| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | NVP-BHG712 perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the NVP-BHG712_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | 0.470725 |
| FN1 | fibronectin 1 | 0.175165 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.16819 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.116826 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.092324 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.08707 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0763458 |
| C3 | complement component 3 | 0.0760005 |
| ENO1 | enolase 1, (alpha) | 0.0660741 |
| APOB | apolipoprotein B | 0.0620932 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0549953 |
| FAT1 | FAT atypical cadherin 1 | 0.0511362 |
| TF | transferrin | 0.0485646 |
| DSPP | dentin sialophosphoprotein | 0.047889 |
| PEG3 | paternally expressed 3 | 0.0425915 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0421946 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0416403 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0402613 |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.0394547 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0380414 |
| TPM4 | tropomyosin 4 | 0.037714 |
| LOC112694756 | uncharaterized LOC112694756 | 0.037343 |
| SVIL | supervillin | 0.0373236 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0354586 |
| GPC3 | glypican 3 | 0.0352646 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0344195 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0342632 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.0338679 |
| AHSG | alpha-2-HS-glycoprotein | 0.0333409 |
| CTSB | cathepsin B | 0.0331651 |
| DLC1 | DLC1 Rho GTPase activating protein | 0.0326552 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.032396 |
| TMEM123 | transmembrane protein 123 | 0.0323942 |
| FOXP1 | forkhead box P1 | 0.0321919 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0320411 |
| GPC6 | glypican 6 | 0.0317668 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.0302568 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0299703 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0296708 |
| BCL2L1 | BCL2-like 1 | 0.029379 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0292509 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0286077 |
| FRMD5 | FERM domain containing 5 | 0.0285482 |
| EHBP1 | EH domain binding protein 1 | 0.0277583 |
| UBC | ubiquitin C | 0.0273584 |
| A2M | alpha-2-macroglobulin | 0.0273256 |
| SMAD3 | SMAD family member 3 | 0.0271911 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0270121 |
| MCL1 | myeloid cell leukemia 1 | 0.0269442 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0268165 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0263907 |
| ITGAV | integrin, alpha V | 0.0261005 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.0254248 |
| EXT1 | exostosin glycosyltransferase 1 | 0.025156 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0245205 |
| ATXN1 | ataxin 1 | 0.0241136 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.0241024 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0236923 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0236197 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.0235875 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | 0.0230495 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0227323 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0226034 |
| ARHGAP9 | Rho GTPase activating protein 9 | 0.0224949 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0222616 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0221433 |
| VCL | vinculin | 0.0220202 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0217958 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0215435 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.0214372 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.021417 |
| ITGB5 | integrin, beta 5 | 0.0213018 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0212479 |
| EGR1 | early growth response 1 | 0.0212377 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0212287 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | 0.0212129 |
| CANX | calnexin | 0.0211367 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0208759 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0205015 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0204155 |
| CPE | carboxypeptidase E | 0.0203922 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0203666 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0201486 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0200978 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.0196102 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0190459 |
| ARHGEF18 | Rho/Rac guanine nucleotide exchange factor (GEF) 18 | 0.0190384 |
| RAB3B | RAB3B, member RAS oncogene family | 0.0189489 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0189396 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0188874 |
| PLEC | plectin | 0.0187105 |
| MYO1E | myosin IE | 0.0186173 |
| RPL3 | ribosomal protein L3 | 0.01841 |
| LCOR | ligand dependent nuclear receptor corepressor | 0.0184005 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0181479 |
| SFTPA2 | surfactant protein A2 | 0.0179486 |
| KYNU | kynureninase | 0.0179201 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.017844 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0177404 |
| CFB | complement factor B | 0.0174782 |
| Symbol | Name | Standardized Value |
|---|---|---|
| RBM39 | RNA binding motif protein 39 | -0.0312685 |
| MT2A | metallothionein 2A | -0.0244933 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0229736 |
