NVP-BHG712_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description NVP-BHG712 perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the NVP-BHG712_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.139594
TMSB10 thymosin beta 10 0.0938014
ACTG1 actin gamma 1 0.0910124
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0905427
MUC6 mucin 6, oligomeric mucus/gel-forming 0.086408
RPS12 ribosomal protein S12 0.0832596
RPS8 ribosomal protein S8 0.0725956
RPL35A ribosomal protein L35a 0.0723649
RPS6 ribosomal protein S6 0.0713113
TPT1 tumor protein, translationally-controlled 1 0.0653769
RPS3 ribosomal protein S3 0.0604039
FTL ferritin, light polypeptide 0.0586419
PTMA prothymosin, alpha 0.0580903
MYO1E myosin IE 0.0567311
RPL37A ribosomal protein L37a 0.0557438
B2M beta-2-microglobulin 0.0552204
RPS19 ribosomal protein S19 0.0537642
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 0.053073
RPL31 ribosomal protein L31 0.0474763
KTN1 kinectin 1 (kinesin receptor) 0.0474443
LOC102724023 ES1 protein homolog, mitochondrial 0.0465238
EEF2 eukaryotic translation elongation factor 2 0.046357
HSPA8 heat shock 70kDa protein 8 0.0450119
ENO1 enolase 1, (alpha) 0.0446657
MT2A metallothionein 2A 0.043785
LOC112694756 uncharaterized LOC112694756 0.0434285
SRRM2 serine/arginine repetitive matrix 2 0.0431028
RPL9 ribosomal protein L9 0.0429661
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0418371
RPL34 ribosomal protein L34 0.0414276
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0410502
RPL36 ribosomal protein L36 0.0400642
RPL23 ribosomal protein L23 0.03831
FAT1 FAT atypical cadherin 1 0.037781
TPM4 tropomyosin 4 0.0370566
MBNL1 muscleblind-like splicing regulator 1 0.0365701
EZR ezrin 0.0365043
EGFR epidermal growth factor receptor 0.0357829
RPS13 ribosomal protein S13 0.0353277
RPL19 ribosomal protein L19 0.0352763
RPS17 ribosomal protein S17 0.0351794
RAD51B RAD51 paralog B 0.035176
VCL vinculin 0.0342672
RPL37 ribosomal protein L37 0.0338499
RPS27 ribosomal protein S27 0.0338078
RPS27A ribosomal protein S27a 0.0333103
RPLP1 ribosomal protein, large, P1 0.0332141
RPL11 ribosomal protein L11 0.0314715
TUBB4B tubulin, beta 4B class IVb 0.031016
VEGFA vascular endothelial growth factor A 0.0309364
RPL12 ribosomal protein L12 0.0304048
RPS14 ribosomal protein S14 0.0303457
EPHB2 EPH receptor B2 0.0301581
SLC38A2 solute carrier family 38, member 2 0.0300112
RPL7 ribosomal protein L7 0.0299874
EXT1 exostosin glycosyltransferase 1 0.0297159
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0296139
RACK1 receptor for activated C kinase 1 0.0290584
RPL27 ribosomal protein L27 0.0288271
LGALS3 lectin, galactoside-binding, soluble, 3 0.0285134
POTEF POTE ankyrin domain family, member F 0.0276916
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0276248
TPI1 triosephosphate isomerase 1 0.0270163
RPL26 ribosomal protein L26 0.0269381
PDLIM5 PDZ and LIM domain 5 0.0268391
LMNA lamin A/C 0.0267828
AFF1 AF4/FMR2 family, member 1 0.0265131
RPS25 ribosomal protein S25 0.0265004
MYH14 myosin, heavy chain 14, non-muscle 0.0263032
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0262297
DSPP dentin sialophosphoprotein 0.0259597
ENO2 enolase 2 (gamma, neuronal) 0.0257748
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0248094
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0242916
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0239922
S100A6 S100 calcium binding protein A6 0.0228535
PRDX2 peroxiredoxin 2 0.0227974
PA2G4 proliferation-associated 2G4, 38kDa 0.022781
ISG15 ISG15 ubiquitin-like modifier 0.0227476
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0225311
MLEC malectin 0.0223619
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.022155
RPL18 ribosomal protein L18 0.0219977
JUN jun proto-oncogene 0.0219295
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.0217882
RPS29 ribosomal protein S29 0.0217768
COX4I1 cytochrome c oxidase subunit IV isoform 1 0.0217491
MARCHF3 membrane associated ring-CH-type finger 3 0.0215114
RPL3 ribosomal protein L3 0.0214878
SOX4 SRY (sex determining region Y)-box 4 0.0213239
MCL1 myeloid cell leukemia 1 0.0212523
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0211276
SPTBN1 spectrin, beta, non-erythrocytic 1 0.020913
RHOA ras homolog family member A 0.0208921
RPLP2 ribosomal protein, large, P2 0.0208651
SOX9 SRY (sex determining region Y)-box 9 0.0208275
RPLP0 ribosomal protein, large, P0 0.0206013
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0205226
PTPRK protein tyrosine phosphatase, receptor type, K 0.0203319
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0203168

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.195234
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.100188
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0960334
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0960306
