NR1H2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description nuclear receptor subfamily 1, group H, member 2|The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]).[supplied by OMIM, Jan 2010] (NCBI Entrez Gene Database, 7376)
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Genes

356 genes differentially expressed following the NR1H2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 2.49554
HORMAD1 HORMA domain containing 1 2.49554
UMOD uromodulin 2.49554
OSR2 odd-skipped related transciption factor 2 2.49554
VSTM2A V-set and transmembrane domain containing 2A 2.49554
PERM1 PPARGC1 and ESRR induced regulator, muscle 1 2.49554
FOXR1 forkhead box R1 2.49554
CSTL1 cystatin-like 1 2.49554
ARHGAP36 Rho GTPase activating protein 36 2.49554
SLC16A6 solute carrier family 16, member 6 2.49554
CD300A CD300a molecule 2.49554
XCL1 chemokine (C motif) ligand 1 2.49554
HES7 hes family bHLH transcription factor 7 2.49554
SLC35G5 solute carrier family 35, member G5 2.49554
LAPTM5 lysosomal protein transmembrane 5 2.49554
HMGCLL1 3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1 2.49554
UPK3A uroplakin 3A 2.49554
INHBC inhibin, beta C 2.49554
RASL10A RAS-like, family 10, member A 2.49554
CEMP1 cementum protein 1 2.49554
SLC26A9 solute carrier family 26 (anion exchanger), member 9 2.49554
IGFL4 IGF-like family member 4 2.49554
IGFL2 IGF-like family member 2 2.49554
OR51A7 olfactory receptor, family 51, subfamily A, member 7 2.49554
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 2.49554
ASPA aspartoacylase 2.49554
C19ORF67 chromosome 19 open reading frame 67 2.49554
SLC35B1 solute carrier family 35, member B1 2.49554
LRRC61 leucine rich repeat containing 61 2.49554
U2SURP U2 snRNP-associated SURP domain containing 2.49554
NPTX1 neuronal pentraxin I 2.49554
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 2.49554
HMX3 H6 family homeobox 3 2.49554
C2ORF78 chromosome 2 open reading frame 78 2.49554
SPON2 spondin 2, extracellular matrix protein 2.49554
TDO2 tryptophan 2,3-dioxygenase 2.49554
PNLDC1 poly(A)-specific ribonuclease (PARN)-like domain containing 1 2.49554
STAP1 signal transducing adaptor family member 1 2.49554
LRRIQ4 leucine-rich repeats and IQ motif containing 4 2.49554
SOWAHB sosondowah ankyrin repeat domain family member B 2.49554
SHCBP1L SHC SH2-domain binding protein 1-like 2.49554
GIMAP8 GTPase, IMAP family member 8 2.49554
TNIP3 TNFAIP3 interacting protein 3 2.49554
PECAM1 platelet/endothelial cell adhesion molecule 1 2.49554
SLC9C2 solute carrier family 9, member C2 (putative) 2.49554
ADAMTSL5 ADAMTS-like 5 2.49554
TDRD9 tudor domain containing 9 2.49554
TMEM217 transmembrane protein 217 2.49554
SMIM5 small integral membrane protein 5 2.49554
CELA1 chymotrypsin-like elastase family, member 1 2.49554
CD69 CD69 molecule 2.49554
GRM6 glutamate receptor, metabotropic 6 2.49554
COL19A1 collagen, type XIX, alpha 1 2.49554
LOC124906892 uncharacterized LOC124906892 2.49554
CFAP65 cilia and flagella associated protein 65 2.49554
STYXL2 serine/threonine/tyrosine interacting like 2 2.49554
PCDHGA9 protocadherin gamma subfamily A, 9 2.49554
OTOA otoancorin 2.49554
LINGO1 leucine rich repeat and Ig domain containing 1 2.49554
PNLIPRP1 pancreatic lipase-related protein 1 2.49554
DUSP8 dual specificity phosphatase 8 2.49554
APOBEC3H apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H 2.49554
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 2.49554
KLB klotho beta 2.49554
ADRB1 adrenoceptor beta 1 2.49554
CCN6 cellular communication network factor 6 2.49554
G6PC1 glucose-6-phosphatase catalytic subunit 1 2.49554
