NTRK2 Gene Set

Dataset KEA Substrates of Kinases
Category physical interactions
Type kinase
Description neurotrophic tyrosine kinase, receptor, type 2|This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014] (NCBI Entrez Gene Database, 4915)
External Link http://www.ncbi.nlm.nih.gov/gene/4915
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13 substrates of the kinase NTRK2 from the curated KEA Substrates of Kinases dataset.

Symbol Name
FRS3 fibroblast growth factor receptor substrate 3
FYN FYN proto-oncogene, Src family tyrosine kinase
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3
NTF4 neurotrophin 4
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PLCG1 phospholipase C, gamma 1
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1
SHC2 SHC (Src homology 2 domain containing) transforming protein 2
SHC3 SHC (Src homology 2 domain containing) transforming protein 3
TIAM1 T-cell lymphoma invasion and metastasis 1
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase