NR5A1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description nuclear receptor subfamily 5, group A, member 1|The protein encoded by this gene is a transcriptional activator involved in sex determination. The encoded protein binds DNA as a monomer. Defects in this gene are a cause of XY sex reversal with or without adrenal failure as well as adrenocortical insufficiency without ovarian defect. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 2516)
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Genes

329 genes differentially expressed following the NR5A1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ADRB2 adrenoceptor beta 2, surface 4.47136
IL17F interleukin 17F 4.47136
LRG1 leucine-rich alpha-2-glycoprotein 1 4.47136
CD8A CD8a molecule 4.47136
KISS1 KiSS-1 metastasis-suppressor 4.47136
SAMD11 sterile alpha motif domain containing 11 4.47136
SHISA8 shisa family member 8 4.47136
CCL5 chemokine (C-C motif) ligand 5 4.47136
ZIC4 Zic family member 4 4.47136
ANXA13 annexin A13 4.47136
TPSB2 tryptase beta 2 (gene/pseudogene) 4.47136
ZNF436 zinc finger protein 436 4.47136
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila) 4.47136
GDPD4 glycerophosphodiester phosphodiesterase domain containing 4 4.47136
RNF39 ring finger protein 39 4.47136
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle) 4.47136
LAMB4 laminin, beta 4 4.47136
NCCRP1 non-specific cytotoxic cell receptor protein 1 homolog (zebrafish) 4.47136
GNRHR gonadotropin-releasing hormone receptor 4.47136
C2ORF78 chromosome 2 open reading frame 78 4.47136
H2BC3 H2B clustered histone 3 4.47136
TECTB tectorin beta 4.47136
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 4.47136
UBA7 ubiquitin-like modifier activating enzyme 7 4.42502
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 4.42502
SLC39A12 solute carrier family 39 (zinc transporter), member 12 4.42502
SGPP2 sphingosine-1-phosphate phosphatase 2 4.42502
PERM1 PPARGC1 and ESRR induced regulator, muscle 1 4.42502
MPO myeloperoxidase 4.42502
DUXB double homeobox B 4.42502
ADTRP androgen-dependent TFPI-regulating protein 4.42502
PRICKLE4 prickle homolog 4 (Drosophila) 4.42502
OR10A6 olfactory receptor, family 10, subfamily A, member 6 (gene/pseudogene) 4.42502
CLEC19A C-type lectin domain family 19, member A 4.42502
PEAR1 platelet endothelial aggregation receptor 1 4.42502
HORMAD1 HORMA domain containing 1 4.42502
JCHAIN joining chain of multimeric IgA and IgM 4.42502
GLUD2 glutamate dehydrogenase 2 4.42502
SCGB3A1 secretoglobin, family 3A, member 1 4.42502
PDYN prodynorphin 4.42502
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 4.42502
OR1D2 olfactory receptor, family 1, subfamily D, member 2 4.42502
PAEP progestagen-associated endometrial protein 4.42502
KHDC3L KH domain containing 3-like, subcortical maternal complex member 4.42502
TDRD6 tudor domain containing 6 4.42502
F7 coagulation factor VII (serum prothrombin conversion accelerator) 4.42502
NRROS negative regulator of reactive oxygen species 4.42502
GFI1 growth factor independent 1 transcription repressor 4.42502
C12ORF71 chromosome 12 open reading frame 71 4.42502
TRIM77 tripartite motif containing 77 4.42502
GIMAP8 GTPase, IMAP family member 8 4.42502
DIRAS2 DIRAS family, GTP-binding RAS-like 2 4.42502
PNOC prepronociceptin 4.42502
TREML2 triggering receptor expressed on myeloid cells-like 2 4.42502
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin 4.42502
PTH2 parathyroid hormone 2 4.42502
