NR3C2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description nuclear receptor subfamily 3, group C, member 2|This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009] (NCBI Entrez Gene Database, 4306)
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Genes

304 genes differentially expressed following the NR3C2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
LRRC74A leucine rich repeat containing 74A 3.65213
PCDHGA12 protocadherin gamma subfamily A, 12 3.65213
TTR transthyretin 3.65213
WT1 Wilms tumor 1 3.65213
IRX1 iroquois homeobox 1 3.65213
CDKN2A cyclin-dependent kinase inhibitor 2A 3.65213
PECAM1 platelet/endothelial cell adhesion molecule 1 3.65213
TRIM55 tripartite motif containing 55 3.65213
TMEM88 transmembrane protein 88 3.65213
NPFFR1 neuropeptide FF receptor 1 3.65213
XCL1 chemokine (C motif) ligand 1 3.65213
OR52A5 olfactory receptor, family 52, subfamily A, member 5 3.65213
PAX2 paired box 2 3.65213
ADAM21 ADAM metallopeptidase domain 21 3.65213
TNR tenascin R 3.65213
SH2D6 SH2 domain containing 6 3.65213
ASB9 ankyrin repeat and SOCS box containing 9 3.65213
ALX4 ALX homeobox 4 3.65213
ENDOU endonuclease, polyU-specific 3.65213
CSNK2A2IP casein kinase 2 subunit alpha' interacting protein 3.65213
RASA4 RAS p21 protein activator 4 3.65213
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20 3.65213
LRRIQ4 leucine-rich repeats and IQ motif containing 4 3.65213
GJC2 gap junction protein, gamma 2, 47kDa 3.65213
TERB1 telomere repeat binding bouquet formation protein 1 3.65213
AFM afamin 3.5293
GSTM5 glutathione S-transferase mu 5 3.5293
OR2AG1 olfactory receptor, family 2, subfamily AG, member 1 (gene/pseudogene) 3.5293
GJB1 gap junction protein, beta 1, 32kDa 3.5293
SPINK13 serine peptidase inhibitor, Kazal type 13 (putative) 3.5293
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 3.5293
DNAJC5B DnaJ (Hsp40) homolog, subfamily C, member 5 beta 3.5293
OR52H1 olfactory receptor, family 52, subfamily H, member 1 3.5293
SIGLECL1 SIGLEC family like 1 3.5293
DAO D-amino-acid oxidase 3.5293
OR51A7 olfactory receptor, family 51, subfamily A, member 7 3.5293
PCDHB7 protocadherin beta 7 3.5293
MILR1 mast cell immunoglobulin-like receptor 1 3.5293
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 3.5293
C1GALT1C1L C1GALT1-specific chaperone 1 like 3.5293
OR5V1 olfactory receptor, family 5, subfamily V, member 1 3.5293
S100A5 S100 calcium binding protein A5 3.5293
ZNF556 zinc finger protein 556 3.5293
PTGER4 prostaglandin E receptor 4 (subtype EP4) 3.5293
CXCL2 chemokine (C-X-C motif) ligand 2 3.5293
OCM2 oncomodulin 2 3.5293
PSCA prostate stem cell antigen 3.5293
BIRC3 baculoviral IAP repeat containing 3 3.5293
OR2W3 olfactory receptor, family 2, subfamily W, member 3 3.5293
SP7 Sp7 transcription factor 3.5293
LRRC63 leucine rich repeat containing 63 3.5293
CLEC5A C-type lectin domain family 5, member A 3.5293
LYNX1 Ly6/neurotoxin 1 3.5293
SOWAHB sosondowah ankyrin repeat domain family member B 3.5293
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 3.5293
DLL4 delta-like 4 (Drosophila) 3.5293
ASB17 ankyrin repeat and SOCS box containing 17 3.5293
BIRC7 baculoviral IAP repeat containing 7 3.5293
SLC28A2 solute carrier family 28 (concentrative nucleoside transporter), member 2 3.5293
MYO7B myosin VIIB 3.5293
LOC124906892 uncharacterized LOC124906892 3.5293
OTOR otoraplin 3.5293
SMLR1 small leucine-rich protein 1 3.5293
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 3.5293
IFIT1B interferon-induced protein with tetratricopeptide repeats 1B 3.5293
FOXD1 forkhead box D1 3.5293
GCSAM germinal center-associated, signaling and motility 3.5293
GATA1 GATA binding protein 1 (globin transcription factor 1) 3.5293
GATA3 GATA binding protein 3 3.5293
DLK2 delta-like 2 homolog (Drosophila) 3.5293
SOHLH1 spermatogenesis and oogenesis specific basic helix-loop-helix 1 3.5293