LRTM3 leucine rich repeat transmembrane protein 3 2.49554
SPATA31G1 SPATA31 subfamily G member 1 2.49554
SPEGNB SPEG neighbor 2.49554
PRR20G proline rich 20G 2.49554
LITAFD LITAF domain containing 2.49554
GREP1 glycine rich extracellular protein 1 2.49554
PVALEF parvalbumin like EF-hand containing 2.49554
OR52P1 olfactory receptor family 52 subfamily P member 1 (gene/pseudogene) 2.49554
IHO1 interactor of HORMAD1 1 2.49554
UBE2L5 ubiquitin conjugating enzyme E2 L5 2.49554
H2BC3 H2B clustered histone 3 2.49554
ZNF606 zinc finger protein 606 2.49554
FCMR Fc fragment of IgM receptor 2.49554
PRRT1 proline-rich transmembrane protein 1 2.49554
SCIMP SLP adaptor and CSK interacting membrane protein 2.49554
LEF1 lymphoid enhancer-binding factor 1 2.49554
ZNF575 zinc finger protein 575 2.49554
NPNT nephronectin 2.49554
CLIP4 CAP-GLY domain containing linker protein family, member 4 2.49554
CLEC3B C-type lectin domain family 3, member B 2.49554
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 2.49554
CLDN5 claudin 5 2.49554
CD300LG CD300 molecule-like family member g 2.49554
LIPF lipase, gastric 2.49554
SCN7A sodium channel, voltage gated, type VII alpha subunit 2.49554
EXOC3L1 exocyst complex component 3-like 1 2.49554
OR52E5 olfactory receptor, family 52, subfamily E, member 5 2.49554
ZNF705A zinc finger protein 705A 2.49554
C15ORF62 chromosome 15 open reading frame 62 2.49554
SDR16C5 short chain dehydrogenase/reductase family 16C, member 5 2.49554
PCDHGC5 protocadherin gamma subfamily C, 5 2.49554
ROPN1 rhophilin associated tail protein 1 2.49554
GDF6 growth differentiation factor 6 2.49554
GPR85 G protein-coupled receptor 85 2.49554
GPR83 G protein-coupled receptor 83 2.49554
CNTFR ciliary neurotrophic factor receptor 2.49554
S100B S100 calcium binding protein B 2.49554
TBX20 T-box 20 2.49554
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion 2.49554
FBP1 fructose-1,6-bisphosphatase 1 2.49554
CALHM1 calcium homeostasis modulator 1 2.49554
C11ORF16 chromosome 11 open reading frame 16 2.49554
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 2.49554
TMED6 transmembrane emp24 protein transport domain containing 6 2.49554
CDH19 cadherin 19, type 2 2.49554
TRIM50 tripartite motif containing 50 2.49554
CGB7 chorionic gonadotropin, beta polypeptide 7 2.49554
DRD4 dopamine receptor D4 2.49554
BCO1 beta-carotene oxygenase 1 2.49554
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 2.49554
WFDC8 WAP four-disulfide core domain 8 2.49554
PTGIR prostaglandin I2 (prostacyclin) receptor (IP) 2.49554
CPSF4L cleavage and polyadenylation specific factor 4-like 2.49554
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 2.49554
NGF nerve growth factor (beta polypeptide) 2.49554
ENDOU endonuclease, polyU-specific 2.49554
GAL3ST2 galactose-3-O-sulfotransferase 2 2.49554
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 2.49554
FNDC1 fibronectin type III domain containing 1 2.49554
RAD21L1 RAD21-like 1 (S. pombe) 2.49554
TNN tenascin N 2.49554
ARG1 arginase 1 2.49554
BTNL9 butyrophilin-like 9 2.49554
C11ORF96 chromosome 11 open reading frame 96 2.49554
VWA7 von Willebrand factor A domain containing 7 2.49554
IL1A interleukin 1, alpha 2.49554
CLEC4A C-type lectin domain family 4, member A 2.49554
CLEC1A C-type lectin domain family 1, member A 2.49554
ADAP1 ArfGAP with dual PH domains 1 2.49554
RIN3 Ras and Rab interactor 3 2.49554
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 2.49554
LAMB4 laminin, beta 4 2.49554
CCNA1 cyclin A1 2.49554
WNT4 wingless-type MMTV integration site family, member 4 2.49554
