| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | NVP-BHG712 perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the NVP-BHG712_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| COL6A3 | collagen, type VI, alpha 3 | 0.108037 |
| FN1 | fibronectin 1 | 0.103703 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0824404 |
| PLEC | plectin | 0.0720108 |
| CDH13 | cadherin 13 | 0.0697021 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0643135 |
| ASPH | aspartate beta-hydroxylase | 0.0576073 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0449037 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | 0.042486 |
| FBN1 | fibrillin 1 | 0.0422108 |
| AHNAK | AHNAK nucleoprotein | 0.0399908 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0397314 |
| COL5A1 | collagen, type V, alpha 1 | 0.0389326 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0322838 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0303521 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0299539 |
| VCL | vinculin | 0.0295765 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0295083 |
| GOLGB1 | golgin B1 | 0.0290579 |
| PRELID2 | PRELI domain containing 2 | 0.0285048 |
| DST | dystonin | 0.02796 |
| ATXN1 | ataxin 1 | 0.0277605 |
| HMGA2 | high mobility group AT-hook 2 | 0.0274232 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0274161 |
| NAV2 | neuron navigator 2 | 0.0272356 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0271809 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0257244 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0256 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0253659 |
| GLIS3 | GLIS family zinc finger 3 | 0.025307 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0250456 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.0248906 |
| FLNA | filamin A, alpha | 0.0232587 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0232173 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0231569 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0227292 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0223418 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0213582 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0207598 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0206302 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0205648 |
| PDIA5 | protein disulfide isomerase family A, member 5 | 0.0204862 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0201122 |
| ARHGAP22 | Rho GTPase activating protein 22 | 0.0199841 |
| HLA-C | major histocompatibility complex, class I, C | 0.019776 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.019597 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0195627 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0195336 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0192661 |
| ANTXR2 | anthrax toxin receptor 2 | 0.0191048 |
| SMYD3 | SET and MYND domain containing 3 | 0.0190246 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0188525 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0186759 |
| HDLBP | high density lipoprotein binding protein | 0.0185045 |
| AP2M1 | adaptor-related protein complex 2, mu 1 subunit | 0.0183188 |
| CAVIN1 | caveolae associated protein 1 | 0.0182825 |
| RRBP1 | ribosome binding protein 1 | 0.0179551 |
| COL4A2 | collagen, type IV, alpha 2 | 0.017949 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.0177493 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0177138 |
| EGFR | epidermal growth factor receptor | 0.0176289 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.0175946 |
| SORBS2 | sorbin and SH3 domain containing 2 | 0.0174615 |
| RPS3 | ribosomal protein S3 | 0.0173165 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0173032 |
| BBS9 | Bardet-Biedl syndrome 9 | 0.0166914 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0164566 |
| ACTG1 | actin gamma 1 | 0.0161952 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.015833 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0156417 |
| RFX8 | RFX family member 8, lacking RFX DNA binding domain | 0.0153875 |
| DPYSL2 | dihydropyrimidinase-like 2 | 0.0153718 |
| APP | amyloid beta (A4) precursor protein | 0.0153601 |
| PGM3 | phosphoglucomutase 3 | 0.0149785 |
| SPSB1 | splA/ryanodine receptor domain and SOCS box containing 1 | 0.0148757 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0145838 |
| HDAC9 | histone deacetylase 9 | 0.0145133 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0145048 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0141967 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.014148 |
| FBXL13 | F-box and leucine-rich repeat protein 13 | 0.014134 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0140701 |
| ENO1 | enolase 1, (alpha) | 0.0140669 |
| FNIP1 | folliculin interacting protein 1 | 0.0139531 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0139439 |
| NAV1 | neuron navigator 1 | 0.0138675 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0138388 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0138007 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0137187 |
| CENPF | centromere protein F, 350/400kDa | 0.0136899 |
| MYO1E | myosin IE | 0.0136584 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0135829 |
| SQSTM1 | sequestosome 1 | 0.0135589 |
| FAM107B | family with sequence similarity 107, member B | 0.0134767 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.013311 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0133038 |
| EFNA5 | ephrin-A5 | 0.0131992 |
| CDK13 | cyclin-dependent kinase 13 | 0.0130161 |
