NR3C1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)|This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011] (NCBI Entrez Gene Database, 2908)
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Genes

339 genes differentially expressed following the NR3C1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
FAM3D family with sequence similarity 3, member D 2.94227
CASP4 caspase 4, apoptosis-related cysteine peptidase 2.94227
MYBPC3 myosin binding protein C, cardiac 2.94227
GJB5 gap junction protein, beta 5, 31.1kDa 2.94227
OR2J2 olfactory receptor, family 2, subfamily J, member 2 2.94227
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 2.94227
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 2.94227
SFXN3 sideroflexin 3 2.94227
NUGGC nuclear GTPase, germinal center associated 2.94227
ADGB androglobin 2.94227
NRROS negative regulator of reactive oxygen species 2.94227
THRSP thyroid hormone responsive 2.94227
F7 coagulation factor VII (serum prothrombin conversion accelerator) 2.94227
HORMAD2 HORMA domain containing 2 2.94227
TM4SF1 transmembrane 4 L six family member 1 2.94227
UPK3B uroplakin 3B 2.94227
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime 2.94227
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 2.94227
CHADL chondroadherin-like 2.94227
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 2.94227
FAM167A family with sequence similarity 167, member A 2.94227
CHRNG cholinergic receptor, nicotinic, gamma (muscle) 2.94227
IZUMO3 IZUMO family member 3 2.94227
IGFL3 IGF-like family member 3 2.94227
CD19 CD19 molecule 2.94227
BTC betacellulin 2.94227
GLUD2 glutamate dehydrogenase 2 2.94227
GUCY2D guanylate cyclase 2D, membrane (retina-specific) 2.94227
B3GALT2 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 2.94227
SPINK14 serine peptidase inhibitor, Kazal type 14 (putative) 2.94227
MISP mitotic spindle positioning 2.94227
SETSIP SET-like protein 2.94227
MMP28 matrix metallopeptidase 28 2.94227
FAM216B family with sequence similarity 216, member B 2.94227
PRDM16 PR domain containing 16 2.94227
CPLX1 complexin 1 2.94227
TMC2 transmembrane channel-like 2 2.94227
ETV2 ets variant 2 2.94227
FAM181B family with sequence similarity 181, member B 2.94227
LOC105378220 macrophage receptor MARCO-like 2.94227
HES2 hes family bHLH transcription factor 2 2.94227
IDUA iduronidase, alpha-L- 2.94227
COL15A1 collagen, type XV, alpha 1 2.94227
PTGER4 prostaglandin E receptor 4 (subtype EP4) 2.94227
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 2.94227
TMEM217 transmembrane protein 217 2.94227
RGPD1 RANBP2-like and GRIP domain containing 1 2.94227
KHDC3L KH domain containing 3-like, subcortical maternal complex member 2.94227
UMODL1 uromodulin-like 1 2.94227
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 2.94227
CD69 CD69 molecule 2.94227
RLN1 relaxin 1 2.94227
MEIKIN meiotic kinetochore factor 2.94227
DPPA3 developmental pluripotency associated 3 2.94227
LONRF3 LON peptidase N-terminal domain and ring finger 3 2.94227
STEAP4 STEAP family member 4 2.94227
LOC107986837 uncharacterized LOC107986837 2.94227
TMEM275 transmembrane protein 275 2.94227
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 2.94227
UNC93A unc-93 homolog A (C. elegans) 2.94227
PROP1 PROP paired-like homeobox 1 2.94227
SPEM1 spermatid maturation 1 2.94227
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3 2.94227
