NVP-BHG712_LOX-IMVI Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description NVP-BHG712 perturbation in LOX-IMVI cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the NVP-BHG712_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0459458
LOC112694756 uncharaterized LOC112694756 0.0405183
EEF2 eukaryotic translation elongation factor 2 0.0390679
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0370573
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0362881
EFNA5 ephrin-A5 0.0344497
DTNA dystrobrevin, alpha 0.0341387
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.031491
INTS6 integrator complex subunit 6 0.0294342
HSPA8 heat shock 70kDa protein 8 0.0293534
SAMD4A sterile alpha motif domain containing 4A 0.0286041
MCL1 myeloid cell leukemia 1 0.0277876
FLNA filamin A, alpha 0.0273689
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0262237
MYO10 myosin X 0.0255534
MYH9 myosin, heavy chain 9, non-muscle 0.0238867
TRIO trio Rho guanine nucleotide exchange factor 0.0225314
GLS2 glutaminase 2 (liver, mitochondrial) 0.0223891
ZSWIM6 zinc finger, SWIM-type containing 6 0.0218733
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0207266
PLEC plectin 0.020457
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0196791
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0193158
FRMD6 FERM domain containing 6 0.0188081
RPL3 ribosomal protein L3 0.0187291
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0186932
CORO1C coronin, actin binding protein, 1C 0.0173168
LDHA lactate dehydrogenase A 0.0173071
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0170378
ERRFI1 ERBB receptor feedback inhibitor 1 0.016282
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0162328
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0160478
MARCHF4 membrane associated ring-CH-type finger 4 0.0159676
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0158987
TRIP12 thyroid hormone receptor interactor 12 0.0158477
PRKCE protein kinase C, epsilon 0.0156102
PBX3 pre-B-cell leukemia homeobox 3 0.0154391
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0147655
MSN moesin 0.0145699
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0144353
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0143805
ASPH aspartate beta-hydroxylase 0.0142084
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0141595
MCTP1 multiple C2 domains, transmembrane 1 0.0141289
NAV1 neuron navigator 1 0.0139964
PICALM phosphatidylinositol binding clathrin assembly protein 0.0138315
HDAC9 histone deacetylase 9 0.0137465
APLP2 amyloid beta (A4) precursor-like protein 2 0.0132707
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0132407
HMGA2 high mobility group AT-hook 2 0.0132376
TPM3 tropomyosin 3 0.0130721
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0130429
EIF4H eukaryotic translation initiation factor 4H 0.0126146
NUP58 nucleoporin 58 0.0126091
ACTN1 actinin, alpha 1 0.0125705
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0124769
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0123963
RUNX1 runt-related transcription factor 1 0.0122001
NABP1 nucleic acid binding protein 1 0.0121711
PRRC2A proline-rich coiled-coil 2A 0.0119569
ADAM32 ADAM metallopeptidase domain 32 0.011955
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.011935
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0119293
FNDC3B fibronectin type III domain containing 3B 0.0117255
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0116771
AHNAK AHNAK nucleoprotein 0.0115254
BCAR3 breast cancer anti-estrogen resistance 3 0.010999
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.010864
EXT1 exostosin glycosyltransferase 1 0.0108252
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0107971
TLE4 transducin-like enhancer of split 4 0.0107844
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0105686
EPG5 ectopic P-granules autophagy protein 5 homolog (C. elegans) 0.0104679
ANO6 anoctamin 6 0.0104493
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0102013
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0100587
EIF4B eukaryotic translation initiation factor 4B 0.0099488
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.00981192
LPP LIM domain containing preferred translocation partner in lipoma 0.00957203
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 0.00950502
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 0.0094969
CUL3 cullin 3 0.00938843
IPO7 importin 7 0.00935205
AEBP2 AE binding protein 2 0.00927291
NCOR2 nuclear receptor corepressor 2 0.00917724
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.00915655
RPS18 ribosomal protein S18 0.00907083
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.00902452
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.00900286
SFPQ splicing factor proline/glutamine-rich 0.00897596
SRRM2 serine/arginine repetitive matrix 2 0.00895923
EIF3H eukaryotic translation initiation factor 3, subunit H 0.00895364
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.00894471
SDCCAG8 serologically defined colon cancer antigen 8 0.00890346
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.00881367
