NRP2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description neuropilin 2|This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 8828)
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Genes

325 genes differentially expressed following the NRP2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ALX4 ALX homeobox 4 3.06073
MUCL3 mucin like 3 3.06073
UBE2L5 ubiquitin conjugating enzyme E2 L5 3.06073
RGPD4 RANBP2-like and GRIP domain containing 4 3.06073
GML glycosylphosphatidylinositol anchored molecule like 3.06073
RAPSN receptor-associated protein of the synapse 3.06073
APOH apolipoprotein H (beta-2-glycoprotein I) 3.06073
COL11A2 collagen, type XI, alpha 2 3.06073
TNR tenascin R 3.06073
OR10A2 olfactory receptor, family 10, subfamily A, member 2 3.06073
GMNC geminin coiled-coil domain containing 3.06073
MINDY4B MINDY family member 4B 3.06073
EDN1 endothelin 1 3.06073
MINK1 misshapen-like kinase 1 3.06073
MILR1 mast cell immunoglobulin-like receptor 1 3.06073
CD226 CD226 molecule 3.06073
MST1 macrophage stimulating 1 3.06073
TAS2R5 taste receptor, type 2, member 5 3.06073
SLC25A34 solute carrier family 25, member 34 3.06073
SIX3 SIX homeobox 3 3.03155
PCDHB6 protocadherin beta 6 3.03155
TMEM176A transmembrane protein 176A 3.03155
SCRG1 stimulator of chondrogenesis 1 3.03155
GJA9 gap junction protein, alpha 9, 59kDa 3.03155
CELF3 CUGBP, Elav-like family member 3 3.03155
CDH5 cadherin 5, type 2 (vascular endothelium) 3.03155
ZNF503 zinc finger protein 503 3.03155
TXLNB taxilin beta 3.03155
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 3.03155
IL12RB1 interleukin 12 receptor, beta 1 3.03155
HES3 hes family bHLH transcription factor 3 3.03155
RNF39 ring finger protein 39 3.03155
C2ORF78 chromosome 2 open reading frame 78 3.03155
HBZ hemoglobin, zeta 3.03155
GNRHR gonadotropin-releasing hormone receptor 3.03155
DRGX dorsal root ganglia homeobox 3.03155
ZNF492 zinc finger protein 492 3.03155
C3ORF22 chromosome 3 open reading frame 22 3.03155
TRPV6 transient receptor potential cation channel, subfamily V, member 6 3.03155
GCKR glucokinase (hexokinase 4) regulator 3.03155
PECAM1 platelet/endothelial cell adhesion molecule 1 3.03155
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin 3.03155
FETUB fetuin B 3.03155
BMP3 bone morphogenetic protein 3 3.03155
OR2J3 olfactory receptor, family 2, subfamily J, member 3 3.03155
SIRPB2 signal-regulatory protein beta 2 3.03155
PGBDF plakoglobin binding and degradation factor 3.03155
IL18R1 interleukin 18 receptor 1 3.03155
DMP1 dentin matrix acidic phosphoprotein 1 3.03155
ITK IL2-inducible T-cell kinase 3.03155
MINAR2 membrane integral NOTCH2 associated receptor 2 3.03155
LBHD2 LBH domain containing 2 3.03155
EIF2S3B eukaryotic translation initiation factor 2 subunit gamma B 3.03155
ST6GALNAC1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 3.03155
BEND2 BEN domain containing 2 3.03155
CAPN9 calpain 9 3.03155
SPATA31H1 SPATA31 subfamily H member 1 3.03155
VN1R1 vomeronasal 1 receptor 1 3.03155
CCDC190 coiled-coil domain containing 190 3.03155
EZHIP EZH inhibitory protein 3.03155
TEX50 testis expressed 50 3.03155
LRRC8C-DT LRRC8C divergent transcript 3.03155
REELD1 reeler domain containing 1 3.03155
