NTRK1 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description neurotrophic tyrosine kinase, receptor, type 1|This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 4914)
External Link http://www.ncbi.nlm.nih.gov/gene/4914
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Genes

267 interacting proteins for NTRK1 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
AAK1 AP2 associated kinase 1
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ACOX3 acyl-CoA oxidase 3, pristanoyl
ACTB actin, beta
ACTN4 actinin, alpha 4
ACVR1 activin A receptor, type I
ACVR1B activin A receptor, type IB
ACVR2B activin A receptor, type IIB
ADAM28 ADAM metallopeptidase domain 28
ADCK1 aarF domain containing kinase 1
ADCK3 aarF domain containing kinase 3
ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
ADK adenosine kinase
ADORA2A adenosine A2a receptor
AFF4 AF4/FMR2 family, member 4
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
AHRR aryl-hydrocarbon receptor repressor
ALDOA aldolase A, fructose-bisphosphate
ALPK3 alpha-kinase 3
ANAPC5 anaphase promoting complex subunit 5
ANAPC7 anaphase promoting complex subunit 7
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ANXA2 annexin A2
AP2A1 adaptor-related protein complex 2, alpha 1 subunit
AP2B1 adaptor-related protein complex 2, beta 1 subunit
AP2M1 adaptor-related protein complex 2, mu 1 subunit
ARAF A-Raf proto-oncogene, serine/threonine kinase
ARHGAP32 Rho GTPase activating protein 32
ATAD3B ATPase family, AAA domain containing 3B
ATF2 activating transcription factor 2
ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
ATP5C1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
AURKA aurora kinase A
AURKB aurora kinase B
AZI2 5-azacytidine induced 2
BMP2K BMP2 inducible kinase
BMPR1A bone morphogenetic protein receptor, type IA
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRD3 bromodomain containing 3
BRD4 bromodomain containing 4
BTK Bruton agammaglobulinemia tyrosine kinase
C2CD5 C2 calcium-dependent domain containing 5
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CAMK2D calcium/calmodulin-dependent protein kinase II delta
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CAV1 caveolin 1, caveolae protein, 22kDa
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCNH cyclin H
CDC37 cell division cycle 37
CDC42 cell division cycle 42
CDK1 cyclin-dependent kinase 1
CDK12 cyclin-dependent kinase 12
CDK13 cyclin-dependent kinase 13
CDK2 cyclin-dependent kinase 2
CDK5 cyclin-dependent kinase 5
CDK7 cyclin-dependent kinase 7
CDK9 cyclin-dependent kinase 9
CHUK conserved helix-loop-helix ubiquitous kinase
CLK1 CDC-like kinase 1
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CSK c-src tyrosine kinase
CSNK1A1 casein kinase 1, alpha 1
CSNK1D casein kinase 1, delta
CSNK1E casein kinase 1, epsilon
CSNK1G1 casein kinase 1, gamma 1
CSNK1G3 casein kinase 1, gamma 3
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CSNK2A2 casein kinase 2, alpha prime polypeptide
CSNK2B casein kinase 2, beta polypeptide
DCK deoxycytidine kinase
DCTPP1 dCTP pyrophosphatase 1
DDR1 discoidin domain receptor tyrosine kinase 1
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DNAL4 dynein, axonemal, light chain 4
DNM1 dynamin 1
DNM2 dynamin 2
DNM3 dynamin 3
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DOK2 docking protein 2, 56kDa
DYNLL1 dynein, light chain, LC8-type 1
DYNLT1 dynein, light chain, Tctex-type 1
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EHD4 EH-domain containing 4
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1
EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4
EIF3J eukaryotic translation initiation factor 3, subunit J
EPB41L1 erythrocyte membrane protein band 4.1-like 1
EPHB1 EPH receptor B1
EPHB2 EPH receptor B2
EPHB4 EPH receptor B4
FER fer (fps/fes related) tyrosine kinase
FGFR1 fibroblast growth factor receptor 1
FRS2 fibroblast growth factor receptor substrate 2
FRS3 fibroblast growth factor receptor substrate 3
FRYL FRY-like
FYN FYN proto-oncogene, Src family tyrosine kinase
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GAB1 GRB2-associated binding protein 1
GAB2 GRB2-associated binding protein 2
GAK cyclin G associated kinase
GAPVD1 GTPase activating protein and VPS9 domains 1
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GIPC1 GIPC PDZ domain containing family, member 1
GRAMD1A GRAM domain containing 1A
GRB2 growth factor receptor-bound protein 2
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
HCK HCK proto-oncogene, Src family tyrosine kinase
HIPK1 homeodomain interacting protein kinase 1
HIST1H4F histone cluster 1, H4f
HIST3H3 histone cluster 3, H3
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
HRNR hornerin
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA4 heat shock 70kDa protein 4
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
INPPL1 inositol polyphosphate phosphatase-like 1
