NVP-BHG712_A498 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description NVP-BHG712 perturbation in A498 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the NVP-BHG712_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.11827
NDRG1 N-myc downstream regulated 1 0.0586975
B2M beta-2-microglobulin 0.0545108
VIM vimentin 0.0504868
FTL ferritin, light polypeptide 0.0493442
MYH9 myosin, heavy chain 9, non-muscle 0.0473536
NAV2 neuron navigator 2 0.0461163
TMSB10 thymosin beta 10 0.0451928
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0407273
PLEC plectin 0.0371792
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.036717
EEF2 eukaryotic translation elongation factor 2 0.0314326
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0304669
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0292762
MT2A metallothionein 2A 0.0279817
FMNL2 formin-like 2 0.0277414
RPL37A ribosomal protein L37a 0.0275251
RPS8 ribosomal protein S8 0.0270083
RPL23 ribosomal protein L23 0.0266339
CALR calreticulin 0.0265597
TPM3 tropomyosin 3 0.0262461
PAX8 paired box 8 0.0260012
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0252421
TRIO trio Rho guanine nucleotide exchange factor 0.0248949
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0242628
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0238795
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0235847
LOC112694756 uncharaterized LOC112694756 0.0234916
PRRC2C proline-rich coiled-coil 2C 0.023063
RPL35A ribosomal protein L35a 0.0229382
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0227242
SEPTIN9 septin 9 0.0226179
EIF4H eukaryotic translation initiation factor 4H 0.0222866
RPS4X ribosomal protein S4, X-linked 0.0222815
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0221361
CTBP2 C-terminal binding protein 2 0.0215572
RPL34 ribosomal protein L34 0.0212739
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.020924
LMNA lamin A/C 0.0207411
RPS6 ribosomal protein S6 0.0205671
DDIT4 DNA-damage-inducible transcript 4 0.0201739
RNF213 ring finger protein 213 0.0201086
RPS17 ribosomal protein S17 0.0200781
RPS19 ribosomal protein S19 0.0198976
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0196152
RTN4 reticulon 4 0.0190896
EIF1 eukaryotic translation initiation factor 1 0.0190791
RPS12 ribosomal protein S12 0.0190541
RND3 Rho family GTPase 3 0.0190414
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0187508
SFTPA2 surfactant protein A2 0.0183224
TNIP1 TNFAIP3 interacting protein 1 0.0182135
RPL31 ribosomal protein L31 0.0180126
MSN moesin 0.0179431
RPL37 ribosomal protein L37 0.0177463
OPTN optineurin 0.0176283
MCL1 myeloid cell leukemia 1 0.0175757
NFE2L1 nuclear factor, erythroid 2-like 1 0.0173005
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0171657
SRRM2 serine/arginine repetitive matrix 2 0.0169866
RPLP1 ribosomal protein, large, P1 0.016982
RPL12 ribosomal protein L12 0.0169093
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.016865
RPL3 ribosomal protein L3 0.0168239
TIMP2 TIMP metallopeptidase inhibitor 2 0.0165974
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0165406
VEGFA vascular endothelial growth factor A 0.0164537
RPL7 ribosomal protein L7 0.016128
UBA6 ubiquitin-like modifier activating enzyme 6 0.0160683
CD44 CD44 molecule (Indian blood group) 0.0159716
ADM adrenomedullin 0.0158805
HLA-A major histocompatibility complex, class I, A 0.0157893
EGFR epidermal growth factor receptor 0.0157671
FLNA filamin A, alpha 0.0157524
P4HB prolyl 4-hydroxylase, beta polypeptide 0.015675
CLIP2 CAP-GLY domain containing linker protein 2 0.0154476
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0153071
RPS20 ribosomal protein S20 0.0151344
CADM1 cell adhesion molecule 1 0.0149579
RPS3 ribosomal protein S3 0.0149554
AHNAK AHNAK nucleoprotein 0.0149348
RPS13 ribosomal protein S13 0.0148477
RPL19 ribosomal protein L19 0.0148163
ADAM9 ADAM metallopeptidase domain 9 0.0145731
PDIA3 protein disulfide isomerase family A, member 3 0.0145588
CTSD cathepsin D 0.0143029
FRMD4A FERM domain containing 4A 0.0142935
ANXA2 annexin A2 0.0142433
IFITM3 interferon induced transmembrane protein 3 0.0140735
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0140696
ZSWIM6 zinc finger, SWIM-type containing 6 0.0139333
ZMIZ1 zinc finger, MIZ-type containing 1 0.0138691
APLP2 amyloid beta (A4) precursor-like protein 2 0.0137046
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.0137019
SAMD4A sterile alpha motif domain containing 4A 0.013584
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0135536
ANXA5 annexin A5 0.0134358
RACK1 receptor for activated C kinase 1 0.0134281
RPL27 ribosomal protein L27 0.0133582
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0133483

decreased expression

Symbol Name Standardized Value
ASPH aspartate beta-hydroxylase -0.0554733
GLIS3 GLIS family zinc finger 3 -0.0444545
NAMPT nicotinamide phosphoribosyltransferase -0.036773