LOC124903372 uncharacterized LOC124903372 3.03155
CFAP97D2 CFAP97 domain containing 2 3.03155
SMIM35 small integral membrane protein 35 3.03155
AKAIN1 A-kinase anchor inhibitor 1 3.03155
LHFPL7 LHFPL tetraspan subfamily member 7 3.03155
DNAAF1 dynein, axonemal, assembly factor 1 3.03155
OR6F1 olfactory receptor, family 6, subfamily F, member 1 3.03155
PRR18 proline rich 18 3.03155
TBX5 T-box 5 3.03155
APOBEC4 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative) 3.03155
CXCL16 chemokine (C-X-C motif) ligand 16 3.03155
AMBP alpha-1-microglobulin/bikunin precursor 3.03155
CHRD chordin 3.03155
OR10AG1 olfactory receptor, family 10, subfamily AG, member 1 3.03155
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 3.03155
CCR9 chemokine (C-C motif) receptor 9 3.03155
S100G S100 calcium binding protein G 3.03155
ASB9 ankyrin repeat and SOCS box containing 9 3.03155
RDH8 retinol dehydrogenase 8 (all-trans) 3.03155
MYL10 myosin, light chain 10, regulatory 3.03155
KHDC1L KH homology domain containing 1-like 3.03155
GATA6 GATA binding protein 6 3.03155
LTB lymphotoxin beta (TNF superfamily, member 3) 3.03155
GPR83 G protein-coupled receptor 83 3.03155
STPG2 sperm-tail PG-rich repeat containing 2 3.03155
LY6S lymphocyte antigen 6 family member S 3.03155
KIAA1755 KIAA1755 3.03155
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 3.03155
KLK11 kallikrein-related peptidase 11 3.03155
KLK3 kallikrein-related peptidase 3 3.03155
KLK2 kallikrein-related peptidase 2 3.03155
TSPAN32 tetraspanin 32 3.03155
PTPN20 protein tyrosine phosphatase, non-receptor type 20 3.03155
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22 3.03155
LY96 lymphocyte antigen 96 3.03155
RIPPLY2 ripply transcriptional repressor 2 3.03155
PDCD1LG2 programmed cell death 1 ligand 2 3.03155
ASTL astacin-like metallo-endopeptidase (M12 family) 3.03155
NUTM2A NUT family member 2A 3.03155
NT5C1B 5'-nucleotidase, cytosolic IB 3.03155
ERMN ermin, ERM-like protein 3.03155
BMX BMX non-receptor tyrosine kinase 3.03155
SEC14L3 SEC14-like 3 (S. cerevisiae) 3.03155
FAM177B family with sequence similarity 177, member B 3.03155
HKDC1 hexokinase domain containing 1 3.03155
SPATA3 spermatogenesis associated 3 3.03155
EFCAB3 EF-hand calcium binding domain 3 3.03155
HUS1B HUS1 checkpoint homolog b (S. pombe) 3.03155
PCDHGA3 protocadherin gamma subfamily A, 3 3.03155
NUPR1 nuclear protein, transcriptional regulator, 1 3.03155
CNTF ciliary neurotrophic factor 3.03155
MUC13 mucin 13, cell surface associated 3.03155
FNDC5 fibronectin type III domain containing 5 3.03155
PCDHGB4 protocadherin gamma subfamily B, 4 3.03155
MS4A7 membrane-spanning 4-domains, subfamily A, member 7 3.03155
RGS8 regulator of G-protein signaling 8 3.03155
QRFP pyroglutamylated RFamide peptide 3.03155
AMER3 APC membrane recruitment protein 3 3.03155
ZPLD1 zona pellucida-like domain containing 1 3.03155
TAS2R43 taste receptor, type 2, member 43 3.03155
DRC1 dynein regulatory complex subunit 1 3.03155
GOLGA8T golgin A8 family, member T 3.03155
ANGPTL5 angiopoietin-like 5 3.03155
MMP10 matrix metallopeptidase 10 3.03155
IL37 interleukin 37 3.03155
OR52N1 olfactory receptor, family 52, subfamily N, member 1 3.03155
R3HDML R3H domain containing-like 3.03155