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
JAK1 Janus kinase 1
JAK2 Janus kinase 2
KIAA0195 KIAA0195
KIDINS220 kinase D-interacting substrate, 220kDa
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
LIMK1 LIM domain kinase 1
LIMK2 LIM domain kinase 2
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae)
LYN LYN proto-oncogene, Src family tyrosine kinase
MAGED1 melanoma antigen family D1
MAP2K2 mitogen-activated protein kinase kinase 2
MAP3K11 mitogen-activated protein kinase kinase kinase 11
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MAP3K3 mitogen-activated protein kinase kinase kinase 3
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK6 mitogen-activated protein kinase 6
MAPK9 mitogen-activated protein kinase 9
MARK1 MAP/microtubule affinity-regulating kinase 1
MARK2 MAP/microtubule affinity-regulating kinase 2
MARK3 MAP/microtubule affinity-regulating kinase 3
MARK4 MAP/microtubule affinity-regulating kinase 4
MATK megakaryocyte-associated tyrosine kinase
MELK maternal embryonic leucine zipper kinase
MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1
MNAT1 MNAT CDK-activating kinase assembly factor 1
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
NCK2 NCK adaptor protein 2
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEK11 NIMA-related kinase 11
NEK9 NIMA-related kinase 9
NGF nerve growth factor (beta polypeptide)
NGFR nerve growth factor receptor
NLK nemo-like kinase
NQO2 NAD(P)H dehydrogenase, quinone 2
NTF3 neurotrophin 3
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PDE4A phosphodiesterase 4A, cAMP-specific
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1
PDPK1 3-phosphoinositide dependent protein kinase 1
PHLDA3 pleckstrin homology-like domain, family A, member 3
PIAS2 protein inhibitor of activated STAT, 2
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIP4K2C phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
PKMYT1 protein kinase, membrane associated tyrosine/threonine 1
PKN1 protein kinase N1
PKN3 protein kinase N3
PLCG1 phospholipase C, gamma 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLK4 polo-like kinase 4
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRKCD protein kinase C, delta
PRKCQ protein kinase C, theta
PRKD2 protein kinase D2
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTK2 protein tyrosine kinase 2
PTK2B protein tyrosine kinase 2 beta
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived)
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPRB protein tyrosine phosphatase, receptor type, B
PTPRC protein tyrosine phosphatase, receptor type, C
PTPRG protein tyrosine phosphatase, receptor type, G
PTPRJ protein tyrosine phosphatase, receptor type, J
PTPRO protein tyrosine phosphatase, receptor type, O
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAP1A RAP1A, member of RAS oncogene family
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1
RGS19 regulator of G-protein signaling 19
RHOA ras homolog family member A
RHOB ras homolog family member B
RHOC ras homolog family member C
RHOG ras homolog family member G
RIPK2 receptor-interacting serine-threonine kinase 2
RIT1 Ras-like without CAAX 1
RIT2 Ras-like without CAAX 2
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
RUSC1 RUN and SH3 domain containing 1
SACK1A scaffolding CK1 anchoring protein A
SEC16A SEC16 homolog A (S. cerevisiae)
SGSM3 small G protein signaling modulator 3
SH2B1 SH2B adaptor protein 1
SH2B2 SH2B adaptor protein 2
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SHC2 SHC (Src homology 2 domain containing) transforming protein 2
SHC3 SHC (Src homology 2 domain containing) transforming protein 3
SIK2 salt-inducible kinase 2
SIK3 SIK family kinase 3
SLK STE20-like kinase
SORBS1 sorbin and SH3 domain containing 1
SOS1 son of sevenless homolog 1 (Drosophila)
SP1 Sp1 transcription factor
SPEG SPEG complex locus
SQSTM1 sequestosome 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRRM2 serine/arginine repetitive matrix 2
SSB Sjogren syndrome antigen B (autoantigen La)
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STK16 serine/threonine kinase 16
SYK spleen tyrosine kinase
TANK TRAF family member-associated NFKB activator
TAOK1 TAO kinase 1
TAOK3 TAO kinase 3
TBK1 TANK-binding kinase 1
TBKBP1 TBK1 binding protein 1
TEC tec protein tyrosine kinase
TESK2 testis-specific kinase 2
TGFBR1 transforming growth factor, beta receptor 1
TMX1 thioredoxin-related transmembrane protein 1
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TNIK TRAF2 and NCK interacting kinase
TNK1 tyrosine kinase, non-receptor, 1
TNK2 tyrosine kinase, non-receptor, 2
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TTN titin
TUBA1B tubulin, alpha 1b
TYK2 tyrosine kinase 2
UBB ubiquitin B
UBC ubiquitin C
ULK1 unc-51 like autophagy activating kinase 1
ULK3 unc-51 like kinase 3
WEE1 WEE1 G2 checkpoint kinase
YES1 YES proto-oncogene 1, Src family tyrosine kinase