FOXN4 forkhead box N4 2.94227
TBC1D3L TBC1 domain family, member 3L 2.94227
GIPR gastric inhibitory polypeptide receptor 2.94227
TRIM31 tripartite motif containing 31 2.94227
ADRB3 adrenoceptor beta 3 2.94227
PROC protein C (inactivator of coagulation factors Va and VIIIa) 2.94227
PLAAT4 phospholipase A and acyltransferase 4 2.94227
G6PC1 glucose-6-phosphatase catalytic subunit 1 2.94227
PNMA6F PNMA family member 6F 2.94227
SMIM47 small integral membrane protein 47 2.94227
LOC124906010 uncharacterized LOC124906010 2.94227
LOC122526780 uncharacterized LOC122526780 2.94227
H4C12 H4 clustered histone 12 2.94227
SERTM2 serine rich and transmembrane domain containing 2 2.94227
LY6L lymphocyte antigen 6 family member L 2.94227
CFAP107 cilia and flagella associated protein 107 2.94227
DNAAF6 dynein axonemal assembly factor 6 2.94227
MEIOSIN meiosis initiator 2.94227
CALHM5 calcium homeostasis modulator family member 5 2.94227
DIPK2B divergent protein kinase domain 2B 2.94227
CYP4F8 cytochrome P450, family 4, subfamily F, polypeptide 8 2.94227
BDKRB1 bradykinin receptor B1 2.94227
HSPB6 heat shock protein, alpha-crystallin-related, B6 2.94227
HAPLN2 hyaluronan and proteoglycan link protein 2 2.94227
HAPLN3 hyaluronan and proteoglycan link protein 3 2.94227
DNASE2B deoxyribonuclease II beta 2.94227
OR2AT4 olfactory receptor, family 2, subfamily AT, member 4 2.94227
MAG myelin associated glycoprotein 2.94227
OR7C1 olfactory receptor, family 7, subfamily C, member 1 2.94227
CYP2F1 cytochrome P450, family 2, subfamily F, polypeptide 1 2.94227
TRIM60 tripartite motif containing 60 2.94227
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 2.94227
OR2A5 olfactory receptor, family 2, subfamily A, member 5 2.94227
BLMH bleomycin hydrolase 2.94227
RNF113B ring finger protein 113B 2.94227
CFAP45 cilia and flagella associated protein 45 2.94227
FOXC1 forkhead box C1 2.94227
XKRX XK, Kell blood group complex subunit-related, X-linked 2.94227
ARL14EPL ADP-ribosylation factor-like 14 effector protein-like 2.94227
OSTN osteocrin 2.94227
LRRN4CL LRRN4 C-terminal like 2.94227
DYNAP dynactin associated protein 2.94227
IL16 interleukin 16 2.94227
LGSN lengsin, lens protein with glutamine synthetase domain 2.94227
GDF6 growth differentiation factor 6 2.94227
GTSF1 gametocyte specific factor 1 2.94227
MS4A13 membrane-spanning 4-domains, subfamily A, member 13 2.94227
ARMS2 age-related maculopathy susceptibility 2 2.94227
FPR1 formyl peptide receptor 1 2.94227
CXCR5 chemokine (C-X-C motif) receptor 5 2.94227
CDK20 cyclin-dependent kinase 20 2.94227
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 2.94227
RAB40AL RAB40A, member RAS oncogene family-like 2.94227
KLK14 kallikrein-related peptidase 14 2.94227
FBXO43 F-box protein 43 2.94227
C20ORF144 chromosome 20 open reading frame 144 2.94227
TEX12 testis expressed 12 2.94227
ZNF596 zinc finger protein 596 2.94227
SAMD5 sterile alpha motif domain containing 5 2.94227
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 2.94227
TAAR1 trace amine associated receptor 1 2.94227
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 2.94227
IL1B interleukin 1, beta 2.94227
ISL2 ISL LIM homeobox 2 2.94227
RRH retinal pigment epithelium-derived rhodopsin homolog 2.94227
ANKRD60 ankyrin repeat domain 60 2.94227
INHA inhibin, alpha 2.94227
NIPAL4 NIPA-like domain containing 4 2.94227
AKNAD1 AKNA domain containing 1 2.94227