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0088133
PRELID2 PRELI domain containing 2 0.00880501
AGO2 argonaute RISC catalytic component 2 0.00874955
DOCK1 dedicator of cytokinesis 1 0.00873868
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.00873195

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.133224
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0849634
TMSB10 thymosin beta 10 -0.0571846
RPS6 ribosomal protein S6 -0.0535958
TPT1 tumor protein, translationally-controlled 1 -0.0362376
PTMA prothymosin, alpha -0.0329321
MMP12 matrix metallopeptidase 12 -0.0300961
AKAP12 A kinase (PRKA) anchor protein 12 -0.0300649
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0279542
MT2A metallothionein 2A -0.0264911
LSAMP limbic system-associated membrane protein -0.0241203
FTL ferritin, light polypeptide -0.0211238
C2CD2 C2 calcium-dependent domain containing 2 -0.0205958
RPLP1 ribosomal protein, large, P1 -0.0196953
RPL35A ribosomal protein L35a -0.0189981
TXNRD1 thioredoxin reductase 1 -0.0180967
IFI16 interferon, gamma-inducible protein 16 -0.0180923
RPL8 ribosomal protein L8 -0.0172369
WSB1 WD repeat and SOCS box containing 1 -0.0162031
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0159275
RPLP2 ribosomal protein, large, P2 -0.0156851
KPNB1 karyopherin (importin) beta 1 -0.0154911
CAVIN1 caveolae associated protein 1 -0.0153472
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0152178
RPS19 ribosomal protein S19 -0.0150169
GNAS GNAS complex locus -0.0147737
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0143912
NAP1L1 nucleosome assembly protein 1-like 1 -0.014391
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0139629
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0138787
TPM4 tropomyosin 4 -0.0137235
RPL36A ribosomal protein L36a -0.0126363
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.012539
ENKUR enkurin, TRPC channel interacting protein -0.0125179
RBMS1 RNA binding motif, single stranded interacting protein 1 -0.0123028
RPS27A ribosomal protein S27a -0.0122784
KIAA1217 KIAA1217 -0.0120852
PRKG1 protein kinase, cGMP-dependent, type I -0.0119304
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0118985
RPS8 ribosomal protein S8 -0.0118193
EIF5B eukaryotic translation initiation factor 5B -0.0117836
PGK1 phosphoglycerate kinase 1 -0.0115387
RPS24 ribosomal protein S24 -0.0115183
RPL38 ribosomal protein L38 -0.0114755
RPL31 ribosomal protein L31 -0.0112507
TNNC1 troponin C type 1 (slow) -0.01122
ARHGAP18 Rho GTPase activating protein 18 -0.0111539
MAP4 microtubule-associated protein 4 -0.0110944
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0110938
RPL12 ribosomal protein L12 -0.0110937
SCAF11 SR-related CTD-associated factor 11 -0.010979
PHACTR1 phosphatase and actin regulator 1 -0.0109436
RBM25 RNA binding motif protein 25 -0.0109018
RPL28 ribosomal protein L28 -0.0106655
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0106588
HAS2 hyaluronan synthase 2 -0.0105529
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0105004
NRP2 neuropilin 2 -0.0104185
GCC2 GRIP and coiled-coil domain containing 2 -0.010331
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0102722
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0102323
RPL37A ribosomal protein L37a -0.0102007
SEPTIN7 septin 7 -0.0100721
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0100447
VDAC1 voltage-dependent anion channel 1 -0.00998832
HMGA1 high mobility group AT-hook 1 -0.00989017
CSTB cystatin B (stefin B) -0.00985389
BTG1 B-cell translocation gene 1, anti-proliferative -0.00973788
POTEF POTE ankyrin domain family, member F -0.00962859
PTBP3 polypyrimidine tract binding protein 3 -0.00950871
ANTXR2 anthrax toxin receptor 2 -0.00947995
HMGB1 high mobility group box 1 -0.00945401
YBX3 Y box binding protein 3 -0.00944367
RPS29 ribosomal protein S29 -0.00932684
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.00922847
RPL9 ribosomal protein L9 -0.00883885
UGCG UDP-glucose ceramide glucosyltransferase -0.00881266
RPS15 ribosomal protein S15 -0.00871884
RPL32 ribosomal protein L32 -0.00867336
KMT2A lysine (K)-specific methyltransferase 2A -0.00866294
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.00861973
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.00861499
LMAN1 lectin, mannose-binding, 1 -0.00857129
ZMYND8 zinc finger, MYND-type containing 8 -0.00854312
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.00854246
PFN1 profilin 1 -0.00850926
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.00850797
RPL36 ribosomal protein L36 -0.00850589
RPL26 ribosomal protein L26 -0.00848845
RPLP0 ribosomal protein, large, P0 -0.00842795
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.00842194
RPL7A ribosomal protein L7a -0.00833394
KANK1 KN motif and ankyrin repeat domains 1 -0.00818312
PNISR PNN-interacting serine/arginine-rich protein -0.00816694
MTDH metadherin -0.00810371
RPS25 ribosomal protein S25 -0.00810364
TTC3 tetratricopeptide repeat domain 3 -0.00809348
RPS16 ribosomal protein S16 -0.00807228
CDH13 cadherin 13 -0.00799323
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.00789721