NUP188 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description nucleoporin 188kDa|The nuclear pore complex (NPC) is found on the nuclear envelope and forms a gateway that regulates the flow of proteins and RNAs between the cytoplasm and nucleoplasm. The NPC is comprised of approximately 30 distinct proteins collectively known as nucleoporins. Nucleoporins are pore-complex-specific glycoproteins which often have cytoplasmically oriented O-linked N-acetylglucosamine residues and numerous repeats of the pentapeptide sequence XFXFG. However, the nucleoporin protein encoded by this gene does not contain the typical FG repeat sequences found in most vertebrate nucleoporins. This nucleoporin is thought to form part of the scaffold for the central channel of the nuclear pore. [provided by RefSeq, Jan 2013] (NCBI Entrez Gene Database, 23511)
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Genes

348 genes differentially expressed following the NUP188 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
BHLHA9 basic helix-loop-helix family, member a9 2.68355
INHBB inhibin, beta B 2.68355
NYAP2 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 2.68355
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7 2.68355
IGFL3 IGF-like family member 3 2.68355
ZFP57 ZFP57 zinc finger protein 2.68355
PRSS41 protease, serine, 41 2.68355
PCDHB6 protocadherin beta 6 2.68355
GRXCR2 glutaredoxin, cysteine rich 2 2.68355
TMEM212 transmembrane protein 212 2.68355
HNF4A hepatocyte nuclear factor 4, alpha 2.68355
P2RY4 pyrimidinergic receptor P2Y, G-protein coupled, 4 2.68355
TMEM235 transmembrane protein 235 2.68355
MEOX1 mesenchyme homeobox 1 2.68355
OR51B5 olfactory receptor, family 51, subfamily B, member 5 2.68355
GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic 2.68355
ERVFRD-1 endogenous retrovirus group FRD, member 1 2.68355
TUBA3D tubulin, alpha 3d 2.68355
LBHD1 LBH domain containing 1 2.68355
USH1G Usher syndrome 1G (autosomal recessive) 2.68355
CXORF65 chromosome X open reading frame 65 2.68355
SPIDR scaffolding protein involved in DNA repair 2.68355
PERM1 PPARGC1 and ESRR induced regulator, muscle 1 2.68355
TTLL8 tubulin tyrosine ligase-like family member 8 2.68355
PTK6 protein tyrosine kinase 6 2.68355
TAS2R19 taste receptor, type 2, member 19 2.68355
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.68355
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow 2.68355
ITIH6 inter-alpha-trypsin inhibitor heavy chain family, member 6 2.68355
TMEM132C transmembrane protein 132C 2.68355
BOLA2 bolA family member 2 2.68355
CUBN cubilin (intrinsic factor-cobalamin receptor) 2.68355
TRPV2 transient receptor potential cation channel, subfamily V, member 2 2.68355
BIRC7 baculoviral IAP repeat containing 7 2.68355
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4 2.68355
PAX7 paired box 7 2.68355
SLC22A13 solute carrier family 22 (organic anion/urate transporter), member 13 2.68355
FETUB fetuin B 2.68355
DIRAS2 DIRAS family, GTP-binding RAS-like 2 2.68355
GPR26 G protein-coupled receptor 26 2.68355
GPR22 G protein-coupled receptor 22 2.68355
ALPK2 alpha-kinase 2 2.68355
SCIN scinderin 2.68355
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 2.68355
LOC114841035 uncharacterized LOC114841035 2.68355
CCDC190 coiled-coil domain containing 190 2.68355
RTL9 retrotransposon Gag like 9 2.68355
PLAAT2 phospholipase A and acyltransferase 2 2.68355
MYOCOS myocilin opposite strand 2.68355
TMEM275 transmembrane protein 275 2.68355
ERVW-1 endogenous retrovirus group W, member 1 2.68355
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 2.68355