CLEC18B C-type lectin domain family 18, member B 2.49554
SLC17A2 solute carrier family 17, member 2 2.49554
GOLGA8H golgin A8 family, member H 2.49554
IDI2 isopentenyl-diphosphate delta isomerase 2 2.49554
CTSF cathepsin F 2.49554
PENK proenkephalin 2.49554
KISS1 KiSS-1 metastasis-suppressor 2.49554
EMILIN1 elastin microfibril interfacer 1 2.49554
PRDM9 PR domain containing 9 2.49554
CATIP ciliogenesis associated TTC17 interacting protein 2.49554
KLK7 kallikrein-related peptidase 7 2.49554
CRTAM cytotoxic and regulatory T cell molecule 2.49554
ARFRP1 ADP-ribosylation factor related protein 1 2.49554
TTC21B tetratricopeptide repeat domain 21B 2.49554
FGG fibrinogen gamma chain 2.49554
RBM24 RNA binding motif protein 24 2.49554
TP63 tumor protein p63 2.49554
CFB complement factor B 2.49554
OXER1 oxoeicosanoid (OXE) receptor 1 2.49554
ACSM1 acyl-CoA synthetase medium-chain family member 1 2.49554
ALOX5AP arachidonate 5-lipoxygenase-activating protein 2.49554
OR51I2 olfactory receptor, family 51, subfamily I, member 2 2.49554
PLA2G1B phospholipase A2, group IB (pancreas) 2.49554
AZU1 azurocidin 1 2.49554
CCDC166 coiled-coil domain containing 166 2.49554
FAM25C family with sequence similarity 25, member C 2.49554
PRRX1 paired related homeobox 1 2.49554
MSLN mesothelin 2.49554
KCNH3 potassium channel, voltage gated eag related subfamily H, member 3 2.49554
PRAP1 proline-rich acidic protein 1 2.49554
GCM2 glial cells missing homolog 2 (Drosophila) 2.49554
NUTM2B NUT family member 2B 2.49554
AMER2 APC membrane recruitment protein 2 2.49554
TMEM213 transmembrane protein 213 2.49554
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8 2.49554
PSORS1C2 psoriasis susceptibility 1 candidate 2 2.49554
SPDYE2B speedy/RINGO cell cycle regulator family member E2B 2.49554
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 2.49554
FRMPD1 FERM and PDZ domain containing 1 2.49554
PGPEP1L pyroglutamyl-peptidase I-like 2.49554
POPDC2 popeye domain containing 2 2.49554
GPBAR1 G protein-coupled bile acid receptor 1 2.49554
PLGLB2 plasminogen-like B2 2.49554
SLCO1C1 solute carrier organic anion transporter family, member 1C1 2.49554
PRSS53 protease, serine, 53 2.49554
CEACAM20 carcinoembryonic antigen-related cell adhesion molecule 20 2.49554
OSGIN1 oxidative stress induced growth inhibitor 1 2.49554
TMPRSS15 transmembrane protease, serine 15 2.49554
TMEM37 transmembrane protein 37 2.48429
RPRM reprimo, TP53 dependent G2 arrest mediator candidate 2.46781
STK40 serine/threonine kinase 40 2.46781
LEKR1 leucine, glutamate and lysine rich 1 2.46781
FZD7 frizzled class receptor 7 2.46781
NAA40 N(alpha)-acetyltransferase 40, NatD catalytic subunit 2.46001
RINL Ras and Rab interactor-like 2.46001
ISM2 isthmin 2 2.455
DRICH1 aspartate-rich 1 2.455
MPST mercaptopyruvate sulfurtransferase 2.44295
LHX6 LIM homeobox 6 2.43733
CST6 cystatin E/M 2.43733
GJA4 gap junction protein, alpha 4, 37kDa 2.43733
RCSD1 RCSD domain containing 1 2.43733
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 2.43733
TMEM82 transmembrane protein 82 2.43733
PIK3IP1 phosphoinositide-3-kinase interacting protein 1 2.42373
ZFP36L2 ZFP36 ring finger protein-like 2 2.37883
SEZ6L seizure related 6 homolog (mouse)-like 2.36947
FAM114A1 family with sequence similarity 114, member A1 2.3654
AKNA AT-hook transcription factor 2.36214
PPAT phosphoribosyl pyrophosphate amidotransferase 2.33363
ERBIN erbb2 interacting protein 2.3158
TRDMT1 tRNA aspartic acid methyltransferase 1 2.31509
GPN2 GPN-loop GTPase 2 2.30422
SCRN3 secernin 3 2.30422
MAP3K21 mitogen-activated protein kinase kinase kinase 21 2.28432
