NVP-BEP800 Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/25210273
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Genes

198 proteins with high or low expression in NVP-BEP800 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
HSPA1L heat shock 70kDa protein 1-like 3.56
BAHCC1 BAH domain and coiled-coil containing 1 3.35
HSPA1A heat shock 70kDa protein 1A 3.25
HSPA6 heat shock 70kDa protein 6 (HSP70B') 3.04
CLU clusterin 2.74
HSPB1 heat shock 27kDa protein 1 2.69
GLUL glutamate-ammonia ligase 2.45
MYT1 myelin transcription factor 1 2.38
BAG3 BCL2-associated athanogene 3 2.31
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 2.13
ENDOV endonuclease V 1.8
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) 1.78
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 1.75
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 1.73
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4 1.68
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4 1.64
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.61
VSIR V-set immunoregulatory receptor 1.61
ENOX1 ecto-NOX disulfide-thiol exchanger 1 1.58
SQOR sulfide quinone oxidoreductase 1.56
KDM5B lysine (K)-specific demethylase 5B 1.49
PTPRS protein tyrosine phosphatase, receptor type, S 1.47
SORBS1 sorbin and SH3 domain containing 1 1.47
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 1.43
ALK anaplastic lymphoma receptor tyrosine kinase 1.38
STARD3 StAR-related lipid transfer (START) domain containing 3 1.38
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1 1.37
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 1.32
TRIM16 tripartite motif containing 16 1.32
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 1.31
HSPA2 heat shock 70kDa protein 2 1.3
PTPRD protein tyrosine phosphatase, receptor type, D 1.29
PTPRF protein tyrosine phosphatase, receptor type, F 1.28
HSPA8 heat shock 70kDa protein 8 1.25
TRIM2 tripartite motif containing 2 1.25
MICB MHC class I polypeptide-related sequence B 1.25
PSAP prosaposin 1.2
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 1.16
HSPH1 heat shock 105kDa/110kDa protein 1 1.16
HSPE1 heat shock 10kDa protein 1 1.14
TJP3 tight junction protein 3 1.1
TSPYL2 TSPY-like 2 1.08
RAB11FIP2 RAB11 family interacting protein 2 (class I) 1.07
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 1.06
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) 1.05
GNA12 guanine nucleotide binding protein (G protein) alpha 12 1.03
HIBCH 3-hydroxyisobutyryl-CoA hydrolase 1.02
HSBP1 heat shock factor binding protein 1 1.01
KMT2B lysine (K)-specific methyltransferase 2B 1.01
PHLDA3 pleckstrin homology-like domain, family A, member 3 1.01
SOD1 superoxide dismutase 1, soluble 1.0
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast) 1.0
CLN3 ceroid-lipofuscinosis, neuronal 3 0.97
DCDC1 doublecortin domain containing 1 0.97
TSPYL1 TSPY-like 1 0.97
HSP90AB4P heat shock protein 90kDa alpha (cytosolic), class B member 4, pseudogene 0.97
TRIML2 tripartite motif family-like 2 0.95
HIKESHI heat shock protein nuclear import factor hikeshi 0.95
BANF1 barrier to autointegration factor 1 0.95
FAS Fas cell surface death receptor 0.94
IRF6 interferon regulatory factor 6 0.94
RBM47 RNA binding motif protein 47 0.92
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.92
FTL ferritin, light polypeptide 0.91
STAT2 signal transducer and activator of transcription 2, 113kDa 0.91
NPNT nephronectin 0.91
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.91
HSPA4L heat shock 70kDa protein 4-like 0.9
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase) 0.9
TMLHE trimethyllysine hydroxylase, epsilon 0.89
BID BH3 interacting domain death agonist 0.89
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.88
MLXIPL MLX interacting protein-like 0.88
CUL9 cullin 9 0.87
TPM4 tropomyosin 4 0.87
ALKBH6 alkB, alkylation repair homolog 6 (E. coli) 0.86
EFCAB7 EF-hand calcium binding domain 7 0.86
GPX8 glutathione peroxidase 8 (putative) 0.86
GOLPH3L golgi phosphoprotein 3-like 0.86
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 0.86
UBQLN1 ubiquilin 1 0.86
ZNF451 zinc finger protein 451 0.86
SULT1A3 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 0.85
ZNF148 zinc finger protein 148 0.85
PPL periplakin 0.85
PHLDB3 pleckstrin homology-like domain, family B, member 3 0.85
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.84
TMEM263 transmembrane protein 263 0.84
NUCB1 nucleobindin 1 0.84
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5 0.83
LAMB3 laminin, beta 3 0.83
KIAA1522 KIAA1522 0.82
SNX19 sorting nexin 19 0.82
CD99 CD99 molecule 0.82
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 0.81
SDHAF4 succinate dehydrogenase complex assembly factor 4 0.8
TIMP2 TIMP metallopeptidase inhibitor 2 0.8
MAP2 microtubule-associated protein 2 0.79
COL6A1 collagen, type VI, alpha 1 0.79