ACER1 alkaline ceramidase 1 2.68355
H2BC3 H2B clustered histone 3 2.68355
DUSP29 dual specificity phosphatase 29 2.68355
MEIOSIN meiosis initiator 2.68355
CIMIP7 ciliary microtubule inner protein 7 2.68355
FAM240A family with sequence similarity 240 member A 2.68355
CPNE8-AS1 CPNE8 antisense RNA 1 2.68355
CCDC201 coiled-coil domain containing 201 2.68355
SMIM45 small integral membrane protein 45 2.68355
GLYATL1B glycine-N-acyltransferase like 1B 2.68355
MUCL3 mucin like 3 2.68355
CFAP107 cilia and flagella associated protein 107 2.68355
DNAAF1 dynein, axonemal, assembly factor 1 2.68355
KRT86 keratin 86, type II 2.68355
SPRR2F small proline-rich protein 2F 2.68355
GATA2 GATA binding protein 2 2.68355
ACE2 angiotensin I converting enzyme 2 2.68355
TAS1R1 taste receptor, type 1, member 1 2.68355
ARHGAP15 Rho GTPase activating protein 15 2.68355
OOSP1 oocyte secreted protein 1, pseudogene 2.68355
PTN pleiotrophin 2.68355
CACNG2 calcium channel, voltage-dependent, gamma subunit 2 2.68355
S100B S100 calcium binding protein B 2.68355
REP15 RAB15 effector protein 2.68355
FCMR Fc fragment of IgM receptor 2.68355
FOXC2 forkhead box C2 2.68355
FMO2 flavin containing monooxygenase 2 (non-functional) 2.68355
PKD2L1 polycystic kidney disease 2-like 1 2.68355
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 2.68355
TMPRSS7 transmembrane protease, serine 7 2.68355
WDR64 WD repeat domain 64 2.68355
OR1C1 olfactory receptor, family 1, subfamily C, member 1 2.68355
TMEM40 transmembrane protein 40 2.68355
ASB4 ankyrin repeat and SOCS box containing 4 2.68355
PRR4 proline rich 4 (lacrimal) 2.68355
PODN podocan 2.68355
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 2.68355
C11ORF91 chromosome 11 open reading frame 91 2.68355
SOSTDC1 sclerostin domain containing 1 2.68355
PRM1 protamine 1 2.68355
PLET1 placenta expressed transcript 1 2.68355
SERINC4 serine incorporator 4 2.68355
NPBWR1 neuropeptides B/W receptor 1 2.68355
PSKH2 protein serine kinase H2 2.68355
APELA apelin receptor early endogenous ligand 2.68355
KCNS2 potassium voltage-gated channel, modifier subfamily S, member 2 2.68355
S100A14 S100 calcium binding protein A14 2.68355
KLHL6 kelch-like family member 6 2.68355
SMYD1 SET and MYND domain containing 1 2.68355
CPO carboxypeptidase O 2.68355
PHOSPHO1 phosphatase, orphan 1 2.68355
FNDC1 fibronectin type III domain containing 1 2.68355
CLRN1 clarin 1 2.68355
CCL27 chemokine (C-C motif) ligand 27 2.68355
DNAH12 dynein, axonemal, heavy chain 12 2.68355
EFCAB3 EF-hand calcium binding domain 3 2.68355
RSPH10B radial spoke head 10 homolog B (Chlamydomonas) 2.68355
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 2.68355
SHISA8 shisa family member 8 2.68355
DCN decorin 2.68355
NKX6-3 NK6 homeobox 3 2.68355
MSMP microseminoprotein, prostate associated 2.68355
HPGDS hematopoietic prostaglandin D synthase 2.68355
LAMB3 laminin, beta 3 2.68355
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) 2.68355
BTG4 B-cell translocation gene 4 2.68355
OR52N1 olfactory receptor, family 52, subfamily N, member 1 2.68355
PENK proenkephalin 2.68355
SYNGR4 synaptogyrin 4 2.68355
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 2.68355
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 2.68355
C17ORF99 chromosome 17 open reading frame 99 2.68355
VWA7 von Willebrand factor A domain containing 7 2.68355
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 2.68355
ZFP92 ZFP92 zinc finger protein 2.68355
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal) 2.68355
CTXN2 cortexin 2 2.68355
ZC3H12D zinc finger CCCH-type containing 12D 2.68355
