NVP-BHG712_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description NVP-BHG712 perturbation in Hs 766T cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the NVP-BHG712_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.214182
TIMP3 TIMP metallopeptidase inhibitor 3 0.149685
PALM2AKAP2 PALM2 and AKAP2 fusion 0.116532
SLC35F3 solute carrier family 35, member F3 0.099004
PLEC plectin 0.0989074
PDE4D phosphodiesterase 4D, cAMP-specific 0.0953734
LMO7 LIM domain 7 0.0909909
LOC112694756 uncharaterized LOC112694756 0.0848044
PDLIM5 PDZ and LIM domain 5 0.0834571
PODXL podocalyxin-like 0.0680861
B2M beta-2-microglobulin 0.0679453
MTSS1 metastasis suppressor 1 0.0622771
FTH1 ferritin, heavy polypeptide 1 0.0618266
IFITM1 interferon induced transmembrane protein 1 0.0578165
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0563564
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0554553
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0547011
IFITM3 interferon induced transmembrane protein 3 0.0545808
ALCAM activated leukocyte cell adhesion molecule 0.0538609
RPS3 ribosomal protein S3 0.0530062
SULF2 sulfatase 2 0.0525526
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.0520118
MT2A metallothionein 2A 0.0517223
RASAL2 RAS protein activator like 2 0.0504316
RPL37 ribosomal protein L37 0.0502649
RPL35A ribosomal protein L35a 0.0500279
GRB10 growth factor receptor-bound protein 10 0.0488834
BCAR3 breast cancer anti-estrogen resistance 3 0.048712
LAMA5 laminin, alpha 5 0.0458104
RPS19 ribosomal protein S19 0.0448332
LAMC2 laminin, gamma 2 0.0435374
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0426712
KIAA1671 KIAA1671 0.0426342
HSPG2 heparan sulfate proteoglycan 2 0.0420843
ANO1 anoctamin 1, calcium activated chloride channel 0.0418271
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.041134
AKAP13 A kinase (PRKA) anchor protein 13 0.0409115
INTS6 integrator complex subunit 6 0.040821
EXT1 exostosin glycosyltransferase 1 0.0405766
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0399225
PRSS23 protease, serine, 23 0.0385376
PALLD palladin, cytoskeletal associated protein 0.0381826
RPS12 ribosomal protein S12 0.0374198
TMSB10 thymosin beta 10 0.0372195
HLA-B major histocompatibility complex, class I, B 0.0367958
FTL ferritin, light polypeptide 0.0358988
RPS4X ribosomal protein S4, X-linked 0.0352427
HDAC9 histone deacetylase 9 0.035117
HMGA2 high mobility group AT-hook 2 0.034986
RACK1 receptor for activated C kinase 1 0.0345072
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0344284
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0343621
AMOTL1 angiomotin like 1 0.0340344
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0336536
RNF217 ring finger protein 217 0.033321
NCOR2 nuclear receptor corepressor 2 0.0332512
RIGI RNA sensor RIG-I 0.0331203
SRRM2 serine/arginine repetitive matrix 2 0.0331183
EFNA5 ephrin-A5 0.0329405
ACTN4 actinin, alpha 4 0.0325136
RABGAP1L RAB GTPase activating protein 1-like 0.0322706
MT1E metallothionein 1E 0.0319703
LDHA lactate dehydrogenase A 0.0318386
RPLP1 ribosomal protein, large, P1 0.031727
EEF2 eukaryotic translation elongation factor 2 0.0313555
CALB1 calbindin 1, 28kDa 0.0311202
RPL34 ribosomal protein L34 0.0310181
CD44 CD44 molecule (Indian blood group) 0.0308345
RPL36 ribosomal protein L36 0.0304262
IFI44L interferon-induced protein 44-like 0.0303156
MPRIP myosin phosphatase Rho interacting protein 0.0302249
KLF5 Kruppel-like factor 5 (intestinal) 0.0300829
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.030082
EGFR epidermal growth factor receptor 0.0299029
FLNA filamin A, alpha 0.0296522
ZMIZ1 zinc finger, MIZ-type containing 1 0.029592
HSPA8 heat shock 70kDa protein 8 0.029425
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0289973
SQSTM1 sequestosome 1 0.0288811
EGR1 early growth response 1 0.0288695
ANXA2 annexin A2 0.0287034
PLXNA2 plexin A2 0.0286095
IFI6 interferon, alpha-inducible protein 6 0.0284715
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0284649
IFI27 interferon, alpha-inducible protein 27 0.0282528
MACF1 microtubule-actin crosslinking factor 1 0.028191
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0281679
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0281243
AGO2 argonaute RISC catalytic component 2 0.0280986
ACTN1 actinin, alpha 1 0.0278709
TINAGL1 tubulointerstitial nephritis antigen-like 1 0.0278223
AHNAK2 AHNAK nucleoprotein 2 0.0275594
RPL31 ribosomal protein L31 0.0274531
RPS13 ribosomal protein S13 0.0273671
IGFBP6 insulin-like growth factor binding protein 6 0.0270021
PLS3 plastin 3 0.0268247
RPL35 ribosomal protein L35 0.0262797
HLA-E major histocompatibility complex, class I, E 0.0262004
HLA-C major histocompatibility complex, class I, C 0.0261695
HELZ2 helicase with zinc finger 2, transcriptional coactivator 0.0261533

decreased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase -0.132323