GBP4 guanylate binding protein 4 3.5293
LOC124900192 uncharacterized LOC124900192 3.5293
SPATA31H1 SPATA31 subfamily H member 1 3.5293
GREP1 glycine rich extracellular protein 1 3.5293
GLYATL1B glycine-N-acyltransferase like 1B 3.5293
ACP4 acid phosphatase 4 3.5293
TEX55 testis expressed 55 3.5293
H2BC3 H2B clustered histone 3 3.5293
VXN vexin 3.5293
FYB1 FYN binding protein 1 3.5293
UTS2 urotensin 2 3.5293
RASAL3 RAS protein activator like 3 3.5293
C1QL2 complement component 1, q subcomponent-like 2 3.5293
OR2A1 olfactory receptor, family 2, subfamily A, member 1 3.5293
OR2A25 olfactory receptor, family 2, subfamily A, member 25 3.5293
KLHL35 kelch-like family member 35 3.5293
GMCL2 germ cell-less 2, spermatogenesis associated 3.5293
WEE2 WEE1 homolog 2 (S. pombe) 3.5293
MS4A6E membrane-spanning 4-domains, subfamily A, member 6E 3.5293
GJA9 gap junction protein, alpha 9, 59kDa 3.5293
INHBB inhibin, beta B 3.5293
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 3.5293
PCDHA7 protocadherin alpha 7 3.5293
WDR31 WD repeat domain 31 3.5293
APOBEC4 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative) 3.5293
MIP major intrinsic protein of lens fiber 3.5293
AWAT2 acyl-CoA wax alcohol acyltransferase 2 3.5293
IL31RA interleukin 31 receptor A 3.5293
CCR6 chemokine (C-C motif) receptor 6 3.5293
VSX2 visual system homeobox 2 3.5293
CLEC3A C-type lectin domain family 3, member A 3.5293
TEX101 testis expressed 101 3.5293
PTGDR2 prostaglandin D2 receptor 2 3.5293
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 3.5293
EHF ets homologous factor 3.5293
POTEI POTE ankyrin domain family, member I 3.5293
KLK11 kallikrein-related peptidase 11 3.5293
MMP3 matrix metallopeptidase 3 3.5293
TDRD10 tudor domain containing 10 3.5293
GALNTL5 polypeptide N-acetylgalactosaminyltransferase-like 5 3.5293
APOL6 apolipoprotein L, 6 3.5293
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 3.5293
SLC51B solute carrier family 51, beta subunit 3.5293
SLC34A1 solute carrier family 34 (type II sodium/phosphate cotransporter), member 1 3.5293
ADRA1B adrenoceptor alpha 1B 3.5293
SDSL serine dehydratase-like 3.5293
TF transferrin 3.5293
RGCC regulator of cell cycle 3.5293
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D 3.5293
AQP9 aquaporin 9 3.5293
GP2 glycoprotein 2 (zymogen granule membrane) 3.5293
ANKRD61 ankyrin repeat domain 61 3.5293
CDH19 cadherin 19, type 2 3.5293
RAD21L1 RAD21-like 1 (S. pombe) 3.5293
BTNL3 butyrophilin-like 3 3.5293
CNTF ciliary neurotrophic factor 3.5293
MORC1 MORC family CW-type zinc finger 1 3.5293
ERMN ermin, ERM-like protein 3.5293
CMTM5 CKLF-like MARVEL transmembrane domain containing 5 3.5293
CRHR1 corticotropin releasing hormone receptor 1 3.5293
ISL2 ISL LIM homeobox 2 3.5293
SMIM17 small integral membrane protein 17 3.5293
GSTA2 glutathione S-transferase alpha 2 3.5293
EMCN endomucin 3.5293
CALY calcyon neuron-specific vesicular protein 3.5293
SPACA1 sperm acrosome associated 1 3.5293
ERVV-1 endogenous retrovirus group V, member 1 3.5293
GPR142 G protein-coupled receptor 142 3.5293
FGF6 fibroblast growth factor 6 3.5293
ADAM18 ADAM metallopeptidase domain 18 3.5293
MYF6 myogenic factor 6 (herculin) 3.5293
MPP4 membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) 3.5293
SLC10A5 solute carrier family 10, member 5 3.5293
PNLDC1 poly(A)-specific ribonuclease (PARN)-like domain containing 1 3.5293
DKK1 dickkopf WNT signaling pathway inhibitor 1 3.5293
ANKRD30A ankyrin repeat domain 30A 3.5293
MAGEC3 melanoma antigen family C3 3.5293
OR14J1 olfactory receptor, family 14, subfamily J, member 1 3.5293
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) 3.5293
FAM216B family with sequence similarity 216, member B 3.5293
SLC38A11 solute carrier family 38, member 11 3.5293
ALDH8A1 aldehyde dehydrogenase 8 family, member A1 3.5293
PRDM14 PR domain containing 14 3.5293
CPLX4 complexin 4 3.5293
