NR1H3 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description nuclear receptor subfamily 1, group H, member 3|The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] (NCBI Entrez Gene Database, 10062)
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Genes

314 genes differentially expressed following the NR1H3 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) 4.65388
SLC15A5 solute carrier family 15, member 5 4.65388
GJB3 gap junction protein, beta 3, 31kDa 4.65388
TMEM100 transmembrane protein 100 4.65388
APLN apelin 4.65388
MYBPC3 myosin binding protein C, cardiac 4.65388
TRPC6 transient receptor potential cation channel, subfamily C, member 6 4.65388
CASP4 caspase 4, apoptosis-related cysteine peptidase 4.65388
SLC4A9 solute carrier family 4, sodium bicarbonate cotransporter, member 9 4.65388
DGAT2L6 diacylglycerol O-acyltransferase 2-like 6 4.65388
PCDHB3 protocadherin beta 3 4.65388
PGAM4 phosphoglycerate mutase family member 4 4.65388
TMEM176B transmembrane protein 176B 4.65388
CABP4 calcium binding protein 4 4.65388
IL22RA1 interleukin 22 receptor, alpha 1 4.65388
LRRD1 leucine-rich repeats and death domain containing 1 4.65388
SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites 4.65388
PLEKHG7 pleckstrin homology domain containing, family G (with RhoGef domain) member 7 4.65388
PLCH2 phospholipase C, eta 2 4.65388
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 4.65388
XCL1 chemokine (C motif) ligand 1 4.65388
KRTAP5-9 keratin associated protein 5-9 4.65388
STAP1 signal transducing adaptor family member 1 4.65388
PRR29 proline rich 29 4.65388
HMX3 H6 family homeobox 3 4.65388
KLLN killin, p53-regulated DNA replication inhibitor 4.65388
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 4.65388
LGALS4 lectin, galactoside-binding, soluble, 4 4.65388
GNRHR gonadotropin-releasing hormone receptor 4.65388
SHE Src homology 2 domain containing E 4.65388
RGPD4 RANBP2-like and GRIP domain containing 4 4.65388
RPL3L ribosomal protein L3-like 4.65388
DRP2 dystrophin related protein 2 4.65388
OXTR oxytocin receptor 4.65388
TPSD1 tryptase delta 1 4.65388
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1 4.65388
C19ORF67 chromosome 19 open reading frame 67 4.65388
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 4.65388
GPR75 G protein-coupled receptor 75 4.65388
FABP9 fatty acid binding protein 9, testis 4.65388
SYCP2 synaptonemal complex protein 2 4.65388
SDR16C5 short chain dehydrogenase/reductase family 16C, member 5 4.65388
CSAG3 CSAG family, member 3 4.65388
KL klotho 4.65388
OR51M1 olfactory receptor, family 51, subfamily M, member 1 4.65388
GPR37L1 G protein-coupled receptor 37 like 1 4.65388
DOK2 docking protein 2, 56kDa 4.65388
GC group-specific component (vitamin D binding protein) 4.65388
ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11 4.65388
FOXN4 forkhead box N4 4.65388
FMO1 flavin containing monooxygenase 1 4.65388
PNLIPRP2 pancreatic lipase-related protein 2 4.65388
FDXACB1 ferredoxin-fold anticodon binding domain containing 1 4.65388
LINGO3 leucine rich repeat and Ig domain containing 3 4.65388
H2BC3 H2B clustered histone 3 4.65388
UBE2L5 ubiquitin conjugating enzyme E2 L5 4.65388
CLEC20A C-type lectin domain containing 20A 4.65388
CIMAP1B ciliary microtubule associated protein 1B 4.65388
TINAG tubulointerstitial nephritis antigen 4.65388
GDF9 growth differentiation factor 9 4.65388
TAS1R1 taste receptor, type 1, member 1 4.65388
ZNF99 zinc finger protein 99 4.65388
RAET1G retinoic acid early transcript 1G 4.65388
SPDYE6 speedy/RINGO cell cycle regulator family member E6 4.65388
DNAI2 dynein, axonemal, intermediate chain 2 4.65388
IL12RB1 interleukin 12 receptor, beta 1 4.65388
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 4.65388
KLHL31 kelch-like family member 31 4.65388
GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic 4.65388
HPR haptoglobin-related protein 4.65388
