NR1D1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description nuclear receptor subfamily 1, group D, member 1|This gene encodes a transcription factor that is a member of the nuclear receptor subfamily 1. The encoded protein is a ligand-sensitive transcription factor that negatively regulates the expression of core clock proteins. In particular this protein represses the circadian clock transcription factor aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL). This protein may also be involved in regulating genes that function in metabolic, inflammatory and cardiovascular processes. [provided by RefSeq, Jan 2013] (NCBI Entrez Gene Database, 9572)
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Genes

312 genes differentially expressed following the NR1D1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
RAG1 recombination activating gene 1 2.81774
IZUMO1 izumo sperm-egg fusion 1 2.81774
TIMD4 T-cell immunoglobulin and mucin domain containing 4 2.81774
AQP3 aquaporin 3 (Gill blood group) 2.81774
IGFL4 IGF-like family member 4 2.81774
ANKRD63 ankyrin repeat domain 63 2.81774
BATF2 basic leucine zipper transcription factor, ATF-like 2 2.81774
TMIGD3 transmembrane and immunoglobulin domain containing 3 2.81774
MEOX2 mesenchyme homeobox 2 2.81774
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 2.81774
PPP1R3C protein phosphatase 1, regulatory subunit 3C 2.81774
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1 2.81774
STRIT1 small transmembrane regulator of ion transport 1 2.81774
BAIAP3 BAI1-associated protein 3 2.81774
SRL sarcalumenin 2.81774
DNAAF6 dynein axonemal assembly factor 6 2.81774
EPB41L5 erythrocyte membrane protein band 4.1 like 5 2.81774
LCNL1 lipocalin-like 1 2.81774
GBX2 gastrulation brain homeobox 2 2.81774
TMEM86A transmembrane protein 86A 2.81774
CD1C CD1c molecule 2.78131
SPINK6 serine peptidase inhibitor, Kazal type 6 2.78131
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 2.78131
AKR1C2 aldo-keto reductase family 1, member C2 2.78131
EPPIN epididymal peptidase inhibitor 2.78131
SLC46A3 solute carrier family 46, member 3 2.78131
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 2.78131
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila) 2.78131
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C 2.78131
LAX1 lymphocyte transmembrane adaptor 1 2.78131
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 2.78131
CD96 CD96 molecule 2.78131
FOLR1 folate receptor 1 (adult) 2.78131
SOX14 SRY (sex determining region Y)-box 14 2.78131
GLYAT glycine-N-acyltransferase 2.78131
LRRC10B leucine rich repeat containing 10B 2.78131
SLC28A3 solute carrier family 28 (concentrative nucleoside transporter), member 3 2.78131
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 2.78131
CPB1 carboxypeptidase B1 (tissue) 2.78131
ANKK1 ankyrin repeat and kinase domain containing 1 2.78131
PTK6 protein tyrosine kinase 6 2.78131
OXT oxytocin/neurophysin I prepropeptide 2.78131
TAS2R10 taste receptor, type 2, member 10 2.78131
SH2D6 SH2 domain containing 6 2.78131
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene) 2.78131
CA7 carbonic anhydrase VII 2.78131
TRPV6 transient receptor potential cation channel, subfamily V, member 6 2.78131
REN renin 2.78131
CCDC141 coiled-coil domain containing 141 2.78131
PAX3 paired box 3 2.78131
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 2.78131
SLC16A6 solute carrier family 16, member 6 2.78131
GFAP glial fibrillary acidic protein 2.78131
MSC musculin 2.78131
TLX2 T-cell leukemia homeobox 2 2.78131
MFAP4 microfibrillar-associated protein 4 2.78131
MFAP5 microfibrillar associated protein 5 2.78131
SLC23A3 solute carrier family 23, member 3 2.78131
CRYAA crystallin, alpha A 2.78131
TEX53 testis expressed 53 2.78131
SAG S-antigen; retina and pineal gland (arrestin) 2.78131
OR52E4 olfactory receptor, family 52, subfamily E, member 4 2.78131
SMCP sperm mitochondria-associated cysteine-rich protein 2.78131
BEST3 bestrophin 3 2.78131