low expression

Symbol Name Standardized Value
STK35 serine/threonine kinase 35 -2.97
FBXL6 F-box and leucine-rich repeat protein 6 -2.87
FOSL1 FOS-like antigen 1 -2.77
TNS4 tensin 4 -2.5
FBXO5 F-box protein 5 -2.49
LRRC42 leucine rich repeat containing 42 -2.41
JUNB jun B proto-oncogene -2.39
AP5B1 adaptor-related protein complex 5, beta 1 subunit -2.38
AEN apoptosis enhancing nuclease -2.33
PEX6 peroxisomal biogenesis factor 6 -2.26
RRM2 ribonucleotide reductase M2 -2.25
PCLAF PCNA clamp associated factor -2.24
CLK3 CDC-like kinase 3 -2.23
PRKCH protein kinase C, eta -2.16
TIFA TRAF-interacting protein with forkhead-associated domain -2.16
MCM10 minichromosome maintenance complex component 10 -2.12
GRK6 G protein-coupled receptor kinase 6 -2.11
SYTL3 synaptotagmin-like 3 -2.08
WDR76 WD repeat domain 76 -1.99
CLSPN claspin -1.99
LRR1 leucine rich repeat protein 1 -1.98
CHEK1 checkpoint kinase 1 -1.94
ONECUT2 one cut homeobox 2 -1.92
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila) -1.91
TRIM39 tripartite motif containing 39 -1.88
KIF18B kinesin family member 18B -1.86
HPS5 Hermansky-Pudlak syndrome 5 -1.84
SETX senataxin -1.83
RDH10 retinol dehydrogenase 10 (all-trans) -1.81
MLPH melanophilin -1.81
RAF1 Raf-1 proto-oncogene, serine/threonine kinase -1.79
ABHD15 abhydrolase domain containing 15 -1.7
RADX RPA1 related single stranded DNA binding protein, X-linked -1.7
PHLDA2 pleckstrin homology-like domain, family A, member 2 -1.7
NR1D1 nuclear receptor subfamily 1, group D, member 1 -1.69
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 -1.68
CDCA7 cell division cycle associated 7 -1.66
MASTL microtubule associated serine/threonine kinase-like -1.64
SRRD SRR1 domain containing -1.61
RECQL4 RecQ protein-like 4 -1.61
TMEM200A transmembrane protein 200A -1.6
CDK1 cyclin-dependent kinase 1 -1.6
EXO1 exonuclease 1 -1.6
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 -1.59
SLBP stem-loop binding protein -1.57
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -1.56
KLHL42 kelch-like family member 42 -1.56
FANCG Fanconi anemia, complementation group G -1.56
NEK4 NIMA-related kinase 4 -1.56
SPATA2L spermatogenesis associated 2-like -1.55
DNA2 DNA replication helicase/nuclease 2 -1.55
ATAD2 ATPase family, AAA domain containing 2 -1.54
LIMK2 LIM domain kinase 2 -1.53
LIMK1 LIM domain kinase 1 -1.53
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -1.53
SAPCD2 suppressor APC domain containing 2 -1.52
CASP8AP2 caspase 8 associated protein 2 -1.51
TRIM27 tripartite motif containing 27 -1.51
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -1.51
BRCA1 breast cancer 1, early onset -1.5
CHUK conserved helix-loop-helix ubiquitous kinase -1.5
ZBED4 zinc finger, BED-type containing 4 -1.49
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 -1.49
FBH1 F-box DNA helicase 1 -1.47
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4 -1.46
SENP5 SUMO1/sentrin specific peptidase 5 -1.46
FTSJ1 FtsJ RNA methyltransferase homolog 1 (E. coli) -1.45
DENND6A DENN/MADD domain containing 6A -1.45
PRR14L proline rich 14-like -1.44
BARD1 BRCA1 associated RING domain 1 -1.43
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A -1.42
RAD51 RAD51 recombinase -1.4
WDR34 WD repeat domain 34 -1.39
STK33 serine/threonine kinase 33 -1.39
AKT1 v-akt murine thymoma viral oncogene homolog 1 -1.39
GRAMD1A GRAM domain containing 1A -1.38
ORC6 origin recognition complex, subunit 6 -1.38
TGFB1 transforming growth factor, beta 1 -1.38
CEP78 centrosomal protein 78kDa -1.38
NUP37 nucleoporin 37kDa -1.38
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy -1.37
ALS2 amyotrophic lateral sclerosis 2 (juvenile) -1.37
DUSP4 dual specificity phosphatase 4 -1.36
ERBB2 erb-b2 receptor tyrosine kinase 2 -1.36
HOXB4 homeobox B4 -1.36
CDK4 cyclin-dependent kinase 4 -1.36
MARCHF7 membrane associated ring-CH-type finger 7 -1.36
BLM Bloom syndrome, RecQ helicase-like -1.36
SPRY4 sprouty homolog 4 (Drosophila) -1.35
CDC20 cell division cycle 20 -1.35
ZRANB3 zinc finger, RAN-binding domain containing 3 -1.35
CDK17 cyclin-dependent kinase 17 -1.34
ADCY3 adenylate cyclase 3 -1.34
NLRP2 NLR family, pyrin domain containing 2 -1.33
USP37 ubiquitin specific peptidase 37 -1.33
THAP4 THAP domain containing 4 -1.33
SATB2 SATB homeobox 2 -1.32
CCNA2 cyclin A2 -1.32
ESCO2 establishment of sister chromatid cohesion N-acetyltransferase 2 -1.32