NVP-BHG712_LoVo Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description NVP-BHG712 perturbation in LoVo cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the NVP-BHG712_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.13913
EEF2 eukaryotic translation elongation factor 2 0.127517
RPL3 ribosomal protein L3 0.0948178
RPS12 ribosomal protein S12 0.084108
LOC112694756 uncharaterized LOC112694756 0.0691607
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0649037
PRELID2 PRELI domain containing 2 0.0489335
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.045415
HSPA8 heat shock 70kDa protein 8 0.0436806
RACK1 receptor for activated C kinase 1 0.0435198
PDZD8 PDZ domain containing 8 0.0382126
EEF1G eukaryotic translation elongation factor 1 gamma 0.0378042
NDRG1 N-myc downstream regulated 1 0.0359168
RPL37 ribosomal protein L37 0.0347932
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0333226
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0330584
RPL37A ribosomal protein L37a 0.0327688
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0324716
PTEN phosphatase and tensin homolog 0.0321215
ANXA11 annexin A11 0.0318197
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.031691
RPS17 ribosomal protein S17 0.0310697
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0309546
ITPRID2 ITPR interacting domain containing 2 0.0308009
MYH9 myosin, heavy chain 9, non-muscle 0.0305265
PLEC plectin 0.030104
RPS8 ribosomal protein S8 0.0300907
MCL1 myeloid cell leukemia 1 0.029854
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0291955
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0291774
PCBP2 poly(rC) binding protein 2 0.0280444
SH3RF1 SH3 domain containing ring finger 1 0.0274107
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0262702
RPS20 ribosomal protein S20 0.02542
SAMD5 sterile alpha motif domain containing 5 0.0250908
RPS27 ribosomal protein S27 0.0250656
RNF43 ring finger protein 43 0.0246939
AVL9 AVL9 homolog (S. cerevisiase) 0.0234495
RPS18 ribosomal protein S18 0.0234152
ATXN1 ataxin 1 0.022876
PGM3 phosphoglucomutase 3 0.0228641
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0225275
RPL27 ribosomal protein L27 0.0224574
ZNF292 zinc finger protein 292 0.0220945
AFF1 AF4/FMR2 family, member 1 0.0219875
DST dystonin 0.0218422
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0217502
TPM3 tropomyosin 3 0.0216872
KMT2E lysine (K)-specific methyltransferase 2E 0.0214311
RPS2 ribosomal protein S2 0.0213836
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0212817
UBA6 ubiquitin-like modifier activating enzyme 6 0.0211086
RPL39 ribosomal protein L39 0.0210528
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0208971
SLK STE20-like kinase 0.0205688
ENO1 enolase 1, (alpha) 0.0205082
RPS4X ribosomal protein S4, X-linked 0.0203786
PKM pyruvate kinase, muscle 0.0203786
MLEC malectin 0.0201893
PRPF8 pre-mRNA processing factor 8 0.0201834
FRMD5 FERM domain containing 5 0.0200718
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0200338
AKAP9 A kinase (PRKA) anchor protein 9 0.0199346
RHOA ras homolog family member A 0.0197932
FHL2 four and a half LIM domains 2 0.0194958
ACBD3 acyl-CoA binding domain containing 3 0.0190751
EPHA2 EPH receptor A2 0.0188399
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0183522
WWOX WW domain containing oxidoreductase 0.0182763
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0182316
CALU calumenin 0.0182018
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.0180698
EIF4B eukaryotic translation initiation factor 4B 0.0179229
CD46 CD46 molecule, complement regulatory protein 0.0177616
TNIP1 TNFAIP3 interacting protein 1 0.0176552
RPL7 ribosomal protein L7 0.0174936
GOLPH3 golgi phosphoprotein 3 (coat-protein) 0.0174798
KIAA1671 KIAA1671 0.0174713
OCLN occludin 0.0174111
NUP58 nucleoporin 58 0.0173838
CLIP2 CAP-GLY domain containing linker protein 2 0.0173402
UGCG UDP-glucose ceramide glucosyltransferase 0.0173129
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0172979
BRD2 bromodomain containing 2 0.0169535
RPS25 ribosomal protein S25 0.0168005