FGF4 fibroblast growth factor 4 3.03155
SLC36A3 solute carrier family 36, member 3 3.03155
SDSL serine dehydratase-like 3.03155
TMPRSS15 transmembrane protease, serine 15 3.03155
FKBP1C FK506 binding protein 1C 3.03155
LMAN1L lectin, mannose-binding, 1 like 3.03155
CGA glycoprotein hormones, alpha polypeptide 3.03155
ADAP1 ArfGAP with dual PH domains 1 3.03155
PHGR1 proline/histidine/glycine-rich 1 3.03155
GRAPL GRB2-related adaptor protein-like 3.03155
OR56B4 olfactory receptor, family 56, subfamily B, member 4 3.03155
LGALS12 lectin, galactoside-binding, soluble, 12 3.03155
DCX doublecortin 3.03155
SLC51B solute carrier family 51, beta subunit 3.03155
CNGB1 cyclic nucleotide gated channel beta 1 2.94665
MAU2 MAU2 sister chromatid cohesion factor 2.89922
ZIC3 Zic family member 3 2.76316
RABEP2 rabaptin, RAB GTPase binding effector protein 2 2.68308
POGK pogo transposable element with KRAB domain 2.64825
NME3 NME/NM23 nucleoside diphosphate kinase 3 2.60916
NACAD NAC alpha domain containing 2.59389
XPO6 exportin 6 2.57218
MRPL22 mitochondrial ribosomal protein L22 2.5597
ECSCR endothelial cell surface expressed chemotaxis and apoptosis regulator 2.55942
CA14 carbonic anhydrase XIV 2.53641
ZNF134 zinc finger protein 134 2.53589
ABHD17C abhydrolase domain containing 17C 2.51222
SLC71A2 solute carrier family 71 member 2 2.50448
DNAL1 dynein, axonemal, light chain 1 2.43934
TMEM50B transmembrane protein 50B 2.42812
FAM167A family with sequence similarity 167, member A 2.42271
SBNO1 strawberry notch homolog 1 (Drosophila) 2.37039
NUP58 nucleoporin 58 2.34613
SULT4A1 sulfotransferase family 4A, member 1 2.33773
EXOSC6 exosome component 6 2.33693
DIPK2A divergent protein kinase domain 2A 2.32962
NAPB N-ethylmaleimide-sensitive factor attachment protein, beta 2.3085
ZNF449 zinc finger protein 449 2.3085
TBC1D19 TBC1 domain family, member 19 2.30396
CD8A CD8a molecule 2.30396
BCO1 beta-carotene oxygenase 1 2.30396
HEG1 heart development protein with EGF-like domains 1 2.30141
SLC25A12 solute carrier family 25 (aspartate/glutamate carrier), member 12 2.28584
CRPPA CDP-L-ribitol pyrophosphorylase A 2.27809
AMMECR1L AMMECR1-like 2.27786
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1 2.26552
SHROOM2 shroom family member 2 2.26448
ZNF805 zinc finger protein 805 2.26448
PRPS1 phosphoribosyl pyrophosphate synthetase 1 2.26448
CCDC192 coiled-coil domain containing 192 2.26448
B3GALNT2 beta-1,3-N-acetylgalactosaminyltransferase 2 2.26135
DTD1 D-tyrosyl-tRNA deacylase 1 2.24694
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 2.21661
SAAL1 serum amyloid A-like 1 2.21405
TBC1D25 TBC1 domain family, member 25 2.21405
SMG9 SMG9 nonsense mediated mRNA decay factor 2.21405
FANCA Fanconi anemia, complementation group A 2.21217
ESPN espin 2.21217
TTC19 tetratricopeptide repeat domain 19 2.20964
LEMD2 LEM domain containing 2 2.19625
CSAD cysteine sulfinic acid decarboxylase 2.19364
SLC25A41 solute carrier family 25, member 41 2.17741
NOP2 NOP2 nucleolar protein 2.17741
FCN3 ficolin (collagen/fibrinogen domain containing) 3 2.17741
ZNF804A zinc finger protein 804A 2.17741
NBDY negative regulator of P-body association 2.17394
C1QTNF3 C1q and tumor necrosis factor related protein 3 2.17394