| RPL3 | ribosomal protein L3 | 0.0130108 |
| PRRC2A | proline-rich coiled-coil 2A | 0.0130104 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.250309 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.15762 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.130588 |
| COL1A1 | collagen, type I, alpha 1 | -0.117638 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0956105 |
| MT2A | metallothionein 2A | -0.0887941 |
| VIM | vimentin | -0.0878533 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0825999 |
| TMSB10 | thymosin beta 10 | -0.0820986 |
| IER3 | immediate early response 3 | -0.0676705 |
| NDRG1 | N-myc downstream regulated 1 | -0.0642909 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.061583 |
| PTMA | prothymosin, alpha | -0.0479326 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0477234 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0461748 |
| ATP13A3 | ATPase type 13A3 | -0.0446601 |
| COL1A2 | collagen, type I, alpha 2 | -0.0439715 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0438157 |
| FTL | ferritin, light polypeptide | -0.0408225 |
| CADM1 | cell adhesion molecule 1 | -0.0401875 |
| MT1X | metallothionein 1X | -0.0381751 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0381288 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.037852 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0359335 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0345628 |
| UBC | ubiquitin C | -0.0341511 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.0334143 |
| RPS6 | ribosomal protein S6 | -0.032922 |
| PFN1 | profilin 1 | -0.0314253 |
| ZNF292 | zinc finger protein 292 | -0.0299332 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.02915 |
| GOLGA4 | golgin A4 | -0.0284459 |
| WASF2 | WAS protein family, member 2 | -0.0283917 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0271311 |
| SETD5 | SET domain containing 5 | -0.0264553 |
| MAP1B | microtubule-associated protein 1B | -0.0262839 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0262488 |
| INHBA | inhibin, beta A | -0.0251338 |
| HLA-B | major histocompatibility complex, class I, B | -0.0250184 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0249162 |
| ADM | adrenomedullin | -0.0247929 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0243832 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0242772 |
| S100A10 | S100 calcium binding protein A10 | -0.0232644 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0231481 |
| S100A9 | S100 calcium binding protein A9 | -0.0227981 |
| PKM | pyruvate kinase, muscle | -0.0226948 |
| POTEF | POTE ankyrin domain family, member F | -0.0226421 |
| SQLE | squalene epoxidase | -0.0225765 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0225541 |
| USP3 | ubiquitin specific peptidase 3 | -0.022459 |
| IL6 | interleukin 6 | -0.0222717 |
| POSTN | periostin, osteoblast specific factor | -0.0221156 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0218608 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.021806 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0217666 |
| CCNL1 | cyclin L1 | -0.0212798 |
| TRAM1 | translocation associated membrane protein 1 | -0.0209974 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0209249 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0207692 |
| S100A6 | S100 calcium binding protein A6 | -0.0206113 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | -0.0205607 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0204669 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0202294 |
| RPL8 | ribosomal protein L8 | -0.020098 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0200853 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0200319 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0199002 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0198989 |
| B2M | beta-2-microglobulin | -0.0198842 |
| QKI | QKI, KH domain containing, RNA binding | -0.019876 |
| TPM2 | tropomyosin 2 (beta) | -0.0197927 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0194952 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0191034 |
| RPL28 | ribosomal protein L28 | -0.0189829 |
| RLF | rearranged L-myc fusion | -0.0188604 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0187582 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0185897 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0182508 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0180997 |
| RPS11 | ribosomal protein S11 | -0.0178931 |
| RNF145 | ring finger protein 145 | -0.0177065 |
| CD99 | CD99 molecule | -0.0176474 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0175286 |
| LDHA | lactate dehydrogenase A | -0.0174566 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0173475 |
| LOX | lysyl oxidase | -0.017012 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0169802 |
| HLA-A | major histocompatibility complex, class I, A | -0.0167641 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.0167314 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0166337 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0165955 |
| TFG | TRK-fused gene | -0.0165195 |
| HMGA1 | high mobility group AT-hook 1 | -0.0161646 |
| SH3BGRL3 | SH3 domain binding glutamate-rich protein like 3 | -0.0160534 |
| FAM162A | family with sequence similarity 162, member A | -0.015852 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0156069 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0153666 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0153015 |
| SEPTIN7 | septin 7 | -0.015278 |
