NR1I2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description nuclear receptor subfamily 1, group I, member 2|This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 8856)
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Genes

357 genes differentially expressed following the NR1I2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
TEX19 testis expressed 19 4.63251
CAPN3 calpain 3, (p94) 4.63251
GMNC geminin coiled-coil domain containing 4.63251
POTEJ POTE ankyrin domain family, member J 4.63251
UNC5CL unc-5 homolog C (C. elegans)-like 4.63251
TTLL8 tubulin tyrosine ligase-like family member 8 4.63251
PTGDS prostaglandin D2 synthase 21kDa (brain) 4.63251
SLC9C2 solute carrier family 9, member C2 (putative) 4.63251
C17ORF99 chromosome 17 open reading frame 99 4.63251
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2 4.63251
PLA2G4B phospholipase A2, group IVB (cytosolic) 4.63251
ST18 suppression of tumorigenicity 18, zinc finger 4.63251
MAGIX MAGI family member, X-linked 4.63251
PCDHGA5 protocadherin gamma subfamily A, 5 4.63251
DRD3 dopamine receptor D3 4.63251
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 4.63251
TUBB8 tubulin, beta 8 class VIII 4.63251
CFAP74 cilia and flagella associated protein 74 4.63251
PCDH8 protocadherin 8 4.63251
ACRBP acrosin binding protein 4.63251
GFY golgi-associated, olfactory signaling regulator 4.63251
SNAI2 snail family zinc finger 2 4.63251
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 4.63251
SPACDR sperm acrosome developmental regulator 4.63251
TMEM52B transmembrane protein 52B 4.63251
MISP mitotic spindle positioning 4.63251
TMEM31 transmembrane protein 31 4.63251
GPR20 G protein-coupled receptor 20 4.61598
PRAMEF20 PRAME family member 20 4.61598
FOXA1 forkhead box A1 4.61598
OSGIN1 oxidative stress induced growth inhibitor 1 4.61598
CCL5 chemokine (C-C motif) ligand 5 4.61598
THRSP thyroid hormone responsive 4.61598
ELSPBP1 epididymal sperm binding protein 1 4.61598
GCKR glucokinase (hexokinase 4) regulator 4.61598
AADACL4 arylacetamide deacetylase-like 4 4.61598
DSG3 desmoglein 3 4.61598
PAX8 paired box 8 4.61598
TBR1 T-box, brain, 1 4.61598
MS4A15 membrane-spanning 4-domains, subfamily A, member 15 4.61598
GNRHR gonadotropin-releasing hormone receptor 4.61598
LBX2 ladybird homeobox 2 4.61598
B3GNT8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 4.61598
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 4.61598
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 4.61598
SP6 Sp6 transcription factor 4.61598
HMX3 H6 family homeobox 3 4.61598
LDHC lactate dehydrogenase C 4.61598
ACY3 aminoacylase 3 4.61598
TMEM121 transmembrane protein 121 4.61598
S100A5 S100 calcium binding protein A5 4.61598
SHISA7 shisa family member 7 4.61598
TNS4 tensin 4 4.61598
ARRDC2 arrestin domain containing 2 4.61598
GLRA3 glycine receptor, alpha 3 4.61598
SPP2 secreted phosphoprotein 2, 24kDa 4.61598
SLC28A2 solute carrier family 28 (concentrative nucleoside transporter), member 2 4.61598
PSCA prostate stem cell antigen 4.61598
TTLL2 tubulin tyrosine ligase-like family member 2 4.61598
DLL4 delta-like 4 (Drosophila) 4.61598
MYL7 myosin, light chain 7, regulatory 4.61598
SPMIP7 sperm microtubule inner protein 7 4.61598
DERPC DERPC proline and glycine rich nuclear protein 4.61598
NECTIN4 nectin cell adhesion molecule 4 4.61598
OPRM1 opioid receptor, mu 1 4.61598
VN1R1 vomeronasal 1 receptor 1 4.61598
ACER1 alkaline ceramidase 1 4.61598
SIM1 single-minded family bHLH transcription factor 1 4.61598
ATP13A4 ATPase type 13A4 4.61598
SPI1 Spi-1 proto-oncogene 4.61598