TXNRD1 thioredoxin reductase 1 -0.0268533
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0205765
CXCL8 chemokine (C-X-C motif) ligand 8 -0.019992
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0197824
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0186463
EHBP1 EH domain binding protein 1 -0.0182492
CP ceruloplasmin (ferroxidase) -0.0181812
PBX1 pre-B-cell leukemia homeobox 1 -0.0176837
STK17A serine/threonine kinase 17a -0.0158013
TGFB2 transforming growth factor, beta 2 -0.0157574
GCC2 GRIP and coiled-coil domain containing 2 -0.0153364
TGFA transforming growth factor, alpha -0.0152823
EML4 echinoderm microtubule associated protein like 4 -0.0147507
ETV6 ets variant 6 -0.0147334
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0146102
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0145707
NRP1 neuropilin 1 -0.0140088
TSHZ2 teashirt zinc finger homeobox 2 -0.0139395
TNS3 tensin 3 -0.0139293
RIC8B RIC8 guanine nucleotide exchange factor B -0.0138389
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0135562
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0135093
NF1 neurofibromin 1 -0.0124217
RAD21 RAD21 homolog (S. pombe) -0.0118515
SCFD2 sec1 family domain containing 2 -0.0117859
SBF2 SET binding factor 2 -0.0117805
SPIDR scaffolding protein involved in DNA repair -0.0117732
P3H2 prolyl 3-hydroxylase 2 -0.0115833
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0115829
RHEX regulator of hemoglobinization and erythroid cell expansion -0.0114028
ZCCHC7 zinc finger, CCHC domain containing 7 -0.011173
ADAM10 ADAM metallopeptidase domain 10 -0.0110773
ANLN anillin, actin binding protein -0.0110342
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0109016
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0108329
BABAM2 BRISC and BRCA1 A complex member 2 -0.0106874
PHF14 PHD finger protein 14 -0.0105972
PTGR1 prostaglandin reductase 1 -0.0105251
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0103551
BICC1 BicC family RNA binding protein 1 -0.0102352
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0102346
MBD5 methyl-CpG binding domain protein 5 -0.0101696
IARS1 isoleucyl-tRNA synthetase 1 -0.0101138
RRBP1 ribosome binding protein 1 -0.01011
OXR1 oxidation resistance 1 -0.00998692
ANAPC5 anaphase promoting complex subunit 5 -0.00993111
CDK13 cyclin-dependent kinase 13 -0.00986221
TMEM263 transmembrane protein 263 -0.00958952
FBXL17 F-box and leucine-rich repeat protein 17 -0.00931732
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.00931163
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.00928425
AOPEP aminopeptidase O (putative) -0.00927171
GDA guanine deaminase -0.00925943
PTH2R parathyroid hormone 2 receptor -0.00920835
PARN poly(A)-specific ribonuclease -0.00919924
GCLM glutamate-cysteine ligase, modifier subunit -0.00916599
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.00911339
AGFG1 ArfGAP with FG repeats 1 -0.00901641
R3HDM1 R3H domain containing 1 -0.00890287
SMYD3 SET and MYND domain containing 3 -0.00886184
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.00863358
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.00845844
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 -0.0084375
MON2 MON2 homolog (S. cerevisiae) -0.00830068
FUS FUS RNA binding protein -0.00828811
RIC1 RAB6A GEF complex partner 1 -0.00827195
NRP2 neuropilin 2 -0.00813546
SCLT1 sodium channel and clathrin linker 1 -0.00811491
DLG1 discs, large homolog 1 (Drosophila) -0.00803845
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.00800546
RBM39 RNA binding motif protein 39 -0.00794796
ATXN10 ataxin 10 -0.00777709
VCAM1 vascular cell adhesion molecule 1 -0.00775053
GPAT3 glycerol-3-phosphate acyltransferase 3 -0.00770507
KANK1 KN motif and ankyrin repeat domains 1 -0.00769756
TTC3 tetratricopeptide repeat domain 3 -0.0076764
CADPS2 Ca++-dependent secretion activator 2 -0.00765971
THOC2 THO complex 2 -0.00764887
CCDC146 coiled-coil domain containing 146 -0.00760767
PTBP3 polypyrimidine tract binding protein 3 -0.00754449
LTN1 listerin E3 ubiquitin protein ligase 1 -0.00748833
ZBTB20 zinc finger and BTB domain containing 20 -0.00742927
GDF15 growth differentiation factor 15 -0.00741421
GORASP2 golgi reassembly stacking protein 2, 55kDa -0.00732683
PRRC1 proline-rich coiled-coil 1 -0.0073143
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 -0.00721947
GNA12 guanine nucleotide binding protein (G protein) alpha 12 -0.00719085
RAI14 retinoic acid induced 14 -0.0071718
RAD54B RAD54 homolog B (S. cerevisiae) -0.00715302
RBBP6 retinoblastoma binding protein 6 -0.00715007
GOLM2 golgi membrane protein 2 -0.00714512
LMAN1 lectin, mannose-binding, 1 -0.00708994
PHKB phosphorylase kinase, beta -0.00706531
ARF1 ADP-ribosylation factor 1 -0.00704751
MFF mitochondrial fission factor -0.00699783
MYSM1 Myb-like, SWIRM and MPN domains 1 -0.00697862
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.00692856