SLC22A25 solute carrier family 22, member 25 4.65388
OVOL3 ovo-like zinc finger 3 4.65388
TLR7 toll-like receptor 7 4.65388
TLR8 toll-like receptor 8 4.65388
MIP major intrinsic protein of lens fiber 4.65388
OVOL1 ovo-like zinc finger 1 4.65388
ZFP3 ZFP3 zinc finger protein 4.65388
IL1R2 interleukin 1 receptor, type II 4.65388
SCPPPQ1 secretory calcium-binding phosphoprotein proline-glutamine rich 1 4.65388
FAM161B family with sequence similarity 161, member B 4.65388
CFI complement factor I 4.65388
TIGD3 tigger transposable element derived 3 4.65388
GOLGA6D golgin A6 family, member D 4.65388
TRIM55 tripartite motif containing 55 4.65388
ODF4 outer dense fiber of sperm tails 4 4.65388
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 4.65388
CDK20 cyclin-dependent kinase 20 4.65388
KISS1 KiSS-1 metastasis-suppressor 4.65388
LOC124901872 uncharacterized LOC124901872 4.65388
GLOD5 glyoxalase domain containing 5 4.65388
CLRN2 clarin 2 4.65388
VWA3B von Willebrand factor A domain containing 3B 4.65388
TMEM132D transmembrane protein 132D 4.65388
KCNK4 potassium channel, two pore domain subfamily K, member 4 4.65388
TCEA3 transcription elongation factor A (SII), 3 4.65388
CST1 cystatin SN 4.65388
SERPINB10 serpin peptidase inhibitor, clade B (ovalbumin), member 10 4.65388
THTPA thiamine triphosphatase 4.65388
CRYBB3 crystallin, beta B3 4.65388
KLK3 kallikrein-related peptidase 3 4.65388
PRPH peripherin 4.65388
C11ORF42 chromosome 11 open reading frame 42 4.65388
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 4.65388
ADAM18 ADAM metallopeptidase domain 18 4.65388
C10ORF105 chromosome 10 open reading frame 105 4.65388
ZPBP zona pellucida binding protein 4.65388
GOLGA8S golgin A8 family, member S 4.65388
RIIAD1 regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1 4.65388
MZB1 marginal zone B and B1 cell-specific protein 4.65388
MOBP myelin-associated oligodendrocyte basic protein 4.65388
CSF1R colony stimulating factor 1 receptor 4.65388
TBX1 T-box 1 4.65388
ADAP1 ArfGAP with dual PH domains 1 4.65388
FGR FGR proto-oncogene, Src family tyrosine kinase 4.65388
EPHA3 EPH receptor A3 4.65388
NT5DC4 5'-nucleotidase domain containing 4 4.65388
NTN5 netrin 5 4.65388
PRH2 proline-rich protein HaeIII subfamily 2 4.65388
MOG myelin oligodendrocyte glycoprotein 4.65388
PCDHGB7 protocadherin gamma subfamily B, 7 4.65388
R3HDML R3H domain containing-like 4.65388
CEACAM16 carcinoembryonic antigen-related cell adhesion molecule 16 4.65388
FCN3 ficolin (collagen/fibrinogen domain containing) 3 4.65388
CLCA2 chloride channel accessory 2 4.65388
AGBL4 ATP/GTP binding protein-like 4 4.65388
LPA lipoprotein, Lp(a) 4.65388
DNAJB7 DnaJ (Hsp40) homolog, subfamily B, member 7 4.65388
TCF21 transcription factor 21 4.65388
ZNF396 zinc finger protein 396 4.65388
PADI1 peptidyl arginine deiminase, type I 4.65388
IRX1 iroquois homeobox 1 4.65388
POTEA POTE ankyrin domain family, member A 4.65388
OR5A1 olfactory receptor, family 5, subfamily A, member 1 4.65388
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 4.65388
CD86 CD86 molecule 4.65388
ESAM endothelial cell adhesion molecule 4.65388
NFE2 nuclear factor, erythroid 2 4.65388
TMEM45B transmembrane protein 45B 4.65388
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2 4.65388
SMYD1 SET and MYND domain containing 1 4.65388
CLCNKA chloride channel, voltage-sensitive Ka 4.65388
RHBG Rh family, B glycoprotein (gene/pseudogene) 4.65388
STAC2 SH3 and cysteine rich domain 2 4.58572
MYCBPAP MYCBP associated protein 4.25412
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 3.80622
DYNLL1 dynein, light chain, LC8-type 1 3.79981
LAG3 lymphocyte-activation gene 3 3.72757
IL6ST-DT IL6ST divergent transcript 3.72757
CYP4X1 cytochrome P450, family 4, subfamily X, polypeptide 1 3.72757
GAB3 GRB2-associated binding protein 3 3.72757
C19ORF73 chromosome 19 open reading frame 73 3.72757
ASMT acetylserotonin O-methyltransferase 3.72757
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1 3.72757
