NR2C2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description nuclear receptor subfamily 2, group C, member 2|This gene encodes a protein that belongs to the nuclear hormone receptor family. Members of this family act as ligand-activated transcription factors and function in many biological processes such as development, cellular differentiation and homeostasis. The activated receptor/ligand complex is translocated to the nucleus where it binds to hormone response elements of target genes. The protein encoded by this gene plays a role in protecting cells from oxidative stress and damage induced by ionizing radiation. The lack of a similar gene in mouse results in growth retardation, severe spinal curvature, subfertility, premature aging, and prostatic intraepithelial neoplasia (PIN) development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014] (NCBI Entrez Gene Database, 7182)
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Genes

357 genes differentially expressed following the NR2C2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
KCNMB1 potassium channel subfamily M regulatory beta subunit 1 2.72027
SIAH3 siah E3 ubiquitin protein ligase family member 3 2.72027
EDN1 endothelin 1 2.72027
TRPC7 transient receptor potential cation channel, subfamily C, member 7 2.72027
NYX nyctalopin 2.72027
COMMD3 COMM domain containing 3 2.72027
DSG4 desmoglein 4 2.72027
CA5A carbonic anhydrase VA, mitochondrial 2.72027
DAPL1 death associated protein-like 1 2.72027
SLC7A4 solute carrier family 7, member 4 2.72027
FOLR1 folate receptor 1 (adult) 2.72027
HCST hematopoietic cell signal transducer 2.72027
IL18R1 interleukin 18 receptor 1 2.72027
C17ORF78 chromosome 17 open reading frame 78 2.72027
SCTR secretin receptor 2.72027
LRRC26 leucine rich repeat containing 26 2.72027
CLRN2 clarin 2 2.72027
C20ORF204 chromosome 20 open reading frame 204 2.72027
GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic 2.72027
PATL2 protein associated with topoisomerase II homolog 2 (yeast) 2.72027
ETNPPL ethanolamine-phosphate phospho-lyase 2.72027
TRPV6 transient receptor potential cation channel, subfamily V, member 6 2.69322
ARRDC5 arrestin domain containing 5 2.69322
GNAT3 guanine nucleotide binding protein, alpha transducing 3 2.69322
CLEC19A C-type lectin domain family 19, member A 2.69322
FHL5 four and a half LIM domains 5 2.69322
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 2.69322
SCNN1G sodium channel, non voltage gated 1 gamma subunit 2.69322
SLC22A13 solute carrier family 22 (organic anion/urate transporter), member 13 2.69322
SUSD2 sushi domain containing 2 2.69322
TKTL2 transketolase-like 2 2.69322
LMO1 LIM domain only 1 (rhombotin 1) 2.69322
GJB5 gap junction protein, beta 5, 31.1kDa 2.69322
SH2D6 SH2 domain containing 6 2.69322
SPP2 secreted phosphoprotein 2, 24kDa 2.69322
RGPD3 RANBP2-like and GRIP domain containing 3 2.69322
ZAR1L zygote arrest 1-like 2.69322
FAM110A family with sequence similarity 110, member A 2.69322
MPP4 membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) 2.69322
TPPP tubulin polymerization promoting protein 2.69322
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 2.69322
BOLA2 bolA family member 2 2.69322
SOST sclerostin 2.69322
OR5A1 olfactory receptor, family 5, subfamily A, member 1 2.69322
PITX2 paired-like homeodomain 2 2.69322
OVCH1 ovochymase 1 2.69322
TMC8 transmembrane channel-like 8 2.69322
SMIM9 small integral membrane protein 9 2.69322
CX3CR1 chemokine (C-X3-C motif) receptor 1 2.69322
GMNC geminin coiled-coil domain containing 2.69322
C1GALT1C1L C1GALT1-specific chaperone 1 like 2.69322
MUC20 mucin 20, cell surface associated 2.69322
BHMT2 betaine--homocysteine S-methyltransferase 2 2.69322
MYO1A myosin IA 2.69322