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0859254
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0712615
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0700423
GOLGA4 golgin A4 -0.0656544
RNF43 ring finger protein 43 -0.0642915
EREG epiregulin -0.0641374
FAM13A family with sequence similarity 13, member A -0.0573043
ZFAND3 zinc finger, AN1-type domain 3 -0.0548178
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0515912
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.0513986
GPHN gephyrin -0.0501754
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.0480676
MON2 MON2 homolog (S. cerevisiae) -0.0443135
KDM3A lysine (K)-specific demethylase 3A -0.0433527
COG5 component of oligomeric golgi complex 5 -0.0423214
OGA O-GlcNAcase -0.0421403
PRSS3 protease, serine, 3 -0.0418034
RBM39 RNA binding motif protein 39 -0.0409974
ARHGAP32 Rho GTPase activating protein 32 -0.0404434
MED13L mediator complex subunit 13-like -0.0403277
ZNF292 zinc finger protein 292 -0.0401312
H1-0 H1.0 linker histone -0.0394579
CD46 CD46 molecule, complement regulatory protein -0.0381324
TNS4 tensin 4 -0.0378536
NDRG1 N-myc downstream regulated 1 -0.0376685
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0369843
INSIG1 insulin induced gene 1 -0.0365995
BTBD9 BTB (POZ) domain containing 9 -0.0356831
NPSR1 neuropeptide S receptor 1 -0.0350886
TRIM2 tripartite motif containing 2 -0.0343553
BIRC6 baculoviral IAP repeat containing 6 -0.0335594
USP3 ubiquitin specific peptidase 3 -0.0333542
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0326268
PPARG peroxisome proliferator-activated receptor gamma -0.0319569
RNF145 ring finger protein 145 -0.0318386
SEC31A SEC31 homolog A (S. cerevisiae) -0.0316782
MBNL2 muscleblind-like splicing regulator 2 -0.0315525
KDM7A lysine (K)-specific demethylase 7A -0.0313944
DSCAM Down syndrome cell adhesion molecule -0.0308314
SETD5 SET domain containing 5 -0.0299718
TM9SF3 transmembrane 9 superfamily member 3 -0.0297118
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.0293843
PUM2 pumilio RNA-binding family member 2 -0.0291224
ZMYM2 zinc finger, MYM-type 2 -0.0290207
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0288693
SREBF2 sterol regulatory element binding transcription factor 2 -0.0286899
KRT8 keratin 8, type II -0.0286581
ABHD17C abhydrolase domain containing 17C -0.0285817
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0284325
NCOR1 nuclear receptor corepressor 1 -0.028359
DERA deoxyribose-phosphate aldolase (putative) -0.0278686
GSK3B glycogen synthase kinase 3 beta -0.0278581
PTEN phosphatase and tensin homolog -0.0278428
SBF2 SET binding factor 2 -0.0277317
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0276216
FNDC3B fibronectin type III domain containing 3B -0.0273533
NFIA nuclear factor I/A -0.0273214
RAB1A RAB1A, member RAS oncogene family -0.0273038
SERINC5 serine incorporator 5 -0.0271454
ETNK1 ethanolamine kinase 1 -0.0269926
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide -0.026874
PDIA4 protein disulfide isomerase family A, member 4 -0.0266885
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 -0.0264714
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 -0.0263562
NBAS neuroblastoma amplified sequence -0.0262604
MBD5 methyl-CpG binding domain protein 5 -0.0259352
STRN3 striatin, calmodulin binding protein 3 -0.0253944
EHF ets homologous factor -0.0249737
SEC24D SEC24 family member D -0.0246904
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.024621
GCC2 GRIP and coiled-coil domain containing 2 -0.0246058
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0245269
PCCA propionyl CoA carboxylase, alpha polypeptide -0.0245053
COPB1 coatomer protein complex, subunit beta 1 -0.0244387
NF1 neurofibromin 1 -0.0243477
DLG1 discs, large homolog 1 (Drosophila) -0.0243093
PTBP3 polypyrimidine tract binding protein 3 -0.0242684
PTPRR protein tyrosine phosphatase, receptor type, R -0.0241256
BRWD1 bromodomain and WD repeat domain containing 1 -0.0240648
ESRP1 epithelial splicing regulatory protein 1 -0.0239781
CANX calnexin -0.0236829
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0236501
TFRC transferrin receptor -0.02363
GDF15 growth differentiation factor 15 -0.0235117
PRELID2 PRELI domain containing 2 -0.0234666
LCORL ligand dependent nuclear receptor corepressor-like -0.0232995
EXOC1 exocyst complex component 1 -0.0232542
GARS1 glycyl-tRNA synthetase 1 -0.023056
CDH17 cadherin 17, LI cadherin (liver-intestine) -0.0230164
NAMPT nicotinamide phosphoribosyltransferase -0.0228517
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.022652
KLF3 Kruppel-like factor 3 (basic) -0.0226261
RRBP1 ribosome binding protein 1 -0.0224321
SHROOM3 shroom family member 3 -0.0223544
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 -0.0222902
WDFY3 WD repeat and FYVE domain containing 3 -0.0222873