| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | NVP-BHG712 perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the NVP-BHG712_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.108743 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0641478 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.053896 |
| RPS12 | ribosomal protein S12 | 0.0451354 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0429089 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0405644 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0394226 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0362528 |
| RPS3 | ribosomal protein S3 | 0.035739 |
| RTN4 | reticulon 4 | 0.0342921 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0328729 |
| ATP11A | ATPase, class VI, type 11A | 0.0315574 |
| YBX1 | Y box binding protein 1 | 0.0313439 |
| RPL3 | ribosomal protein L3 | 0.0313096 |
| TPI1 | triosephosphate isomerase 1 | 0.0308167 |
| AP2M1 | adaptor-related protein complex 2, mu 1 subunit | 0.030438 |
| TPM3 | tropomyosin 3 | 0.0300949 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0299027 |
| RACK1 | receptor for activated C kinase 1 | 0.0298729 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0278454 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0275686 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | 0.0273971 |
| PCBP2 | poly(rC) binding protein 2 | 0.0271522 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0270003 |
| AREG | amphiregulin | 0.0266164 |
| PRRC2A | proline-rich coiled-coil 2A | 0.0260743 |
| BRD2 | bromodomain containing 2 | 0.0256547 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0252187 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0248995 |
| POTEF | POTE ankyrin domain family, member F | 0.0242367 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0236558 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | 0.0232309 |
| RPL36 | ribosomal protein L36 | 0.0226244 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0224925 |
| RPL37A | ribosomal protein L37a | 0.0212825 |
| SDHA | succinate dehydrogenase complex, subunit A, flavoprotein (Fp) | 0.0208582 |
| HSPA8 | heat shock 70kDa protein 8 | 0.020411 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0202697 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0200186 |
| CRISPLD1 | cysteine-rich secretory protein LCCL domain containing 1 | 0.0193899 |
| RPL13A | ribosomal protein L13a | 0.0191299 |
| EZR | ezrin | 0.0189995 |
| CLDND1 | claudin domain containing 1 | 0.0183842 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0182705 |
| GABARAPL1 | GABA(A) receptor-associated protein like 1 | 0.0181439 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0180925 |
| ARRDC3 | arrestin domain containing 3 | 0.0179066 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0178902 |
| PLK2 | polo-like kinase 2 | 0.0178415 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0172684 |
| SET | SET nuclear proto-oncogene | 0.0168644 |
| PFN1 | profilin 1 | 0.0164047 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0163518 |
| RPS19 | ribosomal protein S19 | 0.0162738 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0159056 |
| FTL | ferritin, light polypeptide | 0.0158784 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0157775 |
| PCM1 | pericentriolar material 1 | 0.0155682 |
| MSH6 | mutS homolog 6 | 0.015275 |
| RPS17 | ribosomal protein S17 | 0.0149945 |
| CPOX | coproporphyrinogen oxidase | 0.0148124 |
| NCKAP1 | NCK-associated protein 1 | 0.0146244 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0145822 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0145253 |
| PER1 | period circadian clock 1 | 0.0142669 |
| ETNK1 | ethanolamine kinase 1 | 0.0142265 |
| MPG | N-methylpurine-DNA glycosylase | 0.0141638 |
| EDN1 | endothelin 1 | 0.0140407 |
| ATP11B | ATPase, class VI, type 11B | 0.0140068 |
| CCNL1 | cyclin L1 | 0.0138199 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0134463 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0134313 |
| CSNK1G3 | casein kinase 1, gamma 3 | 0.013372 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.013296 |
| RPL23 | ribosomal protein L23 | 0.0132869 |
| PPP1R12B | protein phosphatase 1, regulatory subunit 12B | 0.0132301 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0131643 |
| COX4I1 | cytochrome c oxidase subunit IV isoform 1 | 0.0131639 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0130834 |
| CEP250 | centrosomal protein 250kDa | 0.0130227 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0129953 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0127785 |
| PNN | pinin, desmosome associated protein | 0.0126031 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0125991 |
| PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | 0.0124947 |
| MRPL51 | mitochondrial ribosomal protein L51 | 0.0123952 |
| CCT7 | chaperonin containing TCP1, subunit 7 (eta) | 0.0123551 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0123507 |
| NFKB2 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | 0.012265 |
| RPL21 | ribosomal protein L21 | 0.0122257 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0121036 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0120803 |
| AFDN | afadin, adherens junction formation factor | 0.0119961 |
| ARHGAP12 | Rho GTPase activating protein 12 | 0.0119058 |
| SSRP1 | structure specific recognition protein 1 | 0.0118383 |
| REL | v-rel avian reticuloendotheliosis viral oncogene homolog | 0.0117913 |
| B2M | beta-2-microglobulin | 0.0117484 |
| DIAPH1 | diaphanous-related formin 1 | 0.0116473 |
