NUCKS1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description nuclear casein kinase and cyclin-dependent kinase substrate 1|This gene encodes a nuclear protein that is highly conserved in vertebrates. The conserved regions of the protein contain several consensus phosphorylation sites for casein kinase II and cyclin-dependent kinases, two putative nuclear localization signals, and a basic DNA-binding domain. It is phosphorylated in vivo by Cdk1 during mitosis of the cell cycle. [provided by RefSeq, Aug 2010] (NCBI Entrez Gene Database, 64710)
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Genes

377 genes differentially expressed following the NUCKS1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
GSDMA gasdermin A 3.36738
GOLGA6C golgin A6 family, member C 3.36738
GLYATL3 glycine-N-acyltransferase-like 3 3.36738
CD68 CD68 molecule 3.36738
LCN15 lipocalin 15 3.36738
FSCN2 fascin actin-bundling protein 2, retinal 3.36738
SIGLEC16 sialic acid binding Ig-like lectin 16 (gene/pseudogene) 3.36738
SSTR5 somatostatin receptor 5 3.36738
SLC22A14 solute carrier family 22, member 14 3.36738
MUC16 mucin 16, cell surface associated 3.36738
PRG4 proteoglycan 4 3.36738
PCDHGA11 protocadherin gamma subfamily A, 11 3.36738
PLGLB2 plasminogen-like B2 3.36738
BTLA B and T lymphocyte associated 3.36738
SQOR sulfide quinone oxidoreductase 3.36738
IRX4 iroquois homeobox 4 3.36738
GCOM1 GRINL1A complex locus 1 3.36738
C9ORF64 chromosome 9 open reading frame 64 3.36738
CFAP276 cilia and flagella associated protein 276 3.36738
CXCR5 chemokine (C-X-C motif) receptor 5 3.36738
DNAAF6 dynein axonemal assembly factor 6 3.36738
IDUA iduronidase, alpha-L- 3.36738
SPON2 spondin 2, extracellular matrix protein 3.36738
GJA9 gap junction protein, alpha 9, 59kDa 3.316
CD163 CD163 molecule 3.316
FABP1 fatty acid binding protein 1, liver 3.316
HEATR9 HEAT repeat containing 9 3.316
TPBGL trophoblast glycoprotein-like 3.316
ENPP6 ectonucleotide pyrophosphatase/phosphodiesterase 6 3.316
SCGN secretagogin, EF-hand calcium binding protein 3.316
FGF23 fibroblast growth factor 23 3.316
TMEM212 transmembrane protein 212 3.316
TMPRSS11F transmembrane protease, serine 11F 3.316
GPR162 G protein-coupled receptor 162 3.316
LRRD1 leucine-rich repeats and death domain containing 1 3.316
PON1 paraoxonase 1 3.316
PDYN prodynorphin 3.316
LBX2 ladybird homeobox 2 3.316
TAS2R10 taste receptor, type 2, member 10 3.316
AVP arginine vasopressin 3.316
GYS2 glycogen synthase 2 (liver) 3.316
SPACA5 sperm acrosome associated 5 3.316
FAM9C family with sequence similarity 9, member C 3.316
NDUFB2 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa 3.316
PMCH pro-melanin-concentrating hormone 3.316
CRYGN crystallin, gamma N 3.316
MINAR2 membrane integral NOTCH2 associated receptor 2 3.316
SOX14 SRY (sex determining region Y)-box 14 3.316
UMOD uromodulin 3.316
OR10A6 olfactory receptor, family 10, subfamily A, member 6 (gene/pseudogene) 3.316
GJB3 gap junction protein, beta 3, 31kDa 3.316
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 3.316
FAM221B family with sequence similarity 221, member B 3.316
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 3.316
PRSS36 protease, serine, 36 3.316
DDN dendrin 3.316
SBK3 SH3 domain binding kinase family, member 3 3.316
COXFA4L2 cytochrome c oxidase hypoxia associated subunit FA4L2 3.316
MT3 metallothionein 3 3.316
MGAT4D MGAT4 family, member D 3.316
FRG2C FSHD region gene 2 family, member C 3.316
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 3.316
C1QTNF9B C1q and tumor necrosis factor related protein 9B 3.316
ASB4 ankyrin repeat and SOCS box containing 4 3.316
RTL1 retrotransposon-like 1 3.316
IMPG1 interphotoreceptor matrix proteoglycan 1 3.316
