NVP-BHG712_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description NVP-BHG712 perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the NVP-BHG712_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
INTS6 integrator complex subunit 6 0.149511
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.0942497
GCLC glutamate-cysteine ligase, catalytic subunit 0.0795945
ACTG1 actin gamma 1 0.0743342
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.071881
PLSCR2 phospholipid scramblase 2 0.0692694
ANXA2 annexin A2 0.0657377
SMAD3 SMAD family member 3 0.0591491
FTL ferritin, light polypeptide 0.058525
SRRM2 serine/arginine repetitive matrix 2 0.0578186
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0553613
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0540685
VCL vinculin 0.05244
EEF2 eukaryotic translation elongation factor 2 0.0506242
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0497629
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.049431
EPHB2 EPH receptor B2 0.0491617
AKAP13 A kinase (PRKA) anchor protein 13 0.0486576
HKDC1 hexokinase domain containing 1 0.0479452
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.0459906
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0448533
RNF213 ring finger protein 213 0.0439214
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.043089
SHB Src homology 2 domain containing adaptor protein B 0.041977
RAD51B RAD51 paralog B 0.0414236
RPL35A ribosomal protein L35a 0.0410733
ZSWIM6 zinc finger, SWIM-type containing 6 0.0403736
SEPTIN9 septin 9 0.0403134
LMO7 LIM domain 7 0.04014
LOC112694756 uncharaterized LOC112694756 0.0401358
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0397838
LCN2 lipocalin 2 0.0388029
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.0386713
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0384751
DST dystonin 0.0373756
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0370492
RPL37A ribosomal protein L37a 0.035801
RPS17 ribosomal protein S17 0.0357755
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0351108
MCTP1 multiple C2 domains, transmembrane 1 0.0350454
PHF3 PHD finger protein 3 0.0345352
MYH9 myosin, heavy chain 9, non-muscle 0.0339102
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0335538
GOLGB1 golgin B1 0.0334238
RPS8 ribosomal protein S8 0.0330253
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0312535
SLC38A2 solute carrier family 38, member 2 0.0311064
RPS12 ribosomal protein S12 0.0310009
RACK1 receptor for activated C kinase 1 0.0308432
RPS3 ribosomal protein S3 0.0300895
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0299091
POU2F2 POU class 2 homeobox 2 0.0293726
RPL7L1 ribosomal protein L7-like 1 0.0290148
HSPA8 heat shock 70kDa protein 8 0.0284492
DIAPH1 diaphanous-related formin 1 0.0284144
UBAP2 ubiquitin associated protein 2 0.027509
PDLIM5 PDZ and LIM domain 5 0.027453
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0271187
SET SET nuclear proto-oncogene 0.0267275
MX1 MX dynamin-like GTPase 1 0.026555
MCL1 myeloid cell leukemia 1 0.0261868
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0258882
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0258515
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0257763
FHIT fragile histidine triad 0.025683
HSPH1 heat shock 105kDa/110kDa protein 1 0.0256091
ANKRD11 ankyrin repeat domain 11 0.0252455
RPL11 ribosomal protein L11 0.0251756
TPM3 tropomyosin 3 0.0243635
ELOF1 elongation factor 1 homolog (S. cerevisiae) 0.0243466
KTN1 kinectin 1 (kinesin receptor) 0.0241263
WNK1 WNK lysine deficient protein kinase 1 0.0238071
BRD2 bromodomain containing 2 0.0237983
SERINC5 serine incorporator 5 0.0235449
JAK1 Janus kinase 1 0.0234579
NCEH1 neutral cholesterol ester hydrolase 1 0.0234412
RPL23 ribosomal protein L23 0.0231695
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0231351
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0230964
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0227119
EIF4H eukaryotic translation initiation factor 4H 0.0226994
OARD1 O-acyl-ADP-ribose deacylase 1 0.0223913
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0223451
COX4I1 cytochrome c oxidase subunit IV isoform 1 0.0223304
ENO1 enolase 1, (alpha) 0.0223049
HDAC4 histone deacetylase 4 0.0222411
ZC3H13 zinc finger CCCH-type containing 13 0.0222288
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0221096
IGF2 insulin-like growth factor 2 0.0220751
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.021887
MYO19 myosin XIX 0.0218768
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.021607
RPL13A ribosomal protein L13a 0.0216002
NACA nascent polypeptide-associated complex alpha subunit 0.0215446
ACTN1 actinin, alpha 1 0.0215103
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) 0.021304
TNS4 tensin 4 0.0211308
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 0.0211285
PLEKHA6 pleckstrin homology domain containing, family A member 6 0.0210162
CCND3 cyclin D3 0.020829

decreased expression

Symbol Name Standardized Value
ZMYND8 zinc finger, MYND-type containing 8 -0.17775
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.163904
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.142408