SPMAP1 sperm microtubule associated protein 1 4.61598
SPRR2E small proline-rich protein 2E 4.61598
HTD2 hydroxyacyl-thioester dehydratase type 2 4.61598
FAM237B family with sequence similarity 237 member B 4.61598
FAM240C family with sequence similarity 240 member C 4.61598
LNC-LBCS lncRNA bladder and prostate cancer suppressor, hnRNPK interacting 4.61598
ZNF593OS ZNF593 opposite strand 4.61598
CD8B2 CD8b2 molecule 4.61598
SMIM35 small integral membrane protein 35 4.61598
MINDY4B MINDY family member 4B 4.61598
LY6L lymphocyte antigen 6 family member L 4.61598
CCDC197 coiled-coil domain containing 197 4.61598
CHCT1 CHD1 helical C-terminal domain containing 1 4.61598
GARIN1A golgi associated RAB2 interactor 1A 4.61598
PKD2L1 polycystic kidney disease 2-like 1 4.61598
C1QTNF9B C1q and tumor necrosis factor related protein 9B 4.61598
TMPRSS6 transmembrane protease, serine 6 4.61598
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 4.61598
FER1L6 fer-1-like family member 6 4.61598
INHBB inhibin, beta B 4.61598
COLEC10 collectin sub-family member 10 (C-type lectin) 4.61598
BSND barttin CLCNK-type chloride channel accessory beta subunit 4.61598
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1 4.61598
HTR5A 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled 4.61598
TMEM176A transmembrane protein 176A 4.61598
TRIM15 tripartite motif containing 15 4.61598
ZEB2 zinc finger E-box binding homeobox 2 4.61598
PVRIG poliovirus receptor related immunoglobulin domain containing 4.61598
KLHL31 kelch-like family member 31 4.61598
SAG S-antigen; retina and pineal gland (arrestin) 4.61598
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3 4.61598
ATP4B ATPase, H+/K+ exchanging, beta polypeptide 4.61598
POU2F3 POU class 2 homeobox 3 4.61598
GPR83 G protein-coupled receptor 83 4.61598
C7 complement component 7 4.61598
S100P S100 calcium binding protein P 4.61598
HAPLN2 hyaluronan and proteoglycan link protein 2 4.61598
CXCL16 chemokine (C-X-C motif) ligand 16 4.61598
PTP4A1 protein tyrosine phosphatase type IVA, member 1 4.61598
ZFP57 ZFP57 zinc finger protein 4.61598
NMUR2 neuromedin U receptor 2 4.61598
PLCD4 phospholipase C, delta 4 4.61598
STMND1 stathmin domain containing 1 4.61598
CISH cytokine inducible SH2-containing protein 4.61598
SPHKAP SPHK1 interactor, AKAP domain containing 4.61598
PLEKHS1 pleckstrin homology domain containing, family S member 1 4.61598
CMTM5 CKLF-like MARVEL transmembrane domain containing 5 4.61598
CMTM2 CKLF-like MARVEL transmembrane domain containing 2 4.61598
OR8H1 olfactory receptor, family 8, subfamily H, member 1 4.61598
SPEF1 sperm flagellar 1 4.61598
CLRN2 clarin 2 4.61598
SLC38A3 solute carrier family 38, member 3 4.61598
FITM1 fat storage-inducing transmembrane protein 1 4.61598
NR2E1 nuclear receptor subfamily 2, group E, member 1 4.61598
EPX eosinophil peroxidase 4.61598
SP100 SP100 nuclear antigen 4.61598
POU3F2 POU class 3 homeobox 2 4.61598
BCL2L15 BCL2-like 15 4.61598
PLGLB2 plasminogen-like B2 4.61598
MAEL maelstrom spermatogenic transposon silencer 4.61598
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 4.61598
SST somatostatin 4.61598
FBXO40 F-box protein 40 4.61598
PCDHGA4 protocadherin gamma subfamily A, 4 4.61598
OR56A3 olfactory receptor, family 56, subfamily A, member 3 4.61598
CLDN34 claudin 34 4.61598
C22ORF42 chromosome 22 open reading frame 42 4.61598
CYSLTR1 cysteinyl leukotriene receptor 1 4.61598
TTC9B tetratricopeptide repeat domain 9B 4.61598
CLEC4C C-type lectin domain family 4, member C 4.61598
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 4.61598