DOK6 docking protein 6 2.17394
ASIC1 acid sensing (proton gated) ion channel 1 2.17365
DCAF8 DDB1 and CUL4 associated factor 8 2.13735
ANKRD49 ankyrin repeat domain 49 2.1204
PIANP PILR alpha associated neural protein 2.10875
CYB5B cytochrome b5 type B (outer mitochondrial membrane) 2.09929
KAT14 lysine acetyltransferase 14 2.09643
TOP3B topoisomerase (DNA) III beta 2.09637
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like 2.06863
ASCC1 activating signal cointegrator 1 complex subunit 1 2.06142
USP28 ubiquitin specific peptidase 28 2.055
MAP9 microtubule-associated protein 9 2.0475
SLC52A2 solute carrier family 52 (riboflavin transporter), member 2 2.0446
CYP27C1 cytochrome P450, family 27, subfamily C, polypeptide 1 2.04358
INTS13 integrator complex subunit 13 2.03131
NECAP1 NECAP endocytosis associated 1 2.01966
XRN1 5'-3' exoribonuclease 1 2.0189

decreased expression

Symbol Name Standardized Value
G0S2 G0/G1 switch 2 -3.06073
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 -3.06073
GOLGA8H golgin A8 family, member H -3.03155
FBP2 fructose-1,6-bisphosphatase 2 -3.03155
ASNS asparagine synthetase (glutamine-hydrolyzing) -2.97362
ALKBH5 AlkB family member 5, RNA demethylase -2.92566
MAMDC4 MAM domain containing 4 -2.89922
CPSF4L cleavage and polyadenylation specific factor 4-like -2.89922
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) -2.89922
FAM161B family with sequence similarity 161, member B -2.89922
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12 -2.89922
TMPRSS5 transmembrane protease, serine 5 -2.89922
RASD1 RAS, dexamethasone-induced 1 -2.89922
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 -2.89922
ZNF534 zinc finger protein 534 -2.89922
PARP15 poly (ADP-ribose) polymerase family, member 15 -2.89922
OPN1SW opsin 1 (cone pigments), short-wave-sensitive -2.89922
POPDC2 popeye domain containing 2 -2.89922
ACOX2 acyl-CoA oxidase 2, branched chain -2.89922
TMEM132E transmembrane protein 132E -2.89922
DYDC1 DPY30 domain containing 1 -2.89922
TOMM20L translocase of outer mitochondrial membrane 20 homolog (yeast)-like -2.89922
C8ORF74 chromosome 8 open reading frame 74 -2.89922
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 -2.89922
ZBED6 zinc finger, BED-type containing 6 -2.89922
CBY2 chibby family member 2 -2.89922
TTC22 tetratricopeptide repeat domain 22 -2.89922
ZEB2 zinc finger E-box binding homeobox 2 -2.89922
TMEM255A transmembrane protein 255A -2.89922
SLC36A2 solute carrier family 36 (proton/amino acid symporter), member 2 -2.89922
MUSK muscle, skeletal, receptor tyrosine kinase -2.89922
ISG20 interferon stimulated exonuclease gene 20kDa -2.89922
SPMAP2L sperm microtubule associated protein 2 like -2.89922
C2ORF80 chromosome 2 open reading frame 80 -2.89922
RFX6 regulatory factor X, 6 -2.89922
LMOD2 leiomodin 2 (cardiac) -2.89922
ACTL8 actin-like 8 -2.89922
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) -2.89922
OPRM1 opioid receptor, mu 1 -2.89922
FXYD3 FXYD domain containing ion transport regulator 3 -2.89922
STMN1 stathmin 1 -2.8591
ZNF599 zinc finger protein 599 -2.77492
BTBD17 BTB (POZ) domain containing 17 -2.75713
SRSF1 serine/arginine-rich splicing factor 1 -2.75002
PGLS 6-phosphogluconolactonase -2.73105
