NR4A2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description nuclear receptor subfamily 4, group A, member 2|This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 4929)
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Genes

329 genes differentially expressed following the NR4A2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
PCDHA7 protocadherin alpha 7 3.07529
MS4A4E membrane-spanning 4-domains, subfamily A, member 4E 3.07529
OR52H1 olfactory receptor, family 52, subfamily H, member 1 3.07529
XAF1 XIAP associated factor 1 3.07529
TXNDC2 thioredoxin domain containing 2 (spermatozoa) 3.07529
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 3.07529
DPEP2 dipeptidase 2 3.07529
UPB1 ureidopropionase, beta 3.07529
PEAR1 platelet endothelial aggregation receptor 1 3.07529
AGTR1 angiotensin II receptor, type 1 3.07529
CD6 CD6 molecule 3.07529
CST11 cystatin 11 3.07529
CD300LG CD300 molecule-like family member g 3.07529
CD300E CD300e molecule 3.07529
FPR1 formyl peptide receptor 1 3.07529
NRN1 neuritin 1 3.07529
MS4A6E membrane-spanning 4-domains, subfamily A, member 6E 3.07529
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 3.07529
TMPRSS11A transmembrane protease, serine 11A 3.07529
ELF4 E74-like factor 4 (ets domain transcription factor) 3.07529
SH2D7 SH2 domain containing 7 3.07529
MBD3L3 methyl-CpG binding domain protein 3-like 3 3.07529
TCP11 t-complex 11, testis-specific 3.07529
B3GNT8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 3.07529
TRPC5OS TRPC5 opposite strand 3.07529
MPL MPL proto-oncogene, thrombopoietin receptor 3.07529
MRC1 mannose receptor, C type 1 3.07529
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 3.07529
OVCH1 ovochymase 1 3.07529
PRDM1 PR domain containing 1, with ZNF domain 3.07529
TTLL8 tubulin tyrosine ligase-like family member 8 3.07529
BDKRB2 bradykinin receptor B2 3.07529
PCDH8 protocadherin 8 3.07529
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 3.07529
TYRP1 tyrosinase-related protein 1 3.07529
ASB12 ankyrin repeat and SOCS box containing 12 3.07529
ASB10 ankyrin repeat and SOCS box containing 10 3.07529
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 3.07529
GYPB glycophorin B (MNS blood group) 3.07529
TGFB2 transforming growth factor, beta 2 3.07529
GADL1 glutamate decarboxylase-like 1 3.07529
ARSH arylsulfatase family, member H 3.07529
POMC proopiomelanocortin 3.07529
LRTM3 leucine rich repeat transmembrane protein 3 3.07529
CCN3 cellular communication network factor 3 3.07529
PHF24 PHD finger protein 24 3.07529
PTH1R parathyroid hormone 1 receptor 3.07529
SOHLH1 spermatogenesis and oogenesis specific basic helix-loop-helix 1 3.07529
CAPN9 calpain 9 3.07529
PNLIPRP3 pancreatic lipase-related protein 3 3.07529
CSN1S1 casein alpha s1 3.07529
PDF peptide deformylase (mitochondrial) 3.07529
CPHXL2 cytoplasmic polyadenylated homeobox like 2 3.07529
MPIG6B megakaryocyte and platelet inhibitory receptor G6b 3.07529
ELOA2 elongin A2 3.07529
OR9H1 olfactory receptor family 9 subfamily H member 1 pseudogene (gene/pseudogene) 3.07529
CIMIP2C ciliary microtubule inner protein 2C 3.07529
PNMA6E PNMA family member 6E 3.07529
LINC02268 long intergenic non-protein coding RNA 2268 3.07529
MINDY4B MINDY family member 4B 3.07529
CIBAR2 CBY1 interacting BAR domain containing 2 3.07529
IHO1 interactor of HORMAD1 1 3.07529
TEX13D TEX13 family member D 3.07529
RDH8 retinol dehydrogenase 8 (all-trans) 3.07529
TBX10 T-box 10 3.07529
MYOT myotilin 3.07529
C1QL2 complement component 1, q subcomponent-like 2 3.07529
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) 3.07529
C10ORF67 chromosome 10 open reading frame 67 3.07529
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 3.07529
AKR1D1 aldo-keto reductase family 1, member D1 3.07529
TRIM63 tripartite motif containing 63, E3 ubiquitin protein ligase 3.07529
COX6B2 cytochrome c oxidase subunit VIb polypeptide 2 (testis) 3.07529
PIWIL1 piwi-like RNA-mediated gene silencing 1 3.07529
CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39) 3.07529
CCR9 chemokine (C-C motif) receptor 9 3.07529
