NVP-BHG712 Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/16747388
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Genes

199 proteins with high or low expression in NVP-BHG712 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
APOB apolipoprotein B 3.68
NDFIP1 Nedd4 family interacting protein 1 3.49
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 3.48
TMEM59 transmembrane protein 59 3.47
LAPTM4A lysosomal protein transmembrane 4 alpha 3.38
ITM2B integral membrane protein 2B 3.32
ITM2C integral membrane protein 2C 3.17
NCOA4 nuclear receptor coactivator 4 3.1
FGFBP1 fibroblast growth factor binding protein 1 2.99
APLP2 amyloid beta (A4) precursor-like protein 2 2.8
LRP10 low density lipoprotein receptor-related protein 10 2.65
RNF130 ring finger protein 130 2.56
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 2.53
TMEM248 transmembrane protein 248 2.48
GINM1 glycoprotein integral membrane 1 2.4
PSAP prosaposin 2.37
APOE apolipoprotein E 2.35
SPINT2 serine peptidase inhibitor, Kunitz type, 2 2.29
NDFIP2 Nedd4 family interacting protein 2 2.27
APP amyloid beta (A4) precursor protein 2.25
NBR1 neighbor of BRCA1 gene 1 2.24
IFNGR1 interferon gamma receptor 1 2.2
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 2.09
SCD stearoyl-CoA desaturase (delta-9-desaturase) 2.09
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 2.02
GRN granulin 2.0
PCSK9 proprotein convertase subtilisin/kexin type 9 1.94
IL10RB interleukin 10 receptor, beta 1.93
INPP5J inositol polyphosphate-5-phosphatase J 1.9
SLC16A6 solute carrier family 16, member 6 1.89
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 1.86
MAP1LC3B2 microtubule-associated protein 1 light chain 3 beta 2 1.84
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 1.84
UGCG UDP-glucose ceramide glucosyltransferase 1.82
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 1.79
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 1.77
AREG amphiregulin 1.76
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 1.73
RNF149 ring finger protein 149 1.7
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 1.7
MFAP3L microfibrillar-associated protein 3-like 1.69
CLDND1 claudin domain containing 1 1.69
FDFT1 farnesyl-diphosphate farnesyltransferase 1 1.67
TTLL4 tubulin tyrosine ligase-like family member 4 1.67
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 1.67
DGCR2 DiGeorge syndrome critical region gene 2 1.65
SLC38A2 solute carrier family 38, member 2 1.64
CALCOCO2 calcium binding and coiled-coil domain 2 1.64
SQSTM1 sequestosome 1 1.63
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 1.61
ADGRG1 adhesion G protein-coupled receptor G1 1.61
FGFR1 fibroblast growth factor receptor 1 1.59
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 1.59
CLU clusterin 1.55
TACSTD2 tumor-associated calcium signal transducer 2 1.55
SERINC1 serine incorporator 1 1.53
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 1.53
PTPRS protein tyrosine phosphatase, receptor type, S 1.53
OSMR oncostatin M receptor 1.53
SERINC5 serine incorporator 5 1.5
ACVR1B activin A receptor, type IB 1.49
BMPR1A bone morphogenetic protein receptor, type IA 1.49
CTSB cathepsin B 1.49
SERINC3 serine incorporator 3 1.49
IDI1 isopentenyl-diphosphate delta isomerase 1 1.49
JAK3 Janus kinase 3 1.47
MFAP3 microfibrillar-associated protein 3 1.46
SQLE squalene epoxidase 1.46
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 1.46
SLC43A2 solute carrier family 43 (amino acid system L transporter), member 2 1.45
FGFR4 fibroblast growth factor receptor 4 1.45
ERBB3 erb-b2 receptor tyrosine kinase 3 1.44
DIXDC1 DIX domain containing 1 1.44
UNC5B unc-5 homolog B (C. elegans) 1.42
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 1.41
MFGE8 milk fat globule-EGF factor 8 protein 1.4
TSPAN3 tetraspanin 3 1.39
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) 1.38
PTPRF protein tyrosine phosphatase, receptor type, F 1.38
MPZL2 myelin protein zero-like 2 1.36
TJP3 tight junction protein 3 1.36
TPBG trophoblast glycoprotein 1.34
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 1.33
PTPRD protein tyrosine phosphatase, receptor type, D 1.33
PRSS23 protease, serine, 23 1.32
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1 1.29
MTMR4 myotubularin related protein 4 1.29
MVK mevalonate kinase 1.29
SDC4 syndecan 4 1.28
TMEM132A transmembrane protein 132A 1.27
CTSV cathepsin V 1.27
CD63 CD63 molecule 1.26
NEO1 neogenin 1 1.26
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 1.26
TRIM2 tripartite motif containing 2 1.25
LPIN1 lipin 1 1.23
ATP5IF1 ATP synthase inhibitory factor subunit 1 1.23
RNF13 ring finger protein 13 1.23
HMOX1 heme oxygenase 1 1.22

