NR3C1 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)|This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011] (NCBI Entrez Gene Database, 2908)
External Link http://www.ncbi.nlm.nih.gov/gene/2908
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Genes

247 interacting proteins for NR3C1 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ACP1 acid phosphatase 1, soluble
ADA adenosine deaminase
AGO1 argonaute RISC catalytic component 1
AGO2 argonaute RISC catalytic component 2
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANKMY2 ankyrin repeat and MYND domain containing 2
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
AR androgen receptor
ARAF A-Raf proto-oncogene, serine/threonine kinase
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa
ASXL1 additional sex combs like transcriptional regulator 1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKB aurora kinase B
BAG1 BCL2-associated athanogene
BRCC3 BRCA1/BRCA2-containing complex, subunit 3
C14ORF80 chromosome 14 open reading frame 80
CACYBP calcyclin binding protein
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CALR calreticulin
CCDC6 coiled-coil domain containing 6
CD2AP CD2-associated protein
CD3D CD3d molecule, delta (CD3-TCR complex)
CD3G CD3g molecule, gamma (CD3-TCR complex)
CD4 CD4 molecule
CDC37 cell division cycle 37
CDC37L1 cell division cycle 37-like 1
CDK11A cyclin-dependent kinase 11A
CDK4 cyclin-dependent kinase 4
CDK5 cyclin-dependent kinase 5
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CDK9 cyclin-dependent kinase 9
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CENPB centromere protein B, 80kDa
CHD9 chromodomain helicase DNA binding protein 9
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CHUK conserved helix-loop-helix ubiquitous kinase
CLIP1 CAP-GLY domain containing linker protein 1
CLTC clathrin, heavy chain (Hc)
CLU clusterin
COPS6 COP9 signalosome subunit 6
CREB1 cAMP responsive element binding protein 1
CREBBP CREB binding protein
CUL2 cullin 2
CWC15 CWC15 spliceosome-associated protein
CXORF57 chromosome X open reading frame 57
DAP3 death associated protein 3
DAXX death-domain associated protein
DCAF6 DDB1 and CUL4 associated factor 6
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2
ECD ecdysoneless homolog (Drosophila)
EGLN1 egl-9 family hypoxia-inducible factor 1
EIF4A2 eukaryotic translation initiation factor 4A2
EIF5B eukaryotic translation initiation factor 5B
ELAVL1 ELAV like RNA binding protein 1
EP300 E1A binding protein p300
EPB41L2 erythrocyte membrane protein band 4.1-like 2
EPB41L3 erythrocyte membrane protein band 4.1-like 3
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FKBP4 FK506 binding protein 4, 59kDa
FKBP5 FK506 binding protein 5
FOS FBJ murine osteosarcoma viral oncogene homolog
FTH1 ferritin, heavy polypeptide 1
FYN FYN proto-oncogene, Src family tyrosine kinase
GAPVD1 GTPase activating protein and VPS9 domains 1
GLMN glomulin, FKBP associated protein
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
GRIP1 glutamate receptor interacting protein 1
GSK3B glycogen synthase kinase 3 beta
HDAC1 histone deacetylase 1
HDAC2 histone deacetylase 2
HDAC6 histone deacetylase 6
HMGB1 high mobility group box 1
HMGB2 high mobility group box 2
HMOX2 heme oxygenase 2
HNF4A hepatocyte nuclear factor 4, alpha
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HNRNPR heterogeneous nuclear ribonucleoprotein R
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
HOXB1 homeobox B1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1B heat shock 70kDa protein 1B
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IDE insulin-degrading enzyme
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1)
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
ILK integrin-linked kinase
JUN jun proto-oncogene
KAT5 K(lysine) acetyltransferase 5
KDM5A lysine (K)-specific demethylase 5A
KIAA0408 KIAA0408
KIF1BP KIF1 binding protein
KMT2A lysine (K)-specific methyltransferase 2A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KTN1 kinectin 1 (kinesin receptor)
LARP7 La ribonucleoprotein domain family, member 7
LCK LCK proto-oncogene, Src family tyrosine kinase
LRIF1 ligand dependent nuclear receptor interacting factor 1
LRRC40 leucine rich repeat containing 40
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA11 melanoma antigen family A11
MAPK1 mitogen-activated protein kinase 1
MAPK10 mitogen-activated protein kinase 10
MAPK11 mitogen-activated protein kinase 11
MAPK14 mitogen-activated protein kinase 14
MAPK15 mitogen-activated protein kinase 15
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MCM4 minichromosome maintenance complex component 4