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 4.42502
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides 4.42502
COPZ2 coatomer protein complex, subunit zeta 2 4.42502
LOC124901872 uncharacterized LOC124901872 4.42502
SLC7A13 solute carrier family 7 (anionic amino acid transporter), member 13 4.42502
GBP4 guanylate binding protein 4 4.42502
ZAR1 zygote arrest 1 4.42502
GPR33 G protein-coupled receptor 33 (gene/pseudogene) 4.42502
MYH4 myosin, heavy chain 4, skeletal muscle 4.42502
C20ORF202 chromosome 20 open reading frame 202 4.42502
CMKLR1 chemerin chemokine-like receptor 1 4.42502
ZNF705D zinc finger protein 705D 4.42502
FAM228A family with sequence similarity 228, member A 4.42502
H3-5 H3.5 histone 4.42502
CCN5 cellular communication network factor 5 4.42502
AJM1 apical junction component 1 homolog 4.42502
FAM90A24 family with sequence similarity 90 member A24 4.42502
SPMAP1 sperm microtubule associated protein 1 4.42502
ACKR5 atypical chemokine receptor 5 4.42502
ZC3H11C zinc finger CCCH-type containing 11C 4.42502
LITAFD LITAF domain containing 4.42502
PPIAL4H peptidylprolyl isomerase A like 4H 4.42502
CFAP97D2 CFAP97 domain containing 2 4.42502
H3C3 H3 clustered histone 3 4.42502
MPIG6B megakaryocyte and platelet inhibitory receptor G6b 4.42502
MLANA melan-A 4.42502
LTB lymphotoxin beta (TNF superfamily, member 3) 4.42502
FGFBP1 fibroblast growth factor binding protein 1 4.42502
IZUMO4 IZUMO family member 4 4.42502
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 4.42502
OVGP1 oviductal glycoprotein 1, 120kDa 4.42502
PDILT protein disulfide isomerase-like, testis expressed 4.42502
MS4A6E membrane-spanning 4-domains, subfamily A, member 6E 4.42502
HLX H2.0-like homeobox 4.42502
RHOXF2B Rhox homeobox family, member 2B 4.42502
COL20A1 collagen, type XX, alpha 1 4.42502
ZACN zinc activated ligand-gated ion channel 4.42502
DMP1 dentin matrix acidic phosphoprotein 1 4.42502
TUBA3E tubulin, alpha 3e 4.42502
DSG1 desmoglein 1 4.42502
FMR1NB fragile X mental retardation 1 neighbor 4.42502
PGA5 pepsinogen 5, group I (pepsinogen A) 4.42502
C9 complement component 9 4.42502
MYOC myocilin, trabecular meshwork inducible glucocorticoid response 4.42502
MIA melanoma inhibitory activity 4.42502
MYH13 myosin, heavy chain 13, skeletal muscle 4.42502
DMBX1 diencephalon/mesencephalon homeobox 1 4.42502
OLAH oleoyl-ACP hydrolase 4.42502
CD48 CD48 molecule 4.42502
VWA5B2 von Willebrand factor A domain containing 5B2 4.42502
KLHL41 kelch-like family member 41 4.42502
MORC1 MORC family CW-type zinc finger 1 4.42502
CATIP ciliogenesis associated TTC17 interacting protein 4.42502
CMTM2 CKLF-like MARVEL transmembrane domain containing 2 4.42502
ZMYND15 zinc finger, MYND-type containing 15 4.42502
ZMYND10 zinc finger, MYND-type containing 10 4.42502
TTC16 tetratricopeptide repeat domain 16 4.42502
FIGLA folliculogenesis specific basic helix-loop-helix 4.42502
DMTN dematin actin binding protein 4.42502
UTS2B urotensin 2B 4.42502
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22 4.42502
CSF3R colony stimulating factor 3 receptor (granulocyte) 4.42502
ZFP92 ZFP92 zinc finger protein 4.42502
ALOX15B arachidonate 15-lipoxygenase, type B 4.42502
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase) 4.42502
ZC3H12D zinc finger CCCH-type containing 12D 4.42502
BCL2A1 BCL2-related protein A1 4.42502
THBD thrombomodulin 4.42502
TAS2R50 taste receptor, type 2, member 50 4.42502
S100Z S100 calcium binding protein Z 4.42502
