NR2E3 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description nuclear receptor subfamily 2, group E, member 3|This protein is part of a large family of nuclear receptor transcription factors involved in signaling pathways. Nuclear receptors have been shown to regulate pathways involved in embryonic development, as well as in maintenance of proper cell function in adults. Members of this family are characterized by discrete domains that function in DNA and ligand binding. This gene encodes a retinal nuclear receptor that is a ligand-dependent transcription factor. Defects in this gene are a cause of enhanced S cone syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 10002)
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Genes

293 genes differentially expressed following the NR2E3 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CXCL16 chemokine (C-X-C motif) ligand 16 3.15216
RBM24 RNA binding motif protein 24 3.15216
C1ORF146 chromosome 1 open reading frame 146 3.15216
LRG1 leucine-rich alpha-2-glycoprotein 1 3.15216
PCDHB13 protocadherin beta 13 3.15216
FOLR1 folate receptor 1 (adult) 3.15216
LBHD2 LBH domain containing 2 3.15216
PARVG parvin, gamma 3.15216
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 3.15216
SIX6 SIX homeobox 6 3.15216
OR2A5 olfactory receptor, family 2, subfamily A, member 5 3.15216
SLC22A9 solute carrier family 22 (organic anion transporter), member 9 3.15216
BHLHA15 basic helix-loop-helix family, member a15 3.15216
SPDYE6 speedy/RINGO cell cycle regulator family member E6 3.15216
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene) 3.15216
ASGR2 asialoglycoprotein receptor 2 3.15216
SCN10A sodium channel, voltage gated, type X alpha subunit 3.15216
TMEM191B transmembrane protein 191B 3.15216
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64) 3.13236
CD14 CD14 molecule 3.13236
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 3.13236
COLEC10 collectin sub-family member 10 (C-type lectin) 3.13236
UCN urocortin 3.13236
AGTR1 angiotensin II receptor, type 1 3.13236
OR52H1 olfactory receptor, family 52, subfamily H, member 1 3.13236
BMP5 bone morphogenetic protein 5 3.13236
HLX H2.0-like homeobox 3.13236
XPNPEP2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound 3.13236
PRB1 proline-rich protein BstNI subfamily 1 3.13236
TCHH trichohyalin 3.13236
DDN dendrin 3.13236
PRR29 proline rich 29 3.13236
ATOH8 atonal homolog 8 (Drosophila) 3.13236
BHMT2 betaine--homocysteine S-methyltransferase 2 3.13236
PTK6 protein tyrosine kinase 6 3.13236
TFF2 trefoil factor 2 3.13236
NPIPA7 nuclear pore complex interacting protein family, member A7 3.13236
TMEM121 transmembrane protein 121 3.13236
LGI1 leucine-rich, glioma inactivated 1 3.13236
PARP10 poly (ADP-ribose) polymerase family, member 10 3.13236
ACTL7A actin-like 7A 3.13236
CACNG1 calcium channel, voltage-dependent, gamma subunit 1 3.13236
GPR21 G protein-coupled receptor 21 3.13236
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide 3.13236
FAM90A1 family with sequence similarity 90, member A1 3.13236
PAX2 paired box 2 3.13236
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 3.13236
CYP4A22 cytochrome P450, family 4, subfamily A, polypeptide 22 3.13236
LIPC lipase, hepatic 3.13236
TLE7 TLE family member 7 3.13236
SELE selectin E 3.13236
AVPR1A arginine vasopressin receptor 1A 3.13236
TUBGCP4 tubulin, gamma complex associated protein 4 3.13236
SPRR2E small proline-rich protein 2E 3.13236
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 3.13236
FOXC1 forkhead box C1 3.13236
DOK2 docking protein 2, 56kDa 3.13236
CLXN calaxin 3.13236
CFAP157 cilia and flagella associated protein 157 3.13236
SPATA31H1 SPATA31 subfamily H member 1 3.13236
ZC3H11C zinc finger CCCH-type containing 11C 3.13236