OR52N4 olfactory receptor, family 52, subfamily N, member 4 (gene/pseudogene) 2.68355
CD177 CD177 molecule 2.68355
ACAN aggrecan 2.68355
CYGB cytoglobin 2.68355
SNTN sentan, cilia apical structure protein 2.68355
CARD6 caspase recruitment domain family, member 6 2.68355
PTCRA pre T-cell antigen receptor alpha 2.68355
ADGRF5 adhesion G protein-coupled receptor F5 2.68355
TRPM5 transient receptor potential cation channel, subfamily M, member 5 2.68355
CLCA4 chloride channel accessory 4 2.68355
PATE1 prostate and testis expressed 1 2.68355
ACKR2 atypical chemokine receptor 2 2.68355
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) 2.68355
HHIPL2 HHIP-like 2 2.68355
WFDC13 WAP four-disulfide core domain 13 2.68355
AMPD1 adenosine monophosphate deaminase 1 2.68355
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 2.68355
IL17B interleukin 17B 2.68355
OXER1 oxoeicosanoid (OXE) receptor 1 2.68355
METTL24 methyltransferase like 24 2.68355
OR13A1 olfactory receptor, family 13, subfamily A, member 1 2.68355
SUN3 Sad1 and UNC84 domain containing 3 2.68355
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit 2.64969
NCF2 neutrophil cytosolic factor 2 2.645
TLCD2 TLC domain containing 2 2.63788
ELOA elongin A 2.57792
CA9 carbonic anhydrase IX 2.56534
C2ORF72 chromosome 2 open reading frame 72 2.56534
UNC93A unc-93 homolog A (C. elegans) 2.56534
RYR3 ryanodine receptor 3 2.56018
CFAP52 cilia and flagella associated protein 52 2.54038
GALNTL5 polypeptide N-acetylgalactosaminyltransferase-like 5 2.54038
TYW1B tRNA-yW synthesizing protein 1 homolog B (S. cerevisiae) 2.53222
LSM11 LSM11, U7 small nuclear RNA associated 2.49087
PARD3 par-3 family cell polarity regulator 2.49087
STX1A syntaxin 1A (brain) 2.46163
ANKRD7 ankyrin repeat domain 7 2.41492
GTF2IRD1 GTF2I repeat domain containing 1 2.41319
SCN5A sodium channel, voltage gated, type V alpha subunit 2.39856
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 2.39434
ZNF222 zinc finger protein 222 2.36182
THADA thyroid adenoma associated 2.35324
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa 2.32139
MMP3 matrix metallopeptidase 3 2.31053
ZNF329 zinc finger protein 329 2.30822
ATP10D ATPase, class V, type 10D 2.30623
ARHGAP33 Rho GTPase activating protein 33 2.30261
SRRM2 serine/arginine repetitive matrix 2 2.28918
H4C13 H4 clustered histone 13 2.26934
FSD1L fibronectin type III and SPRY domain containing 1-like 2.26565
RPL17 ribosomal protein L17 2.26339
PTP4A3 protein tyrosine phosphatase type IVA, member 3 2.24541
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF 2.24541
GVQW3 GVQW motif containing 3 2.21434
EBF3 early B-cell factor 3 2.20018
TTC28 tetratricopeptide repeat domain 28 2.19667
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 2.1947
PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 2.18634
IMMP1L IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae) 2.17592
KDM2A lysine (K)-specific demethylase 2A 2.17592
SMAP1 small ArfGAP 1 2.17434
EIF1 eukaryotic translation initiation factor 1 2.16359
ECT2L epithelial cell transforming 2 like 2.15653
TEX264 testis expressed 264 2.15423
BBS1 Bardet-Biedl syndrome 1 2.14596
LEMD2 LEM domain containing 2 2.13701
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1 2.13701
SF1 splicing factor 1 2.13323
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 2.12953
TCEAL4 transcription elongation factor A (SII)-like 4 2.12349
CFAP46 cilia and flagella associated protein 46 2.11407
ZNF205 zinc finger protein 205 2.11381
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal) 2.11168