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 4.42502
NUPR1 nuclear protein, transcriptional regulator, 1 4.42502
ARR3 arrestin 3, retinal (X-arrestin) 4.42502
TNR tenascin R 4.42502
CLEC18C C-type lectin domain family 18, member C 4.42502
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 4.42502
NXNL1 nucleoredoxin-like 1 4.42502
TEKT5 tektin 5 4.42502
C18ORF63 chromosome 18 open reading frame 63 4.42502
C11ORF97 chromosome 11 open reading frame 97 4.42502
TEX19 testis expressed 19 4.42502
SHOX2 short stature homeobox 2 4.42502
A3GALT2 alpha 1,3-galactosyltransferase 2 4.42502
SCNN1D sodium channel, non voltage gated 1 delta subunit 4.42502
PATE1 prostate and testis expressed 1 4.42502
OPN1LW opsin 1 (cone pigments), long-wave-sensitive 4.42502
ABRA actin binding Rho activating protein 4.42502
EFCC1 EF-hand and coiled-coil domain containing 1 4.42502
CHRDL2 chordin-like 2 4.42502
CASQ2 calsequestrin 2 (cardiac muscle) 4.42502
AOC1 amine oxidase, copper containing 1 4.42502
GJB6 gap junction protein, beta 6, 30kDa 4.42502
MYH7B myosin, heavy chain 7B, cardiac muscle, beta 4.42502
WNT2 wingless-type MMTV integration site family member 2 4.42502
MZB1 marginal zone B and B1 cell-specific protein 4.42502
TLDC2 TBC/LysM-associated domain containing 2 4.42502
TDO2 tryptophan 2,3-dioxygenase 4.42502
SLC22A9 solute carrier family 22 (organic anion transporter), member 9 4.42502
SPACA7 sperm acrosome associated 7 4.42502
ANGPTL5 angiopoietin-like 5 4.42502
APOL3 apolipoprotein L, 3 4.42502
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 4.42502
DLX2 distal-less homeobox 2 4.42502
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15 4.42502
DMRTC1 DMRT-like family C1 4.42502
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 4.42502
KRTAP8-1 keratin associated protein 8-1 4.42502
GRAPL GRB2-related adaptor protein-like 4.42502
FBXL19 F-box and leucine-rich repeat protein 19 3.97483
TMEM150B transmembrane protein 150B 3.72157
CENPB centromere protein B, 80kDa 3.57705
MOSMO modulator of smoothened 3.28705
HMSD histocompatibility (minor) serpin domain containing 3.16642
HCK HCK proto-oncogene, Src family tyrosine kinase 3.13077
LDHC lactate dehydrogenase C 3.13077
GRK7 G protein-coupled receptor kinase 7 3.13077
CTXN2 cortexin 2 3.13077
MFAP4 microfibrillar-associated protein 4 3.13077
ARID3B AT rich interactive domain 3B (BRIGHT-like) 2.88902
MSC musculin 2.88855
UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 2.87197
FFAR4 free fatty acid receptor 4 2.86047
PCDHA11 protocadherin alpha 11 2.76878
UNC93A unc-93 homolog A (C. elegans) 2.76878
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled 2.75939
RTN4RL1 reticulon 4 receptor-like 1 2.75369
NUP58 nucleoporin 58 2.73188
ACTC1 actin, alpha, cardiac muscle 1 2.7245
ARK2C arkadia (RNF111) C-terminal like ring finger ubiquitin ligase 2C 2.71442
UBE2F ubiquitin-conjugating enzyme E2F (putative) 2.60808
SLC27A4 solute carrier family 27 (fatty acid transporter), member 4 2.49871
CFDP1 craniofacial development protein 1 2.47489
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 2.4542
CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit 2.4086
HEG1 heart development protein with EGF-like domains 1 2.37189
DCTPP1 dCTP pyrophosphatase 1 2.34213
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 2.32562
RAB33B RAB33B, member RAS oncogene family 2.30549
TRIM23 tripartite motif containing 23 2.29231