EIF2S3B eukaryotic translation initiation factor 2 subunit gamma B 3.316
VEGFD vascular endothelial growth factor D 3.316
CBLIF cobalamin binding intrinsic factor 3.316
SPATA31G1 SPATA31 subfamily G member 1 3.316
SPMAP1 sperm microtubule associated protein 1 3.316
SPMIP1 sperm microtubule inner protein 1 3.316
THSD8 thrombospondin type 1 domain containing 8 3.316
NOTCH2NLB notch 2 N-terminal like B 3.316
MUCL3 mucin like 3 3.316
CFAP299 cilia and flagella associated protein 299 3.316
RTL5 retrotransposon Gag like 5 3.316
ZNF705A zinc finger protein 705A 3.316
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic 3.316
CSAG2 CSAG family, member 2 3.316
IL31RA interleukin 31 receptor A 3.316
DSG1 desmoglein 1 3.316
SERTAD4 SERTA domain containing 4 3.316
PCDHB11 protocadherin beta 11 3.316
PTPRH protein tyrosine phosphatase, receptor type, H 3.316
SLC22A16 solute carrier family 22 (organic cation/carnitine transporter), member 16 3.316
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 3.316
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 3.316
AXDND1 axonemal dynein light chain domain containing 1 3.316
TMEM276-ZFTRAF1 TMEM276-ZFTRAF1 readthrough 3.316
DNASE2B deoxyribonuclease II beta 3.316
LTK leukocyte receptor tyrosine kinase 3.316
GDF7 growth differentiation factor 7 3.316
VCX3A variable charge, X-linked 3A 3.316
PGLYRP2 peptidoglycan recognition protein 2 3.316
SBSN suprabasin 3.316
CCR7 chemokine (C-C motif) receptor 7 3.316
PRR18 proline rich 18 3.316
IL5 interleukin 5 3.316
SRL sarcalumenin 3.316
ISL1 ISL LIM homeobox 1 3.316
KRT12 keratin 12, type I 3.316
PLEKHS1 pleckstrin homology domain containing, family S member 1 3.316
HSF4 heat shock transcription factor 4 3.316
IL9R interleukin 9 receptor 3.316
CRHBP corticotropin releasing hormone binding protein 3.316
OR14J1 olfactory receptor, family 14, subfamily J, member 1 3.316
IHH indian hedgehog 3.316
TBC1D26 TBC1 domain family, member 26 3.316
ACKR1 atypical chemokine receptor 1 (Duffy blood group) 3.316
AMER3 APC membrane recruitment protein 3 3.316
CARNS1 carnosine synthase 1 3.316
NT5C1A 5'-nucleotidase, cytosolic IA 3.316
CTXN2 cortexin 2 3.316
ASTL astacin-like metallo-endopeptidase (M12 family) 3.316
EDN3 endothelin 3 3.316
IL1B interleukin 1, beta 3.316
ANKS4B ankyrin repeat and sterile alpha motif domain containing 4B 3.316
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3 3.316
PTGIR prostaglandin I2 (prostacyclin) receptor (IP) 3.316
EGR3 early growth response 3 3.316
CRYBB2 crystallin, beta B2 3.316
AQP8 aquaporin 8 3.316
EPGN epithelial mitogen 3.316
KLHL1 kelch-like family member 1 3.316
KLK6 kallikrein-related peptidase 6 3.316
TESPA1 thymocyte expressed, positive selection associated 1 3.316
CST4 cystatin S 3.316
PGR progesterone receptor 3.316
C10ORF90 chromosome 10 open reading frame 90 3.316
SLX1A SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae) 3.316
TTC22 tetratricopeptide repeat domain 22 3.316
SLN sarcolipin 3.316
GCSAML germinal center-associated, signaling and motility-like 3.316
R3HDML R3H domain containing-like 3.316
GPR179 G protein-coupled receptor 179 3.316
CPN2 carboxypeptidase N, polypeptide 2 3.316
CD28 CD28 molecule 3.316
RGS8 regulator of G-protein signaling 8 3.316
OR6B1 olfactory receptor, family 6, subfamily B, member 1 3.316
OTX1 orthodenticle homeobox 1 3.316
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 3.316
IGIP IgA-inducing protein 3.316
FUT5 fucosyltransferase 5 (alpha (1,3) fucosyltransferase) 3.316
BCL2L15 BCL2-like 15 3.316
PXT1 peroxisomal, testis specific 1 3.316
ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 3.316
DAND5 DAN domain family member 5, BMP antagonist 3.316
LRRC74A leucine rich repeat containing 74A 3.316
