 3.40142
C8ORF48 chromosome 8 open reading frame 48 3.40142
GJB3 gap junction protein, beta 3, 31kDa 3.40142
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 3.40142
DSG3 desmoglein 3 3.40142
APOA2 apolipoprotein A-II 3.40142
FOLR3 folate receptor 3 (gamma) 3.40142
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide 3.40142
TLX3 T-cell leukemia homeobox 3 3.40142
NCF1 neutrophil cytosolic factor 1 3.40142
HCRTR1 hypocretin (orexin) receptor 1 3.40142
NANOS2 nanos homolog 2 (Drosophila) 3.40142
FAM90A26 family with sequence similarity 90, member A26, pseudogene 3.40142
CD6 CD6 molecule 3.40142
CLEC12A C-type lectin domain family 12, member A 3.40142
ASB15 ankyrin repeat and SOCS box containing 15 3.40142
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 3.40142
SLC26A1 solute carrier family 26 (anion exchanger), member 1 3.40142
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 3.40142
BSND barttin CLCNK-type chloride channel accessory beta subunit 3.40142
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13 3.40142
ADAD2 adenosine deaminase domain containing 2 3.40142
TRPV5 transient receptor potential cation channel, subfamily V, member 5 3.40142
ACY3 aminoacylase 3 3.40142
SPACA7 sperm acrosome associated 7 3.40142
LOC105378220 macrophage receptor MARCO-like 3.40142
SLC10A5 solute carrier family 10, member 5 3.40142
OR9K2 olfactory receptor, family 9, subfamily K, member 2 3.40142
PSD2 pleckstrin and Sec7 domain containing 2 3.40142
PITX3 paired-like homeodomain 3 3.40142
ANKRD30A ankyrin repeat domain 30A 3.40142
C2ORF78 chromosome 2 open reading frame 78 3.40142
GRP gastrin-releasing peptide 3.40142
ASGR2 asialoglycoprotein receptor 2 3.40142
C3ORF22 chromosome 3 open reading frame 22 3.40142
TMEM217 transmembrane protein 217 3.40142
TTLL2 tubulin tyrosine ligase-like family member 2 3.40142
GNG13 guanine nucleotide binding protein (G protein), gamma 13 3.40142
SPINK13 serine peptidase inhibitor, Kazal type 13 (putative) 3.40142
SETSIP SET-like protein 3.40142
SPRR2D small proline-rich protein 2D 3.40142
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 3.40142
CD226 CD226 molecule 3.40142
SBK3 SH3 domain binding kinase family, member 3 3.40142
OR9H1 olfactory receptor family 9 subfamily H member 1 pseudogene (gene/pseudogene) 3.40142
TENT5C terminal nucleotidyltransferase 5C 3.40142
STING1 stimulator of interferon response cGAMP interactor 1 3.40142
IRAG2 inositol 1,4,5-triphosphate receptor associated 2 3.40142
SEPTIN14 septin 14 3.40142
GPX6 glutathione peroxidase 6 3.40142
TRAPPC3L trafficking protein particle complex 3-like 3.40142
CD300LF CD300 molecule-like family member f 3.40142
ALX4 ALX homeobox 4 3.40142
CATSPERZ catsper channel auxiliary subunit zeta 3.40142
CBY2 chibby family member 2 3.40142
H4C14 H4 clustered histone 14 3.40142
SPMIP9 sperm microtubule inner protein 9 3.40142
CIMIP2C ciliary microtubule inner protein 2C 3.40142
SPEGNB SPEG neighbor 3.40142
PRR20G proline rich 20G 3.40142
NHERF4 NHERF family PDZ scaffold protein 4 3.40142
LOC124906010 uncharacterized LOC124906010 3.40142
CFAP97D2 CFAP97 domain containing 2 3.40142
H4C15 H4 clustered histone 15 3.40142
ACER1 alkaline ceramidase 1 3.40142
GRAP GRB2-related adaptor protein 3.40142
SPATA22 spermatogenesis associated 22 3.40142
PTP4A1 protein tyrosine phosphatase type IVA, member 1 3.40142
CATSPER3 cation channel, sperm associated 3 3.40142
NXPE2 neurexophilin and PC-esterase domain family, member 2 3.40142
ITK IL2-inducible T-cell kinase 3.40142
ARL5C ADP-ribosylation factor-like 5C 3.40142
OASL 2'-5'-oligoadenylate synthetase-like 3.40142
DPF3 D4, zinc and double PHD fingers, family 3 3.40142
MS4A6E membrane-spanning 4-domains, subfamily A, member 6E 3.40142
