| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | NVP-BHG712 perturbation in HEC-1-A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the NVP-BHG712_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FLNA | filamin A, alpha | 0.150245 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.149721 |
| ACTG1 | actin gamma 1 | 0.141891 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.112022 |
| PLEC | plectin | 0.0972958 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0808242 |
| SMAD3 | SMAD family member 3 | 0.0793997 |
| KRT7 | keratin 7, type II | 0.0787893 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.078341 |
| LAMB3 | laminin, beta 3 | 0.0744285 |
| RACK1 | receptor for activated C kinase 1 | 0.0693278 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0651001 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0638864 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0615627 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0580807 |
| WWC1 | WW and C2 domain containing 1 | 0.0578007 |
| RPS4X | ribosomal protein S4, X-linked | 0.055582 |
| PKM | pyruvate kinase, muscle | 0.0550847 |
| RPS12 | ribosomal protein S12 | 0.0541277 |
| ACTN4 | actinin, alpha 4 | 0.0515728 |
| RPS2 | ribosomal protein S2 | 0.0511768 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0494636 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0494512 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0493577 |
| APP | amyloid beta (A4) precursor protein | 0.0488655 |
| INTS6 | integrator complex subunit 6 | 0.0485047 |
| RPL31 | ribosomal protein L31 | 0.0480316 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0475187 |
| FTL | ferritin, light polypeptide | 0.046903 |
| RPL3 | ribosomal protein L3 | 0.0464021 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0459062 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0456687 |
| LDHA | lactate dehydrogenase A | 0.04443 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0415113 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0395314 |
| RPL13A | ribosomal protein L13a | 0.0393839 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0393263 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0392043 |
| PCSK5 | proprotein convertase subtilisin/kexin type 5 | 0.0384268 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0381266 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0381174 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0380413 |
| RPL34 | ribosomal protein L34 | 0.0379607 |
| RPL23 | ribosomal protein L23 | 0.0377548 |
| SEPTIN9 | septin 9 | 0.0376619 |
| SQSTM1 | sequestosome 1 | 0.0376507 |
| TMSB4X | thymosin beta 4, X-linked | 0.0374124 |
| CALR | calreticulin | 0.0369458 |
| LMNA | lamin A/C | 0.0365264 |
| RPL12 | ribosomal protein L12 | 0.0363702 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0363019 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.035781 |
| SET | SET nuclear proto-oncogene | 0.0356129 |
| ANXA2 | annexin A2 | 0.0354958 |
| RPS3 | ribosomal protein S3 | 0.0354558 |
| CCND1 | cyclin D1 | 0.0352261 |
| RPL27 | ribosomal protein L27 | 0.0350782 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0346129 |
| B2M | beta-2-microglobulin | 0.0343168 |
| GOLGB1 | golgin B1 | 0.0342882 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0342156 |
| FLNB | filamin B, beta | 0.0342022 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0341087 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0341001 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | 0.034026 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0337882 |
| RPS17 | ribosomal protein S17 | 0.032644 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0326291 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0321201 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0319419 |
| TPM4 | tropomyosin 4 | 0.0318104 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0316192 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0312791 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0312052 |
| USP53 | ubiquitin specific peptidase 53 | 0.0308042 |
| RPS8 | ribosomal protein S8 | 0.0306276 |
| KRT86 | keratin 86, type II | 0.0304303 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0303851 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0302913 |
| SPAG9 | sperm associated antigen 9 | 0.0300883 |
| MYO1E | myosin IE | 0.0295556 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.029494 |
| CHST15 | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 | 0.0293202 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0293201 |
| RPL7 | ribosomal protein L7 | 0.0291076 |
| RPL37 | ribosomal protein L37 | 0.0289136 |
| FAT1 | FAT atypical cadherin 1 | 0.0288126 |
| EGFR | epidermal growth factor receptor | 0.0287431 |
| MICAL3 | microtubule associated monooxygenase, calponin and LIM domain containing 3 | 0.0284557 |
| RPLP1 | ribosomal protein, large, P1 | 0.028338 |
| ANKRD33B | ankyrin repeat domain 33B | 0.028257 |
| HDLBP | high density lipoprotein binding protein | 0.0277827 |
| LAMC2 | laminin, gamma 2 | 0.0277809 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0277266 |
| RPL35 | ribosomal protein L35 | 0.0276305 |
| RAB3IP | RAB3A interacting protein | 0.027595 |
| ACTN1 | actinin, alpha 1 | 0.0275738 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0275693 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0275349 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0273381 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | -0.0684351 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0683459 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0564141 |
