NR1I2 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description nuclear receptor subfamily 1, group I, member 2|This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 8856)
External Link http://www.ncbi.nlm.nih.gov/gene/8856
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39 interacting proteins for NR1I2 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ACTN2 actinin, alpha 2
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1
CDK2 cyclin-dependent kinase 2
CHMP1A charged multivesicular body protein 1A
DDB1 damage-specific DNA binding protein 1, 127kDa
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
EIF3I eukaryotic translation initiation factor 3, subunit I
FGR FGR proto-oncogene, Src family tyrosine kinase
HNF4A hepatocyte nuclear factor 4, alpha
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
MAPK7 mitogen-activated protein kinase 7
NCOA1 nuclear receptor coactivator 1
NCOA2 nuclear receptor coactivator 2
NCOA3 nuclear receptor coactivator 3
NCOA6 nuclear receptor coactivator 6
NCOR1 nuclear receptor corepressor 1
NCOR2 nuclear receptor corepressor 2
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
NUCB2 nucleobindin 2
ONECUT1 one cut homeobox 1
POU1F1 POU class 1 homeobox 1
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PRMT1 protein arginine methyltransferase 1
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5
RBBP7 retinoblastoma binding protein 7
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1
RXRA retinoid X receptor, alpha
RXRB retinoid X receptor, beta
RXRG retinoid X receptor, gamma
SDF4 stromal cell derived factor 4
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SUMO1 small ubiquitin-like modifier 1
SUMO2 small ubiquitin-like modifier 2
SUMO3 small ubiquitin-like modifier 3
TADA3 transcriptional adaptor 3
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
UBC ubiquitin C
UBR5 ubiquitin protein ligase E3 component n-recognin 5