NTRK3 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description neurotrophic tyrosine kinase, receptor, type 3|This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011] (NCBI Entrez Gene Database, 4916)
External Link http://www.ncbi.nlm.nih.gov/gene/4916
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Genes

42 interacting proteins for NTRK3 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
APP amyloid beta (A4) precursor protein
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
DOK5 docking protein 5
DYNLL1 dynein, light chain, LC8-type 1
EHD4 EH-domain containing 4
FRS2 fibroblast growth factor receptor substrate 2
FRS3 fibroblast growth factor receptor substrate 3
GAB1 GRB2-associated binding protein 1
GRB2 growth factor receptor-bound protein 2
HRAS Harvey rat sarcoma viral oncogene homolog
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
IRAK1 interleukin-1 receptor-associated kinase 1
IRAK3 interleukin-1 receptor-associated kinase 3
JUN jun proto-oncogene
KIDINS220 kinase D-interacting substrate, 220kDa
KRAS Kirsten rat sarcoma viral oncogene homolog
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MCF2L MCF.2 cell line derived transforming sequence-like
NGFR nerve growth factor receptor
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NTF3 neurotrophin 3
PKM pyruvate kinase, muscle
PLCG1 phospholipase C, gamma 1
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1
RIT1 Ras-like without CAAX 1
RIT2 Ras-like without CAAX 2
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SHC2 SHC (Src homology 2 domain containing) transforming protein 2
SOS1 son of sevenless homolog 1 (Drosophila)
SQSTM1 sequestosome 1
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TIAM1 T-cell lymphoma invasion and metastasis 1
TNK2 tyrosine kinase, non-receptor, 2