| ANLN | anillin, actin binding protein | -0.0562866 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0559959 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0512175 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0506643 |
| RHEX | regulator of hemoglobinization and erythroid cell expansion | -0.0475514 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0470723 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0469454 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.044874 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0422875 |
| NF1 | neurofibromin 1 | -0.0421267 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0404048 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0389979 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.038646 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0382492 |
| THOC2 | THO complex 2 | -0.0378213 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0364464 |
| ZNF292 | zinc finger protein 292 | -0.0359728 |
| VIM | vimentin | -0.0352982 |
| BBX | bobby sox homolog (Drosophila) | -0.0346531 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0343977 |
| ITGB8 | integrin, beta 8 | -0.034364 |
| H1-0 | H1.0 linker histone | -0.0341878 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0338609 |
| CD2AP | CD2-associated protein | -0.0335653 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0334821 |
| TMSB10 | thymosin beta 10 | -0.0334014 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0333692 |
| ADAM10 | ADAM metallopeptidase domain 10 | -0.0333676 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0324074 |
| PTK2 | protein tyrosine kinase 2 | -0.0322561 |
| ADAMTS9 | ADAM metallopeptidase with thrombospondin type 1 motif, 9 | -0.0318335 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0309832 |
| OGA | O-GlcNAcase | -0.0306863 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0303241 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.030182 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.030161 |
| PARD6B | par-6 family cell polarity regulator beta | -0.0283564 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0282226 |
| KIF18B | kinesin family member 18B | -0.0280441 |
| UBE2K | ubiquitin-conjugating enzyme E2K | -0.0279633 |
| PERP | PERP, TP53 apoptosis effector | -0.0274417 |
| VCAN | versican | -0.0271938 |
| VEZT | vezatin, adherens junctions transmembrane protein | -0.0269671 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0265895 |
| SBF2 | SET binding factor 2 | -0.0264691 |
| FBXL2 | F-box and leucine-rich repeat protein 2 | -0.0264669 |
| PGK1 | phosphoglycerate kinase 1 | -0.0259164 |
| XPO1 | exportin 1 | -0.0257156 |
| RNF145 | ring finger protein 145 | -0.0256968 |
| MKI67 | marker of proliferation Ki-67 | -0.0256719 |
| ADNP | activity-dependent neuroprotector homeobox | -0.0254924 |
| GOLGA4 | golgin A4 | -0.0253847 |
| RBM39 | RNA binding motif protein 39 | -0.0252889 |
| PDE8A | phosphodiesterase 8A | -0.0250076 |
| HMGA2 | high mobility group AT-hook 2 | -0.0246398 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0246341 |
| PLEKHA1 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 | -0.024491 |
| MAP4 | microtubule-associated protein 4 | -0.0244591 |
| SETD5 | SET domain containing 5 | -0.0243154 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0242096 |
| FCHSD2 | FCH and double SH3 domains 2 | -0.0241789 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0241314 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0241152 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0238049 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0237855 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0237206 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0234882 |
| GAS2L3 | growth arrest-specific 2 like 3 | -0.0229354 |
| DNAAF9 | dynein axonemal assembly factor 9 | -0.022903 |
| FHIT | fragile histidine triad | -0.0226163 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0224617 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0221317 |
| RFX7 | regulatory factor X, 7 | -0.022059 |
| PTBP2 | polypyrimidine tract binding protein 2 | -0.0218912 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.021857 |
| WASF2 | WAS protein family, member 2 | -0.0218089 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0217884 |
| FANCD2 | Fanconi anemia, complementation group D2 | -0.0217272 |
| OXR1 | oxidation resistance 1 | -0.0213801 |
| DHX9 | DEAH (Asp-Glu-Ala-His) box helicase 9 | -0.02132 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0211031 |
| KIF4A | kinesin family member 4A | -0.0210165 |
| ZFR | zinc finger RNA binding protein | -0.0209214 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0206265 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0205655 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.0204576 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0204081 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0202871 |
| NKTR | natural killer cell triggering receptor | -0.0202859 |
| PRELID2 | PRELI domain containing 2 | -0.0202295 |
| TMEM87A | transmembrane protein 87A | -0.0200774 |
| YEATS2 | YEATS domain containing 2 | -0.0200227 |
| INVS | inversin | -0.0199949 |
| MT1X | metallothionein 1X | -0.0199853 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0198891 |
| IMMT | inner membrane protein, mitochondrial | -0.0198789 |
| SHTN1 | shootin 1 | -0.0198448 |