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit 2.28999
ATG12 autophagy related 12 2.28236
NXPH3 neurexophilin 3 2.25989
ERN2 endoplasmic reticulum to nucleus signaling 2 2.25989
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast) 2.25989
CCN3 cellular communication network factor 3 2.25989
EFCAB9 EF-hand calcium binding domain 9 2.25989
BTLA B and T lymphocyte associated 2.25989
CAMK1G calcium/calmodulin-dependent protein kinase IG 2.25989
GPS2 G protein pathway suppressor 2 2.25497
KCTD11 potassium channel tetramerization domain containing 11 2.25391
ANKRD10 ankyrin repeat domain 10 2.24818
PNPLA7 patatin-like phospholipase domain containing 7 2.24818
NOTCH2NLB notch 2 N-terminal like B 2.2402
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 2.2402
CDK1 cyclin-dependent kinase 1 2.21445
FGF9 fibroblast growth factor 9 2.20072
PHF1 PHD finger protein 1 2.18483
MPRIP myosin phosphatase Rho interacting protein 2.18307
KRIT1 KRIT1, ankyrin repeat containing 2.18307
ETV5 ets variant 5 2.16528
EFCAB6 EF-hand calcium binding domain 6 2.16468
FMN1 formin 1 2.16468
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9 2.1621
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 2.15823
PCDHA2 protocadherin alpha 2 2.14588
DNAL1 dynein, axonemal, light chain 1 2.12134
AGTR1 angiotensin II receptor, type 1 2.12134
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.11552
PCDH7 protocadherin 7 2.11288
LRRC2 leucine rich repeat containing 2 2.10306
SYAP1 synapse associated protein 1 2.10306
FAM168A family with sequence similarity 168, member A 2.10042
GATAD1 GATA zinc finger domain containing 1 2.09606
DUSP23 dual specificity phosphatase 23 2.06557
AGAP5 ArfGAP with GTPase domain, ankyrin repeat and PH domain 5 2.06366
CCBE1 collagen and calcium binding EGF domains 1 2.02632
FGD3 FYVE, RhoGEF and PH domain containing 3 2.0217
PPP1R17 protein phosphatase 1, regulatory subunit 17 2.00937

decreased expression

Symbol Name Standardized Value
ARG1 arginase 1 -4.47136
DRC3 dynein regulatory complex subunit 3 -4.47136
C17ORF114 chromosome 17 open reading frame 114 -4.47136
ADH6 alcohol dehydrogenase 6 (class V) -4.47136
PCDHA7 protocadherin alpha 7 -4.42502
RAB36 RAB36, member RAS oncogene family -4.42502
NFAM1 NFAT activating protein with ITAM motif 1 -4.42502
POSTN periostin, osteoblast specific factor -4.42502
RNF112 ring finger protein 112 -4.42502
KPNA7 karyopherin alpha 7 (importin alpha 8) -4.42502
IER5L immediate early response 5-like -4.42502
SP6 Sp6 transcription factor -4.42502
SYTL3 synaptotagmin-like 3 -4.42502
MEIG1 meiosis/spermiogenesis associated 1 -4.42502
ATP6V0D2 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 -4.42502
SV2B synaptic vesicle glycoprotein 2B -4.42502
AWAT1 acyl-CoA wax alcohol acyltransferase 1 -4.42502
NRIP2 nuclear receptor interacting protein 2 -4.42502
PCDH20 protocadherin 20 -4.42502
UBXN10 UBX domain protein 10 -4.42502
VXN vexin -4.42502
RTL5 retrotransposon Gag like 5 -4.42502
KCNV1 potassium channel, voltage gated modifier subfamily V, member 1 -4.42502
GNGT2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 -4.42502
TMPRSS6 transmembrane protease, serine 6 -4.42502
SLCO1C1 solute carrier organic anion transporter family, member 1C1 -4.42502
SFXN3 sideroflexin 3 -4.42502
SDR16C5 short chain dehydrogenase/reductase family 16C, member 5 -4.42502
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 -4.42502
CEND1 cell cycle exit and neuronal differentiation 1 -4.25353