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 2.78131
LGSN lengsin, lens protein with glutamine synthetase domain 2.78131
PABPC1L2A poly(A) binding protein, cytoplasmic 1-like 2A 2.78131
VCX3B variable charge, X-linked 3B 2.78131
UTS2 urotensin 2 2.78131
FMO3 flavin containing monooxygenase 3 2.78131
KRT80 keratin 80, type II 2.78131
CCER2 coiled-coil glutamate-rich protein 2 2.78131
NOTCH2NLB notch 2 N-terminal like B 2.78131
LHFPL7 LHFPL tetraspan subfamily member 7 2.78131
H2BW1 H2B.W histone 1 2.78131
GARIN1A golgi associated RAB2 interactor 1A 2.78131
STING1 stimulator of interferon response cGAMP interactor 1 2.78131
H2BC1 H2B clustered histone 1 2.78131
CAVIN2 caveolae associated protein 2 2.78131
SPMIP9 sperm microtubule inner protein 9 2.78131
TAS2R60 taste receptor, type 2, member 60 2.78131
RGS21 regulator of G-protein signaling 21 2.78131
PGLYRP1 peptidoglycan recognition protein 1 2.78131
DSG1 desmoglein 1 2.78131
DTHD1 death domain containing 1 2.78131
SECTM1 secreted and transmembrane 1 2.78131
GAGE2A G antigen 2A 2.78131
ATP13A5 ATPase type 13A5 2.78131
CPNE6 copine VI (neuronal) 2.78131
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 2.78131
SLCO1B3 solute carrier organic anion transporter family, member 1B3 2.78131
SIX6 SIX homeobox 6 2.78131
BBS5 Bardet-Biedl syndrome 5 2.78131
GOLGA6L4 golgin A6 family-like 4 2.78131
SCRT1 scratch family zinc finger 1 2.78131
S100B S100 calcium binding protein B 2.78131
ARMS2 age-related maculopathy susceptibility 2 2.78131
SPDYE16 speedy/RINGO cell cycle regulator family member E16 2.78131
C1QTNF9 C1q and tumor necrosis factor related protein 9 2.78131
PRRT4 proline-rich transmembrane protein 4 2.78131
SLAMF7 SLAM family member 7 2.78131
LEF1 lymphoid enhancer-binding factor 1 2.78131
BHLHA9 basic helix-loop-helix family, member a9 2.78131
OR2A14 olfactory receptor, family 2, subfamily A, member 14 2.78131
HLF hepatic leukemia factor 2.78131
STAB2 stabilin 2 2.78131
ANKRD65 ankyrin repeat domain 65 2.78131
CAMK2B calcium/calmodulin-dependent protein kinase II beta 2.78131
HPD 4-hydroxyphenylpyruvate dioxygenase 2.78131
SERINC4 serine incorporator 4 2.78131
IRGM immunity-related GTPase family, M 2.78131
BAHCC1 BAH domain and coiled-coil containing 1 2.78131
MUC13 mucin 13, cell surface associated 2.78131
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 2.78131
TTC16 tetratricopeptide repeat domain 16 2.78131
ADORA3 adenosine A3 receptor 2.78131
EHF ets homologous factor 2.78131
APOB apolipoprotein B 2.78131
GP1BB glycoprotein Ib (platelet), beta polypeptide 2.78131
LRRC46 leucine rich repeat containing 46 2.78131
CCL27 chemokine (C-C motif) ligand 27 2.78131
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8 2.78131
SRRM5 serine/arginine repetitive matrix 5 2.78131
ERICH4 glutamate-rich 4 2.78131
EDN3 endothelin 3 2.78131
RGSL1 regulator of G-protein signaling like 1 2.78131
KLK2 kallikrein-related peptidase 2 2.78131
PRPH peripherin 2.78131
KRTAP10-2 keratin associated protein 10-2 2.78131
CAPSL calcyphosine-like 2.78131
CLUL1 clusterin-like 1 (retinal) 2.78131
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 2.78131
ADAM18 ADAM metallopeptidase domain 18 2.78131
WNT4 wingless-type MMTV integration site family, member 4 2.78131
CXORF58 chromosome X open reading frame 58 2.78131
ZNF835 zinc finger protein 835 2.78131
CCDC174 coiled-coil domain containing 174 2.78131
CCNI2 cyclin I family, member 2 2.78131
RGS4 regulator of G-protein signaling 4 2.78131
LRRC19 leucine rich repeat containing 19 2.78131
CHIT1 chitinase 1 (chitotriosidase) 2.78131
ITGB7 integrin, beta 7 2.78131
ANKRD55 ankyrin repeat domain 55 2.78131
SIGLEC11 sialic acid binding Ig-like lectin 11 2.78131
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 2.78131
PRTN3 proteinase 3 2.78131
SLC38A3 solute carrier family 38, member 3 2.78131
GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa 2.78131
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 2.78131
ABCA6 ATP-binding cassette, sub-family A (ABC1), member 6 2.78131