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.126733
CLU clusterin -0.112465
RBM39 RNA binding motif protein 39 -0.0881792
ANLN anillin, actin binding protein -0.0854567
MEF2A myocyte enhancer factor 2A -0.0843274
CUL4B cullin 4B -0.0835708
GOLGA4 golgin A4 -0.0827364
TRIO trio Rho guanine nucleotide exchange factor -0.0770348
ITCH itchy E3 ubiquitin protein ligase -0.0705057
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.068242
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0682258
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0621023
OGA O-GlcNAcase -0.060305
NDRG1 N-myc downstream regulated 1 -0.059303
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0591888
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0588686
KMT2E lysine (K)-specific methyltransferase 2E -0.0570499
MYOF myoferlin -0.0568454
FLNB filamin B, beta -0.0535206
KDM3A lysine (K)-specific demethylase 3A -0.0501314
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0493494
H1-0 H1.0 linker histone -0.0490667
CANX calnexin -0.0474745
COPB1 coatomer protein complex, subunit beta 1 -0.047151
ANKRD33B ankyrin repeat domain 33B -0.0467058
ZNF292 zinc finger protein 292 -0.0466434
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0458167
SUCO SUN domain containing ossification factor -0.0457328
PTMA prothymosin, alpha -0.0452191
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0448116
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.044024
DSTN destrin (actin depolymerizing factor) -0.0439428
TPX2 TPX2, microtubule-associated -0.0434102
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0432627
SPAG9 sperm associated antigen 9 -0.0420752
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.0420354
PGK1 phosphoglycerate kinase 1 -0.0418164
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0411506
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0411292
RLF rearranged L-myc fusion -0.0402271
SBF2 SET binding factor 2 -0.039922
RPS2 ribosomal protein S2 -0.0396536
BCL2L1 BCL2-like 1 -0.0394162
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0389237
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0388626
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0381044
KDM6A lysine (K)-specific demethylase 6A -0.0373692
KIAA1217 KIAA1217 -0.0371649
WASF2 WAS protein family, member 2 -0.036415
PDK3 pyruvate dehydrogenase kinase, isozyme 3 -0.0363908
NPEPPS aminopeptidase puromycin sensitive -0.0363755
COG5 component of oligomeric golgi complex 5 -0.0362225
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.036068
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 -0.0354787
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0353881
PLAT plasminogen activator, tissue -0.0352634
NCOA3 nuclear receptor coactivator 3 -0.0352319
SEC31A SEC31 homolog A (S. cerevisiae) -0.0351576
ACBD3 acyl-CoA binding domain containing 3 -0.0348477
PDLIM1 PDZ and LIM domain 1 -0.0346968
MARCHF6 membrane associated ring-CH-type finger 6 -0.0345544
YBX3 Y box binding protein 3 -0.0340695
ARHGAP29 Rho GTPase activating protein 29 -0.0340476
BRWD3 bromodomain and WD repeat domain containing 3 -0.033878
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.033593
BZW2 basic leucine zipper and W2 domains 2 -0.0333521
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0332331
SKIC3 SKI3 subunit of superkiller complex -0.0326952
ESYT2 extended synaptotagmin-like protein 2 -0.0326201
METTL15 methyltransferase like 15 -0.0323443
KTN1 kinectin 1 (kinesin receptor) -0.0322589
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0321301
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0320683
EMP1 epithelial membrane protein 1 -0.0319587
CALU calumenin -0.0319411
FNIP1 folliculin interacting protein 1 -0.031826
PNISR PNN-interacting serine/arginine-rich protein -0.0315495
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0315143
PDGFB platelet-derived growth factor beta polypeptide -0.0312605
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0310644
RIN2 Ras and Rab interactor 2 -0.0310638
CENPF centromere protein F, 350/400kDa -0.0307953
NKTR natural killer cell triggering receptor -0.0304852
LMAN1 lectin, mannose-binding, 1 -0.0304641
SRP54 signal recognition particle 54kDa -0.0303903
DLG1 discs, large homolog 1 (Drosophila) -0.030135
CD99 CD99 molecule -0.0301099
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0298584
RNF19B ring finger protein 19B -0.0296448
COPA coatomer protein complex, subunit alpha -0.0292983
COG6 component of oligomeric golgi complex 6 -0.0292353
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 -0.0291212
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.029013
CKAP5 cytoskeleton associated protein 5 -0.0289569
HELZ helicase with zinc finger -0.0283448
ASPH aspartate beta-hydroxylase -0.0282924
WSB1 WD repeat and SOCS box containing 1 -0.0281709
KDM5B lysine (K)-specific demethylase 5B -0.0281097
CKAP2 cytoskeleton associated protein 2 -0.0279633