MAGOH mago-nashi homolog, proliferation-associated (Drosophila) 2.09517
LEPROT leptin receptor overlapping transcript 2.09517
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1 2.09337
ATXN7L1 ataxin 7-like 1 2.09337
MYOM1 myomesin 1 2.09337
ZNF280C zinc finger protein 280C 2.09172
SORBS2 sorbin and SH3 domain containing 2 2.08837
COG3 component of oligomeric golgi complex 3 2.08701
MRC2 mannose receptor, C type 2 2.06491
ARMC10 armadillo repeat containing 10 2.05624
PCID2 PCI domain containing 2 2.04927
PHB2 prohibitin 2 2.04588
CAMTA1 calmodulin binding transcription activator 1 2.043
CDC45 cell division cycle 45 2.03624
UNC13D unc-13 homolog D (C. elegans) 2.03616
PLD5 phospholipase D family, member 5 2.03616
CLDND2 claudin domain containing 2 2.02709
DHX16 DEAH (Asp-Glu-Ala-His) box polypeptide 16 2.02478
ZNF442 zinc finger protein 442 2.02276
SAXO1 stabilizer of axonemal microtubules 1 2.02276
VWA5A von Willebrand factor A domain containing 5A 2.00984
ZNF638 zinc finger protein 638 2.00003

decreased expression

Symbol Name Standardized Value
UPK3B uroplakin 3B -2.68355
RSPH1 radial spoke head 1 homolog (Chlamydomonas) -2.68355
BNC1 basonuclin 1 -2.68355
FAM110D family with sequence similarity 110, member D -2.68355
ZNF804A zinc finger protein 804A -2.68355
TLDC2 TBC/LysM-associated domain containing 2 -2.68355
FGF8 fibroblast growth factor 8 (androgen-induced) -2.68355
DNAH1 dynein, axonemal, heavy chain 1 -2.68355
THY1 Thy-1 cell surface antigen -2.68355
RAB36 RAB36, member RAS oncogene family -2.68355
ZNF527 zinc finger protein 527 -2.68355
ARMCX6 armadillo repeat containing, X-linked 6 -2.68355
PLGLB1 plasminogen-like B1 -2.68355
ACKR1 atypical chemokine receptor 1 (Duffy blood group) -2.68355
ABHD1 abhydrolase domain containing 1 -2.68355
GIPR gastric inhibitory polypeptide receptor -2.68355
OSTN osteocrin -2.68355
TUB tubby bipartite transcription factor -2.68355
CRYAB crystallin, alpha B -2.68355
TXLNB taxilin beta -2.68355
ACTG2 actin, gamma 2, smooth muscle, enteric -2.68355
PCDHB13 protocadherin beta 13 -2.68355
THPO thrombopoietin -2.68355
PCDHB9 protocadherin beta 9 -2.68355
CDC42 cell division cycle 42 -2.68355
MANSC4 MANSC domain containing 4 -2.68355
ZNF230 zinc finger protein 230 -2.68355
ALYREF Aly/REF export factor -2.68355
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1 -2.68355
SLC5A11 solute carrier family 5 (sodium/inositol cotransporter), member 11 -2.68355
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4 -2.68355
TMEM79 transmembrane protein 79 -2.68355
STAB2 stabilin 2 -2.68355
FBXO48 F-box protein 48 -2.68355
SMIM17 small integral membrane protein 17 -2.68355
SCNN1D sodium channel, non voltage gated 1 delta subunit -2.68355
GSTT2B glutathione S-transferase theta 2B (gene/pseudogene) -2.68355
PGAM2 phosphoglycerate mutase 2 (muscle) -2.68355
MINDY4B MINDY family member 4B -2.68355
GLTP glycolipid transfer protein -2.68355
MRAP melanocortin 2 receptor accessory protein -2.68355
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated) -2.68355
C17ORF113 chromosome 17 open reading frame 113 -2.68355
WDR11 WD repeat domain 11 -2.68355
C20ORF144 chromosome 20 open reading frame 144 -2.68355
MEIS2 Meis homeobox 2 -2.68355
TTC29 tetratricopeptide repeat domain 29 -2.68355
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -2.68355
CASR calcium-sensing receptor -2.645
SHD Src homology 2 domain containing transforming protein D -2.645
MEOX2 mesenchyme homeobox 2 -2.645
GOLGA1 golgin A1 -2.62405
GARIN2 golgi associated RAB2 interactor family member 2 -2.62271
MXRA8 matrix-remodelling associated 8 -2.61701
