| Dataset | PhosphoSitePlus Substrates of Kinases |
| Category | physical interactions |
| Type | kinase |
| Description | neurotrophic tyrosine kinase, receptor, type 1|This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 4914) |
| External Link | http://www.ncbi.nlm.nih.gov/gene/4914 |
| Similar Terms | |
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5 substrates of the kinase NTRK1 from the curated PhosphoSitePlus Substrates of Kinases dataset.