CPA2 carboxypeptidase A2 (pancreatic) 2.94227
APOC4 apolipoprotein C-IV 2.94227
CBX8 chromobox homolog 8 2.94227
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 2.94227
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2 2.94227
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 2.94227
P2RY13 purinergic receptor P2Y, G-protein coupled, 13 2.94227
CCDC183 coiled-coil domain containing 183 2.94227
CRYBA1 crystallin, beta A1 2.94227
CALHM3 calcium homeostasis modulator 3 2.94227
CASQ2 calsequestrin 2 (cardiac muscle) 2.94227
ETV3L ets variant 3-like 2.94227
DENND2D DENN/MADD domain containing 2D 2.94227
FBXO15 F-box protein 15 2.94227
C1ORF185 chromosome 1 open reading frame 185 2.94227
TTC22 tetratricopeptide repeat domain 22 2.94227
DRC7 dynein regulatory complex subunit 7 2.94227
ZPBP zona pellucida binding protein 2.94227
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 2.94227
SLC36A2 solute carrier family 36 (proton/amino acid symporter), member 2 2.94227
GALNTL5 polypeptide N-acetylgalactosaminyltransferase-like 5 2.94227
NLRP14 NLR family, pyrin domain containing 14 2.94227
GPRC6A G protein-coupled receptor, class C, group 6, member A 2.94227
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 2.94227
C11ORF42 chromosome 11 open reading frame 42 2.94227
ANKRD55 ankyrin repeat domain 55 2.94227
DEFA5 defensin, alpha 5, Paneth cell-specific 2.94227
VAV1 vav 1 guanine nucleotide exchange factor 2.94227
OR14J1 olfactory receptor, family 14, subfamily J, member 1 2.94227
GPR68 G protein-coupled receptor 68 2.94227
B9D2 B9 protein domain 2 2.94227
OR4D2 olfactory receptor, family 4, subfamily D, member 2 2.94227
MYH7B myosin, heavy chain 7B, cardiac muscle, beta 2.94227
GFY golgi-associated, olfactory signaling regulator 2.94227
CLUL1 clusterin-like 1 (retinal) 2.94227
ERVV-1 endogenous retrovirus group V, member 1 2.94227
RASA4 RAS p21 protein activator 4 2.94227
ART4 ADP-ribosyltransferase 4 (Dombrock blood group) 2.94227
KIAA1755 KIAA1755 2.94227
ST18 suppression of tumorigenicity 18, zinc finger 2.94227
TEX38 testis expressed 38 2.94227
TMPRSS13 transmembrane protease, serine 13 2.94227
TMEM156 transmembrane protein 156 2.94227
C4BPA complement component 4 binding protein, alpha 2.94227
ABCD2 ATP-binding cassette, sub-family D (ALD), member 2 2.94227
CD80 CD80 molecule 2.94227
PPEF1 protein phosphatase, EF-hand calcium binding domain 1 2.94227
ROM1 retinal outer segment membrane protein 1 2.94227
NUTM2A NUT family member 2A 2.94227
PRR15L proline rich 15-like 2.94227
SPNS3 spinster homolog 3 (Drosophila) 2.94227
ASB17 ankyrin repeat and SOCS box containing 17 2.94227
MMP10 matrix metallopeptidase 10 2.94227
EPHB3 EPH receptor B3 2.94227
NR4A3 nuclear receptor subfamily 4, group A, member 3 2.94227
MEIG1 meiosis/spermiogenesis associated 1 2.94227
FXYD3 FXYD domain containing ion transport regulator 3 2.94227
CD34 CD34 molecule 2.94227
CD226 CD226 molecule 2.94227
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 2.94227
ZNF396 zinc finger protein 396 2.94227
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4 2.94227
RAB7B RAB7B, member RAS oncogene family 2.94227
OPN1LW opsin 1 (cone pigments), long-wave-sensitive 2.94227
ANKRD33 ankyrin repeat domain 33 2.94227
SV2B synaptic vesicle glycoprotein 2B 2.94227
SEMG1 semenogelin I 2.94227
CCL27 chemokine (C-C motif) ligand 27 2.94227