TMEM235 transmembrane protein 235 3.40142
RASAL3 RAS protein activator like 3 3.40142
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 3.40142
IMPG1 interphotoreceptor matrix proteoglycan 1 3.40142
GATA1 GATA binding protein 1 (globin transcription factor 1) 3.40142
PRDM6 PR domain containing 6 3.40142
DLK2 delta-like 2 homolog (Drosophila) 3.40142
OR13H1 olfactory receptor, family 13, subfamily H, member 1 3.40142
ASIC3 acid sensing (proton gated) ion channel 3 3.40142
ASIC4 acid sensing (proton gated) ion channel family member 4 3.40142
C7ORF57 chromosome 7 open reading frame 57 3.40142
NDRG1 N-myc downstream regulated 1 3.40142
CLEC4G C-type lectin domain family 4, member G 3.40142
DGCR6 DiGeorge syndrome critical region gene 6 3.40142
C9ORF64 chromosome 9 open reading frame 64 3.40142
BCL2A1 BCL2-related protein A1 3.40142
KCNS2 potassium voltage-gated channel, modifier subfamily S, member 2 3.40142
GSTT2B glutathione S-transferase theta 2B (gene/pseudogene) 3.40142
CST4 cystatin S 3.40142
RGSL1 regulator of G-protein signaling like 1 3.40142
SUPT20HL1 suppressor of Ty 20 homolog (S. cerevisiae)-like 1 3.40142
LENEP lens epithelial protein 3.40142
RSAD2 radical S-adenosyl methionine domain containing 2 3.40142
GSTA1 glutathione S-transferase alpha 1 3.40142
TMEM132E transmembrane protein 132E 3.40142
HIGD2B HIG1 hypoxia inducible domain family, member 2B 3.40142
PSG9 pregnancy specific beta-1-glycoprotein 9 3.40142
CABP7 calcium binding protein 7 3.40142
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 3.40142
FSHR follicle stimulating hormone receptor 3.40142
VWA7 von Willebrand factor A domain containing 7 3.40142
APOC2 apolipoprotein C-II 3.40142
MAMLD1 mastermind-like domain containing 1 3.40142
MAB21L3 mab-21-like 3 (C. elegans) 3.40142
FAM209B family with sequence similarity 209, member B 3.40142
CPA5 carboxypeptidase A5 3.40142
SPINK9 serine peptidase inhibitor, Kazal type 9 3.40142
C11ORF16 chromosome 11 open reading frame 16 3.40142
NPFFR1 neuropeptide FF receptor 1 3.40142
TRADD TNFRSF1A-associated via death domain 3.40142
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17 3.40142
SHISA8 shisa family member 8 3.40142
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 3.40142
CCDC185 coiled-coil domain containing 185 3.40142
MUC17 mucin 17, cell surface associated 3.40142
C17ORF99 chromosome 17 open reading frame 99 3.40142
MORC1 MORC family CW-type zinc finger 1 3.40142
NRGN neurogranin (protein kinase C substrate, RC3) 3.40142
GPBAR1 G protein-coupled bile acid receptor 1 3.40142
NLRP8 NLR family, pyrin domain containing 8 3.40142
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 3.40142
PRAP1 proline-rich acidic protein 1 3.40142
THEM5 thioesterase superfamily member 5 3.40142
TGM1 transglutaminase 1 3.40142
GLRA1 glycine receptor, alpha 1 3.40142
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) 3.40142
MAEL maelstrom spermatogenic transposon silencer 3.40142
BANF2 barrier to autointegration factor 2 3.40142
TEX26 testis expressed 26 3.40142
CDCP2 CUB domain containing protein 2 3.40142
SLC18A1 solute carrier family 18 (vesicular monoamine transporter), member 1 3.40142
ASCL1 achaete-scute family bHLH transcription factor 1 3.40142
GOLGA8R golgin A8 family, member R 3.40142
NPAS4 neuronal PAS domain protein 4 3.40142
WFDC10A WAP four-disulfide core domain 10A 3.40142
KCNA4 potassium channel, voltage gated shaker related subfamily A, member 4 3.40142
C5AR2 complement component 5a receptor 2 3.40142
MC5R melanocortin 5 receptor 3.40142
POU3F3 POU class 3 homeobox 3 3.40142
ALOX5AP arachidonate 5-lipoxygenase-activating protein 3.40142
PFN3 profilin 3 3.40142
TBC1D26 TBC1 domain family, member 26 3.40142