SMIM32 small integral membrane protein 32 3.13236
H4C12 H4 clustered histone 12 3.13236
MYMK myomaker, myoblast fusion factor 3.13236
POU2AF2 POU class 2 homeobox associating factor 2 3.13236
CFAP107 cilia and flagella associated protein 107 3.13236
GARIN1A golgi associated RAB2 interactor 1A 3.13236
OR52E5 olfactory receptor, family 52, subfamily E, member 5 3.13236
SELL selectin L 3.13236
SH3TC1 SH3 domain and tetratricopeptide repeats 1 3.13236
SLC45A2 solute carrier family 45, member 2 3.13236
ANXA13 annexin A13 3.13236
WNT11 wingless-type MMTV integration site family, member 11 3.13236
TRIM60 tripartite motif containing 60 3.13236
TSPO2 translocator protein 2 3.13236
TMEM95 transmembrane protein 95 3.13236
CD300LG CD300 molecule-like family member g 3.13236
SPDYC speedy/RINGO cell cycle regulator family member C 3.13236
CDSN corneodesmosin 3.13236
SOAT2 sterol O-acyltransferase 2 3.13236
LRRC70 leucine rich repeat containing 70 3.13236
TAS1R1 taste receptor, type 1, member 1 3.13236
TARM1 T cell-interacting, activating receptor on myeloid cells 1 3.13236
PGA4 pepsinogen 4, group I (pepsinogen A) 3.13236
CAPN8 calpain 8 3.13236
SAA1 serum amyloid A1 3.13236
CDKN2A cyclin-dependent kinase inhibitor 2A 3.13236
CATSPERH catsper channel auxiliary subunit eta 3.13236
PMCH pro-melanin-concentrating hormone 3.13236
CFB complement factor B 3.13236
TBXA2R thromboxane A2 receptor 3.13236
FIBIN fin bud initiation factor homolog (zebrafish) 3.13236
RANBP3L RAN binding protein 3-like 3.13236
TRIM55 tripartite motif containing 55 3.13236
IL36R interleukin 36 receptor 3.13236
DUOX2 dual oxidase 2 3.13236
GLOD5 glyoxalase domain containing 5 3.13236
HSPA1L heat shock 70kDa protein 1-like 3.13236
BTNL8 butyrophilin-like 8 3.13236
UBQLNL ubiquilin-like 3.13236
CST1 cystatin SN 3.13236
CSTA cystatin A (stefin A) 3.13236
TMEM132D transmembrane protein 132D 3.13236
MBOAT4 membrane bound O-acyltransferase domain containing 4 3.13236
DYTN dystrotelin 3.13236
DES desmin 3.13236
CYBB cytochrome b-245, beta polypeptide 3.13236
BAHCC1 BAH domain and coiled-coil containing 1 3.13236
FOXE3 forkhead box E3 3.13236
KIAA1210 KIAA1210 3.13236
MZB1 marginal zone B and B1 cell-specific protein 3.13236
GJC2 gap junction protein, gamma 2, 47kDa 3.13236
ADAM18 ADAM metallopeptidase domain 18 3.13236
GJB6 gap junction protein, beta 6, 30kDa 3.13236
HPGDS hematopoietic prostaglandin D synthase 3.13236
ADCY4 adenylate cyclase 4 3.13236
FAIM2 Fas apoptotic inhibitory molecule 2 3.13236
LMAN1L lectin, mannose-binding, 1 like 3.13236
LGALS14 lectin, galactoside-binding, soluble, 14 3.13236
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 3.13236
GSTA2 glutathione S-transferase alpha 2 3.13236
PLA2G12B phospholipase A2, group XIIB 3.13236
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 3.13236
PIP prolactin-induced protein 3.13236
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 3.13236
C8B complement component 8, beta polypeptide 3.13236
KLK7 kallikrein-related peptidase 7 3.13236
CALML6 calmodulin-like 6 3.13236
HEMGN hemogen 3.13236
MNX1 motor neuron and pancreas homeobox 1 3.13236
NPR3 natriuretic peptide receptor 3 3.13236
ANXA8 annexin A8 3.13236
LST1 leukocyte specific transcript 1 3.13236
MMEL1 membrane metallo-endopeptidase-like 1 3.13236
MAGEA9B melanoma antigen family A9B 3.13236
TUBAL3 tubulin, alpha-like 3 3.13236
CD34 CD34 molecule 3.13236
SSX1 synovial sarcoma, X breakpoint 1 3.13236
GLT6D1 glycosyltransferase 6 domain containing 1 3.13236
NLRP6 NLR family, pyrin domain containing 6 3.13236
ASCL1 achaete-scute family bHLH transcription factor 1 3.13236
IL17B interleukin 17B 3.13236
SMCO1 single-pass membrane protein with coiled-coil domains 1 3.13236
ERP27 endoplasmic reticulum protein 27 3.13236