ZNF648 zinc finger protein 648 3.5293
CLEC1A C-type lectin domain family 1, member A 3.5293
CPLX3 complexin 3 3.5293
SLC18A1 solute carrier family 18 (vesicular monoamine transporter), member 1 3.5293
C22ORF31 chromosome 22 open reading frame 31 3.5293
SEC22C SEC22 vesicle trafficking protein homolog C (S. cerevisiae) 3.48409
CBX4 chromobox homolog 4 3.43847
ZNF431 zinc finger protein 431 3.38674
QARS1 glutaminyl-tRNA synthetase 1 3.06037
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 2.98994
GREM2 gremlin 2, DAN family BMP antagonist 2.91347
COL12A1 collagen, type XII, alpha 1 2.91347
TMEM253 transmembrane protein 253 2.91347
DUSP8 dual specificity phosphatase 8 2.91325
NBPF12 neuroblastoma breakpoint family, member 12 2.81693
EIF2B5 eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa 2.6349
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase 2.5913
UNC13A unc-13 homolog A (C. elegans) 2.46635
SNAPC3 small nuclear RNA activating complex, polypeptide 3, 50kDa 2.43986
CDNF cerebral dopamine neurotrophic factor 2.43865
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 2.40996
PATL1 protein associated with topoisomerase II homolog 1 (yeast) 2.39374
PLPPR5 phospholipid phosphatase related 5 2.39046
ISYNA1 inositol-3-phosphate synthase 1 2.37452
LYSMD2 LysM, putative peptidoglycan-binding, domain containing 2 2.37452
CCDC83 coiled-coil domain containing 83 2.37452
PRRT4 proline-rich transmembrane protein 4 2.37452
SLCO6A1 solute carrier organic anion transporter family, member 6A1 2.35209
GRIP1 glutamate receptor interacting protein 1 2.33804
C6ORF58 chromosome 6 open reading frame 58 2.33804
PSEN1 presenilin 1 2.317
HDAC10 histone deacetylase 10 2.30593
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 2.30034
ZBED6 zinc finger, BED-type containing 6 2.29249
NELL1 NEL-like 1 (chicken) 2.28667
PISD phosphatidylserine decarboxylase 2.26526
RBL2 retinoblastoma-like 2 2.25674
SIGLEC10 sialic acid binding Ig-like lectin 10 2.25522
EPX eosinophil peroxidase 2.2539
CFAP57 cilia and flagella associated protein 57 2.2539
CLEC2A C-type lectin domain family 2, member A 2.24884
PARPBP PARP1 binding protein 2.24115
PPWD1 peptidylprolyl isomerase domain and WD repeat containing 1 2.2344
ZNF154 zinc finger protein 154 2.22646
ZNF878 zinc finger protein 878 2.21349
DYRK1B dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B 2.21349
RRAGD Ras-related GTP binding D 2.21277
TSNAXIP1 translin-associated factor X interacting protein 1 2.21277
TMEM31 transmembrane protein 31 2.21277
SLC44A5 solute carrier family 44, member 5 2.19834
PEX14 peroxisomal biogenesis factor 14 2.17108
ZKSCAN7 zinc finger with KRAB and SCAN domains 7 2.11189
EML5 echinoderm microtubule associated protein like 5 2.11098
ZBTB26 zinc finger and BTB domain containing 26 2.11098
RABEPK Rab9 effector protein with kelch motifs 2.10538
SDHAF3 succinate dehydrogenase complex assembly factor 3 2.09523
ORMDL1 ORMDL sphingolipid biosynthesis regulator 1 2.09338
MYT1 myelin transcription factor 1 2.09069
MAP3K15 mitogen-activated protein kinase kinase kinase 15 2.09069
NLRC4 NLR family, CARD domain containing 4 2.09069
SLC9B2 solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2 2.07746
EFHD1 EF-hand domain family, member D1 2.07183
MARCHF8 membrane associated ring-CH-type finger 8 2.06461
KLC1 kinesin light chain 1 2.06361
KCTD1 potassium channel tetramerization domain containing 1 2.04798
SCGN secretagogin, EF-hand calcium binding protein 2.04331
SSR1 signal sequence receptor, alpha 2.02916
DYRK4 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 2.01398

decreased expression

Symbol Name Standardized Value
CTSO cathepsin O -3.65213
SCT secretin -3.65213
SPMIP11 sperm microtubule inner protein 11 -3.65213
ABCB5 ATP-binding cassette, sub-family B (MDR/TAP), member 5 -3.65213
ILDR2 immunoglobulin-like domain containing receptor 2 -3.65213