CD8A CD8a molecule 2.78131
NR2F1 nuclear receptor subfamily 2, group F, member 1 2.78131
FXYD3 FXYD domain containing ion transport regulator 3 2.78131
WFDC11 WAP four-disulfide core domain 11 2.78131
R3HDML R3H domain containing-like 2.78131
VWC2L von Willebrand factor C domain containing protein 2-like 2.78131
RP1 retinitis pigmentosa 1 (autosomal dominant) 2.78131
FOXB2 forkhead box B2 2.78131
TAS2R46 taste receptor, type 2, member 46 2.78131
ATP6V0D2 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 2.78131
TSKS testis-specific serine kinase substrate 2.78131
TRPM5 transient receptor potential cation channel, subfamily M, member 5 2.78131
APOL5 apolipoprotein L, 5 2.78131
EPHB3 EPH receptor B3 2.78131
BOLA2 bolA family member 2 2.78131
ONECUT3 one cut homeobox 3 2.78131
SSH3 slingshot protein phosphatase 3 2.78131
HCAR1 hydroxycarboxylic acid receptor 1 2.78131
C9ORF50 chromosome 9 open reading frame 50 2.78131
NUTM2F NUT family member 2F 2.78131
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal) 2.78131
CCDC83 coiled-coil domain containing 83 2.78131
TPH1 tryptophan hydroxylase 1 2.78131
GH1 growth hormone 1 2.78131
SDSL serine dehydratase-like 2.78131
SLC25A24 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24 2.77646
ACAD11 acyl-CoA dehydrogenase family, member 11 2.69346
ANGEL1 angel homolog 1 (Drosophila) 2.62775
PKLR pyruvate kinase, liver and RBC 2.58482
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase 2.57125
BTG2 BTG family, member 2 2.52701
LAMB1 laminin, beta 1 2.51952
ADARB1 adenosine deaminase, RNA-specific, B1 2.50602
VPS13B vacuolar protein sorting 13 homolog B (yeast) 2.49832
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8 2.48537
LGALS9 lectin, galactoside-binding, soluble, 9 2.46507
TF transferrin 2.46507
CLDN6 claudin 6 2.4631
FOXJ2 forkhead box J2 2.45298
FMR1 fragile X mental retardation 1 2.33995
GALK1 galactokinase 1 2.32013
TRIM39 tripartite motif containing 39 2.30938
TOMM34 translocase of outer mitochondrial membrane 34 2.30938
SET SET nuclear proto-oncogene 2.3035
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.29064
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12 2.26956
PCDHB12 protocadherin beta 12 2.26956
CARMIL3 capping protein regulator and myosin 1 linker 3 2.26193
REEP6 receptor accessory protein 6 2.24015
C6ORF52 chromosome 6 open reading frame 52 2.22775
EEF1AKMT3 EEF1A lysine methyltransferase 3 2.16972
HYAL3 hyaluronoglucosaminidase 3 2.16972
STK10 serine/threonine kinase 10 2.15232
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) 2.14725
PPP1R16B protein phosphatase 1, regulatory subunit 16B 2.14608
CD302 CD302 molecule 2.13911
AUTS2 autism susceptibility candidate 2 2.13808
SP110 SP110 nuclear body protein 2.13542
LIG1 ligase I, DNA, ATP-dependent 2.08847
THSD4 thrombospondin, type I, domain containing 4 2.08485
G6PD glucose-6-phosphate dehydrogenase 2.08008
NUAK2 NUAK family, SNF1-like kinase, 2 2.07986
EEIG2 EEIG family member 2 2.0602
EMC10 ER membrane protein complex subunit 10 2.04362
CLIC4 chloride intracellular channel 4 2.0275
ZNF485 zinc finger protein 485 2.01267
ZNF622 zinc finger protein 622 2.00428

decreased expression

Symbol Name Standardized Value
UPK1A uroplakin 1A -2.81774
WAS Wiskott-Aldrich syndrome -2.81774
MYO1H myosin IH -2.81774
RGPD1 RANBP2-like and GRIP domain containing 1 -2.81774
ZNF296 zinc finger protein 296 -2.81774
C1ORF116 chromosome 1 open reading frame 116 -2.81774
CXCL17 chemokine (C-X-C motif) ligand 17 -2.81774
CYP3A7 cytochrome P450, family 3, subfamily A, polypeptide 7 -2.78131
MOGAT3 monoacylglycerol O-acyltransferase 3 -2.78131
FOXJ3 forkhead box J3 -2.78131
LRRC61 leucine rich repeat containing 61 -2.78131
CABCOCO1 ciliary associated calcium binding coiled-coil 1 -2.78131
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -2.78131
ATP5MGL ATP synthase membrane subunit g like -2.78131
CD38 CD38 molecule -2.78131
DCST1 DC-STAMP domain containing 1 -2.78131
MMP10 matrix metallopeptidase 10 -2.78131