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic 3.07529
ARL14EPL ADP-ribosylation factor-like 14 effector protein-like 3.07529
PRDM7 PR domain containing 7 3.07529
OOSP1 oocyte secreted protein 1, pseudogene 3.07529
PTH parathyroid hormone 3.07529
C7 complement component 7 3.07529
OVOL1 ovo-like zinc finger 1 3.07529
CDKN2A cyclin-dependent kinase inhibitor 2A 3.07529
STAR steroidogenic acute regulatory protein 3.07529
LHX6 LIM homeobox 6 3.07529
CIDEC cell death-inducing DFFA-like effector c 3.07529
SMIM23 small integral membrane protein 23 3.07529
CDHR4 cadherin-related family member 4 3.07529
TAS2R50 taste receptor, type 2, member 50 3.07529
GOLGA6C golgin A6 family, member C 3.07529
CALHM1 calcium homeostasis modulator 1 3.07529
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 3.07529
TPSB2 tryptase beta 2 (gene/pseudogene) 3.07529
HKDC1 hexokinase domain containing 1 3.07529
CTAGE4 CTAGE family, member 4 3.07529
BTNL8 butyrophilin-like 8 3.07529
PIH1D2 PIH1 domain containing 2 3.07529
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion 3.07529
ADGRA1 adhesion G protein-coupled receptor A1 3.07529
VAX2 ventral anterior homeobox 2 3.07529
OR56A3 olfactory receptor, family 56, subfamily A, member 3 3.07529
ZBP1 Z-DNA binding protein 1 3.07529
LRTM2 leucine-rich repeats and transmembrane domains 2 3.07529
UBQLNL ubiquilin-like 3.07529
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 3.07529
C2CD4B C2 calcium-dependent domain containing 4B 3.07529
MUC15 mucin 15, cell surface associated 3.07529
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 3.07529
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 3.07529
IL27 interleukin 27 3.07529
MEPE matrix extracellular phosphoglycoprotein 3.07529
C10ORF105 chromosome 10 open reading frame 105 3.07529
SFTA2 surfactant associated 2 3.07529
GOLGA8K golgin A8 family, member K 3.07529
OR52N2 olfactory receptor, family 52, subfamily N, member 2 3.07529
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 3.07529
TCAP titin-cap 3.07529
RGS8 regulator of G-protein signaling 8 3.07529
BCO1 beta-carotene oxygenase 1 3.07529
NIM1K NIM1 serine/threonine protein kinase 3.07529
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 3.07529
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 3.07529
TSPYL4 TSPY-like 4 3.07529
NT5C1A 5'-nucleotidase, cytosolic IA 3.07529
NT5C1B 5'-nucleotidase, cytosolic IB 3.07529
GPR61 G protein-coupled receptor 61 3.07529
OR52N5 olfactory receptor, family 52, subfamily N, member 5 3.07529
ADGRF5 adhesion G protein-coupled receptor F5 3.07529
MEIG1 meiosis/spermiogenesis associated 1 3.07529
FITM1 fat storage-inducing transmembrane protein 1 3.07529
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 3.07529
EMCN endomucin 3.07529
DCAF8L2 DDB1 and CUL4 associated factor 8-like 2 3.07529
MROH2A maestro heat-like repeat family member 2A 3.07529
C9ORF50 chromosome 9 open reading frame 50 3.07529
BTBD16 BTB (POZ) domain containing 16 3.07529
PTGDR prostaglandin D2 receptor (DP) 3.07529
GPRC5D G protein-coupled receptor, class C, group 5, member D 3.07529
DMBT1 deleted in malignant brain tumors 1 3.07529
NLRP5 NLR family, pyrin domain containing 5 3.07529
CHTF8 CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae) 3.07529
CHRDL2 chordin-like 2 3.07529
GH2 growth hormone 2 3.07529
LRRC74B leucine rich repeat containing 74B 3.07529
ALDH8A1 aldehyde dehydrogenase 8 family, member A1 3.07529
ATG4A autophagy related 4A, cysteine peptidase 3.00471
FAM209B family with sequence similarity 209, member B 3.00471
GPR20 G protein-coupled receptor 20 2.86689
MTSS1 metastasis suppressor 1 2.79362
TOP6BL TOP6B like initiator of meiotic double strand breaks 2.74945
MSTO1 misato 1, mitochondrial distribution and morphology regulator 2.65608
ANKRD49 ankyrin repeat domain 49 2.62181
FGF19 fibroblast growth factor 19 2.62181
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.54252
ATP11C ATPase, class VI, type 11C 2.50498
CD160 CD160 molecule 2.47566
FSHR follicle stimulating hormone receptor 2.47566
DESI2 desumoylating isopeptidase 2 2.43267
ERCC6L excision repair cross-complementation group 6-like 2.42924
CMIP c-Maf inducing protein 2.42913
TUBGCP4 tubulin, gamma complex associated protein 4 2.4078
LOX lysyl oxidase 2.40038
SLC41A3 solute carrier family 41, member 3 2.38314
MRPL24 mitochondrial ribosomal protein L24 2.37864
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 2.37573
ACBD3 acyl-CoA binding domain containing 3 2.3471
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 2.32419
CAMK1G calcium/calmodulin-dependent protein kinase IG 2.28866
TPH1 tryptophan hydroxylase 1 2.28866
RHOG ras homolog family member G 2.2622
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 2.25453
ZNF148 zinc finger protein 148 2.21854
ABHD2 abhydrolase domain containing 2 2.20842
RAB20 RAB20, member RAS oncogene family 2.20842
REEP2 receptor accessory protein 2 2.19343
CIART circadian associated repressor of transcription 2.19271
RANBP1 RAN binding protein 1 2.1651
ZNF711 zinc finger protein 711 2.15355
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.15263
INTS15 integrator complex subunit 15 2.13183
SLC35F5 solute carrier family 35, member F5 2.13183
HAVCR2 hepatitis A virus cellular receptor 2 2.13183
ZNF141 zinc finger protein 141 2.13183
PNPLA8 patatin-like phospholipase domain containing 8 2.12511
SZRD1 SUZ RNA binding domain containing 1 2.12401
ZNF646 zinc finger protein 646 2.12233
EEF1E1 eukaryotic translation elongation factor 1 epsilon 1 2.11799
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast) 2.11523
HYAL3 hyaluronoglucosaminidase 3 2.0885
PRDM10 PR domain containing 10 2.0885
CENPI centromere protein I 2.0877
TUNAR TCL1 upstream neural differentiation-associated RNA 2.0877
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa 2.06793
SLC22A14 solute carrier family 22, member 14 2.06129
TMEM151A transmembrane protein 151A 2.06129
RFESD Rieske (Fe-S) domain containing 2.06129
COL6A6 collagen, type VI, alpha 6 2.06129
TTC16 tetratricopeptide repeat domain 16 2.06129
PRODH proline dehydrogenase (oxidase) 1 2.06129
TFDP1 transcription factor Dp-1 2.06129
MPZL2 myelin protein zero-like 2 2.06129
TPTE transmembrane phosphatase with tensin homology 2.06129
KLF9 Kruppel-like factor 9 2.06129
CCDC13 coiled-coil domain containing 13 2.06129
ZNF527 zinc finger protein 527 2.05674
CTNNA3 catenin (cadherin-associated protein), alpha 3 2.04538
HEATR5A HEAT repeat containing 5A 2.04193
PTPRB protein tyrosine phosphatase, receptor type, B 2.01156

decreased expression

Symbol Name Standardized Value
DORIP1 dopamine receptor interacting protein 1 -3.07529
CIITA class II, major histocompatibility complex, transactivator -3.07529
ALX3 ALX homeobox 3 -3.07529
MYCT1 myc target 1 -3.07529
RFPL2 ret finger protein-like 2 -3.07529
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 -3.07529
CXCL2 chemokine (C-X-C motif) ligand 2 -3.07529
HAS1 hyaluronan synthase 1 -3.07529
MEIKIN meiotic kinetochore factor -3.07529
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18 -3.07529
CPLX1 complexin 1 -3.07529
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13 -3.07529
CRYAA crystallin, alpha A -3.07529
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 -3.07529
LEP leptin -3.07529
NRGN neurogranin (protein kinase C substrate, RC3) -3.07529
SHBG sex hormone-binding globulin -3.07529
FAM86B2 family with sequence similarity 86, member B2 -3.07529
PDZD9 PDZ domain containing 9 -3.07529
GNG5B G protein subunit gamma 5B -3.07529
H3C14 H3 clustered histone 14 -3.07529
CRACDL CRACD like -3.07529
BBOF1 basal body orientation factor 1 -3.07529
FMO3 flavin containing monooxygenase 3 -3.07529
C1QL3 complement component 1, q subcomponent-like 3 -3.07529
CFAP45 cilia and flagella associated protein 45 -3.07529
GZMM granzyme M (lymphocyte met-ase 1) -3.07529
ZNF577 zinc finger protein 577 -3.07529
CLIP4 CAP-GLY domain containing linker protein family, member 4 -3.07529
CCDC17 coiled-coil domain containing 17 -3.07529
TMEM229A transmembrane protein 229A -3.07529
LBHD1 LBH domain containing 1 -3.07529
TSSK6 testis-specific serine kinase 6 -3.07529
FER1L6 fer-1-like family member 6 -3.07529
SPINK1 serine peptidase inhibitor, Kazal type 1 -3.07529