MCMBP minichromosome maintenance complex binding protein
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MED1 mediator complex subunit 1
MED14 mediator complex subunit 14
MED25 mediator complex subunit 25
MSX2 msh homeobox 2
MTA2 metastasis associated 1 family, member 2
NCOA1 nuclear receptor coactivator 1
NCOA2 nuclear receptor coactivator 2
NCOA3 nuclear receptor coactivator 3
NCOA4 nuclear receptor coactivator 4
NCOA6 nuclear receptor coactivator 6
NCOR1 nuclear receptor corepressor 1
NCOR2 nuclear receptor corepressor 2
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NR0B1 nuclear receptor subfamily 0, group B, member 1
NR1H3 nuclear receptor subfamily 1, group H, member 3
NR2E3 nuclear receptor subfamily 2, group E, member 3
NR2F2 nuclear receptor subfamily 2, group F, member 2
NR2F6 nuclear receptor subfamily 2, group F, member 6
NR3C2 nuclear receptor subfamily 3, group C, member 2
NR4A1 nuclear receptor subfamily 4, group A, member 1
NRIP1 nuclear receptor interacting protein 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUCLEOLIN nucleolin multifunctional protein
NUDC nudC nuclear distribution protein
NUDCD3 NudC domain containing 3
ONECUT1 one cut homeobox 1
OSGEP O-sialoglycoprotein endopeptidase
PBX1 pre-B-cell leukemia homeobox 1
PDCD2 programmed cell death 2
PELP1 proline, glutamate and leucine rich protein 1
PHF3 PHD finger protein 3
PIAS2 protein inhibitor of activated STAT, 2
PML promyelocytic leukemia
PNPLA2 patatin-like phospholipase domain containing 2
POLR1D polymerase (RNA) I polypeptide D, 16kDa
POU1F1 POU class 1 homeobox 1
POU2F1 POU class 2 homeobox 1
POU2F2 POU class 2 homeobox 2
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPID peptidylprolyl isomerase D
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PPP5C protein phosphatase 5, catalytic subunit
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRPF6 pre-mRNA processing factor 6
PRRC2C proline-rich coiled-coil 2C
PSMC3IP PSMC3 interacting protein
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
PTGES3 prostaglandin E synthase 3 (cytosolic)
PTMS parathymosin
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
PYGL phosphorylase, glycogen, liver
RABEP2 rabaptin, RAB GTPase binding effector protein 2
RAD54L2 RAD54-like 2 (S. cerevisiae)
RAD9A RAD9 homolog A (S. pombe)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RAN RAN, member RAS oncogene family
RANBP9 RAN binding protein 9
RARA retinoic acid receptor, alpha
RBM14 RNA binding motif protein 14
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RNF14 ring finger protein 14
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
RXRB retinoid X receptor, beta
SET SET nuclear proto-oncogene
SF3A1 splicing factor 3a, subunit 1, 120kDa
SFN stratifin
SFPQ splicing factor proline/glutamine-rich
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SMAD3 SMAD family member 3
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
SRA1 steroid receptor RNA activator 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRSF5 serine/arginine-rich splicing factor 5
SSB Sjogren syndrome antigen B (autoantigen La)
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
STIP1 stress-induced phosphoprotein 1
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
SUGT1 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)
SUMO1 small ubiquitin-like modifier 1
SUMO2 small ubiquitin-like modifier 2
SUMO4 small ubiquitin-like modifier 4
SVIL supervillin
SYT1 synaptotagmin I
TADA2A transcriptional adaptor 2A
TBP TATA box binding protein
TCEAL2 transcription elongation factor A (SII)-like 2
TDG thymine-DNA glycosylase
TGFB1I1 transforming growth factor beta 1 induced transcript 1
THRAP3 thyroid hormone receptor associated protein 3
TJP2 tight junction protein 2
TMF1 TATA element modulatory factor 1
TP53 tumor protein p53
TP53BP1 tumor protein p53 binding protein 1
TRIM24 tripartite motif containing 24
TRIM28 tripartite motif containing 28
TSG101 tumor susceptibility 101
TSPYL2 TSPY-like 2
TTC3 tetratricopeptide repeat domain 3
TTC4 tetratricopeptide repeat domain 4
TUBA1A tubulin, alpha 1a
TXN thioredoxin
UBB ubiquitin B
UBC ubiquitin C
UBE2I ubiquitin-conjugating enzyme E2I
UBE2L3 ubiquitin-conjugating enzyme E2L 3
UBE3A ubiquitin protein ligase E3A
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
ZBTB16 zinc finger and BTB domain containing 16
ZBTB20 zinc finger and BTB domain containing 20
ZBTB3 zinc finger and BTB domain containing 3
ZBTB9 zinc finger and BTB domain containing 9
ZHX1 zinc fingers and homeoboxes 1
ZNF483 zinc finger protein 483
ZNF496 zinc finger protein 496