NVP-BHG712_AN3 CA Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description NVP-BHG712 perturbation in AN3 CA cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the NVP-BHG712_AN3 CA drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.310704
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.150295
EEF2 eukaryotic translation elongation factor 2 0.149298
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.103745
LOC112694756 uncharaterized LOC112694756 0.093544
RPS6 ribosomal protein S6 0.0882077
RPS8 ribosomal protein S8 0.0731538
RACK1 receptor for activated C kinase 1 0.0717524
RPL34 ribosomal protein L34 0.0687308
RPS4X ribosomal protein S4, X-linked 0.0662384
RPLP1 ribosomal protein, large, P1 0.0655275
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0646281
RPS12 ribosomal protein S12 0.0632795
ENO1 enolase 1, (alpha) 0.0629736
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0617513
HMGA1 high mobility group AT-hook 1 0.0611603
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0610475
FGFR1 fibroblast growth factor receptor 1 0.060853
RPL3 ribosomal protein L3 0.0602729
TSHZ2 teashirt zinc finger homeobox 2 0.0598653
LDHA lactate dehydrogenase A 0.059597
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0591941
GSE1 Gse1 coiled-coil protein 0.0563425
RPS2 ribosomal protein S2 0.0545367
MT2A metallothionein 2A 0.0544037
RPL23 ribosomal protein L23 0.0530192
RPL37A ribosomal protein L37a 0.0514007
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.050906
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0500445
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0481295
RPS3 ribosomal protein S3 0.0478985
RPS17 ribosomal protein S17 0.0477266
ACTG1 actin gamma 1 0.0471695
TUBB tubulin, beta class I 0.0469582
RPS13 ribosomal protein S13 0.0469571
IPO7 importin 7 0.0442792
RPL12 ribosomal protein L12 0.043897
RPL7 ribosomal protein L7 0.0435529
RPLP0 ribosomal protein, large, P0 0.0434337
RPL37 ribosomal protein L37 0.0427843
SFTPA2 surfactant protein A2 0.0424133
TMSB4X thymosin beta 4, X-linked 0.0423316
RPS23 ribosomal protein S23 0.0422617
RPL13A ribosomal protein L13a 0.0410119
MGP matrix Gla protein 0.0408381
MATR3 matrin 3 0.0405061
PRRC2C proline-rich coiled-coil 2C 0.0400109
HDLBP high density lipoprotein binding protein 0.0396817
RPL30 ribosomal protein L30 0.0396786
VEGFA vascular endothelial growth factor A 0.0392061
TRIO trio Rho guanine nucleotide exchange factor 0.0391634
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0389479
EIF1 eukaryotic translation initiation factor 1 0.0384251
HSPA8 heat shock 70kDa protein 8 0.0383362
EEF1G eukaryotic translation elongation factor 1 gamma 0.0381954
CALR calreticulin 0.0381547
RPL7A ribosomal protein L7a 0.0381424
TPM4 tropomyosin 4 0.0381272
ZMIZ1 zinc finger, MIZ-type containing 1 0.0379675
RPL35A ribosomal protein L35a 0.0377554
AFF4 AF4/FMR2 family, member 4 0.0376855
TPT1 tumor protein, translationally-controlled 1 0.0375855
CSNK1A1 casein kinase 1, alpha 1 0.0371236
RPL11 ribosomal protein L11 0.0367796
SET SET nuclear proto-oncogene 0.0366854
RPS25 ribosomal protein S25 0.0359863
CSDE1 cold shock domain containing E1, RNA-binding 0.0358079
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0358057
RPL19 ribosomal protein L19 0.0356877
RPS14 ribosomal protein S14 0.0356261
PKM pyruvate kinase, muscle 0.0350301
RPS19 ribosomal protein S19 0.0347935
RPL26 ribosomal protein L26 0.0344812
VCL vinculin 0.0343956
RPLP2 ribosomal protein, large, P2 0.0341543
SRRM2 serine/arginine repetitive matrix 2 0.0337898
EXT1 exostosin glycosyltransferase 1 0.0337049
SERBP1 SERPINE1 mRNA binding protein 1 0.0334768
FTH1 ferritin, heavy polypeptide 1 0.0332873
RPS24 ribosomal protein S24 0.0331861
SHROOM3 shroom family member 3 0.0328025
DDIT4 DNA-damage-inducible transcript 4 0.0326228
RPS20 ribosomal protein S20 0.0321127
CLIP2 CAP-GLY domain containing linker protein 2 0.0319983
EIF4H eukaryotic translation initiation factor 4H 0.0319006
ZFP36L1 ZFP36 ring finger protein-like 1 0.0317551
POTEF POTE ankyrin domain family, member F 0.0315449
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0312634
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0312143
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0311625
PRRC2A proline-rich coiled-coil 2A 0.0311469
YBX1 Y box binding protein 1 0.0308934
RPL4 ribosomal protein L4 0.0307619
RPS11 ribosomal protein S11 0.030606
B2M beta-2-microglobulin 0.0303738
NACA nascent polypeptide-associated complex alpha subunit 0.0302044
FTL ferritin, light polypeptide 0.0300172
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0299845
RPL8 ribosomal protein L8 0.0298048
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.0297939

decreased expression

Symbol Name Standardized Value
PRKG1 protein kinase, cGMP-dependent, type I -0.211826
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.166532
CADM2 cell adhesion molecule 2 -0.0987448
