NVP-BHG712_KATO III Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description NVP-BHG712 perturbation in KATO III cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the NVP-BHG712_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0736436
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0724825
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.072313
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0639259
GOLGA4 golgin A4 0.0632234
LOC112694756 uncharaterized LOC112694756 0.0628015
PDIA3 protein disulfide isomerase family A, member 3 0.0588885
SEPTIN9 septin 9 0.05653
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0544176
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0535734
EIF1 eukaryotic translation initiation factor 1 0.0464711
AKAP9 A kinase (PRKA) anchor protein 9 0.0463187
PLEC plectin 0.0460519
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0448578
CALR calreticulin 0.0442295
PDIA6 protein disulfide isomerase family A, member 6 0.0405393
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0403774
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.040021
HYOU1 hypoxia up-regulated 1 0.0386632
EZR ezrin 0.0379934
AKAP13 A kinase (PRKA) anchor protein 13 0.0378959
AVL9 AVL9 homolog (S. cerevisiase) 0.0373273
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0368313
FTL ferritin, light polypeptide 0.0368293
SNX9 sorting nexin 9 0.0358282
S100A6 S100 calcium binding protein A6 0.0350313
KRT18 keratin 18, type I 0.0339359
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0335778
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0335425
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0329992
RTN4 reticulon 4 0.032302
ANXA2 annexin A2 0.0321577
FTH1 ferritin, heavy polypeptide 1 0.031362
GARS1 glycyl-tRNA synthetase 1 0.03092
UBE2H ubiquitin-conjugating enzyme E2H 0.0302742
B2M beta-2-microglobulin 0.0301892
NDRG1 N-myc downstream regulated 1 0.0300234
POTEF POTE ankyrin domain family, member F 0.0298916
BCL2L1 BCL2-like 1 0.0293093
PICALM phosphatidylinositol binding clathrin assembly protein 0.0291748
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.029145
EEF2 eukaryotic translation elongation factor 2 0.029041
MUC17 mucin 17, cell surface associated 0.028552
FAT1 FAT atypical cadherin 1 0.0284916
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0283554
TMC5 transmembrane channel-like 5 0.0283043
ADAM9 ADAM metallopeptidase domain 9 0.0282521
MACC1 metastasis associated in colon cancer 1 0.0281292
RPS25 ribosomal protein S25 0.0280519
DSTN destrin (actin depolymerizing factor) 0.0280336
TPM4 tropomyosin 4 0.0279821
TXNRD1 thioredoxin reductase 1 0.0272072
ARCN1 archain 1 0.0270907
HKDC1 hexokinase domain containing 1 0.0270255
LYZ lysozyme 0.0269267
MYH9 myosin, heavy chain 9, non-muscle 0.0261294
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0259657
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0259421
EMP1 epithelial membrane protein 1 0.0259317
EIF4A2 eukaryotic translation initiation factor 4A2 0.0258323
RAB6A RAB6A, member RAS oncogene family 0.0257487
SMAD3 SMAD family member 3 0.02562
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.025456
ARHGAP42 Rho GTPase activating protein 42 0.025384
CLDN7 claudin 7 0.025144
TES testin LIM domain protein 0.0250154
SRP54 signal recognition particle 54kDa 0.0249585
ESRP1 epithelial splicing regulatory protein 1 0.0249032
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0248183
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0244893
TMF1 TATA element modulatory factor 1 0.0243636
CLTC clathrin, heavy chain (Hc) 0.0243085
DSPP dentin sialophosphoprotein 0.0239601
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0239009
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.0236737
MBNL2 muscleblind-like splicing regulator 2 0.0232579
RPL39 ribosomal protein L39 0.0231172
PKM pyruvate kinase, muscle 0.0230269
SPINT2 serine peptidase inhibitor, Kunitz type, 2 0.0228455
PCBP2 poly(rC) binding protein 2 0.0227728
IQGAP1 IQ motif containing GTPase activating protein 1 0.0226037
RPS12 ribosomal protein S12 0.0225758
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.022462
EXT1 exostosin glycosyltransferase 1 0.022311
CALU calumenin 0.0219142
STK24 serine/threonine kinase 24 0.0218496
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0217825
MANF mesencephalic astrocyte-derived neurotrophic factor 0.0215892
LIPH lipase, member H 0.0215397
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0212861
KIDINS220 kinase D-interacting substrate, 220kDa 0.021188
KTN1 kinectin 1 (kinesin receptor) 0.0209115
BPTF bromodomain PHD finger transcription factor 0.020836
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 0.0208184
UBC ubiquitin C 0.0206093
ZFAND3 zinc finger, AN1-type domain 3 0.0205339
HDLBP high density lipoprotein binding protein 0.0204507
RHOA ras homolog family member A 0.0203137
LDHA lactate dehydrogenase A 0.0202441
SEC31A SEC31 homolog A (S. cerevisiae) 0.0197997

decreased expression

Symbol Name Standardized Value
NPSR1 neuropeptide S receptor 1 -0.203784
FGFR2 fibroblast growth factor receptor 2 -0.175449