SLC38A3 solute carrier family 38, member 3 3.316
RNF222 ring finger protein 222 3.316
RSRC1 arginine/serine-rich coiled-coil 1 3.21629
FBXO21 F-box protein 21 3.16896
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 3.16896
TP53I3 tumor protein p53 inducible protein 3 3.05138
TMEM132B transmembrane protein 132B 3.00151
USP36 ubiquitin specific peptidase 36 3.00011
PRR15 proline rich 15 2.98098
SELENON selenoprotein N 2.9563
UBXN2A UBX domain protein 2A 2.90696
PDE9A phosphodiesterase 9A 2.90665
HAPLN3 hyaluronan and proteoglycan link protein 3 2.90665
TPGS1 tubulin polyglutamylase complex subunit 1 2.83904
GADD45G growth arrest and DNA-damage-inducible, gamma 2.8025
WFDC2 WAP four-disulfide core domain 2 2.79528
DUSP16 dual specificity phosphatase 16 2.79304
NLGN3 neuroligin 3 2.72979
SUMF1 sulfatase modifying factor 1 2.69372
SAPCD2 suppressor APC domain containing 2 2.66706
ERLIN1 ER lipid raft associated 1 2.61276
ERICH1 glutamate-rich 1 2.61276
AFG1L AFG1 like ATPase 2.61276
SLCO3A1 solute carrier organic anion transporter family, member 3A1 2.5814
S100B S100 calcium binding protein B 2.56299
CHGA chromogranin A 2.56267
KCTD14 potassium channel tetramerization domain containing 14 2.55782
PON2 paraoxonase 2 2.55256
RNF220 ring finger protein 220 2.53276
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial 2.51734
WIPI1 WD repeat domain, phosphoinositide interacting 1 2.51527
MICA MHC class I polypeptide-related sequence A 2.51527
TMEM158 transmembrane protein 158 (gene/pseudogene) 2.51527
JARID2 jumonji, AT rich interactive domain 2 2.48853
HPS5 Hermansky-Pudlak syndrome 5 2.47136
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta 2.43973
UTP15 UTP15, U3 small nucleolar ribonucleoprotein, homolog (S. cerevisiae) 2.4306
CLIC5 chloride intracellular channel 5 2.43032
ANKRD61 ankyrin repeat domain 61 2.43032
MYL7 myosin, light chain 7, regulatory 2.43032
IRX3 iroquois homeobox 3 2.43032
NR4A2 nuclear receptor subfamily 4, group A, member 2 2.43032
FAM178B family with sequence similarity 178, member B 2.43032
SEMA4F sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F 2.43032
WWC2 WW and C2 domain containing 2 2.39643
SLC22A23 solute carrier family 22, member 23 2.36726
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila) 2.36443
KPNA1 karyopherin alpha 1 (importin alpha 5) 2.3512
SLC35E3 solute carrier family 35, member E3 2.31391
ZC3HAV1 zinc finger CCCH-type, antiviral 1 2.25738
SGO2 shugoshin 2 2.19122
CLDN3 claudin 3 2.1886
EMB embigin 2.17875
COMMD3 COMM domain containing 3 2.17848
MICB MHC class I polypeptide-related sequence B 2.17418
RTKN2 rhotekin 2 2.17211
MEGF10-DT MEGF10 divergent transcript 2.17012
TMEM182 transmembrane protein 182 2.15301
DLGAP2 discs, large (Drosophila) homolog-associated protein 2 2.14459
SRSF4 serine/arginine-rich splicing factor 4 2.14167
TEN1 TEN1 CST complex subunit 2.14153
RIOK1 RIO kinase 1 2.13187
FBXO43 F-box protein 43 2.13037
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 2.1219
ZNF253 zinc finger protein 253 2.10407
MATN4 matrilin 4 2.10407
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2 2.07618
ZNF385D zinc finger protein 385D 2.0759
NUP214 nucleoporin 214kDa 2.07318
NTMT2 N-terminal Xaa-Pro-Lys N-methyltransferase 2 2.06797
PDZD8 PDZ domain containing 8 2.05963
DCAF4L1 DDB1 and CUL4 associated factor 4-like 1 2.05963
LYN LYN proto-oncogene, Src family tyrosine kinase 2.0595
PDZD7 PDZ domain containing 7 2.05112
CASD1 CAS1 domain containing 1 2.04436
PRPF38B pre-mRNA processing factor 38B 2.03991
EPHA8 EPH receptor A8 2.02579
KIN Kin17 DNA and RNA binding protein 2.02154
FYTTD1 forty-two-three domain containing 1 2.02154
PLD1 phospholipase D1, phosphatidylcholine-specific 2.01081