TXNIP thioredoxin interacting protein -0.106972
H1-0 H1.0 linker histone -0.0919768
TMPRSS4 transmembrane protease, serine 4 -0.0918928
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.087184
FNDC3B fibronectin type III domain containing 3B -0.0815416
PTBP3 polypyrimidine tract binding protein 3 -0.0774281
RHOBTB3 Rho-related BTB domain containing 3 -0.0734208
HLA-B major histocompatibility complex, class I, B -0.073352
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.072356
TPT1 tumor protein, translationally-controlled 1 -0.0708553
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.070243
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0701758
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0644537
NDRG1 N-myc downstream regulated 1 -0.0629638
UBC ubiquitin C -0.0627703
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0622318
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0608798
PTMA prothymosin, alpha -0.0566975
CCNL1 cyclin L1 -0.0555577
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0552774
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0544173
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0541265
BTBD9 BTB (POZ) domain containing 9 -0.0522464
NPEPPS aminopeptidase puromycin sensitive -0.0521786
RNF149 ring finger protein 149 -0.051459
PDIA3 protein disulfide isomerase family A, member 3 -0.0512099
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0505831
XAF1 XIAP associated factor 1 -0.0501874
MBNL2 muscleblind-like splicing regulator 2 -0.0498471
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0497175
SREBF2 sterol regulatory element binding transcription factor 2 -0.0494931
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0467741
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -0.046735
APOL1 apolipoprotein L, 1 -0.0462972
IFNGR1 interferon gamma receptor 1 -0.0453208
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0446509
EPSTI1 epithelial stromal interaction 1 (breast) -0.0434782
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0431299
B2M beta-2-microglobulin -0.0428406
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.0422879
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.0422578
SSH2 slingshot protein phosphatase 2 -0.041753
MACC1 metastasis associated in colon cancer 1 -0.0406256
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0402035
EHF ets homologous factor -0.0399992
ABLIM1 actin binding LIM protein 1 -0.039922
ARHGAP32 Rho GTPase activating protein 32 -0.039811
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0398107
HLA-E major histocompatibility complex, class I, E -0.0391033
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0390896
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0379102
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.037303
UBR2 ubiquitin protein ligase E3 component n-recognin 2 -0.0370786
IRF1 interferon regulatory factor 1 -0.0364309
RBM39 RNA binding motif protein 39 -0.0361285
GCC2 GRIP and coiled-coil domain containing 2 -0.0360896
IFI6 interferon, alpha-inducible protein 6 -0.0349476
SORBS1 sorbin and SH3 domain containing 1 -0.0348998
CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic -0.0340822
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0338976
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0337475
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -0.0336062
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0335959
LOC102724023 ES1 protein homolog, mitochondrial -0.0335336
ATP10B ATPase, class V, type 10B -0.0328419
TM9SF3 transmembrane 9 superfamily member 3 -0.0321301
PTEN phosphatase and tensin homolog -0.0320881
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0319451
ARHGAP5 Rho GTPase activating protein 5 -0.0318678
DENND4C DENN/MADD domain containing 4C -0.0317946
PGK1 phosphoglycerate kinase 1 -0.031623
ST14 suppression of tumorigenicity 14 (colon carcinoma) -0.0315289
ZMYM2 zinc finger, MYM-type 2 -0.0313545
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme -0.0310437
UBAC2 UBA domain containing 2 -0.0310142
RUNX1 runt-related transcription factor 1 -0.0309186
FNDC3A fibronectin type III domain containing 3A -0.0308459
ESYT2 extended synaptotagmin-like protein 2 -0.0306969
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.030297
EXT1 exostosin glycosyltransferase 1 -0.0302775
TMEM123 transmembrane protein 123 -0.0300589
SLC38A1 solute carrier family 38, member 1 -0.0300311
LY6E lymphocyte antigen 6 complex, locus E -0.0298937
WDR45B WD repeat domain 45B -0.0298202
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0294548
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0294363
TMEM62 transmembrane protein 62 -0.0293998
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 -0.029217
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0291447
PRSS3 protease, serine, 3 -0.0290091
PDK3 pyruvate dehydrogenase kinase, isozyme 3 -0.0289411
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0289235
DLG1 discs, large homolog 1 (Drosophila) -0.0285426
UFM1 ubiquitin-fold modifier 1 -0.0282372
FNIP1 folliculin interacting protein 1 -0.0282046
APOL6 apolipoprotein L, 6 -0.0280046
NAMPT nicotinamide phosphoribosyltransferase -0.0279936