VCX variable charge, X-linked 2.69322
ASGR2 asialoglycoprotein receptor 2 2.69322
PLA2G1B phospholipase A2, group IB (pancreas) 2.69322
EPCIP exosomal polycystin 1 interacting protein 2.69322
OR6F1 olfactory receptor, family 6, subfamily F, member 1 2.69322
FOXC2 forkhead box C2 2.69322
SPATA22 spermatogenesis associated 22 2.69322
OR2D2 olfactory receptor, family 2, subfamily D, member 2 2.69322
IL1R2 interleukin 1 receptor, type II 2.69322
CAPN8 calpain 8 2.69322
C7 complement component 7 2.69322
CFAP45 cilia and flagella associated protein 45 2.69322
MYH15 myosin, heavy chain 15 2.69322
MGAM maltase-glucoamylase 2.69322
H1-6 H1.6 linker histone, cluster member 2.69322
PLPP4 phospholipid phosphatase 4 2.69322
PNMA6F PNMA family member 6F 2.69322
FAM240C family with sequence similarity 240 member C 2.69322
KIF1C-AS1 KIF1C antisense RNA 1 2.69322
TMDD1 transmembrane and death domain 1 2.69322
SMIM43 small integral membrane protein 43 2.69322
SMIM35 small integral membrane protein 35 2.69322
LHFPL7 LHFPL tetraspan subfamily member 7 2.69322
CFAP161 cilia and flagella associated protein 161 2.69322
RNF227 ring finger protein 227 2.69322
AWAT1 acyl-CoA wax alcohol acyltransferase 1 2.69322
MAG myelin associated glycoprotein 2.69322
OR2A42 olfactory receptor, family 2, subfamily A, member 42 2.69322
OR1A1 olfactory receptor, family 1, subfamily A, member 1 2.69322
ZNF662 zinc finger protein 662 2.69322
FOXA2 forkhead box A2 2.69322
SLC35G5 solute carrier family 35, member G5 2.69322
SSTR1 somatostatin receptor 1 2.69322
GLYAT glycine-N-acyltransferase 2.69322
DPEP2 dipeptidase 2 2.69322
PGBDF plakoglobin binding and degradation factor 2.69322
PRELP proline/arginine-rich end leucine-rich repeat protein 2.69322
SLC46A3 solute carrier family 46, member 3 2.69322
SACK1A scaffolding CK1 anchoring protein A 2.69322
NXPE1 neurexophilin and PC-esterase domain family, member 1 2.69322
MAGEB1 melanoma antigen family B1 2.69322
ERAS ES cell expressed Ras 2.69322
NRN1 neuritin 1 2.69322
HRH1 histamine receptor H1 2.69322
COL20A1 collagen, type XX, alpha 1 2.69322
ACKR5 atypical chemokine receptor 5 2.69322
CHRNG cholinergic receptor, nicotinic, gamma (muscle) 2.69322
MS4A4E membrane-spanning 4-domains, subfamily A, member 4E 2.69322
IL5RA interleukin 5 receptor, alpha 2.69322
LRRC15 leucine rich repeat containing 15 2.69322
TIGD3 tigger transposable element derived 3 2.69322
SIGLEC15 sialic acid binding Ig-like lectin 15 2.69322
C9ORF64 chromosome 9 open reading frame 64 2.69322
VAV1 vav 1 guanine nucleotide exchange factor 2.69322
ARR3 arrestin 3, retinal (X-arrestin) 2.69322
DQX1 DEAQ box RNA-dependent ATPase 1 2.69322
LY9 lymphocyte antigen 9 2.69322
EBLN1 endogenous Bornavirus-like nucleoprotein 1 2.69322
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal) 2.69322
GP5 glycoprotein V (platelet) 2.69322
NLRC3 NLR family, CARD domain containing 3 2.69322
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8 2.69322
ORM2 orosomucoid 2 2.69322
PEG10 paternally expressed 10 2.69322
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 2.69322
GP1BB glycoprotein Ib (platelet), beta polypeptide 2.69322
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9 2.69322
PIP prolactin-induced protein 2.69322
PRR35 proline rich 35 2.69322
KLK2 kallikrein-related peptidase 2 2.69322
LRRK2 leucine-rich repeat kinase 2 2.69322
RGCC regulator of cell cycle 2.69322
LIN7A lin-7 homolog A (C. elegans) 2.69322
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene) 2.69322
ILDR2 immunoglobulin-like domain containing receptor 2 2.69322
MUC17 mucin 17, cell surface associated 2.69322
TMEM139 transmembrane protein 139 2.69322
PCDHGA4 protocadherin gamma subfamily A, 4 2.69322
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 2.69322