BSG basigin (Ok blood group) 2.272
CDAN1 codanin 1 2.24322
MARCHF7 membrane associated ring-CH-type finger 7 2.24054
ANKHD1 ankyrin repeat and KH domain containing 1 2.22885
PNRC2 proline-rich nuclear receptor coactivator 2 2.19389
SCG3 secretogranin III 2.17825
LRRC19 leucine rich repeat containing 19 2.16055
AP5S1 adaptor-related protein complex 5, sigma 1 subunit 2.16055
OPN1SW opsin 1 (cone pigments), short-wave-sensitive 2.16055
CRMP1 collapsin response mediator protein 1 2.15148
BASP1 brain abundant, membrane attached signal protein 1 2.14423
TMEM69 transmembrane protein 69 2.14423
RABEP1 rabaptin, RAB GTPase binding effector protein 1 2.14423
ICA1 islet cell autoantigen 1, 69kDa 2.13903
PDCD11 programmed cell death 11 2.12961
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 2.11605
AIM2 absent in melanoma 2 2.11119
RAD1 RAD1 checkpoint DNA exonuclease 2.10344
WAPL WAPL cohesin release factor 2.1034
TMEM109 transmembrane protein 109 2.09862
TMEM198 transmembrane protein 198 2.0933
NMRK1 nicotinamide riboside kinase 1 2.08318
WDR62 WD repeat domain 62 2.06768
CRB3 crumbs family member 3 2.06358
SH3BP1 SH3-domain binding protein 1 2.06008
BBIP1 BBSome interacting protein 1 2.05423
MYADM myeloid-associated differentiation marker 2.04722
SLC25A42 solute carrier family 25, member 42 2.03578
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 2.02886
NMNAT3 nicotinamide nucleotide adenylyltransferase 3 2.02886
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 2.02203
METRNL meteorin, glial cell differentiation regulator-like 2.02203
TSPAN2 tetraspanin 2 2.01658
RTF2 replication termination factor 2 2.01383
CNGA1 cyclic nucleotide gated channel alpha 1 2.01383
BCS1L BC1 (ubiquinol-cytochrome c reductase) synthesis-like 2.00906
ATP1B2 ATPase, Na+/K+ transporting, beta 2 polypeptide 2.00819

decreased expression

Symbol Name Standardized Value
KCNQ4 potassium channel, voltage gated KQT-like subfamily Q, member 4 -2.49554
HNRNPL heterogeneous nuclear ribonucleoprotein L -2.49554
MMP26 matrix metallopeptidase 26 -2.49554
PHF5A PHD finger protein 5A -2.49554
SLC22A3 solute carrier family 22 (organic cation transporter), member 3 -2.49554
SPTSSB serine palmitoyltransferase, small subunit B -2.49554
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -2.49554
PPP4R1 protein phosphatase 4, regulatory subunit 1 -2.49554
FBXO30 F-box protein 30 -2.49554
NCKAP1 NCK-associated protein 1 -2.49554
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 -2.49554
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 -2.49554
DMAP1 DNA methyltransferase 1 associated protein 1 -2.49554
MALRD1 MAM and LDL receptor class A domain containing 1 -2.49554
MIOS missing oocyte, meiosis regulator, homolog (Drosophila) -2.49554
MYO19 myosin XIX -2.49554
MYH2 myosin, heavy chain 2, skeletal muscle, adult -2.49554
CLDN20 claudin 20 -2.49554
ADGRB3 adhesion G protein-coupled receptor B3 -2.49554
SPDYE1 speedy/RINGO cell cycle regulator family member E1 -2.49554
CCDC112 coiled-coil domain containing 112 -2.49554
RELL2 RELT-like 2 -2.49554
ASF1A anti-silencing function 1A histone chaperone -2.49554
KANK3 KN motif and ankyrin repeat domains 3 -2.49554
SQSTM1 sequestosome 1 -2.48458
SLC35H1 solute carrier family 35 member H1 -2.4766
BCOR BCL6 corepressor -2.46242
PDCD1 programmed cell death 1 -2.46001
ACSL6 acyl-CoA synthetase long-chain family member 6 -2.46001
TBC1D9 TBC1 domain family, member 9 (with GRAM domain) -2.46001
FAM209A family with sequence similarity 209, member A -2.46001
FLRT1 fibronectin leucine rich transmembrane protein 1 -2.46001