PDE4D phosphodiesterase 4D, cAMP-specific -0.0894614
MEOX2 mesenchyme homeobox 2 -0.0642475
TPK1 thiamin pyrophosphokinase 1 -0.0589349
ZEB1 zinc finger E-box binding homeobox 1 -0.0581663
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0536691
NFIA nuclear factor I/A -0.0524256
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0450833
COL1A2 collagen, type I, alpha 2 -0.044377
EXOC4 exocyst complex component 4 -0.0435392
PDGFC platelet derived growth factor C -0.0404032
RNF130 ring finger protein 130 -0.038809
TET1 tet methylcytosine dioxygenase 1 -0.035764
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0356129
TET2 tet methylcytosine dioxygenase 2 -0.0349225
IGF2R insulin-like growth factor 2 receptor -0.0348675
NFIB nuclear factor I/B -0.0347853
HMGA2 high mobility group AT-hook 2 -0.0332343
DMXL1 Dmx-like 1 -0.0325412
MEIS2 Meis homeobox 2 -0.0302169
LCORL ligand dependent nuclear receptor corepressor-like -0.0300266
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0297538
MARCHF6 membrane associated ring-CH-type finger 6 -0.0296885
SBF2 SET binding factor 2 -0.0295327
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0282562
CENPE centromere protein E, 312kDa -0.0278954
RFC3 replication factor C (activator 1) 3, 38kDa -0.0278526
TTC28 tetratricopeptide repeat domain 28 -0.0277747
PARP8 poly (ADP-ribose) polymerase family, member 8 -0.0277035
RFX7 regulatory factor X, 7 -0.0273079
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0254871
WSB1 WD repeat and SOCS box containing 1 -0.0251698
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0247502
USP9X ubiquitin specific peptidase 9, X-linked -0.0237952
NAMPT nicotinamide phosphoribosyltransferase -0.0237586
SSBP2 single-stranded DNA binding protein 2 -0.0236217
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 -0.0232268
RHOBTB3 Rho-related BTB domain containing 3 -0.0230556
BRWD1 bromodomain and WD repeat domain containing 1 -0.0228422
MIS18BP1 MIS18 binding protein 1 -0.0221611
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0219793
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0219432
FGFR2 fibroblast growth factor receptor 2 -0.021931
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0216997
JAM3 junctional adhesion molecule 3 -0.0216296
SBNO1 strawberry notch homolog 1 (Drosophila) -0.021507
GNG2 guanine nucleotide binding protein (G protein), gamma 2 -0.0213979
RBM26 RNA binding motif protein 26 -0.0211926
FBXL7 F-box and leucine-rich repeat protein 7 -0.020976
CD46 CD46 molecule, complement regulatory protein -0.0207664
TPST1 tyrosylprotein sulfotransferase 1 -0.0207446
GPC6 glypican 6 -0.0203897
FNBP1 formin binding protein 1 -0.0203459
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -0.0202772
NNT nicotinamide nucleotide transhydrogenase -0.0201835
NEMF nuclear export mediator factor -0.0201624
FNIP1 folliculin interacting protein 1 -0.0200802
TCERG1 transcription elongation regulator 1 -0.0200374
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0199958
PRPF39 pre-mRNA processing factor 39 -0.0199106
HBP1 HMG-box transcription factor 1 -0.0198765
PIAS2 protein inhibitor of activated STAT, 2 -0.0197919
CERT1 ceramide transporter 1 -0.0196555
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -0.0195885
SCMH1 sex comb on midleg homolog 1 (Drosophila) -0.0195325
PRELID2 PRELI domain containing 2 -0.0193556
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0193176
RAD51B RAD51 paralog B -0.0191694
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.019018
POU2F1 POU class 2 homeobox 1 -0.0186924
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0185339
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.0183509
BBX bobby sox homolog (Drosophila) -0.018327
KANTR KDM5C adjacent non-coding transcript -0.0183039
RSRC1 arginine/serine-rich coiled-coil 1 -0.0183017
TOP2B topoisomerase (DNA) II beta 180kDa -0.018293
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 -0.018243
CHD9 chromodomain helicase DNA binding protein 9 -0.0181909
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0180534
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11 -0.017953
MEST mesoderm specific transcript -0.0178569
ZMYM2 zinc finger, MYM-type 2 -0.0177927
AHI1 Abelson helper integration site 1 -0.0176407
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0175858
DENND1A DENN/MADD domain containing 1A -0.0175411
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0175075
FAF1 Fas (TNFRSF6) associated factor 1 -0.0174438
RAB6A RAB6A, member RAS oncogene family -0.0172986
ZNF680 zinc finger protein 680 -0.017234
DYM dymeclin -0.0171965
SMC4 structural maintenance of chromosomes 4 -0.0169263
FAM13A family with sequence similarity 13, member A -0.0169057
ANKRD26 ankyrin repeat domain 26 -0.0168051
ATM ATM serine/threonine kinase -0.0167016
COL4A5 collagen, type IV, alpha 5 -0.016635
ZNF638 zinc finger protein 638 -0.0165855
DIAPH3 diaphanous-related formin 3 -0.0165525
ZNF236 zinc finger protein 236 -0.0164135