NUTM2F NUT family member 2F 3.13236
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A 3.13236
NLRP3 NLR family, pyrin domain containing 3 3.13236
ARMC12 armadillo repeat containing 12 3.13231
PRSS53 protease, serine, 53 3.13231
GK5 glycerol kinase 5 (putative) 3.03213
TBCC tubulin folding cofactor C 2.84929
PEX11A peroxisomal biogenesis factor 11 alpha 2.73031
CLEC2D C-type lectin domain family 2, member D 2.68769
RTN4IP1 reticulon 4 interacting protein 1 2.68769
SOD3 superoxide dismutase 3, extracellular 2.59296
GTPBP4 GTP binding protein 4 2.58568
ZSWIM5 zinc finger, SWIM-type containing 5 2.57201
DELE1 DAP3 binding cell death enhancer 1 2.46747
HSPA13 heat shock protein 70kDa family, member 13 2.39725
MNT MAX network transcriptional repressor 2.38661
TIMP3 TIMP metallopeptidase inhibitor 3 2.38661
NKAIN3 Na+/K+ transporting ATPase interacting 3 2.38661
HBEGF heparin-binding EGF-like growth factor 2.344
MFSD12 major facilitator superfamily domain containing 12 2.33355
ZDHHC14 zinc finger, DHHC-type containing 14 2.33355
STOX1 storkhead box 1 2.31414
THSD1 thrombospondin, type I, domain containing 1 2.28904
KIAA1549L KIAA1549-like 2.27881
ANO9 anoctamin 9 2.27647
SLCO1A2 solute carrier organic anion transporter family, member 1A2 2.26071
MECP2 methyl CpG binding protein 2 2.2583
GOLGA6L4 golgin A6 family-like 4 2.24456
GAB1 GRB2-associated binding protein 1 2.23508
NPIPA8 nuclear pore complex interacting protein family, member A8 2.22593
SLC71A2 solute carrier family 71 member 2 2.21326
TMOD3 tropomodulin 3 (ubiquitous) 2.20009
CERS1 ceramide synthase 1 2.19585
ETV2 ets variant 2 2.17955
CISH cytokine inducible SH2-containing protein 2.17955
TERB1 telomere repeat binding bouquet formation protein 1 2.17955
IL1R1 interleukin 1 receptor, type I 2.17955
ARHGAP20 Rho GTPase activating protein 20 2.17955
GFRA3 GDNF family receptor alpha 3 2.17955
ULK4 unc-51 like kinase 4 2.16289
FLI1 Fli-1 proto-oncogene, ETS transcription factor 2.16289
IVD isovaleryl-CoA dehydrogenase 2.16289
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) 2.16289
CBS cystathionine-beta-synthase 2.16098
GPSM1 G-protein signaling modulator 1 2.13024
KLK10 kallikrein-related peptidase 10 2.12436
CCDC148 coiled-coil domain containing 148 2.09645
MTIF2 mitochondrial translational initiation factor 2 2.09384
RPRD1A regulation of nuclear pre-mRNA domain containing 1A 2.08612
DVL2 dishevelled segment polarity protein 2 2.08228
MAGEL2 melanoma antigen family L2 2.0811
ADCY6 adenylate cyclase 6 2.06441
GADD45B growth arrest and DNA-damage-inducible, beta 2.05595
RBP2 retinol binding protein 2, cellular 2.04438
NRG3 neuregulin 3 2.0376
H2AC13 H2A clustered histone 13 2.0376
ELK1 ELK1, member of ETS oncogene family 2.01898
USP38 ubiquitin specific peptidase 38 2.00197

decreased expression

Symbol Name Standardized Value
APOH apolipoprotein H (beta-2-glycoprotein I) -3.15216
RRH retinal pigment epithelium-derived rhodopsin homolog -3.15216
MUC6 mucin 6, oligomeric mucus/gel-forming -3.15216
PCDHA4 protocadherin alpha 4 -3.15216
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 -3.15216
REV1 REV1, polymerase (DNA directed) -3.14968
SLC22A25 solute carrier family 22, member 25 -3.13236
ALLC allantoicase -3.13236
MSANTD1 Myb/SANT-like DNA-binding domain containing 1 -3.13236
AHSG alpha-2-HS-glycoprotein -3.13236
SOX30 SRY (sex determining region Y)-box 30 -3.13236
PCDHA9 protocadherin alpha 9 -3.13236
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 -3.13236
REN renin -3.13236
SLC23A3 solute carrier family 23, member 3 -3.13236
CFAP100 cilia and flagella associated protein 100 -3.13236
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide -3.13236
TEPSIN TEPSIN adaptor related protein complex 4 accessory protein -3.13236