RIPK4 receptor-interacting serine-threonine kinase 4 -2.60215
MUC19 mucin 19, oligomeric -2.60215
HACD4 3-hydroxyacyl-CoA dehydratase 4 -2.55205
KIAA0586 KIAA0586 -2.53641
DUOX1 dual oxidase 1 -2.53641
CACNB1 calcium channel, voltage-dependent, beta 1 subunit -2.53641
SNAPC3 small nuclear RNA activating complex, polypeptide 3, 50kDa -2.53641
WDR72 WD repeat domain 72 -2.53641
PHACTR1 phosphatase and actin regulator 1 -2.53312
SLC45A1 solute carrier family 45, member 1 -2.52859
VARS1 valyl-tRNA synthetase 1 -2.5271
PPP1R3E protein phosphatase 1, regulatory subunit 3E -2.52536
CADM3 cell adhesion molecule 3 -2.39221
C17ORF75 chromosome 17 open reading frame 75 -2.38826
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 -2.38783
FBXO31 F-box protein 31 -2.38351
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) -2.37039
CCDC93 coiled-coil domain containing 93 -2.37039
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa -2.35121
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1 -2.33326
C1QTNF6 C1q and tumor necrosis factor related protein 6 -2.33326
FOXP1 forkhead box P1 -2.30621
AKR1E2 aldo-keto reductase family 1, member E2 -2.30396
HYPK huntingtin interacting protein K -2.27406
PKLR pyruvate kinase, liver and RBC -2.27406
FXYD2 FXYD domain containing ion transport regulator 2 -2.27406
NFIX nuclear factor I/X (CCAAT-binding transcription factor) -2.27406
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase -2.27406
GIPC2 GIPC PDZ domain containing family, member 2 -2.27129
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 -2.26448
HORMAD2 HORMA domain containing 2 -2.26448
TMEM79 transmembrane protein 79 -2.26448
AHI1 Abelson helper integration site 1 -2.23609
RECQL5 RecQ protein-like 5 -2.2332
SYT16 synaptotagmin XVI -2.2332
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma -2.20947
MICALL1 MICAL-like 1 -2.20947
CMC1 C-x(9)-C motif containing 1 -2.20096
PAH phenylalanine hydroxylase -2.19364
KCNIP4 Kv channel interacting protein 4 -2.19364
TIAM1 T-cell lymphoma invasion and metastasis 1 -2.19364
ALDH1L2 aldehyde dehydrogenase 1 family, member L2 -2.17394
RPS26 ribosomal protein S26 -2.15998
MIEF1 mitochondrial elongation factor 1 -2.15558
HFE hemochromatosis -2.15466
C3 complement component 3 -2.15466
MRPL48 mitochondrial ribosomal protein L48 -2.15017
CABLES2 Cdk5 and Abl enzyme substrate 2 -2.14502
TMEM141 transmembrane protein 141 -2.1295
ABLIM2 actin binding LIM protein family, member 2 -2.1204
WDR81 WD repeat domain 81 -2.10467
POLR1G RNA polymerase I subunit G -2.10272
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -2.09637
MYL5 myosin, light chain 5, regulatory -2.09637
S1PR1 sphingosine-1-phosphate receptor 1 -2.09637
KIF24 kinesin family member 24 -2.07979
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 -2.055
RNF38 ring finger protein 38 -2.055
FGF1 fibroblast growth factor 1 (acidic) -2.0475
CA2 carbonic anhydrase II -2.0475
ATF5 activating transcription factor 5 -2.0475
C2ORF69 chromosome 2 open reading frame 69 -2.0475
FAM120C family with sequence similarity 120C -2.0356
TRIM39 tripartite motif containing 39 -2.01966
PCSK4 proprotein convertase subtilisin/kexin type 4 -2.01966
THADA thyroid adenoma associated -2.01583