TTC9B tetratricopeptide repeat domain 9B 2.69322
TMEFF2 transmembrane protein with EGF-like and two follistatin-like domains 2 2.69322
HUS1B HUS1 checkpoint homolog b (S. pombe) 2.69322
CRYBA1 crystallin, beta A1 2.69322
AKNAD1 AKNA domain containing 1 2.69322
APOB apolipoprotein B 2.69322
POU4F1 POU class 4 homeobox 1 2.69322
NXF3 nuclear RNA export factor 3 2.69322
LPAR5 lysophosphatidic acid receptor 5 2.69322
ACKR3 atypical chemokine receptor 3 2.69322
FITM1 fat storage-inducing transmembrane protein 1 2.69322
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) 2.69322
SYT5 synaptotagmin V 2.69322
OR8H1 olfactory receptor, family 8, subfamily H, member 1 2.69322
SP6 Sp6 transcription factor 2.69322
RNF224 ring finger protein 224 2.69322
ZPBP zona pellucida binding protein 2.69322
SLCO1C1 solute carrier organic anion transporter family, member 1C1 2.69322
TTC36 tetratricopeptide repeat domain 36 2.69322
SLC36A3 solute carrier family 36, member 3 2.69322
ART4 ADP-ribosyltransferase 4 (Dombrock blood group) 2.69322
GREM1 gremlin 1, DAN family BMP antagonist 2.69322
BCL2A1 BCL2-related protein A1 2.69322
TMSB15B thymosin beta 15B 2.69322
CGA glycoprotein hormones, alpha polypeptide 2.69322
OTP orthopedia homeobox 2.69322
MEPE matrix extracellular phosphoglycoprotein 2.69322
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion 2.69322
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 2.69322
GNG8 guanine nucleotide binding protein (G protein), gamma 8 2.69322
PLEKHS1 pleckstrin homology domain containing, family S member 1 2.69322
GPR50 G protein-coupled receptor 50 2.69322
DKK1 dickkopf WNT signaling pathway inhibitor 1 2.69322
SMIM22 small integral membrane protein 22 2.69322
ADAM12 ADAM metallopeptidase domain 12 2.69322
PCNT pericentrin 2.68821
CALD1 caldesmon 1 2.67542
RAD54L RAD54-like (S. cerevisiae) 2.64996
ITGB4 integrin, beta 4 2.64996
ATXN10 ataxin 10 2.63749
IQGAP2 IQ motif containing GTPase activating protein 2 2.62663
NELFB negative elongation factor complex member B 2.55077
NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa 2.5243
PABPC5 poly(A) binding protein, cytoplasmic 5 2.51947
ADGRG3 adhesion G protein-coupled receptor G3 2.48346
ZBTB1 zinc finger and BTB domain containing 1 2.46166
IGFBP3 insulin-like growth factor binding protein 3 2.4488
MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.44369
DENND6B DENN/MADD domain containing 6B 2.44369
GNS glucosamine (N-acetyl)-6-sulfatase 2.42849
PHAX phosphorylated adaptor for RNA export 2.42844
FRMPD3 FERM and PDZ domain containing 3 2.3963
ZBED11 zinc finger BED-type containing 11 2.39358
BTD biotinidase 2.39295
CALCB calcitonin-related polypeptide beta 2.37572
TWNK twinkle mtDNA helicase 2.37572
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 2.37572
SLA2 Src-like-adaptor 2 2.36564
USP20 ubiquitin specific peptidase 20 2.36236
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4 2.34663
NARS1 asparaginyl-tRNA synthetase 1 2.33834
TRIM61 tripartite motif containing 61 2.3226
HDHD3 haloacid dehalogenase-like hydrolase domain containing 3 2.31648
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2 2.30228
ATP8A2 ATPase, aminophospholipid transporter, class I, type 8A, member 2 2.28327
TUBB4A tubulin, beta 4A class IVa 2.27087
SETD1A SET domain containing 1A 2.27087
SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 2.25918
CTNNBIP1 catenin, beta interacting protein 1 2.2565
PHYH phytanoyl-CoA 2-hydroxylase 2.2538
POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae) 2.2538
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor 2.2538
DUSP4 dual specificity phosphatase 4 2.23741
SPRTN SprT-like N-terminal domain 2.23741
GNAS GNAS complex locus 2.23741
RPS18 ribosomal protein S18 2.23534