PRDM14 PR domain containing 14 3.45441
GXYLT1 glucoside xylosyltransferase 1 3.36289
CASP10 caspase 10, apoptosis-related cysteine peptidase 3.25936
C2 complement component 2 3.25936
NUDT4B nudix hydrolase 4B 3.25936
NLK nemo-like kinase 3.1214
SHLD2 shieldin complex subunit 2 2.81879
LRP2 low density lipoprotein receptor-related protein 2 2.64385
CDKL3 cyclin-dependent kinase-like 3 2.63761
CCNG2 cyclin G2 2.62633
PPIH peptidylprolyl isomerase H (cyclophilin H) 2.61479
EIF5A2 eukaryotic translation initiation factor 5A2 2.54466
ENDOD1 endonuclease domain containing 1 2.54448
KCNIP2 Kv channel interacting protein 2 2.54448
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2.44194
ARID4A AT rich interactive domain 4A (RBP1-like) 2.43621
TRIM33 tripartite motif containing 33 2.42817
MAT2B methionine adenosyltransferase II, beta 2.41738
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 2.41738
ABHD3 abhydrolase domain containing 3 2.39862
CCDC92 coiled-coil domain containing 92 2.38846
TRDN triadin 2.37238
BTK Bruton agammaglobulinemia tyrosine kinase 2.37238
COX4I1 cytochrome c oxidase subunit IV isoform 1 2.22659
ST14 suppression of tumorigenicity 14 (colon carcinoma) 2.22659
GLYATL2 glycine-N-acyltransferase-like 2 2.21847
FNDC3B fibronectin type III domain containing 3B 2.17761
CREB3L1 cAMP responsive element binding protein 3-like 1 2.16591
MTERF4 mitochondrial transcription termination factor 4 2.16561
ZNF428 zinc finger protein 428 2.16536
SNX1 sorting nexin 1 2.13518
NUDT21 nudix (nucleoside diphosphate linked moiety X)-type motif 21 2.13518
RABGAP1 RAB GTPase activating protein 1 2.11671
PET100 PET100 homolog (S. cerevisiae) 2.09131
KHSRP KH-type splicing regulatory protein 2.07515
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit 2.06499
ACY1 aminoacylase 1 2.04596
MCU mitochondrial calcium uniporter 2.04596
TEC tec protein tyrosine kinase 2.04135
HMGCL 3-hydroxymethyl-3-methylglutaryl-CoA lyase 2.03499
CNGA1 cyclic nucleotide gated channel alpha 1 2.02243
SIK2 salt-inducible kinase 2 2.02166
MMP24 matrix metallopeptidase 24 (membrane-inserted) 2.00414

decreased expression

Symbol Name Standardized Value
FBP1 fructose-1,6-bisphosphatase 1 -4.65388
PMP22 peripheral myelin protein 22 -4.65388
SOAT1 sterol O-acyltransferase 1 -4.65388
STRAP serine/threonine kinase receptor associated protein -4.65388
ZNF404 zinc finger protein 404 -4.65388
ANKRD36B ankyrin repeat domain 36B -4.54195
SOX30 SRY (sex determining region Y)-box 30 -4.45965
GJB5 gap junction protein, beta 5, 31.1kDa -4.45965
CCDC68 coiled-coil domain containing 68 -4.45965
ACOX2 acyl-CoA oxidase 2, branched chain -4.45965
GAGE10 G antigen 10 -4.45965
SLC14A2 solute carrier family 14 (urea transporter), member 2 -4.45965
SLC26A7 solute carrier family 26 (anion exchanger), member 7 -4.45965
FAM222A family with sequence similarity 222, member A -4.45965
DNAJC5G DnaJ (Hsp40) homolog, subfamily C, member 5 gamma -4.45965
PODNL1 podocan-like 1 -4.45965
NLRP3 NLR family, pyrin domain containing 3 -4.45965
TMEM213 transmembrane protein 213 -4.45965
C16ORF86 chromosome 16 open reading frame 86 -4.45965
APOL6 apolipoprotein L, 6 -4.45965
RHOV ras homolog family member V -4.45965
ITGB1BP2 integrin beta 1 binding protein (melusin) 2 -4.45965
WDR5B WD repeat domain 5B -4.45965
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 -4.45965
BATF2 basic leucine zipper transcription factor, ATF-like 2 -4.45965
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13 -4.45965
TDRD10 tudor domain containing 10 -4.45965
CD52 CD52 molecule -4.45965
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) -4.45965
HLA-DMB major histocompatibility complex, class II, DM beta -4.45965
MINAR1 membrane integral NOTCH2 associated receptor 1 -4.45965
MXRA5 matrix-remodelling associated 5 -4.45965
C17ORF78 chromosome 17 open reading frame 78 -4.45965
RBM24 RNA binding motif protein 24 -4.45965
