NS-398-6911 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the NS-398-6911 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACVR1B activin A receptor, type IB
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9
ALPPL2 alkaline phosphatase, placental-like 2
AP2A2 adaptor-related protein complex 2, alpha 2 subunit
ARTN artemin
ASB9 ankyrin repeat and SOCS box containing 9
ATF3 activating transcription factor 3
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
CACFD1 calcium channel flower domain containing 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CASP1 caspase 1, apoptosis-related cysteine peptidase
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2
CBR4 carbonyl reductase 4
CD200 CD200 molecule
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CENPQ centromere protein Q
CEP162 centrosomal protein 162kDa
CEP57 centrosomal protein 57kDa
CLDND1 claudin domain containing 1
COL4A5 collagen, type IV, alpha 5
DDR1-AS1 DDR1 antisense RNA 1 (head to head)
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
ELSPBP1 epididymal sperm binding protein 1
EMID1 EMI domain containing 1
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
EPOR erythropoietin receptor
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
GAN gigaxonin
GCA grancalcin, EF-hand calcium binding protein
GINS3 GINS complex subunit 3 (Psf3 homolog)
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
GLIPR1 GLI pathogenesis-related 1
GON4L gon-4-like (C. elegans)
HABP4 hyaluronan binding protein 4
HNMT histamine N-methyltransferase
HOXA10 homeobox A10
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma
IGL immunoglobulin lambda locus
KCNK12 potassium channel, two pore domain subfamily K, member 12
KCTD17 potassium channel tetramerization domain containing 17
KIAA0368 KIAA0368
KLF9 Kruppel-like factor 9
LOC257152 uncharacterized LOC257152
LOC644450 uncharacterized LOC644450
LTBP4 latent transforming growth factor beta binding protein 4
METAP2 methionyl aminopeptidase 2
MID1 midline 1
MORC3 MORC family CW-type zinc finger 3
MRPL52 mitochondrial ribosomal protein L52
MTM1 myotubularin 1
MYRF myelin regulatory factor
NAG18 NAG18 mRNA
NF2 neurofibromin 2 (merlin)
NR5A2 nuclear receptor subfamily 5, group A, member 2
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PBLD phenazine biosynthesis-like protein domain containing
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PKP3 plakophilin 3
PLCD1 phospholipase C, delta 1
PORCN porcupine homolog (Drosophila)
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PPP5C protein phosphatase 5, catalytic subunit
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
PRR14L proline rich 14-like
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2
PTPN2 protein tyrosine phosphatase, non-receptor type 2
RABGAP1L RAB GTPase activating protein 1-like
RIN3 Ras and Rab interactor 3
RNMT RNA (guanine-7-) methyltransferase
RORA RAR-related orphan receptor A
RPL10 ribosomal protein L10
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
RUNX3 runt-related transcription factor 3
SIM2 single-minded family bHLH transcription factor 2
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SMAD6 SMAD family member 6
SMEK1 SMEK homolog 1, suppressor of mek1 (Dictyostelium)
SOCS6 suppressor of cytokine signaling 6
SOX9 SRY (sex determining region Y)-box 9
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TCTN2 tectonic family member 2
TJAP1 tight junction associated protein 1 (peripheral)
TM2D1 TM2 domain containing 1
TMEM80 transmembrane protein 80
TNK1 tyrosine kinase, non-receptor, 1
TRIM14 tripartite motif containing 14
TRPV6 transient receptor potential cation channel, subfamily V, member 6
TSFM Ts translation elongation factor, mitochondrial
UBQLN4 ubiquilin 4
WDR25 WD repeat domain 25
WWTR1 WW domain containing transcription regulator 1
ZCCHC24 zinc finger, CCHC domain containing 24
ZNF43 zinc finger protein 43
ZNF586 zinc finger protein 586
ZNF701 zinc finger protein 701
ZNF710 zinc finger protein 710

decreased expression

Symbol Name
ABT1 activator of basal transcription 1
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ALG12 ALG12, alpha-1,6-mannosyltransferase
ANKEF1 ankyrin repeat and EF-hand domain containing 1
ARAF A-Raf proto-oncogene, serine/threonine kinase
ARC activity-regulated cytoskeleton-associated protein
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2
C16ORF59 chromosome 16 open reading frame 59
C22ORF29 chromosome 22 open reading frame 29
C8ORF33 chromosome 8 open reading frame 33
CAMK1 calcium/calmodulin-dependent protein kinase I
CCBL1 cysteine conjugate-beta lyase, cytoplasmic
CCNO cyclin O
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
CDC37 cell division cycle 37
CENPB centromere protein B, 80kDa
CENPJ centromere protein J
CIC capicua transcriptional repressor
CRIP2 cysteine-rich protein 2
CUL9 cullin 9
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae)
CYB561D2 cytochrome b561 family, member D2
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1
DDA1 DET1 and DDB1 associated 1
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DHRS11 dehydrogenase/reductase (SDR family) member 11
DHRS3 dehydrogenase/reductase (SDR family) member 3
DPM2 dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit
EDC3 enhancer of mRNA decapping 3
EPHA2 EPH receptor A2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FAM86C1 family with sequence similarity 86, member C1
FANCE Fanconi anemia, complementation group E
FURIN furin (paired basic amino acid cleaving enzyme)
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C
GINS4 GINS complex subunit 4 (Sld5 homolog)
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2
GPX3 glutathione peroxidase 3
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
HDAC5 histone deacetylase 5
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITPKB inositol-trisphosphate 3-kinase B
KIAA0125 KIAA0125
KIAA0319L KIAA0319-like
KLF11 Kruppel-like factor 11
LIG1 ligase I, DNA, ATP-dependent
LRRC61 leucine rich repeat containing 61
LRRC8E leucine rich repeat containing 8 family, member E
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
MCAT malonyl CoA:ACP acyltransferase (mitochondrial)
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
MLF2 myeloid leukemia factor 2
MPDU1 mannose-P-dolichol utilization defect 1
MPI mannose phosphate isomerase
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NLRX1 NLR family member X1
NUBP2 nucleotide binding protein 2
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
PGD phosphogluconate dehydrogenase
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLK1 polo-like kinase 1
POLR2J2 polymerase (RNA) II (DNA directed) polypeptide J2
PPAP2C phosphatidic acid phosphatase type 2C
PSENEN presenilin enhancer gamma secretase subunit
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
QTRT1 queuine tRNA-ribosyltransferase 1
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3
SH3GLB2 SH3-domain GRB2-like endophilin B2
SIPA1 signal-induced proliferation-associated 1
SIRT6 sirtuin 6
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SLC22A18 solute carrier family 22, member 18
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SOX3 SRY (sex determining region Y)-box 3
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TBC1D17 TBC1 domain family, member 17
TLN1 talin 1
TM7SF2 transmembrane 7 superfamily member 2
TMUB2 transmembrane and ubiquitin-like domain containing 2
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast)
UBE2M ubiquitin-conjugating enzyme E2M
UFSP2 UFM1-specific peptidase 2
WWC2 WW and C2 domain containing 2
ZFYVE21 zinc finger, FYVE domain containing 21
ZMAT3 zinc finger, matrin-type 3
ZMAT5 zinc finger, matrin-type 5
ZNF571 zinc finger protein 571
ZNF654 zinc finger protein 654