NVP-BHG712_BT-474 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description NVP-BHG712 perturbation in BT-474 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the NVP-BHG712_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPL19 ribosomal protein L19 0.142044
CEP250 centrosomal protein 250kDa 0.0704589
RPL23 ribosomal protein L23 0.0699443
RPS3 ribosomal protein S3 0.0582921
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0462768
IFI6 interferon, alpha-inducible protein 6 0.0422812
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0373043
RPL35A ribosomal protein L35a 0.0372471
DTNA dystrobrevin, alpha 0.0364462
INTS6 integrator complex subunit 6 0.0360935
RPL37A ribosomal protein L37a 0.0328687
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0321138
STAT1 signal transducer and activator of transcription 1, 91kDa 0.031742
SP100 SP100 nuclear antigen 0.0300654
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0286987
CDK12 cyclin-dependent kinase 12 0.0283848
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0275379
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.026868
PTK2 protein tyrosine kinase 2 0.0263589
GRB10 growth factor receptor-bound protein 10 0.0253108
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0240106
PRRC2B proline-rich coiled-coil 2B 0.0234984
LPP LIM domain containing preferred translocation partner in lipoma 0.0232122
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0226709
UNC13B unc-13 homolog B (C. elegans) 0.0222483
DENND1A DENN/MADD domain containing 1A 0.0218825
ACTG1 actin gamma 1 0.0217168
PRRC2C proline-rich coiled-coil 2C 0.0214692
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 0.0214055
NDRG1 N-myc downstream regulated 1 0.0201895
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 0.0197671
EFNA5 ephrin-A5 0.0196777
RAD51B RAD51 paralog B 0.0191308
STXBP4 syntaxin binding protein 4 0.018893
GMDS GDP-mannose 4,6-dehydratase 0.018713
SRRM2 serine/arginine repetitive matrix 2 0.0186152
PNN pinin, desmosome associated protein 0.0185499
PLSCR2 phospholipid scramblase 2 0.018431
RPS17 ribosomal protein S17 0.0184239
RPS12 ribosomal protein S12 0.0182985
SET SET nuclear proto-oncogene 0.0182731
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0178351
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0176892
PARP14 poly (ADP-ribose) polymerase family, member 14 0.017477
B2M beta-2-microglobulin 0.0172024
NCOA3 nuclear receptor coactivator 3 0.0171884
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1 0.0163605
PTPRK protein tyrosine phosphatase, receptor type, K 0.0163516
ANKRD17 ankyrin repeat domain 17 0.0162805
PLEKHG4B pleckstrin homology domain containing, family G (with RhoGef domain) member 4B 0.0161162
ENAH enabled homolog (Drosophila) 0.0160228
EIF4H eukaryotic translation initiation factor 4H 0.0159463
NACA nascent polypeptide-associated complex alpha subunit 0.0158385
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 0.0157449
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0156199
RCOR1 REST corepressor 1 0.01539
AEBP2 AE binding protein 2 0.0152698
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0150857
ANKHD1 ankyrin repeat and KH domain containing 1 0.0149721
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0149259
CATSPERB catsper channel auxiliary subunit beta 0.0148275
RTN3 reticulon 3 0.0148173
RPL35 ribosomal protein L35 0.0147563
PRLR prolactin receptor 0.014753
TBL1X transducin (beta)-like 1X-linked 0.0145997
LARP4B La ribonucleoprotein domain family, member 4B 0.0145711
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C 0.0144424
PLSCR1 phospholipid scramblase 1 0.0143697
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.014254
RNF213 ring finger protein 213 0.0142281
TRPS1 trichorhinophalangeal syndrome I 0.014149
LMNA lamin A/C 0.0141272
ANKRD11 ankyrin repeat domain 11 0.0140853
STIP1 stress-induced phosphoprotein 1 0.0140852
HLA-B major histocompatibility complex, class I, B 0.0140563
LOC112694756 uncharaterized LOC112694756 0.0139977
RPL36 ribosomal protein L36 0.0139715
PRRC2A proline-rich coiled-coil 2A 0.0138026
CREB5 cAMP responsive element binding protein 5 0.013678
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0136095
SLFN5 schlafen family member 5 0.0135112
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0135085
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0133902
ZSWIM6 zinc finger, SWIM-type containing 6 0.0132992
RPS19 ribosomal protein S19 0.0130631
RBM47 RNA binding motif protein 47 0.013033
MCL1 myeloid cell leukemia 1 0.0130018
RPL37 ribosomal protein L37 0.0129559
EXOC4 exocyst complex component 4 0.012949
RPL30 ribosomal protein L30 0.0129442
KRT86 keratin 86, type II 0.0129309
PBX1 pre-B-cell leukemia homeobox 1 0.0128705
RPL12 ribosomal protein L12 0.0127719
ADAR adenosine deaminase, RNA-specific 0.0126661
GDF5 growth differentiation factor 5 0.0125907
ZHX2 zinc fingers and homeoboxes 2 0.0124472
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0123799
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0123485
ZNF148 zinc finger protein 148 0.0121225
POLD3 polymerase (DNA-directed), delta 3, accessory subunit 0.0120238