LAMB4 laminin, beta 4 3.40142
PCDH20 protocadherin 20 3.40142
DCAF8L2 DDB1 and CUL4 associated factor 8-like 2 3.40142
CNGB1 cyclic nucleotide gated channel beta 1 3.40142
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 3.40142
DCT dopachrome tautomerase 3.40142
SMIM17 small integral membrane protein 17 3.36975
LINC02560 long intergenic non-protein coding RNA 2560 3.36975
PYDC1 PYD (pyrin domain) containing 1 3.36975
FGF18 fibroblast growth factor 18 3.36975
TRMT13 tRNA methyltransferase 13 homolog (S. cerevisiae) 3.34506
CCNL2 cyclin L2 3.32387
RPS4X ribosomal protein S4, X-linked 3.27326
PFKM phosphofructokinase, muscle 3.20656
CPSF2 cleavage and polyadenylation specific factor 2, 100kDa 3.1876
MCTS1 malignant T cell amplified sequence 1 2.98704
CSF1 colony stimulating factor 1 (macrophage) 2.98314
CIART circadian associated repressor of transcription 2.97699
TSHZ2 teashirt zinc finger homeobox 2 2.8853
TXNL4A thioredoxin-like 4A 2.88174
TACC3 transforming, acidic coiled-coil containing protein 3 2.80248
ATAT1 alpha tubulin acetyltransferase 1 2.76431
KPTN kaptin (actin binding protein) 2.73591
RPL7A ribosomal protein L7a 2.71838
CPNE9 copine family member IX 2.64674
ZNF462 zinc finger protein 462 2.61686
ZNF79 zinc finger protein 79 2.60187
CTHRC1 collagen triple helix repeat containing 1 2.57454
ZNF490 zinc finger protein 490 2.51879
ICAM3 intercellular adhesion molecule 3 2.47802
C11ORF96 chromosome 11 open reading frame 96 2.44058
MYZAP myocardial zonula adherens protein 2.44058
CACNG6 calcium channel, voltage-dependent, gamma subunit 6 2.41507
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 2.38851
ABTB3 ankyrin repeat and BTB domain containing 3 2.37991
CD276 CD276 molecule 2.37983
CHTF8 CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae) 2.37983
PTPRK protein tyrosine phosphatase, receptor type, K 2.36057
INSR insulin receptor 2.35204
PLCXD2 phosphatidylinositol-specific phospholipase C, X domain containing 2 2.34939
METRN meteorin, glial cell differentiation regulator 2.2754
HAPLN2 hyaluronan and proteoglycan link protein 2 2.2754
PNRC1 proline-rich nuclear receptor coactivator 1 2.27346
AKAP6 A kinase (PRKA) anchor protein 6 2.24312
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 2.18375
HAX1 HCLS1 associated protein X-1 2.17519
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 2.17293
LZIC leucine zipper and CTNNBIP1 domain containing 2.15744
RORB RAR-related orphan receptor B 2.14226
WDR90 WD repeat domain 90 2.13052
HGH1 HGH1 homolog (S. cerevisiae) 2.10959
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10 2.09647
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 2.09647
MEX3A mex-3 RNA binding family member A 2.07685
LONP1 lon peptidase 1, mitochondrial 2.06131
NDUFB10 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa 2.03741
CAPN13 calpain 13 2.03427
USP12 ubiquitin specific peptidase 12 2.03427
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 2.02295

decreased expression

Symbol Name Standardized Value
ZC3H12A zinc finger CCCH-type containing 12A -3.40142
ZNF821 zinc finger protein 821 -3.40142
LEF1 lymphoid enhancer-binding factor 1 -3.40142
KBTBD12 kelch repeat and BTB (POZ) domain containing 12 -3.40142
CACNA2D4 calcium channel, voltage-dependent, alpha 2/delta subunit 4 -3.40142
C3ORF18 chromosome 3 open reading frame 18 -3.40142
POU5F2 POU domain class 5, transcription factor 2 -3.40142
CTRL chymotrypsin-like -3.40142
PRPH2 peripherin 2 (retinal degeneration, slow) -3.40142
PLXDC1 plexin domain containing 1 -3.40142
ZNF419 zinc finger protein 419 -3.40142
C11ORF86 chromosome 11 open reading frame 86 -3.40142
AANAT aralkylamine N-acetyltransferase -3.40142