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 2.01081
MED25 mediator complex subunit 25 2.01056
LINGO2 leucine rich repeat and Ig domain containing 2 2.00783
CFLAR CASP8 and FADD-like apoptosis regulator 2.00257

decreased expression

Symbol Name Standardized Value
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -4.7293
PITPNM3 PITPNM family member 3 -3.36738
MARS1 methionyl-tRNA synthetase 1 -3.316
MGAM maltase-glucoamylase -3.316
EMILIN1 elastin microfibril interfacer 1 -3.316
MYO3B myosin IIIB -3.316
CTCFL CCCTC-binding factor (zinc finger protein)-like -3.316
CLPSL2 colipase-like 2 -3.316
ALAD aminolevulinate dehydratase -3.316
SAMD10 sterile alpha motif domain containing 10 -3.316
ARID3A AT rich interactive domain 3A (BRIGHT-like) -3.316
CLVS1 clavesin 1 -3.29688
MPZ myelin protein zero -3.19537
CHL1 cell adhesion molecule L1-like -3.16896
ADPRHL1 ADP-ribosylhydrolase like 1 -3.16896
NWD2 NACHT and WD repeat domain containing 2 -3.16896
SFTA2 surfactant associated 2 -3.16896
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 -3.16896
ERVW-1 endogenous retrovirus group W, member 1 -3.16896
FRMPD1 FERM and PDZ domain containing 1 -3.16896
RGPD5 RANBP2-like and GRIP domain containing 5 -3.16896
PIH1D2 PIH1 domain containing 2 -3.16896
NT5E 5'-nucleotidase, ecto (CD73) -3.16896
ITGB1BP2 integrin beta 1 binding protein (melusin) 2 -3.16896
TMPRSS13 transmembrane protease, serine 13 -3.16896
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) -3.16896
C4ORF50 chromosome 4 open reading frame 50 -3.16896
SNAI2 snail family zinc finger 2 -3.16896
ZSCAN22 zinc finger and SCAN domain containing 22 -3.16896
OR2T8 olfactory receptor, family 2, subfamily T, member 8 -3.16896
DMP1 dentin matrix acidic phosphoprotein 1 -3.16896
CPED1 cadherin-like and PC-esterase domain containing 1 -3.16896
WNT4 wingless-type MMTV integration site family, member 4 -3.16896
NPPC natriuretic peptide C -3.16896
TTC29 tetratricopeptide repeat domain 29 -3.16896
NOTO notochord homeobox -3.16896
OR52N2 olfactory receptor, family 52, subfamily N, member 2 -3.16896
CD7 CD7 molecule -3.16896
HSD3B7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 -3.16896
MSC musculin -3.16896
F7 coagulation factor VII (serum prothrombin conversion accelerator) -3.16896
BAAT bile acid CoA:amino acid N-acyltransferase -3.16896
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1 -3.16896
POLR2J2 polymerase (RNA) II (DNA directed) polypeptide J2 -3.16896
REN renin -3.16896
FAM86B2 family with sequence similarity 86, member B2 -3.16896
XIRP2 xin actin binding repeat containing 2 -3.16896
ASB14 ankyrin repeat and SOCS box containing 14 -3.16896
IL4I1 interleukin 4 induced 1 -3.16896
LIME1 Lck interacting transmembrane adaptor 1 -3.14016
ADGRF3 adhesion G protein-coupled receptor F3 -3.14016
AGER advanced glycosylation end product-specific receptor -3.1367
XRN2 5'-3' exoribonuclease 2 -3.09792
KYNU kynureninase -3.03356
ADGRB1 adhesion G protein-coupled receptor B1 -3.03356
B3GAT3 beta-1,3-glucuronyltransferase 3 -2.85955
FBXL19 F-box and leucine-rich repeat protein 19 -2.85543
ARNT aryl hydrocarbon receptor nuclear translocator -2.85364
PSMG4 proteasome (prosome, macropain) assembly chaperone 4 -2.82465
CADM2 cell adhesion molecule 2 -2.75241
TRMO tRNA methyltransferase O -2.72893
DHRS11 dehydrogenase/reductase (SDR family) member 11 -2.72388
ZC3H15 zinc finger CCCH-type containing 15 -2.71009
KMT5C lysine methyltransferase 5C -2.69372
SGK1 serum/glucocorticoid regulated kinase 1 -2.61746
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -2.60554
SULF1 sulfatase 1 -2.56267
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -2.54024
FRMD5 FERM domain containing 5 -2.51734