MOB2 MOB kinase activator 2 2.23534
RNF25 ring finger protein 25 2.23114
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 2.22102
NEBL nebulette 2.21708
UQCC3 ubiquinol-cytochrome c reductase complex assembly factor 3 2.19364
LSM10 LSM10, U7 small nuclear RNA associated 2.19059
SLC66A3 solute carrier family 66 member 3 2.17678
GTF2E1 general transcription factor IIE, polypeptide 1, alpha 56kDa 2.16839
NACA nascent polypeptide-associated complex alpha subunit 2.15204
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 2.15204
RAB3A RAB3A, member RAS oncogene family 2.14833
TSC2 tuberous sclerosis 2 2.14571
TMEM177 transmembrane protein 177 2.14485
GARIN1B golgi associated RAB2 interactor 1B 2.13968
GRPR gastrin-releasing peptide receptor 2.13441
CDO1 cysteine dioxygenase type 1 2.13205
CAMK2D calcium/calmodulin-dependent protein kinase II delta 2.12555
HSPG2 heparan sulfate proteoglycan 2 2.11527
ADAM22 ADAM metallopeptidase domain 22 2.10825
PHF7 PHD finger protein 7 2.10614
COPG1 coatomer protein complex, subunit gamma 1 2.10402
GNG3 guanine nucleotide binding protein (G protein), gamma 3 2.09657
RPS19BP1 ribosomal protein S19 binding protein 1 2.05261
SIPA1L3 signal-induced proliferation-associated 1 like 3 2.0389
CDC16 cell division cycle 16 2.03202
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 2.03118
CEP44 centrosomal protein 44kDa 2.02283
CRACR2B calcium release activated channel regulator 2B 2.02283
RPA2 replication protein A2, 32kDa 2.02039
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 2.01788
TOR1A torsin family 1, member A (torsin A) 2.01788
HIPK2 homeodomain interacting protein kinase 2 2.01788
ZNF141 zinc finger protein 141 2.01571

decreased expression

Symbol Name Standardized Value
RAD21 RAD21 homolog (S. pombe) -2.72027
COQ7 coenzyme Q7 homolog, ubiquinone (yeast) -2.72027
PANX1 pannexin 1 -2.69322
SRC SRC proto-oncogene, non-receptor tyrosine kinase -2.69322
TRA2A transformer 2 alpha homolog (Drosophila) -2.69322
ZSCAN10 zinc finger and SCAN domain containing 10 -2.69322
BFSP1 beaded filament structural protein 1, filensin -2.69322
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 -2.69322
ZNF774 zinc finger protein 774 -2.69322
LIG4 ligase IV, DNA, ATP-dependent -2.69322
TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa -2.69322
NHLH1 nescient helix loop helix 1 -2.69322
QPCT glutaminyl-peptide cyclotransferase -2.69322
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B -2.69322
HPSE heparanase -2.69322
PROC protein C (inactivator of coagulation factors Va and VIIIa) -2.64996
SCIN scinderin -2.64996
ITPRID1 ITPR interacting domain containing 1 -2.64996
SGMS2 sphingomyelin synthase 2 -2.64996
TMEM213 transmembrane protein 213 -2.64996
IFITM10 interferon induced transmembrane protein 10 -2.64996
TMEM225B transmembrane protein 225B -2.64996
NPIPA6 nuclear pore complex interacting protein family, member A6 -2.64996
FGF18 fibroblast growth factor 18 -2.64996
SLITRK3 SLIT and NTRK-like family, member 3 -2.64996
CFAP141 cilia and flagella associated protein 141 -2.64996
NPFF neuropeptide FF-amide peptide precursor -2.64996
ZFP57 ZFP57 zinc finger protein -2.64996
CFAP99 cilia and flagella associated protein 99 -2.64996
ECT2L epithelial cell transforming 2 like -2.64996
LOX lysyl oxidase -2.64996
PAPOLB poly(A) polymerase beta (testis specific) -2.64996
REN renin -2.64996
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 -2.64996
LOC114841035 uncharacterized LOC114841035 -2.64996
DNAI7 dynein axonemal intermediate chain 7 -2.64996
RUNX3 runt-related transcription factor 3 -2.64996
NLRP10 NLR family, pyrin domain containing 10 -2.64996
ZNF365 zinc finger protein 365 -2.64996
LRRC19 leucine rich repeat containing 19 -2.64996
MOG myelin oligodendrocyte glycoprotein -2.64996