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0718405
VMP1 vacuole membrane protein 1 -0.0681435
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0654565
FTH1 ferritin, heavy polypeptide 1 -0.0638681
UBC ubiquitin C -0.0438839
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0405732
S100A8 S100 calcium binding protein A8 -0.0364416
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0364406
AHNAK AHNAK nucleoprotein -0.0350881
NAMPT nicotinamide phosphoribosyltransferase -0.0331046
ASPH aspartate beta-hydroxylase -0.0322185
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0316505
S100A9 S100 calcium binding protein A9 -0.0313179
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0295402
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0291165
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.0290242
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0289107
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0288269
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0281618
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0271063
CCNI cyclin I -0.0268211
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0261163
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0260656
ACSS2 acyl-CoA synthetase short-chain family member 2 -0.0247746
NTN4 netrin 4 -0.024626
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0245897
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 -0.0245003
TXNRD1 thioredoxin reductase 1 -0.024445
SDC4 syndecan 4 -0.0244252
OSMR oncostatin M receptor -0.0242062
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4 -0.0241592
LMAN1 lectin, mannose-binding, 1 -0.0235616
SLC38A1 solute carrier family 38, member 1 -0.0233083
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0232962
IGFBP5 insulin-like growth factor binding protein 5 -0.0232262
ELL2 elongation factor, RNA polymerase II, 2 -0.0231105
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0227366
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0224134
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) -0.0222619
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0220124
ZNF217 zinc finger protein 217 -0.0218735
NIBAN2 niban apoptosis regulator 2 -0.0209427
ZMYND8 zinc finger, MYND-type containing 8 -0.0200586
TOM1L1 target of myb1 (chicken)-like 1 -0.0191935
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0184942
TSC22D2 TSC22 domain family, member 2 -0.0182833
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0182747
GSK3B glycogen synthase kinase 3 beta -0.0182615
TMEM45B transmembrane protein 45B -0.018175
UGCG UDP-glucose ceramide glucosyltransferase -0.0179994
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0179875
CEMIP2 cell migration inducing hyaluronidase 2 -0.0178928
RAB22A RAB22A, member RAS oncogene family -0.0178921
ARHGAP29 Rho GTPase activating protein 29 -0.0177072
TMEM123 transmembrane protein 123 -0.0176538
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0175787
ARID5B AT rich interactive domain 5B (MRF1-like) -0.0171893
TMEM165 transmembrane protein 165 -0.0170503
SMIM14 small integral membrane protein 14 -0.0170493
PTMA prothymosin, alpha -0.0169608
S100A6 S100 calcium binding protein A6 -0.0169389
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0168476
ANKRD36C ankyrin repeat domain 36C -0.0164778
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0164428
AREG amphiregulin -0.0164223
PDIA3 protein disulfide isomerase family A, member 3 -0.0163678
MT2A metallothionein 2A -0.0163642
CALR calreticulin -0.0162298
SETX senataxin -0.0158704
S100A14 S100 calcium binding protein A14 -0.0158324
YPEL2 yippee-like 2 (Drosophila) -0.0156029
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0155155
NT5C2 5'-nucleotidase, cytosolic II -0.0154217
MSMO1 methylsterol monooxygenase 1 -0.0153986
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0149202
ACACA acetyl-CoA carboxylase alpha -0.0148638
SOD2 superoxide dismutase 2, mitochondrial -0.0146696
LDLR low density lipoprotein receptor -0.0144303
FADS2 fatty acid desaturase 2 -0.0142884
NCOA7 nuclear receptor coactivator 7 -0.0142504
IFNGR1 interferon gamma receptor 1 -0.0142001
CDH15 cadherin 15, type 1, M-cadherin (myotubule) -0.0141794
FUS FUS RNA binding protein -0.0136875
TC2N tandem C2 domains, nuclear -0.0132787
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0131059
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0130253
MAP1B microtubule-associated protein 1B -0.0127835
UBE2H ubiquitin-conjugating enzyme E2H -0.0127073
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0126121
ELOVL5 ELOVL fatty acid elongase 5 -0.0125684
ADAM9 ADAM metallopeptidase domain 9 -0.0123377
CFB complement factor B -0.0122127
USP53 ubiquitin specific peptidase 53 -0.0122125
KRT8 keratin 8, type II -0.0121923
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0121235
DUSP6 dual specificity phosphatase 6 -0.0120386
RAB27B RAB27B, member RAS oncogene family -0.0119628
APP amyloid beta (A4) precursor protein -0.0119523
SQLE squalene epoxidase -0.0119026
GDPD1 glycerophosphodiester phosphodiesterase domain containing 1 -0.011848