CLEC4A C-type lectin domain family 4, member A -3.65213
RSPH10B2 radial spoke head 10 homolog B2 (Chlamydomonas) -3.5293
GCOM1 GRINL1A complex locus 1 -3.5293
NFAM1 NFAT activating protein with ITAM motif 1 -3.5293
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa -3.5293
FABP12 fatty acid binding protein 12 -3.5293
C8ORF74 chromosome 8 open reading frame 74 -3.5293
HCST hematopoietic cell signal transducer -3.5293
FOSB FBJ murine osteosarcoma viral oncogene homolog B -3.5293
MC5R melanocortin 5 receptor -3.5293
NWD1 NACHT and WD repeat domain containing 1 -3.5293
ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 -3.5293
FAM181B family with sequence similarity 181, member B -3.5293
CD160 CD160 molecule -3.5293
TMPRSS4 transmembrane protease, serine 4 -3.5293
PNLIPRP2 pancreatic lipase-related protein 2 -3.5293
ABHD15 abhydrolase domain containing 15 -3.5293
CCDC17 coiled-coil domain containing 17 -3.5293
FAM151A family with sequence similarity 151, member A -3.5293
SH2D1B SH2 domain containing 1B -3.5293
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 -3.5293
LRTM3 leucine rich repeat transmembrane protein 3 -3.5293
ACTN1 actinin, alpha 1 -3.5293
NOXO1 NADPH oxidase organizer 1 -3.20328
ATP5MF ATP synthase membrane subunit f -3.11028
LAMTOR4 late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 -3.02982
MRO maestro -3.01756
RPRD1A regulation of nuclear pre-mRNA domain containing 1A -2.948
MYO1B myosin IB -2.91325
CLNS1A chloride channel, nucleotide-sensitive, 1A -2.86155
NID1 nidogen 1 -2.84137
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.74766
UBB ubiquitin B -2.7165
FGD3 FYVE, RhoGEF and PH domain containing 3 -2.64965
DNAJC18 DnaJ (Hsp40) homolog, subfamily C, member 18 -2.55385
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1 -2.52147
PDZRN4 PDZ domain containing ring finger 4 -2.49587
SCN3B sodium channel, voltage gated, type III beta subunit -2.49587
MYLK4 myosin light chain kinase family, member 4 -2.49587
APOB apolipoprotein B -2.49587
CDH15 cadherin 15, type 1, M-cadherin (myotubule) -2.49587
SPDYE16 speedy/RINGO cell cycle regulator family member E16 -2.48983
WARS2 tryptophanyl tRNA synthetase 2, mitochondrial -2.42383
LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 -2.41192
RABIF RAB interacting factor -2.41181
GARNL3 GTPase activating Rap/RanGAP domain-like 3 -2.37733
SCN7A sodium channel, voltage gated, type VII alpha subunit -2.34441
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -2.29405
GRM5 glutamate receptor, metabotropic 5 -2.29249
RMDN3 regulator of microtubule dynamics 3 -2.29077
KCNH1 potassium channel, voltage gated eag related subfamily H, member 1 -2.29077
MKI67 marker of proliferation Ki-67 -2.2539
ZNF551 zinc finger protein 551 -2.24884
PFAS phosphoribosylformylglycinamidine synthase -2.24215
PDGFD platelet derived growth factor D -2.23767
BLOC1S1 biogenesis of lysosomal organelles complex-1, subunit 1 -2.19737
CRLF1 cytokine receptor-like factor 1 -2.19204
SYNPR synaptoporin -2.18746
WEE1 WEE1 G2 checkpoint kinase -2.17108
SLC13A4 solute carrier family 13 (sodium/sulfate symporter), member 4 -2.16771
CDC34 cell division cycle 34 -2.11189
NIPSNAP3A nipsnap homolog 3A (C. elegans) -2.11098
TMEM179B transmembrane protein 179B -2.11098
CLK3 CDC-like kinase 3 -2.10918
CGRRF1 cell growth regulator with ring finger domain 1 -2.09069
CLTB clathrin, light chain B -2.09069
MGAT4C MGAT4 family, member C -2.09069
OGT O-linked N-acetylglucosamine (GlcNAc) transferase -2.08695
VAMP5 vesicle-associated membrane protein 5 -2.08157
KLK10 kallikrein-related peptidase 10 -2.07373
RIT1 Ras-like without CAAX 1 -2.07373
CCDC12 coiled-coil domain containing 12 -2.06958
ITGA9 integrin, alpha 9 -2.04017
KLC3 kinesin light chain 3 -2.02738
MRPL14 mitochondrial ribosomal protein L14 -2.01028
BCL2L12 BCL2-like 12 (proline rich) -2.01024