NTRK2 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description neurotrophic tyrosine kinase, receptor, type 2|This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014] (NCBI Entrez Gene Database, 4915)
External Link http://www.ncbi.nlm.nih.gov/gene/4915
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Genes

59 interacting proteins for NTRK2 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
ADORA2A adenosine A2a receptor
AP1B1 adaptor-related protein complex 1, beta 1 subunit
BDNF brain-derived neurotrophic factor
CDC42 cell division cycle 42
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTNND1 catenin (cadherin-associated protein), delta 1
DLG4 discs, large homolog 4 (Drosophila)
DOK5 docking protein 5
DYNLL1 dynein, light chain, LC8-type 1
DYNLT1 dynein, light chain, Tctex-type 1
EHD4 EH-domain containing 4
FRS2 fibroblast growth factor receptor substrate 2
FRS3 fibroblast growth factor receptor substrate 3
FYN FYN proto-oncogene, Src family tyrosine kinase
GAB1 GRB2-associated binding protein 1
GIPC1 GIPC PDZ domain containing family, member 1
GRB2 growth factor receptor-bound protein 2
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3
KIDINS220 kinase D-interacting substrate, 220kDa
NCK1 NCK adaptor protein 1
NCK2 NCK adaptor protein 2
NGFR nerve growth factor receptor
NMNAT1 nicotinamide nucleotide adenylyltransferase 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NTF3 neurotrophin 3
NTF4 neurotrophin 4
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PKM pyruvate kinase, muscle
PLCG1 phospholipase C, gamma 1
POLR2G polymerase (RNA) II (DNA directed) polypeptide G
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RANBP9 RAN binding protein 9
RAP1A RAP1A, member of RAS oncogene family
RAP1B RAP1B, member of RAS oncogene family
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1
RIT1 Ras-like without CAAX 1
RIT2 Ras-like without CAAX 2
SH2B1 SH2B adaptor protein 1
SH2B2 SH2B adaptor protein 2
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SHC2 SHC (Src homology 2 domain containing) transforming protein 2
SHC3 SHC (Src homology 2 domain containing) transforming protein 3
SOS1 son of sevenless homolog 1 (Drosophila)
SQSTM1 sequestosome 1
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TNK2 tyrosine kinase, non-receptor, 2
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
UBB ubiquitin B
UBC ubiquitin C