CLCNKA chloride channel, voltage-sensitive Ka -3.07529
PDZRN4 PDZ domain containing ring finger 4 -3.07529
SEMG1 semenogelin I -3.07529
INSL6 insulin-like 6 -3.07529
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3 -3.07529
RSPH10B2 radial spoke head 10 homolog B2 (Chlamydomonas) -3.07529
PABPC4L poly(A) binding protein, cytoplasmic 4-like -3.07529
B4GALNT2 beta-1,4-N-acetyl-galactosaminyl transferase 2 -3.07529
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 -3.07529
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal -3.07529
TDRD10 tudor domain containing 10 -3.07529
ACSS1 acyl-CoA synthetase short-chain family member 1 -3.07529
PLET1 placenta expressed transcript 1 -3.07529
EBF3 early B-cell factor 3 -3.07529
HCLS1 hematopoietic cell-specific Lyn substrate 1 -3.07529
TTC22 tetratricopeptide repeat domain 22 -3.07529
ZBED6 zinc finger, BED-type containing 6 -3.07529
ALOXE3 arachidonate lipoxygenase 3 -3.07529
TTBK1 tau tubulin kinase 1 -3.07529
ECM1 extracellular matrix protein 1 -3.07529
QPCTL glutaminyl-peptide cyclotransferase-like -3.00471
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1 -2.98696
BST1 bone marrow stromal cell antigen 1 -2.96071
MYO15A myosin XVA -2.96071
LRRC8E leucine rich repeat containing 8 family, member E -2.96071
ZNF594 zinc finger protein 594 -2.91273
CACNG4 calcium channel, voltage-dependent, gamma subunit 4 -2.81115
DKKL1 dickkopf-like 1 -2.75132
SAT1 spermidine/spermine N1-acetyltransferase 1 -2.72613
SAV1 salvador family WW domain containing protein 1 -2.71082
ABR active BCR-related -2.68084
PTPN23 protein tyrosine phosphatase, non-receptor type 23 -2.65524
CDYL chromodomain protein, Y-like -2.64988
EFNB3 ephrin-B3 -2.56762
FARP2 FERM, RhoGEF and pleckstrin domain protein 2 -2.54541
SYT15B synaptotagmin 15B -2.54497
BATF2 basic leucine zipper transcription factor, ATF-like 2 -2.53762
TMT1B thiol methyltransferase 1B -2.53608
DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) -2.52511
NINJ2 ninjurin 2 -2.46011
PMFBP1 polyamine modulated factor 1 binding protein 1 -2.45177
ZNF106 zinc finger protein 106 -2.39751
ITGB1BP2 integrin beta 1 binding protein (melusin) 2 -2.36842
COASY CoA synthase -2.32641
CCDC92B coiled-coil domain containing 92B -2.32502
RMDN3 regulator of microtubule dynamics 3 -2.29062
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) -2.21854
TMED9 transmembrane emp24 protein transport domain containing 9 -2.21475
B4GALT3 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 -2.20991
LLGL2 lethal giant larvae homolog 2 (Drosophila) -2.20842
KCNIP1 Kv channel interacting protein 1 -2.20652
HARS1 histidyl-tRNA synthetase 1 -2.2017
PI4K2A phosphatidylinositol 4-kinase type 2 alpha -2.18188
ZNF687 zinc finger protein 687 -2.16456
MID2 midline 2 -2.15887
SNURF SNRPN upstream reading frame -2.14537
LRR1 leucine rich repeat protein 1 -2.13836
NSDHL NAD(P) dependent steroid dehydrogenase-like -2.13736
MSN moesin -2.12602
SESN1 sestrin 1 -2.11429
AARS1 alanyl-tRNA synthetase 1 -2.10597
LMTK2 lemur tyrosine kinase 2 -2.10597
BRPF1 bromodomain and PHD finger containing, 1 -2.10597
EIF2B1 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa -2.10543
PDGFD platelet derived growth factor D -2.09763
OBSL1 obscurin-like 1 -2.08798
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 -2.08565
PHB2 prohibitin 2 -2.07718
TMEM200A transmembrane protein 200A -2.06659
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1 -2.0654
RBM22 RNA binding motif protein 22 -2.06129
TLE3 transducin-like enhancer of split 3 -2.06129
NUP42 nucleoporin 42 -2.06129
NUBP2 nucleotide binding protein 2 -2.06129
RAB37 RAB37, member RAS oncogene family -2.06129
SFXN4 sideroflexin 4 -2.05057
CTCFL CCCTC-binding factor (zinc finger protein)-like -2.04699
ZNF525 zinc finger protein 525 -2.04193
MYO5C myosin VC -2.03296
HHAT hedgehog acyltransferase -2.03296
ZNF189 zinc finger protein 189 -2.03129
ZNF45 zinc finger protein 45 -2.02518
SORBS1 sorbin and SH3 domain containing 1 -2.01948
PLAAT3 phospholipase A and acyltransferase 3 -2.01156
SMIM10L1 small integral membrane protein 10 like 1 -2.00828