AHSP alpha hemoglobin stabilizing protein -3.3802
OR6B1 olfactory receptor, family 6, subfamily B, member 1 -3.32387
ZBTB16 zinc finger and BTB domain containing 16 -3.32387
MS4A12 membrane-spanning 4-domains, subfamily A, member 12 -3.32387
PCDHB10 protocadherin beta 10 -3.32387
SOX18 SRY (sex determining region Y)-box 18 -3.32387
SCNN1G sodium channel, non voltage gated 1 gamma subunit -3.32387
LCN15 lipocalin 15 -3.32387
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 -3.32387
PRR29 proline rich 29 -3.32387
TAS2R19 taste receptor, type 2, member 19 -3.32387
LRRC61 leucine rich repeat containing 61 -3.32387
XPNPEP2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound -3.32387
GMNC geminin coiled-coil domain containing -3.32387
F7 coagulation factor VII (serum prothrombin conversion accelerator) -3.32387
TDRD6 tudor domain containing 6 -3.32387
LRRC63 leucine rich repeat containing 63 -3.32387
XCR1 chemokine (C motif) receptor 1 -3.32387
TTC9B tetratricopeptide repeat domain 9B -3.32387
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type -3.32387
LRTM3 leucine rich repeat transmembrane protein 3 -3.32387
CTSF cathepsin F -3.32387
WNT9B wingless-type MMTV integration site family, member 9B -3.32387
LEKR1 leucine, glutamate and lysine rich 1 -3.32387
ERVV-2 endogenous retrovirus group V, member 2 -3.32387
PHF24 PHD finger protein 24 -3.32387
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2 -3.32387
SPDYE17 speedy/RINGO cell cycle regulator family member E17 -3.32387
PLET1 placenta expressed transcript 1 -3.32387
TMEM132D transmembrane protein 132D -3.32387
LIX1 Lix1 homolog (chicken) -3.32387
CARMIL3 capping protein regulator and myosin 1 linker 3 -3.32387
PDCL2 phosducin-like 2 -3.22586
IFI16 interferon, gamma-inducible protein 16 -3.14539
PHKA1 phosphorylase kinase, alpha 1 (muscle) -3.08422
SRSF8 serine/arginine-rich splicing factor 8 -2.99743
HHAT hedgehog acyltransferase -2.92663
ADCY8 adenylate cyclase 8 (brain) -2.84737
ATF7IP2 activating transcription factor 7 interacting protein 2 -2.75702
CA10 carbonic anhydrase X -2.58194
INPP1 inositol polyphosphate-1-phosphatase -2.57851
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2) -2.52652
PCNP PEST proteolytic signal containing nuclear protein -2.47802
CENPW centromere protein W -2.4526
TADA1 transcriptional adaptor 1 -2.4526
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 -2.4392
AMBP alpha-1-microglobulin/bikunin precursor -2.36057
CYSRT1 cysteine-rich tail protein 1 -2.36057
TYMP thymidine phosphorylase -2.35963
PKNOX1 PBX/knotted 1 homeobox 1 -2.35699
SGO1 shugoshin 1 -2.33345
GPR135 G protein-coupled receptor 135 -2.33201
CPM carboxypeptidase M -2.29385
PHEX phosphate regulating endopeptidase homolog, X-linked -2.25078
PBX1 pre-B-cell leukemia homeobox 1 -2.25078
AK7 adenylate kinase 7 -2.24312
AEN apoptosis enhancing nuclease -2.22631
GAA glucosidase, alpha; acid -2.22452
SUFU suppressor of fused homolog (Drosophila) -2.17293
PCDHA1 protocadherin alpha 1 -2.17293
ABLIM3 actin binding LIM protein family, member 3 -2.17293
MOGAT3 monoacylglycerol O-acyltransferase 3 -2.17293
C3 complement component 3 -2.11952
SH3BP2 SH3-domain binding protein 2 -2.10274
MRPL30 mitochondrial ribosomal protein L30 -2.10274
MSH5 mutS homolog 5 -2.09965
RCN3 reticulocalbin 3, EF-hand calcium binding domain -2.09647
BTN1A1 butyrophilin, subfamily 1, member A1 -2.08954
AP1S1 adaptor-related protein complex 1, sigma 1 subunit -2.07685
SELENON selenoprotein N -2.06131
DPYS dihydropyrimidinase -2.06131
DBT dihydrolipoamide branched chain transacylase E2 -2.03427
MMP9 matrix metallopeptidase 9 -2.02288
GLOD4 glyoxalase domain containing 4 -2.0155
SMTNL2 smoothelin-like 2 -2.01546