GBA3 glucosidase, beta, acid 3 (gene/pseudogene) 2.94227
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group) 2.94227
STOML3 stomatin (EPB72)-like 3 2.94227
HHATL hedgehog acyltransferase-like 2.94227
BOLL boule-like RNA-binding protein 2.94227
SYNDIG1 synapse differentiation inducing 1 2.84747
MPPE1 metallophosphoesterase 1 2.8286
BLTP1 bridge-like lipid transfer protein family member 1 2.81708
SLIT1 slit homolog 1 (Drosophila) 2.80579
TMEM141 transmembrane protein 141 2.7928
DNAH14 dynein, axonemal, heavy chain 14 2.7818
FCSK fucose kinase 2.73974
OSBPL7 oxysterol binding protein-like 7 2.73974
ACTA2 actin, alpha 2, smooth muscle, aorta 2.73974
GLRX glutaredoxin (thioltransferase) 2.72361
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 2.61262
TMEM214 transmembrane protein 214 2.5873
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 2.57593
SNX3 sorting nexin 3 2.46422
TRIM33 tripartite motif containing 33 2.43943
SAPCD2 suppressor APC domain containing 2 2.38614
UTS2B urotensin 2B 2.36719
JAM2 junctional adhesion molecule 2 2.34273
KALRN kalirin, RhoGEF kinase 2.32896
CEL carboxyl ester lipase 2.31471
RRM1 ribonucleotide reductase M1 2.30818
GIP gastric inhibitory polypeptide 2.27599
POU5F2 POU domain class 5, transcription factor 2 2.27599
PES1 pescadillo ribosomal biogenesis factor 1 2.25581
COL4A2 collagen, type IV, alpha 2 2.25237
SPAG5 sperm associated antigen 5 2.25223
NOSIP nitric oxide synthase interacting protein 2.25223
TRAIP TRAF interacting protein 2.19893
AGO2 argonaute RISC catalytic component 2 2.18047
DBF4B DBF4 zinc finger B 2.14068
TMEM50B transmembrane protein 50B 2.14068
VPS52 vacuolar protein sorting 52 homolog (S. cerevisiae) 2.14068
ICOSLG inducible T-cell co-stimulator ligand 2.13421
EXOSC6 exosome component 6 2.12378
ITPKC inositol-trisphosphate 3-kinase C 2.11058
NOTCH2NLA notch 2 N-terminal like A 2.09308
RACGAP1 Rac GTPase activating protein 1 2.08698
SH3RF2 SH3 domain containing ring finger 2 2.08698
HMG20B high mobility group 20B 2.08475
HSPE1 heat shock 10kDa protein 1 2.05609
TMC6 transmembrane channel-like 6 2.04935
MANF mesencephalic astrocyte-derived neurotrophic factor 2.02365
ZNF267 zinc finger protein 267 2.01784
ANKRD35 ankyrin repeat domain 35 2.00743
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2 2.00632

decreased expression

Symbol Name Standardized Value
VAMP7 vesicle-associated membrane protein 7 -2.94227
PRSS51 protease, serine, 51 -2.94227
ASIC4 acid sensing (proton gated) ion channel family member 4 -2.94227
MTMR11 myotubularin related protein 11 -2.94227
ROR2 receptor tyrosine kinase-like orphan receptor 2 -2.94227
FMO3 flavin containing monooxygenase 3 -2.94227
CXCL17 chemokine (C-X-C motif) ligand 17 -2.94227
CCDC81 coiled-coil domain containing 81 -2.94227
ZC3HAV1L zinc finger CCCH-type, antiviral 1-like -2.94227
NATD1 N-acetyltransferase domain containing 1 -2.94227
TNS2 tensin 2 -2.94227
TAS2R4 taste receptor, type 2, member 4 -2.94227
CCDC85A coiled-coil domain containing 85A -2.94227
ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3 -2.94227
FGF22 fibroblast growth factor 22 -2.94227
SYNPO2L synaptopodin 2-like -2.94227
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 -2.94227
ORAI3 ORAI calcium release-activated calcium modulator 3 -2.94227
LRRC47 leucine rich repeat containing 47 -2.94227
DENND4B DENN/MADD domain containing 4B -2.94227