| DTNA | dystrobrevin, alpha | -0.0214606 |
| FTL | ferritin, light polypeptide | -0.0176637 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | -0.0175772 |
| CCNL1 | cyclin L1 | -0.0172426 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0170714 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0170685 |
| RBM25 | RNA binding motif protein 25 | -0.0164784 |
| FBXO11 | F-box protein 11 | -0.0152575 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0148986 |
| PTK2 | protein tyrosine kinase 2 | -0.0148367 |
| FAM13A | family with sequence similarity 13, member A | -0.0148171 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | -0.0146088 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | -0.0145856 |
| RPL37A | ribosomal protein L37a | -0.0140188 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0137119 |
| VEGFA | vascular endothelial growth factor A | -0.0133269 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0124702 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0124401 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0123154 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0120693 |
| COLEC11 | collectin sub-family member 11 | -0.0116969 |
| CDC7 | cell division cycle 7 | -0.011674 |
| DHFR | dihydrofolate reductase | -0.0116257 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | -0.0115685 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0112852 |
| RNF145 | ring finger protein 145 | -0.0110419 |
| RRBP1 | ribosome binding protein 1 | -0.010733 |
| PPIG | peptidylprolyl isomerase G (cyclophilin G) | -0.0106039 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0105794 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0104954 |
| TNRC6A | trinucleotide repeat containing 6A | -0.0104674 |
| MED13L | mediator complex subunit 13-like | -0.0104108 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0103723 |
| PDS5B | PDS5 cohesin associated factor B | -0.0103609 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0103315 |
| SHOC2 | soc-2 suppressor of clear homolog (C. elegans) | -0.0101797 |
| CCAR1 | cell division cycle and apoptosis regulator 1 | -0.0100567 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0100448 |
| HELZ | helicase with zinc finger | -0.00996772 |
| UBE3A | ubiquitin protein ligase E3A | -0.00993057 |
| COPA | coatomer protein complex, subunit alpha | -0.00968152 |
| ZNF292 | zinc finger protein 292 | -0.0095806 |
| PDE8A | phosphodiesterase 8A | -0.00948461 |
| TRPM7 | transient receptor potential cation channel, subfamily M, member 7 | -0.00940618 |
| NF1 | neurofibromin 1 | -0.00936773 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.00933907 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.00932922 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | -0.00927693 |
| BRD4 | bromodomain containing 4 | -0.00924125 |
| EP400 | E1A binding protein p400 | -0.00921228 |
| NDRG1 | N-myc downstream regulated 1 | -0.00916827 |
| PRRC2C | proline-rich coiled-coil 2C | -0.00912795 |
| TBCK | TBC1 domain containing kinase | -0.00893621 |
| TIAL1 | TIA1 cytotoxic granule-associated RNA binding protein-like 1 | -0.00892673 |
| PPHLN1 | periphilin 1 | -0.00892612 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.00886439 |
| PPME1 | protein phosphatase methylesterase 1 | -0.00886099 |
| MT1X | metallothionein 1X | -0.00879272 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.00872265 |
| KDM6A | lysine (K)-specific demethylase 6A | -0.00869226 |
| DUSP6 | dual specificity phosphatase 6 | -0.00868939 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.00867095 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.00862275 |
| PRPF4B | pre-mRNA processing factor 4B | -0.00859621 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.00858148 |
| TUT4 | terminal uridylyl transferase 4 | -0.00857967 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.00851332 |
| EZR | ezrin | -0.00834814 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0082769 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.00826385 |
| RPS3 | ribosomal protein S3 | -0.0082104 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | -0.00820154 |
| BDP1 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | -0.00813569 |
| TTC21B | tetratricopeptide repeat domain 21B | -0.00809414 |
| GOLGA4 | golgin A4 | -0.0080879 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.00806705 |
| UTRN | utrophin | -0.00803236 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.00800945 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.00797449 |
| HSPG2 | heparan sulfate proteoglycan 2 | -0.00795197 |
| OGA | O-GlcNAcase | -0.00793038 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.00787925 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.00786588 |
| PCF11 | PCF11 cleavage and polyadenylation factor subunit | -0.00784078 |
| CAMKMT | calmodulin-lysine N-methyltransferase | -0.00782979 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.00782241 |
| HMBOX1 | homeobox containing 1 | -0.00777685 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.00777259 |
| DYM | dymeclin | -0.00770578 |
| ARHGAP12 | Rho GTPase activating protein 12 | -0.0076202 |
| SMC6 | structural maintenance of chromosomes 6 | -0.00755657 |
| FCHSD2 | FCH and double SH3 domains 2 | -0.00751424 |
| PSPC1 | paraspeckle component 1 | -0.00749408 |
| CNOT8 | CCR4-NOT transcription complex, subunit 8 | -0.00740503 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | -0.00737769 |
| SRRM1 | serine/arginine repetitive matrix 1 | -0.00736176 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | -0.00733687 |