IL17D interleukin 17D -3.7155
HYPK huntingtin interacting protein K -3.7155
TEX11 testis expressed 11 -3.7155
AMIGO1 adhesion molecule with Ig-like domain 1 -3.7155
SLC9B1 solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1 -3.40798
CEP104 centrosomal protein 104kDa -3.23456
ZNF713 zinc finger protein 713 -3.14867
MAP2K3 mitogen-activated protein kinase kinase 3 -3.0138
CCDC63 coiled-coil domain containing 63 -2.98528
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 -2.93017
UPF3B UPF3 regulator of nonsense transcripts homolog B (yeast) -2.90631
PIGL phosphatidylinositol glycan anchor biosynthesis, class L -2.83221
LHFPL3 lipoma HMGIC fusion partner-like 3 -2.77965
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 -2.72057
SDCCAG8 serologically defined colon cancer antigen 8 -2.66623
DPYSL3 dihydropyrimidinase-like 3 -2.58542
PTPMT1 protein tyrosine phosphatase, mitochondrial 1 -2.57981
FAM120B family with sequence similarity 120B -2.50037
CAMSAP3 calmodulin regulated spectrin-associated protein family, member 3 -2.47489
NTHL1 nth endonuclease III-like 1 (E. coli) -2.4542
CASP2 caspase 2, apoptosis-related cysteine peptidase -2.42926
EVC Ellis van Creveld protein -2.36346
SNTA1 syntrophin, alpha 1 -2.32805
GABARAP GABA(A) receptor-associated protein -2.32562
TMEM131 transmembrane protein 131 -2.32562
ARSI arylsulfatase family, member I -2.32477
IL4I1 interleukin 4 induced 1 -2.32477
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 -2.32417
IGFLR1 IGF-like family receptor 1 -2.32258
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -2.27894
TMEM229A transmembrane protein 229A -2.27306
ADAMTS18 ADAM metallopeptidase with thrombospondin type 1 motif, 18 -2.27306
PCDHB10 protocadherin beta 10 -2.27306
CNTFR ciliary neurotrophic factor receptor -2.27306
RPS21-DT RPS21 divergent transcript -2.27306
C1ORF202 chromosome 1 open reading frame 202 -2.27306
TMX2 thioredoxin-related transmembrane protein 2 -2.27306
LRRC7 leucine rich repeat containing 7 -2.26798
CRISPLD1 cysteine-rich secretory protein LCCL domain containing 1 -2.25989
ITFG2 integrin alpha FG-GAP repeat containing 2 -2.25989
KCNH4 potassium channel, voltage gated eag related subfamily H, member 4 -2.25497
GPR143 G protein-coupled receptor 143 -2.2525
PIKFYVE phosphoinositide kinase, FYVE finger containing -2.2402
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -2.2142
CISD3 CDGSH iron sulfur domain 3 -2.19215
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila) -2.16662
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B -2.16468
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.14588
ESD esterase D -2.12134
EBAG9 estrogen receptor binding site associated, antigen, 9 -2.12134
MIS12 MIS12 kinetochore complex component -2.12134
SH3RF3 SH3 domain containing ring finger 3 -2.10487
EHD2 EH-domain containing 2 -2.10487
POLL polymerase (DNA directed), lambda -2.10042
SUPT4H1 suppressor of Ty 4 homolog 1 (S. cerevisiae) -2.09772
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1 -2.08525
PTGES prostaglandin E synthase -2.05827
DIXDC1 DIX domain containing 1 -2.05827
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial -2.05637
RANBP2 RAN binding protein 2 -2.05429
ST8SIA3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 -2.05409
AMOTL2 angiomotin like 2 -2.03341
GALE UDP-galactose-4-epimerase -2.02166
GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1 -2.00937
ZNF766 zinc finger protein 766 -2.00737