SBSPON somatomedin B and thrombospondin, type 1 domain containing -2.94227
IQCN IQ motif containing N -2.94227
TAFA1 TAFA chemokine like family member 1 -2.94227
TPTE2 transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 -2.94227
LINGO3 leucine rich repeat and Ig domain containing 3 -2.94227
APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2 -2.94227
ZNF599 zinc finger protein 599 -2.94227
PLLP plasmolipin -2.94227
ZNF837 zinc finger protein 837 -2.94227
NLRC5 NLR family, CARD domain containing 5 -2.94227
EFCAB8 EF-hand calcium binding domain 8 -2.94227
HPD 4-hydroxyphenylpyruvate dioxygenase -2.94227
CDH18 cadherin 18, type 2 -2.94227
PIRT phosphoinositide-interacting regulator of transient receptor potential channels -2.94227
BCAN brevican -2.94227
MFSD6L major facilitator superfamily domain containing 6-like -2.94227
DACT1 dishevelled-binding antagonist of beta-catenin 1 -2.93536
COL5A3 collagen, type V, alpha 3 -2.8916
CCDC32 coiled-coil domain containing 32 -2.8751
PUDP pseudouridine 5'-phosphatase -2.82076
DRC10 dynein regulatory complex subunit 10 -2.76968
FN3KRP fructosamine 3 kinase related protein -2.7489
GALR1 galanin receptor 1 -2.67907
ZMYND19 zinc finger, MYND-type containing 19 -2.66121
FDXR ferredoxin reductase -2.65703
CPXM1 carboxypeptidase X (M14 family), member 1 -2.64264
ZSCAN20 zinc finger and SCAN domain containing 20 -2.64264
TMEM154 transmembrane protein 154 -2.63319
SOX10 SRY (sex determining region Y)-box 10 -2.63319
INTS8 integrator complex subunit 8 -2.63319
RPS10 ribosomal protein S10 -2.5778
COQ3 coenzyme Q3 methyltransferase -2.56107
TPRKB TP53RK binding protein -2.46818
GPAT4 glycerol-3-phosphate acyltransferase 4 -2.46151
LAT linker for activation of T cells -2.45442
RDH5 retinol dehydrogenase 5 (11-cis/9-cis) -2.43488
MARVELD1 MARVEL domain containing 1 -2.43203
TTC26 tetratricopeptide repeat domain 26 -2.42296
DNAAF4 dynein axonemal assembly factor 4 -2.39996
RBM43 RNA binding motif protein 43 -2.39686
AEBP1 AE binding protein 1 -2.36764
IGSF8 immunoglobulin superfamily, member 8 -2.36207
PTER phosphotriesterase related -2.35658
NPIPB6 nuclear pore complex interacting protein family, member B6 -2.35658
RNF5 ring finger protein 5, E3 ubiquitin protein ligase -2.35474
RHBG Rh family, B glycoprotein (gene/pseudogene) -2.34658
ASTN2 astrotactin 2 -2.31565
TRAP1 TNF receptor-associated protein 1 -2.30904
EGFR epidermal growth factor receptor -2.30559
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 -2.29945
EMILIN2 elastin microfibril interfacer 2 -2.29945
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 -2.29945
GOLGA6L9 golgin A6 family-like 9 -2.22017
NHLRC3 NHL repeat containing 3 -2.1934
CNIH1 cornichon family AMPA receptor auxiliary protein 1 -2.16654
IGFBP6 insulin-like growth factor binding protein 6 -2.15016
STYK1 serine/threonine/tyrosine kinase 1 -2.14787
RNF41 ring finger protein 41, E3 ubiquitin protein ligase -2.14068
SH2B3 SH2B adaptor protein 3 -2.13421
ANKRD10 ankyrin repeat domain 10 -2.10327
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -2.08961
ASGR1 asialoglycoprotein receptor 1 -2.08056
H3C11 H3 clustered histone 11 -2.07503
ZNF143 zinc finger protein 143 -2.06639
ANO6 anoctamin 6 -2.05654
DTWD1 DTW domain containing 1 -2.03887
SNF8 SNF8, ESCRT-II complex subunit -2.011
KDSR 3-ketodihydrosphingosine reductase -2.00805
SYT16 synaptotagmin XVI -2.00743