HNF1B HNF1 homeobox B -3.13236
GJA9 gap junction protein, alpha 9, 59kDa -3.13236
MIA melanoma inhibitory activity -3.13236
C1ORF162 chromosome 1 open reading frame 162 -3.13236
PAX5 paired box 5 -3.13236
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2 -3.13236
PLET1 placenta expressed transcript 1 -3.13236
PSKH2 protein serine kinase H2 -3.13236
CXORF58 chromosome X open reading frame 58 -3.13236
LMX1B LIM homeobox transcription factor 1, beta -3.13236
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9 -3.13236
NUPR1 nuclear protein, transcriptional regulator, 1 -3.13236
MSMP microseminoprotein, prostate associated -3.13236
CALR3 calreticulin 3 -3.13236
SPDYE16 speedy/RINGO cell cycle regulator family member E16 -3.05858
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 -3.02917
CSAG3 CSAG family, member 3 -3.02917
CST6 cystatin E/M -3.00413
MPZ myelin protein zero -2.96748
NBPF3 neuroblastoma breakpoint family, member 3 -2.90643
GSKIP GSK3B interacting protein -2.8813
RIMS4 regulating synaptic membrane exocytosis 4 -2.80421
LRFN3 leucine rich repeat and fibronectin type III domain containing 3 -2.7838
RAB39A RAB39A, member RAS oncogene family -2.76105
CNGA1 cyclic nucleotide gated channel alpha 1 -2.71907
C1ORF35 chromosome 1 open reading frame 35 -2.68988
UBR2 ubiquitin protein ligase E3 component n-recognin 2 -2.66303
RUSC1 RUN and SH3 domain containing 1 -2.62273
NAP1L2 nucleosome assembly protein 1-like 2 -2.56859
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C -2.4646
KCTD8 potassium channel tetramerization domain containing 8 -2.45094
PEX16 peroxisomal biogenesis factor 16 -2.41401
BORCS7 BLOC-1 related complex subunit 7 -2.41401
S100PBP S100P binding protein -2.39725
ABHD11 abhydrolase domain containing 11 -2.38345
ZKSCAN5 zinc finger with KRAB and SCAN domains 5 -2.33717
SPDYE1 speedy/RINGO cell cycle regulator family member E1 -2.32351
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene) -2.32351
RIPK4 receptor-interacting serine-threonine kinase 4 -2.32351
ATP5MGL ATP synthase membrane subunit g like -2.32351
ACP3 acid phosphatase 3 -2.32351
DHRS11 dehydrogenase/reductase (SDR family) member 11 -2.25249
ARMH4 armadillo like helical domain containing 4 -2.23928
INPP5J inositol polyphosphate-5-phosphatase J -2.23569
MPHOSPH10 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein) -2.23156
ADO 2-aminoethanethiol (cysteamine) dioxygenase -2.21607
DIO2 deiodinase, iodothyronine, type II -2.21326
PDZD2 PDZ domain containing 2 -2.19585
STX1B syntaxin 1B -2.1885
NR1H3 nuclear receptor subfamily 1, group H, member 3 -2.17955
FSD1 fibronectin type III and SPRY domain containing 1 -2.17955
EIF3CL eukaryotic translation initiation factor 3, subunit C-like -2.17836
CCDC85B coiled-coil domain containing 85B -2.17836
GPR78 G protein-coupled receptor 78 -2.1777
ADGRG1 adhesion G protein-coupled receptor G1 -2.1777
IGIP IgA-inducing protein -2.1777
MGARP mitochondria-localized glutamic acid-rich protein -2.16289
CAPN1 calpain 1, (mu/I) large subunit -2.16289
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 -2.16202
SIRAL2 SIR2 antiphage like 2 -2.14906
CETN2 centrin, EF-hand protein, 2 -2.14906
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha -2.13422
JOSD1 Josephin domain containing 1 -2.12436
RNF144B ring finger protein 144B -2.11998
NTNG1 netrin G1 -2.11879
VAV2 vav 2 guanine nucleotide exchange factor -2.11853
HAUS6 HAUS augmin-like complex, subunit 6 -2.09301
MTX2 metaxin 2 -2.07113
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) -2.04438
PXMP2 peroxisomal membrane protein 2, 22kDa -2.04438
TSC1 tuberous sclerosis 1 -2.04438
DPY19L4 dpy-19-like 4 (C. elegans) -2.04438
SPINT2 serine peptidase inhibitor, Kunitz type, 2 -2.02767