| TCP1 | t-complex 1 | 0.0116287 |
| DTNA | dystrobrevin, alpha | 0.0114538 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.316643 |
| NLGN1 | neuroligin 1 | -0.219618 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.145514 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.121572 |
| VIM | vimentin | -0.117726 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.108151 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0923218 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0873056 |
| MMP12 | matrix metallopeptidase 12 | -0.0822304 |
| EHBP1 | EH domain binding protein 1 | -0.0713613 |
| PTMA | prothymosin, alpha | -0.07015 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0692423 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | -0.0633255 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0630563 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.061089 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0605122 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0578736 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0548817 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.052943 |
| ZNF804A | zinc finger protein 804A | -0.0509274 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0500572 |
| USP34 | ubiquitin specific peptidase 34 | -0.0481267 |
| RASAL2 | RAS protein activator like 2 | -0.0467053 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0465956 |
| JMJD1C | jumonji domain containing 1C | -0.0451623 |
| HMGA2 | high mobility group AT-hook 2 | -0.0431561 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0421811 |
| CANX | calnexin | -0.0405875 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0405525 |
| TMEM123 | transmembrane protein 123 | -0.0403639 |
| TMEM41B | transmembrane protein 41B | -0.0389973 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0389735 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0386683 |
| MTAP | methylthioadenosine phosphorylase | -0.0384175 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0377614 |
| TUBA1B | tubulin, alpha 1b | -0.0370094 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0353616 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0349995 |
| MKI67 | marker of proliferation Ki-67 | -0.0341661 |
| YAP1 | Yes-associated protein 1 | -0.0339991 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0338492 |
| FUS | FUS RNA binding protein | -0.0337756 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0331981 |
| NHSL1 | NHS-like 1 | -0.0330343 |
| S100A10 | S100 calcium binding protein A10 | -0.0329342 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0327703 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | -0.0326665 |
| VMP1 | vacuole membrane protein 1 | -0.0319395 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0317903 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0314161 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | -0.0313618 |
| CUX1 | cut-like homeobox 1 | -0.0308879 |
| RPS24 | ribosomal protein S24 | -0.0305297 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.0296236 |
| RAB10 | RAB10, member RAS oncogene family | -0.0295759 |
| TRMT112 | tRNA methyltransferase 11-2 homolog (S. cerevisiae) | -0.0292506 |
| GCG | glucagon | -0.0291565 |
| RPS23 | ribosomal protein S23 | -0.0290697 |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | -0.0285594 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.027696 |
| CCND1 | cyclin D1 | -0.0274566 |
| CLDN1 | claudin 1 | -0.0273328 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0271214 |
| ASPH | aspartate beta-hydroxylase | -0.0270473 |
| ADIPOR2 | adiponectin receptor 2 | -0.0264932 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0260798 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0260448 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0256891 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0256823 |
| NAV3 | neuron navigator 3 | -0.025444 |
| RPL36A | ribosomal protein L36a | -0.0251272 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0250392 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.024986 |
| RPS15 | ribosomal protein S15 | -0.0246774 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0245157 |
| NF1 | neurofibromin 1 | -0.024513 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0244499 |
| TENM3 | teneurin transmembrane protein 3 | -0.0242835 |
| H1-0 | H1.0 linker histone | -0.0241558 |
| L3MBTL4 | l(3)mbt-like 4 (Drosophila) | -0.0241521 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0240461 |
| LARP1 | La ribonucleoprotein domain family, member 1 | -0.0240233 |
| SPATS2 | spermatogenesis associated, serine-rich 2 | -0.0238908 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0238141 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0235589 |
| MAP1B | microtubule-associated protein 1B | -0.0235478 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0235437 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0233771 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0229541 |
| TPM4 | tropomyosin 4 | -0.0228593 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0228551 |
| GNAS | GNAS complex locus | -0.0228174 |
| ACTG1 | actin gamma 1 | -0.0226646 |
| MAP4 | microtubule-associated protein 4 | -0.022639 |
| ANXA1 | annexin A1 | -0.0221933 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0220573 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0218779 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0216819 |
| BPTF | bromodomain PHD finger transcription factor | -0.0216044 |
| S100A6 | S100 calcium binding protein A6 | -0.0215308 |