URAD ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase 4.61598
IGFBP7 insulin-like growth factor binding protein 7 4.61598
COL17A1 collagen, type XVII, alpha 1 4.61598
MYF5 myogenic factor 5 4.61598
MUC19 mucin 19, oligomeric 4.61598
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 4.61598
DNAJB13 DnaJ (Hsp40) homolog, subfamily B, member 13 4.61598
LMOD2 leiomodin 2 (cardiac) 4.61598
WNT7B wingless-type MMTV integration site family, member 7B 4.61598
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 4.61598
TBC1D10C TBC1 domain family, member 10C 4.61598
POTEH POTE ankyrin domain family, member H 4.61598
GPAT2 glycerol-3-phosphate acyltransferase 2, mitochondrial 4.61598
DLEC1 deleted in lung and esophageal cancer 1 4.61598
RAB7B RAB7B, member RAS oncogene family 4.61598
OR52N2 olfactory receptor, family 52, subfamily N, member 2 4.61598
LOXL4 lysyl oxidase-like 4 4.61598
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble) 4.61598
EPN3 epsin 3 4.61598
GHRH growth hormone releasing hormone 4.61598
MNX1 motor neuron and pancreas homeobox 1 4.61598
SLC38A11 solute carrier family 38, member 11 4.61598
CD34 CD34 molecule 4.61598
RHOJ ras homolog family member J 4.61598
DHRS9 dehydrogenase/reductase (SDR family) member 9 4.61598
ART1 ADP-ribosyltransferase 1 4.61598
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) 4.61598
NWD2 NACHT and WD repeat domain containing 2 4.61598
PF4V1 platelet factor 4 variant 1 4.61598
SLX1B SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae) 4.61598
ZPBP zona pellucida binding protein 4.61598
SULT1C4 sulfotransferase family, cytosolic, 1C, member 4 4.61598
PRAP1 proline-rich acidic protein 1 4.61598
TSKS testis-specific serine kinase substrate 4.61598
TRPM8 transient receptor potential cation channel, subfamily M, member 8 4.61598
MYH7B myosin, heavy chain 7B, cardiac muscle, beta 4.61598
ALLC allantoicase 4.61598
CAPSL calcyphosine-like 4.61598
TEX36 testis expressed 36 4.61598
ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 4.61598
DEFB134 defensin, beta 134 4.61598
TTC36 tetratricopeptide repeat domain 36 4.61598
HAPLN1 hyaluronan and proteoglycan link protein 1 4.46316
XPC xeroderma pigmentosum, complementation group C 4.08557
MYO1D myosin ID 3.67556
PRR14 proline rich 14 3.5335
CHMP5 charged multivesicular body protein 5 3.48875
ANG angiogenin, ribonuclease, RNase A family, 5 3.48425
RBP2 retinol binding protein 2, cellular 3.32082
PCDHA6 protocadherin alpha 6 3.32082
MYO7A myosin VIIA 3.32082
DUSP13B dual specificity phosphatase 13B 3.32082
DUSP15 dual specificity phosphatase 15 3.32082
ALPK1 alpha-kinase 1 3.32082
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated) 3.32082
APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2 3.32082
CD164L2 CD164 sialomucin-like 2 3.32082
ENGASE endo-beta-N-acetylglucosaminidase 3.28481
PHACTR2 phosphatase and actin regulator 2 3.05241
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 3.02617
UCK2 uridine-cytidine kinase 2 2.98022
MRPL35 mitochondrial ribosomal protein L35 2.89481
FAS Fas cell surface death receptor 2.88594
ADD3 adducin 3 (gamma) 2.80384
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28 2.77671
GLMN glomulin, FKBP associated protein 2.77108
CCNYL1 cyclin Y-like 1 2.71089
TTC39C tetratricopeptide repeat domain 39C 2.65932
MYT1 myelin transcription factor 1 2.63922
RHBG Rh family, B glycoprotein (gene/pseudogene) 2.59186
KIF13B kinesin family member 13B 2.5555
NALF2 NALCN channel auxiliary factor 2 2.50497
CLSTN1 calsyntenin 1 2.42345
SNX7 sorting nexin 7 2.41216