EXOSC2 exosome component 2 -2.59934
PAQR8 progestin and adipoQ receptor family member VIII -2.55763
RHBG Rh family, B glycoprotein (gene/pseudogene) -2.50808
SHLD3 shieldin complex subunit 3 -2.50808
CPTP ceramide-1-phosphate transfer protein -2.50808
METTL8 methyltransferase like 8 -2.45691
ZNF516 zinc finger protein 516 -2.45691
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 -2.43047
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit -2.43039
NCAM1 neural cell adhesion molecule 1 -2.4094
PIGT phosphatidylinositol glycan anchor biosynthesis, class T -2.40041
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4 -2.34397
SLCO1A2 solute carrier organic anion transporter family, member 1A2 -2.3389
TTLL5 tubulin tyrosine ligase-like family member 5 -2.33886
PKD1 polycystic kidney disease 1 (autosomal dominant) -2.28557
KRIT1 KRIT1, ankyrin repeat containing -2.24541
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -2.24203
FZD2 frizzled class receptor 2 -2.22651
SLC16A6 solute carrier family 16, member 6 -2.22651
F11 coagulation factor XI -2.22651
COL1A2 collagen, type I, alpha 2 -2.22651
RPGRIP1 retinitis pigmentosa GTPase regulator interacting protein 1 -2.19945
DCTN1 dynactin 1 -2.19495
CCNDBP1 cyclin D-type binding-protein 1 -2.19482
LYPD1 LY6/PLAUR domain containing 1 -2.1947
SH3PXD2A SH3 and PX domains 2A -2.1947
MOB3B MOB kinase activator 3B -2.19118
PTPRS protein tyrosine phosphatase, receptor type, S -2.19118
ZNF468 zinc finger protein 468 -2.19118
ALDH16A1 aldehyde dehydrogenase 16 family, member A1 -2.17713
NBPF1 neuroblastoma breakpoint family, member 1 -2.17103
SSH2 slingshot protein phosphatase 2 -2.17103
CCNJL cyclin J-like -2.16359
MFSD6L major facilitator superfamily domain containing 6-like -2.16359
SCN1B sodium channel, voltage gated, type I beta subunit -2.16359
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8 -2.16359
FSIP2 fibrous sheath interacting protein 2 -2.16359
CWF19L1 CWF19-like 1, cell cycle control (S. pombe) -2.16359
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 -2.16331
MARK1 MAP/microtubule affinity-regulating kinase 1 -2.15952
YPEL5 yippee-like 5 (Drosophila) -2.15541
TAC3 tachykinin 3 -2.13701
SMS spermine synthase -2.13323
DRG2 developmentally regulated GTP binding protein 2 -2.13323
HAUS3 HAUS augmin-like complex, subunit 3 -2.13181
APTX aprataxin -2.12861
CCDC51 coiled-coil domain containing 51 -2.11762
JADE2 jade family PHD finger 2 -2.10741
AFG2A AFG2 AAA ATPase homolog A -2.07918
CORO2A coronin, actin binding protein, 2A -2.06491
IFNGR1 interferon gamma receptor 1 -2.05319
BLOC1S4 biogenesis of lysosomal organelles complex-1, subunit 4, cappuccino -2.04927
COQ6 coenzyme Q6 monooxygenase -2.04588
P3H1 prolyl 3-hydroxylase 1 -2.04588
KCNH7 potassium channel, voltage gated eag related subfamily H, member 7 -2.04588
GAA glucosidase, alpha; acid -2.03616
SPICE1 spindle and centriole associated protein 1 -2.03616
RETSAT retinol saturase (all-trans-retinol 13,14-reductase) -2.03149
GLMP glycosylated lysosomal membrane protein -2.03149
GPLD1 glycosylphosphatidylinositol specific phospholipase D1 -2.02709
SLC43A2 solute carrier family 43 (amino acid system L transporter), member 2 -2.02648
CTCFL CCCTC-binding factor (zinc finger protein)-like -2.02364
LIPA lipase A, lysosomal acid, cholesterol esterase -2.02276
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) -2.01948
ARG2 arginase 2 -2.01948
SYT13 synaptotagmin XIII -2.01456
DCUN1D3 DCN1, defective in cullin neddylation 1, domain containing 3 -2.01302
BCHE butyrylcholinesterase -2.00984
RNF122 ring finger protein 122 -2.00135