| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | NVP-BHG712 perturbation in H4 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the NVP-BHG712_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.119134 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.090409 |
| NDRG1 | N-myc downstream regulated 1 | 0.0832387 |
| FTL | ferritin, light polypeptide | 0.0750152 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0640614 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0619274 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.055476 |
| FAM13A | family with sequence similarity 13, member A | 0.054057 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0478362 |
| RTN4 | reticulon 4 | 0.0456936 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0441719 |
| HELZ | helicase with zinc finger | 0.0428584 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0421219 |
| STC1 | stanniocalcin 1 | 0.0419532 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0384135 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0380312 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0350019 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0337214 |
| YBX1 | Y box binding protein 1 | 0.0330151 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.032949 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0317751 |
| JUN | jun proto-oncogene | 0.0312611 |
| LDHA | lactate dehydrogenase A | 0.0301751 |
| CANX | calnexin | 0.0292613 |
| GOLGA4 | golgin A4 | 0.0289867 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0284719 |
| RACK1 | receptor for activated C kinase 1 | 0.0283513 |
| ANXA2 | annexin A2 | 0.0269021 |
| TPM3 | tropomyosin 3 | 0.0265154 |
| RPL3 | ribosomal protein L3 | 0.0263874 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0260271 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0260092 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0259359 |
| ATP13A3 | ATPase type 13A3 | 0.0256404 |
| SRP54 | signal recognition particle 54kDa | 0.0256063 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.025489 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0252793 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0251213 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0249739 |
| SNX13 | sorting nexin 13 | 0.0245341 |
| RPS19 | ribosomal protein S19 | 0.02443 |
| PLEC | plectin | 0.0241553 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0235975 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0234109 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0233469 |
| ZNF841 | zinc finger protein 841 | 0.0232748 |
| TXNIP | thioredoxin interacting protein | 0.0232736 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0227065 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.022554 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0225507 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0223924 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0222136 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0221141 |
| FLNA | filamin A, alpha | 0.0220546 |
| MATR3 | matrin 3 | 0.0219906 |
| MON2 | MON2 homolog (S. cerevisiae) | 0.021878 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0217752 |
| HYOU1 | hypoxia up-regulated 1 | 0.0217359 |
| SMAD3 | SMAD family member 3 | 0.0217002 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0216321 |
| ADM | adrenomedullin | 0.0214701 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0212965 |
| AP2M1 | adaptor-related protein complex 2, mu 1 subunit | 0.0212964 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0208351 |
| SPTY2D1 | SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae) | 0.0207959 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0205421 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0205382 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0204505 |
| CLTC | clathrin, heavy chain (Hc) | 0.0204454 |
| USP3 | ubiquitin specific peptidase 3 | 0.0200484 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0199395 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.019778 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0196537 |
| TFG | TRK-fused gene | 0.0195235 |
| MXI1 | MAX interactor 1, dimerization protein | 0.019448 |
| OGA | O-GlcNAcase | 0.0193609 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0193608 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0193026 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0192734 |
| MIDEAS | mitotic deacetylase associated SANT domain protein | 0.0192413 |
| TNNC1 | troponin C type 1 (slow) | 0.0191722 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0191199 |
| RPS2 | ribosomal protein S2 | 0.0190709 |
| PCBP2 | poly(rC) binding protein 2 | 0.0190657 |
| COPA | coatomer protein complex, subunit alpha | 0.0190279 |
| PIK3C3 | phosphatidylinositol 3-kinase, catalytic subunit type 3 | 0.0189548 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.018807 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 0.018623 |
| BRD2 | bromodomain containing 2 | 0.0185366 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0184182 |
| RPS3 | ribosomal protein S3 | 0.0180587 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0180563 |
| TLN1 | talin 1 | 0.0178401 |
| SON | SON DNA binding protein | 0.0177701 |
| ZNF148 | zinc finger protein 148 | 0.0176236 |
| HDAC9 | histone deacetylase 9 | 0.0174355 |
| FNIP1 | folliculin interacting protein 1 | 0.0174311 |
| VEGFA | vascular endothelial growth factor A | 0.0173826 |