FAM24B family with sequence similarity 24, member B 2.39189
TPX2 TPX2, microtubule-associated 2.39189
ABI3BP ABI family, member 3 (NESH) binding protein 2.37291
KLLN killin, p53-regulated DNA replication inhibitor 2.37291
SLC22A17 solute carrier family 22, member 17 2.28462
POGLUT3 protein O-glucosyltransferase 3 2.27668
OLA1 Obg-like ATPase 1 2.27668
LMO1 LIM domain only 1 (rhombotin 1) 2.25162
GJA5 gap junction protein, alpha 5, 40kDa 2.24277
KYAT3 kynurenine aminotransferase 3 2.22963
LNX2 ligand of numb-protein X 2 2.22963
POPDC3 popeye domain containing 3 2.19843
UBA1 ubiquitin-like modifier activating enzyme 1 2.17455
NT5DC1 5'-nucleotidase domain containing 1 2.16972
GPANK1 G patch domain and ankyrin repeats 1 2.16852
POLG polymerase (DNA directed), gamma 2.16852
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 2.15992
HABP4 hyaluronan binding protein 4 2.15534
CNTLN centlein, centrosomal protein 2.13907
IP6K1 inositol hexakisphosphate kinase 1 2.12324
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 2.12031
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit 2.11907
JADE2 jade family PHD finger 2 2.10326
CELF1 CUGBP, Elav-like family member 1 2.09936
PLSCR3 phospholipid scramblase 3 2.09574
HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2 2.08734
THAP12 THAP domain containing 12 2.07317
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit 2.06932
SPCS1 signal peptidase complex subunit 1 homolog (S. cerevisiae) 2.05769
KLF12 Kruppel-like factor 12 2.05435
PRPF31 pre-mRNA processing factor 31 2.04679
ZNF667 zinc finger protein 667 2.04679
ZNF790 zinc finger protein 790 2.04679
FANCE Fanconi anemia, complementation group E 2.04679
ATP5F1D ATP synthase F1 subunit delta 2.03828
CDYL2 chromodomain protein, Y-like 2 2.03145
TMCC3 transmembrane and coiled-coil domain family 3 2.02109
CEP131 centrosomal protein 131kDa 2.01495
ZSWIM7 zinc finger, SWIM-type containing 7 2.01278

decreased expression

Symbol Name Standardized Value
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2 -4.63251
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2 -4.63251
PCDHB9 protocadherin beta 9 -4.61598
GIP gastric inhibitory polypeptide -4.61598
IZUMO1 izumo sperm-egg fusion 1 -4.61598
ALAS2 5'-aminolevulinate synthase 2 -4.61598
NPPA natriuretic peptide A -4.61598
CYP2F1 cytochrome P450, family 2, subfamily F, polypeptide 1 -4.61598
PRRT4 proline-rich transmembrane protein 4 -4.61598
ZNF703 zinc finger protein 703 -4.61598
SPDYE6 speedy/RINGO cell cycle regulator family member E6 -4.61598
P2RY8 purinergic receptor P2Y, G-protein coupled, 8 -4.61598
NOD2 nucleotide-binding oligomerization domain containing 2 -4.61598
TRAM1L1 translocation associated membrane protein 1-like 1 -4.61598
COL20A1 collagen, type XX, alpha 1 -4.61598
TRIM73 tripartite motif containing 73 -4.61598
FAM216B family with sequence similarity 216, member B -4.61598
RGPD1 RANBP2-like and GRIP domain containing 1 -4.61598
FBXW9 F-box and WD repeat domain containing 9 -4.61598
STARD6 StAR-related lipid transfer (START) domain containing 6 -4.61598
SHC4 SHC (Src homology 2 domain containing) family, member 4 -4.61598
TEKT3 tektin 3 -4.61598
BEAN1 brain expressed, associated with NEDD4, 1 -4.61598
TTC16 tetratricopeptide repeat domain 16 -4.61598
TRIM34 tripartite motif containing 34 -4.61598
SMIM41 small integral membrane protein 41 -4.61598
MISP3 MISP family member 3 -4.61598
NPM2 nucleophosmin/nucleoplasmin 2 -4.61598
ZNF831 zinc finger protein 831 -4.61598
SYT10 synaptotagmin X -4.05114
CRIP2 cysteine-rich protein 2 -3.79217
