NR3C2 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description nuclear receptor subfamily 3, group C, member 2|This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009] (NCBI Entrez Gene Database, 4306)
External Link http://www.ncbi.nlm.nih.gov/gene/4306
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32 interacting proteins for NR3C2 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ACSL1 acyl-CoA synthetase long-chain family member 1
ACTA1 actin, alpha 1, skeletal muscle
ACTG1 actin gamma 1
AIP aryl hydrocarbon receptor interacting protein
AR androgen receptor
CAND1 cullin-associated and neddylation-dissociated 1
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7
EIF3I eukaryotic translation initiation factor 3, subunit I
FKBP4 FK506 binding protein 4, 59kDa
FKBP5 FK506 binding protein 5
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA4 heat shock 70kDa protein 4
NCOA1 nuclear receptor coactivator 1
NCOA2 nuclear receptor coactivator 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRIP1 nuclear receptor interacting protein 1
PIAS1 protein inhibitor of activated STAT, 1
PIAS3 protein inhibitor of activated STAT, 3
PPID peptidylprolyl isomerase D
PPP5C protein phosphatase 5, catalytic subunit
PROX1 prospero homeobox 1
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5
PTGES3 prostaglandin E synthase 3 (cytosolic)
RABAC1 Rab acceptor 1 (prenylated)
RXRA retinoid X receptor, alpha
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
SUMO1 small ubiquitin-like modifier 1
TRIM24 tripartite motif containing 24
UBC ubiquitin C
UBE2I ubiquitin-conjugating enzyme E2I