| SUCO | SUN domain containing ossification factor | 0.0173312 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0169317 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0990086 |
| PTMA | prothymosin, alpha | -0.0976356 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0915813 |
| FN1 | fibronectin 1 | -0.0871733 |
| TMSB10 | thymosin beta 10 | -0.0811381 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0793622 |
| HLA-B | major histocompatibility complex, class I, B | -0.0781267 |
| NLGN1 | neuroligin 1 | -0.07382 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0735947 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.062201 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0512408 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.047055 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0421884 |
| TPM4 | tropomyosin 4 | -0.0413674 |
| VIM | vimentin | -0.0385977 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0385742 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0384579 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.03827 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0352951 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0337843 |
| NAV1 | neuron navigator 1 | -0.0328066 |
| IGF2 | insulin-like growth factor 2 | -0.0316366 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0307709 |
| RPS13 | ribosomal protein S13 | -0.0301345 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0298861 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0297636 |
| RPS25 | ribosomal protein S25 | -0.029503 |
| TNS3 | tensin 3 | -0.029345 |
| CALD1 | caldesmon 1 | -0.0288342 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.0279025 |
| RPL38 | ribosomal protein L38 | -0.027364 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0271131 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0265716 |
| RPS23 | ribosomal protein S23 | -0.0265652 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0265281 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0264025 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0263962 |
| MT2A | metallothionein 2A | -0.0262795 |
| ACTG1 | actin gamma 1 | -0.0261284 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0255003 |
| NAV3 | neuron navigator 3 | -0.0251985 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0249073 |
| RPL35A | ribosomal protein L35a | -0.0248948 |
| LAMB3 | laminin, beta 3 | -0.0241078 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.02384 |
| ATXN1 | ataxin 1 | -0.0235807 |
| FBXO11 | F-box protein 11 | -0.0234787 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0233189 |
| PRSS23 | protease, serine, 23 | -0.0231163 |
| S100A10 | S100 calcium binding protein A10 | -0.0230669 |
| DGKI | diacylglycerol kinase, iota | -0.023 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0225532 |
| RPL7A | ribosomal protein L7a | -0.0221851 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0220155 |
| HLA-A | major histocompatibility complex, class I, A | -0.021749 |
| CKAP4 | cytoskeleton-associated protein 4 | -0.0216985 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0216795 |
| ZNF804A | zinc finger protein 804A | -0.021327 |
| CD44 | CD44 molecule (Indian blood group) | -0.0208135 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0207363 |
| RPLP2 | ribosomal protein, large, P2 | -0.0206419 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0206406 |
| EFNA5 | ephrin-A5 | -0.020352 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0202558 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0200867 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0200068 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | -0.0199958 |
| PXDN | peroxidasin | -0.0199465 |
| HIPK2 | homeodomain interacting protein kinase 2 | -0.0199232 |
| RPL9 | ribosomal protein L9 | -0.0199159 |
| RAN | RAN, member RAS oncogene family | -0.0198956 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0198421 |
| GLIS3 | GLIS family zinc finger 3 | -0.0197505 |
| RPS24 | ribosomal protein S24 | -0.0197216 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0196385 |
| AEBP2 | AE binding protein 2 | -0.0195583 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.019491 |
| SP100 | SP100 nuclear antigen | -0.0194739 |
| SLC25A51 | solute carrier family 25, member 51 | -0.0194664 |
| CAVIN1 | caveolae associated protein 1 | -0.0194508 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0194494 |
| RPL37A | ribosomal protein L37a | -0.0192676 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0191342 |
| EGFR | epidermal growth factor receptor | -0.0191091 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0190997 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0190451 |
| CDK13 | cyclin-dependent kinase 13 | -0.0187978 |
| SYT1 | synaptotagmin I | -0.0186708 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | -0.0185703 |
| SEPTIN9 | septin 9 | -0.0185658 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0180996 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0180598 |
| PGK1 | phosphoglycerate kinase 1 | -0.0179613 |
| ANKUB1 | ankyrin repeat and ubiquitin domain containing 1 | -0.0178829 |
| CARS1 | cysteinyl-tRNA synthetase 1 | -0.0178358 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0177819 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0176376 |
| MAP4 | microtubule-associated protein 4 | -0.0174115 |
| MKI67 | marker of proliferation Ki-67 | -0.0173772 |
| RPS29 | ribosomal protein S29 | -0.0173542 |