SLC38A8 solute carrier family 38, member 8 -2.46001
BCAP29 B-cell receptor-associated protein 29 -2.46001
ADGRD1 adhesion G protein-coupled receptor D1 -2.46001
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) -2.46001
ZC3H12D zinc finger CCCH-type containing 12D -2.46001
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13 -2.46001
IP6K3 inositol hexakisphosphate kinase 3 -2.46001
TTC16 tetratricopeptide repeat domain 16 -2.46001
CRYBA4 crystallin, beta A4 -2.46001
PDE6G phosphodiesterase 6G, cGMP-specific, rod, gamma -2.46001
CD160 CD160 molecule -2.46001
CUTC cutC copper transporter -2.46001
ASGR2 asialoglycoprotein receptor 2 -2.46001
LDLRAD2 low density lipoprotein receptor class A domain containing 2 -2.46001
STRIT1 small transmembrane regulator of ion transport 1 -2.46001
C3ORF49 chromosome 3 open reading frame 49 -2.46001
IQCN IQ motif containing N -2.46001
ODAD4 outer dynein arm docking complex subunit 4 -2.46001
TENT5C terminal nucleotidyltransferase 5C -2.46001
SLC49A4 solute carrier family 49 member 4 -2.46001
CPM carboxypeptidase M -2.46001
A1CF APOBEC1 complementation factor -2.46001
CEL carboxyl ester lipase -2.46001
PLA2G4B phospholipase A2, group IVB (cytosolic) -2.46001
ZNF541 zinc finger protein 541 -2.46001
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 -2.46001
CERS3 ceramide synthase 3 -2.46001
ADGRG3 adhesion G protein-coupled receptor G3 -2.46001
TRPC7 transient receptor potential cation channel, subfamily C, member 7 -2.46001
ANGPTL4 angiopoietin-like 4 -2.46001
INSYN2A inhibitory synaptic factor 2A -2.45131
TRIM65 tripartite motif containing 65 -2.44414
PCCA propionyl CoA carboxylase, alpha polypeptide -2.36605
PIGX phosphatidylinositol glycan anchor biosynthesis, class X -2.3654
AGPS alkylglycerone phosphate synthase -2.33363
ARL15 ADP-ribosylation factor-like 15 -2.30387
BEST2 bestrophin 2 -2.29036
VAMP5 vesicle-associated membrane protein 5 -2.24916
IL6R interleukin 6 receptor -2.24916
NOL7 nucleolar protein 7, 27kDa -2.23384
FRRS1L ferric-chelate reductase 1-like -2.23122
HSDL1 hydroxysteroid dehydrogenase like 1 -2.23016
MMP21 matrix metallopeptidase 21 -2.22809
KCTD8 potassium channel tetramerization domain containing 8 -2.22457
H4C16 H4 histone 16 -2.2084
ZFAND6 zinc finger, AN1-type domain 6 -2.20335
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A -2.18668
VGLL4 vestigial-like family member 4 -2.16055
EHD1 EH-domain containing 1 -2.16055
C3ORF70 chromosome 3 open reading frame 70 -2.16055
CDKN3 cyclin-dependent kinase inhibitor 3 -2.15979
RFX8 RFX family member 8, lacking RFX DNA binding domain -2.14151
TMEM129 transmembrane protein 129, E3 ubiquitin protein ligase -2.13287
IDS iduronate 2-sulfatase -2.13185
GORASP1 golgi reassembly stacking protein 1, 65kDa -2.12328
JHY junctional cadherin complex regulator -2.121
SLC35A5 solute carrier family 35, member A5 -2.10344
EID3 EP300 interacting inhibitor of differentiation 3 -2.10344
ARRDC4 arrestin domain containing 4 -2.10344
ANKRD35 ankyrin repeat domain 35 -2.09862
PIP4P2 phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 -2.09483
CPSF1 cleavage and polyadenylation specific factor 1, 160kDa -2.07665
ATE1 arginyltransferase 1 -2.07441
BCL2L14 BCL2-like 14 (apoptosis facilitator) -2.07145
NEMP1 nuclear envelope integral membrane protein 1 -2.05565
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 -2.04722
RGN regucalcin -2.04333
RASSF5 Ras association (RalGDS/AF-6) domain family member 5 -2.03016
ZNF112 zinc finger protein 112 -2.02886
OMA1 OMA1 zinc metallopeptidase -2.02701
CARD10 caspase recruitment domain family, member 10 -2.00156