CD79B CD79b molecule, immunoglobulin-associated beta -3.79217
EML5 echinoderm microtubule associated protein like 5 -3.79217
OXSM 3-oxoacyl-ACP synthase, mitochondrial -3.79217
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) -3.79217
NECAP1 NECAP endocytosis associated 1 -3.73717
FAM110C family with sequence similarity 110, member C -3.6218
PLAAT3 phospholipase A and acyltransferase 3 -3.45504
ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa -3.37088
TCEAL1 transcription elongation factor A (SII)-like 1 -3.32082
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1 -3.32082
SLC29A4 solute carrier family 29 (equilibrative nucleoside transporter), member 4 -3.16276
RARB retinoic acid receptor, beta -3.05356
ELN elastin -3.05058
RUBCNL rubicon like autophagy enhancer -3.01693
TRMT5 tRNA methyltransferase 5 -2.986
CEP68 centrosomal protein 68kDa -2.66916
GXYLT2 glucoside xylosyltransferase 2 -2.62912
N4BP2L1 NEDD4 binding protein 2-like 1 -2.6274
NR1H2 nuclear receptor subfamily 1, group H, member 2 -2.61691
CNOT11 CCR4-NOT transcription complex, subunit 11 -2.59186
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa -2.53723
PLCG1 phospholipase C, gamma 1 -2.51761
NEK7 NIMA-related kinase 7 -2.5065
AGBL3 ATP/GTP binding protein-like 3 -2.50189
TPO thyroid peroxidase -2.44638
CFAP92 cilia and flagella associated protein 92 (putative) -2.44263
NFS1 NFS1 cysteine desulfurase -2.44263
PCDH19 protocadherin 19 -2.41216
AKAP5 A kinase (PRKA) anchor protein 5 -2.41216
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) -2.39189
PLPP7 phospholipid phosphatase 7 (inactive) -2.38557
MYO3B myosin IIIB -2.38371
ZWILCH zwilch kinetochore protein -2.37693
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) -2.36796
C6ORF163 chromosome 6 open reading frame 163 -2.36228
BCL6B B-cell CLL/lymphoma 6, member B -2.36228
IGSF6 immunoglobulin superfamily, member 6 -2.36228
MYD88 myeloid differentiation primary response 88 -2.31454
CYP4V2 cytochrome P450, family 4, subfamily V, polypeptide 2 -2.29596
USP48 ubiquitin specific peptidase 48 -2.29543
EIF2B5 eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa -2.29037
DCAF1 DDB1 and CUL4 associated factor 1 -2.2856
GDPGP1 GDP-D-glucose phosphorylase 1 -2.26187
ZSCAN32 zinc finger and SCAN domain containing 32 -2.22863
RUFY1 RUN and FYVE domain containing 1 -2.20038
PLSCR1 phospholipid scramblase 1 -2.1968
LRRC27 leucine rich repeat containing 27 -2.1968
RPS27 ribosomal protein S27 -2.17547
IFT20 intraflagellar transport 20 -2.17029
ARMH3 armadillo like helical domain containing 3 -2.16972
FDPS farnesyl diphosphate synthase -2.16972
NFX1 nuclear transcription factor, X-box binding 1 -2.16852
FAHD2B fumarylacetoacetate hydrolase domain containing 2B -2.16574
PTEN phosphatase and tensin homolog -2.1569
UBAP2 ubiquitin associated protein 2 -2.15194
C8ORF58 chromosome 8 open reading frame 58 -2.15194
MAP1S microtubule-associated protein 1S -2.11989
LPAR3 lysophosphatidic acid receptor 3 -2.10921
TLCD5 TLC domain containing 5 -2.10694
UBE3C ubiquitin protein ligase E3C -2.09541
ARHGAP29 Rho GTPase activating protein 29 -2.08867
KIAA1958 KIAA1958 -2.08734
LYRM4 LYR motif containing 4 -2.08734
NAT10 N-acetyltransferase 10 (GCN5-related) -2.08675
KIAA2012 KIAA2012 -2.07317
TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa -2.07287
CCNC cyclin C -2.0719
TMEM107 transmembrane protein 107 -2.04445
WDR55 WD repeat domain 55 -2.03145
ZCWPW1 zinc finger, CW type with PWWP domain 1 -2.02898
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -2.02771
ZNF799 zinc finger protein 799 -2.00868