OTOP2 otopetrin 2 -4.45965
LHX8 LIM homeobox 8 -4.45965
LOC124906010 uncharacterized LOC124906010 -4.45965
CMKLR1 chemerin chemokine-like receptor 1 -4.45965
SOX7 SRY (sex determining region Y)-box 7 -4.45965
PCDHB16 protocadherin beta 16 -4.45965
THPO thrombopoietin -4.45965
DLEC1 deleted in lung and esophageal cancer 1 -4.45965
TMEM179 transmembrane protein 179 -4.45965
PNPLA1 patatin-like phospholipase domain containing 1 -4.45965
STIM2 stromal interaction molecule 2 -4.4202
DOC2A double C2-like domains, alpha -3.76727
ZBTB22 zinc finger and BTB domain containing 22 -3.71994
NPHS1 nephrosis 1, congenital, Finnish type (nephrin) -3.71994
LIPT1 lipoyltransferase 1 -3.28966
RAB40C RAB40C, member RAS oncogene family -3.25309
H3-3A H3.3 histone A -3.22843
CCBE1 collagen and calcium binding EGF domains 1 -3.14183
OXCT2 3-oxoacid CoA transferase 2 -3.1282
NPIPA5 nuclear pore complex interacting protein family, member A5 -3.1282
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae) -3.08381
TMEM178B transmembrane protein 178B -2.92942
WDR72 WD repeat domain 72 -2.83947
ITGB4 integrin, beta 4 -2.83171
SUSD4 sushi domain containing 4 -2.80116
KCNIP4 Kv channel interacting protein 4 -2.79204
SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G -2.77729
RHOBTB2 Rho-related BTB domain containing 2 -2.7661
ZFAND4 zinc finger, AN1-type domain 4 -2.70344
IDI1 isopentenyl-diphosphate delta isomerase 1 -2.67051
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 -2.65681
ALDH5A1 aldehyde dehydrogenase 5 family, member A1 -2.61792
MEST mesoderm specific transcript -2.51728
AFTPH aftiphilin -2.51534
PCYT1B phosphate cytidylyltransferase 1, choline, beta -2.49613
VMA22 vacuolar ATPase assembly factor VMA22 -2.48785
AK2 adenylate kinase 2 -2.42817
ALKAL2 ALK and LTK ligand 2 -2.41738
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -2.3956
DPY19L2 dpy-19-like 2 (C. elegans) -2.3956
SCTR secretin receptor -2.38846
PFKL phosphofructokinase, liver -2.38846
RFT1 RFT1 homolog (S. cerevisiae) -2.38258
COL14A1 collagen, type XIV, alpha 1 -2.37238
WWC2 WW and C2 domain containing 2 -2.35876
WBP1L WW domain binding protein 1-like -2.31574
DLL3 delta-like 3 (Drosophila) -2.30855
NUP43 nucleoporin 43kDa -2.29765
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 -2.27123
SRCIN1 SRC kinase signaling inhibitor 1 -2.2687
CLDN1 claudin 1 -2.22798
C16ORF54 chromosome 16 open reading frame 54 -2.22659
MAOB monoamine oxidase B -2.22659
SOX9 SRY (sex determining region Y)-box 9 -2.21006
BAZ2B bromodomain adjacent to zinc finger domain, 2B -2.20597
NPIPB6 nuclear pore complex interacting protein family, member B6 -2.20326
OTOGL otogelin-like -2.20108
LEKR1 leucine, glutamate and lysine rich 1 -2.20108
RAMP3 receptor (G protein-coupled) activity modifying protein 3 -2.20108
DRC3 dynein regulatory complex subunit 3 -2.20108
BEST1 bestrophin 1 -2.20108
MCF2 MCF.2 cell line derived transforming sequence -2.20108
ZNF385B zinc finger protein 385B -2.20108
EHD2 EH-domain containing 2 -2.20108
CASS4 Cas scaffolding protein family member 4 -2.20108
SRP9 signal recognition particle 9kDa -2.17761
VPS9D1 VPS9 domain containing 1 -2.17553
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 -2.1691
PLPP2 phospholipid phosphatase 2 -2.16536
EZR ezrin -2.14022
B4GALT4 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4 -2.14016
JAG2 jagged 2 -2.13518
ALS2CL ALS2 C-terminal like -2.13518
L3MBTL3 l(3)mbt-like 3 (Drosophila) -2.13518
FLAD1 flavin adenine dinucleotide synthetase 1 -2.13156
ELMOD3 ELMO/CED-12 domain containing 3 -2.11702
HSPB11 heat shock protein family B (small), member 11 -2.0965
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 -2.09131
CEP112 centrosomal protein 112kDa -2.06368
CLEC2D C-type lectin domain family 2, member D -2.04066
POLL polymerase (DNA directed), lambda -2.03072
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -2.02243
GOLGB1 golgin B1 -2.02243
IPO4 importin 4 -2.02166