LSM11 LSM11, U7 small nuclear RNA associated -2.78131
C1ORF146 chromosome 1 open reading frame 146 -2.78131
B3GALNT1 beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group) -2.78131
CATSPERD catsper channel auxiliary subunit delta -2.78131
APP-DT APP divergent transcript -2.78131
HNF4G hepatocyte nuclear factor 4, gamma -2.78131
ELF4 E74-like factor 4 (ets domain transcription factor) -2.78131
LRRTM1 leucine rich repeat transmembrane neuronal 1 -2.78131
ADRB2 adrenoceptor beta 2, surface -2.78131
HSPB6 heat shock protein, alpha-crystallin-related, B6 -2.78131
SAMD15 sterile alpha motif domain containing 15 -2.78131
NRROS negative regulator of reactive oxygen species -2.78131
TNNI1 troponin I type 1 (skeletal, slow) -2.78131
UBXN10 UBX domain protein 10 -2.78131
IFI35 interferon-induced protein 35 -2.78131
CIDEA cell death-inducing DFFA-like effector a -2.78131
RUMY3 RUMY family member 3 -2.78131
RHPN1 rhophilin, Rho GTPase binding protein 1 -2.78131
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -2.78131
RRH retinal pigment epithelium-derived rhodopsin homolog -2.78131
TEX29 testis expressed 29 -2.78131
SLC51A solute carrier family 51, alpha subunit -2.78131
SAXO4 stabilizer of axonemal microtubules 4 -2.71561
TGFB2 transforming growth factor, beta 2 -2.71561
PPP1R15A protein phosphatase 1, regulatory subunit 15A -2.69055
SLCO1B1 solute carrier organic anion transporter family, member 1B1 -2.68758
NKTR natural killer cell triggering receptor -2.63843
TRMT1L tRNA methyltransferase 1 homolog (S. cerevisiae)-like -2.62659
BCL6B B-cell CLL/lymphoma 6, member B -2.59697
LYG2 lysozyme G-like 2 -2.59697
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15 -2.58106
RNF130 ring finger protein 130 -2.58106
GPC4 glypican 4 -2.57125
TRIM45 tripartite motif containing 45 -2.55832
PODXL podocalyxin-like -2.54894
CLPTM1 cleft lip and palate associated transmembrane protein 1 -2.51952
NAA20 N(alpha)-acetyltransferase 20, NatB catalytic subunit -2.49288
RAB25 RAB25, member RAS oncogene family -2.48852
BMP2K BMP2 inducible kinase -2.48852
COPS2 COP9 signalosome subunit 2 -2.46334
CLU clusterin -2.43339
FBXW11 F-box and WD repeat domain containing 11 -2.41369
PGAP4 post-GPI attachment to proteins GalNAc transferase 4 -2.41367
PRODH proline dehydrogenase (oxidase) 1 -2.41367
RPL24 ribosomal protein L24 -2.38781
BAG4 BCL2-associated athanogene 4 -2.36787
NPIPA5 nuclear pore complex interacting protein family, member A5 -2.3658
APH1A APH1A gamma secretase subunit -2.36255
GTF2H2 general transcription factor IIH, polypeptide 2, 44kDa -2.36255
CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2 -2.35643
DOCK10 dedicator of cytokinesis 10 -2.331
SAMD14 sterile alpha motif domain containing 14 -2.331
RTN3 reticulon 3 -2.3224
CAPN5 calpain 5 -2.32161
SCML1 sex comb on midleg-like 1 (Drosophila) -2.30441
SFXN1 sideroflexin 1 -2.29855
EDEM2 ER degradation enhancer, mannosidase alpha-like 2 -2.28038
MT2A metallothionein 2A -2.27238
KBTBD12 kelch repeat and BTB (POZ) domain containing 12 -2.26956
MCM4 minichromosome maintenance complex component 4 -2.26416
MRPL36 mitochondrial ribosomal protein L36 -2.26145
ANKRD26 ankyrin repeat domain 26 -2.23474
LSM8 LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.23423
STBD1 starch binding domain 1 -2.23413
PUS7 pseudouridylate synthase 7 (putative) -2.23185
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) -2.23185
SGPL1 sphingosine-1-phosphate lyase 1 -2.21169
SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa -2.16886
TRAPPC14 trafficking protein particle complex subunit 14 -2.1546
RAB8A RAB8A, member RAS oncogene family -2.14799
CDK10 cyclin-dependent kinase 10 -2.11513
ITGB1BP1 integrin beta 1 binding protein 1 -2.11093
TEF thyrotrophic embryonic factor -2.10243
TBCE tubulin folding cofactor E -2.08583
SUZ12 SUZ12 polycomb repressive complex 2 subunit -2.07986
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa -2.07838
TMEM125 transmembrane protein 125 -2.0602
MTMR14 myotubularin related protein 14 -2.0275