GMDS GDP-mannose 4,6-dehydratase -0.162527
MAML2 mastermind-like 2 (Drosophila) -0.0928414
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0544297
EHBP1 EH domain binding protein 1 -0.0538813
ATF7IP2 activating transcription factor 7 interacting protein 2 -0.0487225
CDK6 cyclin-dependent kinase 6 -0.0475993
KLF5 Kruppel-like factor 5 (intestinal) -0.0447878
TMSB10 thymosin beta 10 -0.0441188
RUNX1 runt-related transcription factor 1 -0.0436027
LMO7 LIM domain 7 -0.0416029
TRPS1 trichorhinophalangeal syndrome I -0.0411156
PTMA prothymosin, alpha -0.0408142
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0381019
TFRC transferrin receptor -0.0372875
CEMIP cell migration inducing protein, hyaluronan binding -0.036136
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.034603
INTS6 integrator complex subunit 6 -0.0342276
POF1B premature ovarian failure, 1B -0.0324747
LCN2 lipocalin 2 -0.0319768
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.0314186
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0309029
DIAPH2 diaphanous-related formin 2 -0.0291107
ATXN1 ataxin 1 -0.0284334
ARHGAP32 Rho GTPase activating protein 32 -0.0271627
CATSPERB catsper channel auxiliary subunit beta -0.0267925
IFRD1 interferon-related developmental regulator 1 -0.026004
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0258506
PTPRK protein tyrosine phosphatase, receptor type, K -0.0255654
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.0244049
H1-0 H1.0 linker histone -0.0241972
KRT8 keratin 8, type II -0.0241756
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0236537
ANO1 anoctamin 1, calcium activated chloride channel -0.0234395
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 -0.0230378
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -0.0228252
ANLN anillin, actin binding protein -0.021869
TM4SF1 transmembrane 4 L six family member 1 -0.0216914
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0216626
DIAPH3 diaphanous-related formin 3 -0.0211071
ECT2 epithelial cell transforming 2 -0.0208572
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0206785
SLC25A51 solute carrier family 25, member 51 -0.0205747
MTUS1 microtubule associated tumor suppressor 1 -0.0201576
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 -0.0199942
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0198096
ADAM32 ADAM metallopeptidase domain 32 -0.0197021
FUS FUS RNA binding protein -0.0194255
EYA2 EYA transcriptional coactivator and phosphatase 2 -0.0194251
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -0.0193761
SOX4 SRY (sex determining region Y)-box 4 -0.0192906
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit -0.0191125
RBM39 RNA binding motif protein 39 -0.0189768
E2F3 E2F transcription factor 3 -0.0189124
AHR aryl hydrocarbon receptor -0.0187617
COTL1 coactosin-like F-actin binding protein 1 -0.0186937
SPATA13 spermatogenesis associated 13 -0.0185205
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0184812
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.0183634
TNIK TRAF2 and NCK interacting kinase -0.0183098
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0179937
EFNB2 ephrin-B2 -0.0179264
WWOX WW domain containing oxidoreductase -0.0177403
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0177081
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0175932
PTPRB protein tyrosine phosphatase, receptor type, B -0.0169548
SP100 SP100 nuclear antigen -0.0169057
RPL38 ribosomal protein L38 -0.0166217
HMGB1 high mobility group box 1 -0.0164636
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0162831
ARHGAP6 Rho GTPase activating protein 6 -0.0160116
XYLT1 xylosyltransferase I -0.0158177
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0156988
TAS2R14 taste receptor, type 2, member 14 -0.0156734
TLE4 transducin-like enhancer of split 4 -0.0155366
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0155111
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0154548
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0152972
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0151724
LMNA lamin A/C -0.0151569
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0150843
MED13 mediator complex subunit 13 -0.0149293
PRKCA protein kinase C, alpha -0.0148808
SPIDR scaffolding protein involved in DNA repair -0.0147492
BACE2 beta-site APP-cleaving enzyme 2 -0.0145692
AUTS2 autism susceptibility candidate 2 -0.014569
TIAM2 T-cell lymphoma invasion and metastasis 2 -0.0143958
YAP1 Yes-associated protein 1 -0.0142968
IGSF9B immunoglobulin superfamily, member 9B -0.0141786
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) -0.014067
DEK DEK proto-oncogene -0.0140508
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0139855
RFC3 replication factor C (activator 1) 3, 38kDa -0.0139455
RRM2 ribonucleotide reductase M2 -0.0138962
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 -0.0138323
XAF1 XIAP associated factor 1 -0.013771
NABP1 nucleic acid binding protein 1 -0.0137688
DGKH diacylglycerol kinase, eta -0.0137597
PEAK1 pseudopodium-enriched atypical kinase 1 -0.0136795