NR1H3 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description nuclear receptor subfamily 1, group H, member 3|The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] (NCBI Entrez Gene Database, 10062)
External Link http://www.ncbi.nlm.nih.gov/gene/10062
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42 interacting proteins for NR1H3 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
AARSD1 alanyl-tRNA synthetase domain containing 1
ACTN1 actinin, alpha 1
APP amyloid beta (A4) precursor protein
BARD1 BRCA1 associated RING domain 1
CEP350 centrosomal protein 350kDa
CSNK2A1 casein kinase 2, alpha 1 polypeptide
EDF1 endothelial differentiation-related factor 1
EIF3I eukaryotic translation initiation factor 3, subunit I
FKBP5 FK506 binding protein 5
FKBPL FK506 binding protein like
FOXO3 forkhead box O3
HNF4A hepatocyte nuclear factor 4, alpha
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
ING3 inhibitor of growth family, member 3
KAT2B K(lysine) acetyltransferase 2B
KDM1A lysine (K)-specific demethylase 1A
LZTR1 leucine-zipper-like transcription regulator 1
MLF1 myeloid leukemia factor 1
MSTO1 misato 1, mitochondrial distribution and morphology regulator
NCOA1 nuclear receptor coactivator 1
NCOA3 nuclear receptor coactivator 3
NCOA6 nuclear receptor coactivator 6
NCOR1 nuclear receptor corepressor 1
NR0B2 nuclear receptor subfamily 0, group B, member 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRIP1 nuclear receptor interacting protein 1
PIAS1 protein inhibitor of activated STAT, 1
PPARA peroxisome proliferator-activated receptor alpha
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5
RARA retinoic acid receptor, alpha
RXRA retinoid X receptor, alpha
RXRB retinoid X receptor, beta
RXRG retinoid X receptor, gamma
SIRT1 sirtuin 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SS18L1 synovial sarcoma translocation gene on chromosome 18-like 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYT1 synaptotagmin I
TMEM161A transmembrane protein 161A
UBC ubiquitin C
ZXDC ZXD family zinc finger C