TENT5C terminal nucleotidyltransferase 5C -2.48853
ANAPC2 anaphase promoting complex subunit 2 -2.48853
PER3 period circadian clock 3 -2.47136
TMEM106C transmembrane protein 106C -2.46955
ZNF865 zinc finger protein 865 -2.45751
TMEM242 transmembrane protein 242 -2.45751
PRKCD protein kinase C, delta -2.44195
IGSF10 immunoglobulin superfamily, member 10 -2.44195
PCDHGB7 protocadherin gamma subfamily B, 7 -2.44195
ZNF587B zinc finger protein 587B -2.44195
ZNF777 zinc finger protein 777 -2.4333
FBXL18 F-box and leucine-rich repeat protein 18 -2.41642
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5 -2.39343
H4C6 H4 clustered histone 6 -2.39091
RPS24 ribosomal protein S24 -2.38288
PLXDC1 plexin domain containing 1 -2.37926
TMBIM4 transmembrane BAX inhibitor motif containing 4 -2.37594
RHOBTB3 Rho-related BTB domain containing 3 -2.36368
TLK1 tousled-like kinase 1 -2.34996
CACNG4 calcium channel, voltage-dependent, gamma subunit 4 -2.33834
PABIR2 PABIR family member 2 -2.30798
NECAP2 NECAP endocytosis associated 2 -2.30571
ZNF143 zinc finger protein 143 -2.30135
FBLN1 fibulin 1 -2.30135
MIER3 mesoderm induction early response 1, family member 3 -2.29539
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 -2.27179
PEPD peptidase D -2.27179
RPS23 ribosomal protein S23 -2.2712
CKMT1A creatine kinase, mitochondrial 1A -2.26627
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog -2.25814
EPS8L2 EPS8-like 2 -2.25001
THAP10 THAP domain containing 10 -2.24655
C6ORF163 chromosome 6 open reading frame 163 -2.24411
LOC107985101 uncharacterized LOC107985101 -2.24044
BCHE butyrylcholinesterase -2.23905
ATP5F1C ATP synthase F1 subunit gamma -2.23905
TUBGCP6 tubulin, gamma complex associated protein 6 -2.23502
TNNI3K TNNI3 interacting kinase -2.22315
PGAP4 post-GPI attachment to proteins GalNAc transferase 4 -2.22315
CHMP4C charged multivesicular body protein 4C -2.22315
ISOC2 isochorismatase domain containing 2 -2.22008
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3 -2.20801
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -2.20801
TCEANC transcription elongation factor A (SII) N-terminal and central domain containing -2.20801
PNRC2 proline-rich nuclear receptor coactivator 2 -2.20764
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2 -2.20216
DUS4L dihydrouridine synthase 4-like (S. cerevisiae) -2.19122
KLHL34 kelch-like family member 34 -2.17086
IL23A interleukin 23, alpha subunit p19 -2.17086
PLEKHA7 pleckstrin homology domain containing, family A member 7 -2.15727
PAXBP1 PAX3 and PAX7 binding protein 1 -2.13468
RNF2 ring finger protein 2 -2.13468
PLA2G3 phospholipase A2, group III -2.13037
GAN gigaxonin -2.109
KAT2B K(lysine) acetyltransferase 2B -2.10439
SLC39A7 solute carrier family 39 (zinc transporter), member 7 -2.08327
DENND4C DENN/MADD domain containing 4C -2.07318
PDLIM1 PDZ and LIM domain 1 -2.05974
RNF114 ring finger protein 114 -2.05963
MEIS1 Meis homeobox 1 -2.05112
GMEB2 glucocorticoid modulatory element binding protein 2 -2.05112
ZNF792 zinc finger protein 792 -2.05112
SND1 staphylococcal nuclease and tudor domain containing 1 -2.05112
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -2.05112
C5AR1 complement component 5a receptor 1 -2.05112
DNAH1 dynein, axonemal, heavy chain 1 -2.05112
AACS acetoacetyl-CoA synthetase -2.04846
EIF3D eukaryotic translation initiation factor 3, subunit D -2.03991
PCNX1 pecanex 1 -2.03872
RAMAC RNA guanine-7 methyltransferase activating subunit -2.03872
SUMO2 small ubiquitin-like modifier 2 -2.02154
CDKN3 cyclin-dependent kinase inhibitor 3 -2.02138
EEA1 early endosome antigen 1 -2.01216
POLR1A polymerase (RNA) I polypeptide A, 194kDa -2.01081
PRMT6 protein arginine methyltransferase 6 -2.00118