MDGA1 MAM domain containing glycosylphosphatidylinositol anchor 1 -2.64996
DLX3 distal-less homeobox 3 -2.64996
NRIP2 nuclear receptor interacting protein 2 -2.64996
EFCAB3 EF-hand calcium binding domain 3 -2.64996
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase) -2.64996
VWA7 von Willebrand factor A domain containing 7 -2.64996
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4 -2.64996
PCDHAC1 protocadherin alpha subfamily C, 1 -2.64996
KRTAP5-11 keratin associated protein 5-11 -2.64996
PPP1R1C protein phosphatase 1, regulatory (inhibitor) subunit 1C -2.62663
PPP1R13L protein phosphatase 1, regulatory subunit 13 like -2.62663
VSTM2L V-set and transmembrane domain containing 2 like -2.58696
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1 -2.57231
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -2.57038
CRIPT cysteine-rich PDZ-binding protein -2.50207
RELT RELT tumor necrosis factor receptor -2.4966
MAVS mitochondrial antiviral signaling protein -2.49258
HAPLN3 hyaluronan and proteoglycan link protein 3 -2.48346
SLCO3A1 solute carrier organic anion transporter family, member 3A1 -2.4488
TRIOBP TRIO and F-actin binding protein -2.41434
SLC35F3 solute carrier family 35, member F3 -2.41434
ZHX1 zinc fingers and homeoboxes 1 -2.40546
MAX MYC associated factor X -2.38801
SMIM10L2B small integral membrane protein 10 like 2B -2.38801
NPB neuropeptide B -2.37572
TMEM191C transmembrane protein 191C -2.37572
FGF1 fibroblast growth factor 1 (acidic) -2.36745
RPS26 ribosomal protein S26 -2.34915
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -2.34099
CLEC2L C-type lectin domain family 2, member L -2.34099
REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae) -2.33834
TMEM132A transmembrane protein 132A -2.33834
ZNF516 zinc finger protein 516 -2.33834
ZNF670 zinc finger protein 670 -2.31472
STXBP3 syntaxin binding protein 3 -2.3099
TMED1 transmembrane emp24 protein transport domain containing 1 -2.3099
PALS2 protein associated with LIN7 2, MAGUK p55 family member -2.30228
PAM peptidylglycine alpha-amidating monooxygenase -2.27826
NEU1 sialidase 1 (lysosomal sialidase) -2.26304
WDR44 WD repeat domain 44 -2.2565
PRRC2C proline-rich coiled-coil 2C -2.24282
PSTK phosphoseryl-tRNA kinase -2.23741
NEK11 NIMA-related kinase 11 -2.23534
PTTG1 pituitary tumor-transforming 1 -2.23146
ZNF773 zinc finger protein 773 -2.21345
CRYAB crystallin, alpha B -2.21345
SRR serine racemase -2.20466
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3 -2.19942
GP6 glycoprotein VI (platelet) -2.19942
ZMYM6 zinc finger, MYM-type 6 -2.19673
FOXO6 forkhead box O6 -2.19027
LINGO3 leucine rich repeat and Ig domain containing 3 -2.19023
GAREM2 GRB2 associated regulator of MAPK1 subtype 2 -2.17711
KIF13A kinesin family member 13A -2.16835
BZW1 basic leucine zipper and W2 domains 1 -2.14596
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1 -2.14571
LMF1 lipase maturation factor 1 -2.14571
FZD5 frizzled class receptor 5 -2.14456
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled -2.13205
PCDH17 protocadherin 17 -2.11436
SH3BGR SH3 domain binding glutamate-rich protein -2.10825
OCLN occludin -2.10663
PPIL3 peptidylprolyl isomerase (cyclophilin)-like 3 -2.10402
NDUFA12 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12 -2.06704
IFT54 intraflagellar transport 54 -2.06693
TMEM140 transmembrane protein 140 -2.06183
OSER1 oxidative stress responsive serine-rich 1 -2.05397
PEX13 peroxisomal biogenesis factor 13 -2.05261
SLC22A23 solute carrier family 22, member 23 -2.05261
HSPBAP1 HSPB (heat shock 27kDa) associated protein 1 -2.0423
MSRB2 methionine sulfoxide reductase B2 -2.03438
EXOSC4 exosome component 4 -2.03352
STX6 syntaxin 6 -2.02039
RRAGD Ras-related GTP binding D -2.02039