low expression

Symbol Name Standardized Value
TNS4 tensin 4 -2.03
DUSP4 dual specificity phosphatase 4 -1.97
FOSL1 FOS-like antigen 1 -1.91
CCNB1 cyclin B1 -1.78
FNIP1 folliculin interacting protein 1 -1.63
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F -1.62
JUNB jun B proto-oncogene -1.56
KIF18B kinesin family member 18B -1.53
DUOX1 dual oxidase 1 -1.5
UBE2C ubiquitin-conjugating enzyme E2C -1.49
CDC20 cell division cycle 20 -1.46
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -1.45
CCNA2 cyclin A2 -1.43
MCM10 minichromosome maintenance complex component 10 -1.43
DEPDC1 DEP domain containing 1 -1.41
CLSPN claspin -1.41
KIF22 kinesin family member 22 -1.37
TPX2 TPX2, microtubule-associated -1.36
CCNA1 cyclin A1 -1.36
MLPH melanophilin -1.36
RRM2 ribonucleotide reductase M2 -1.36
BUB1 BUB1 mitotic checkpoint serine/threonine kinase -1.35
ARHGAP11A Rho GTPase activating protein 11A -1.35
CCNB2 cyclin B2 -1.34
FBXO5 F-box protein 5 -1.34
SHROOM1 shroom family member 1 -1.3
COL11A1 collagen, type XI, alpha 1 -1.3
SACK1D scaffolding CK1 anchoring protein D -1.28
HMMR hyaluronan-mediated motility receptor (RHAMM) -1.26
DUSP5 dual specificity phosphatase 5 -1.25
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -1.24
CDC7 cell division cycle 7 -1.23
CCNF cyclin F -1.22
SLBP stem-loop binding protein -1.21
CDC6 cell division cycle 6 -1.21
WDR76 WD repeat domain 76 -1.2
ANLN anillin, actin binding protein -1.2
KIF11 kinesin family member 11 -1.2
CDCA2 cell division cycle associated 2 -1.19
PCLAF PCNA clamp associated factor -1.19
DUSP6 dual specificity phosphatase 6 -1.18
PLK1 polo-like kinase 1 -1.18
SATB2 SATB homeobox 2 -1.18
GMNN geminin, DNA replication inhibitor -1.18
ANKRD20A4 ankyrin repeat domain 20 family, member A4 -1.17
ORC6 origin recognition complex, subunit 6 -1.17
CDCA5 cell division cycle associated 5 -1.16
PTTG1 pituitary tumor-transforming 1 -1.15
NUSAP1 nucleolar and spindle associated protein 1 -1.14
H3C1 H3 clustered histone 1 -1.14
SASS6 spindle assembly 6 homolog (C. elegans) -1.14
C5ORF34 chromosome 5 open reading frame 34 -1.14
PSRC1 proline/serine-rich coiled-coil 1 -1.14
KIF20B kinesin family member 20B -1.12
RAD51 RAD51 recombinase -1.11
CDCA8 cell division cycle associated 8 -1.11
AEN apoptosis enhancing nuclease -1.1
AURKA aurora kinase A -1.08
UBE2S ubiquitin-conjugating enzyme E2S -1.08
PIMREG PICALM interacting mitotic regulator -1.07
CENPE centromere protein E, 312kDa -1.07
CKAP2L cytoskeleton associated protein 2-like -1.07
CENPF centromere protein F, 350/400kDa -1.07
SGO1 shugoshin 1 -1.06
GTSE1 G-2 and S-phase expressed 1 -1.05
TTK TTK protein kinase -1.05
DNA2 DNA replication helicase/nuclease 2 -1.04
SPRY4 sprouty homolog 4 (Drosophila) -1.03
KIF18A kinesin family member 18A -1.03
ZFP36L1 ZFP36 ring finger protein-like 1 -1.03
CCNE2 cyclin E2 -1.03
AURKB aurora kinase B -1.03
TOP2A topoisomerase (DNA) II alpha 170kDa -1.02
SGO2 shugoshin 2 -1.02
KIF2C kinesin family member 2C -1.01
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila) -1.0
EXO1 exonuclease 1 -1.0
KIFC1 kinesin family member C1 -1.0
CKAP2 cytoskeleton associated protein 2 -0.99
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase -0.99
SPDL1 spindle apparatus coiled-coil protein 1 -0.98
MCM8 minichromosome maintenance complex component 8 -0.98
VCAN versican -0.97
MCPH1 microcephalin 1 -0.97
STIL SCL/TAL1 interrupting locus -0.96
CDCA7 cell division cycle associated 7 -0.96
RUNX1 runt-related transcription factor 1 -0.94
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.94
PIM1 Pim-1 proto-oncogene, serine/threonine kinase -0.93
ATAD2 ATPase family, AAA domain containing 2 -0.93
CEP152 centrosomal protein 152kDa -0.93
RNF115 ring finger protein 115 -0.93
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy -0.9
TK1 thymidine kinase 1, soluble -0.9
CRCP CGRP receptor component -0.9
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1 -0.89
TRAIP TRAF interacting protein -0.89
DDX12P DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 12, pseudogene -0.89
SLF2 SMC5-SMC6 complex localization factor 2 -0.89
EHBP1 EH domain binding protein 1 -0.88