ASS1 argininosuccinate synthase 1 0.0167153
FAT1 FAT atypical cadherin 1 0.0167101
OPTN optineurin 0.0166716
TMEM106B transmembrane protein 106B 0.0165795
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0163763
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0163003
CYP2S1 cytochrome P450, family 2, subfamily S, polypeptide 1 0.0162184
MIDEAS mitotic deacetylase associated SANT domain protein 0.0161397
CALR calreticulin 0.0160418
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0160358
SRRM2 serine/arginine repetitive matrix 2 0.0157909
RTN4 reticulon 4 0.0157311
ITGB4 integrin, beta 4 0.0157052
FLNA filamin A, alpha 0.0156766
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3 0.0155957

decreased expression

Symbol Name Standardized Value
THSD4 thrombospondin, type I, domain containing 4 -0.149724
LMO7 LIM domain 7 -0.126245
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.11822
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.111169
FLNB filamin B, beta -0.0888636
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0860124
EPS8 epidermal growth factor receptor pathway substrate 8 -0.075701
PTMA prothymosin, alpha -0.0743711
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0741283
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0736672
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0716955
PTPRB protein tyrosine phosphatase, receptor type, B -0.0705308
PDE4D phosphodiesterase 4D, cAMP-specific -0.0696911
TMSB10 thymosin beta 10 -0.0674833
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0671726
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0670348
MSI2 musashi RNA-binding protein 2 -0.066042
RBM25 RNA binding motif protein 25 -0.065759
PTPRK protein tyrosine phosphatase, receptor type, K -0.0626853
SP100 SP100 nuclear antigen -0.0585077
RIGI RNA sensor RIG-I -0.0571776
ACTG1 actin gamma 1 -0.0565193
GMDS GDP-mannose 4,6-dehydratase -0.0543257
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0542899
B4GALNT3 beta-1,4-N-acetyl-galactosaminyl transferase 3 -0.0517968
LAMA4 laminin, alpha 4 -0.0508118
OXSR1 oxidative stress responsive 1 -0.0505345
IARS1 isoleucyl-tRNA synthetase 1 -0.0503691
MYOF myoferlin -0.0502089
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0501906
PTPRR protein tyrosine phosphatase, receptor type, R -0.0493876
NT5C2 5'-nucleotidase, cytosolic II -0.0487632
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0481837
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0478385
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0471962
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0466725
PTPRG protein tyrosine phosphatase, receptor type, G -0.0458679
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0444184
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0436797
RAP1B RAP1B, member of RAS oncogene family -0.0436404
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0429942
TCF12 transcription factor 12 -0.0427759
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0422858
P3H2 prolyl 3-hydroxylase 2 -0.0420912
MYO1E myosin IE -0.0418342
CATSPERB catsper channel auxiliary subunit beta -0.0416698
RIMKLB ribosomal modification protein rimK-like family member B -0.0413722
FBXO11 F-box protein 11 -0.0411235
AOPEP aminopeptidase O (putative) -0.0411156
YBX3 Y box binding protein 3 -0.0411126
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0405964
PLSCR1 phospholipid scramblase 1 -0.0404055
RAB7A RAB7A, member RAS oncogene family -0.0401407
GCC2 GRIP and coiled-coil domain containing 2 -0.0395367
ANKRD11 ankyrin repeat domain 11 -0.0392078
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0392016
TC2N tandem C2 domains, nuclear -0.0386598
GARS1 glycyl-tRNA synthetase 1 -0.0381043
CYSTM1 cysteine-rich transmembrane module containing 1 -0.0378828
MYO1D myosin ID -0.0378467
RPL32 ribosomal protein L32 -0.0375396
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0370672
SLC38A2 solute carrier family 38, member 2 -0.0369135
MX2 MX dynamin-like GTPase 2 -0.036721
IER3 immediate early response 3 -0.0361429
PATJ PATJ crumbs cell polarity complex component -0.0361395
GDF15 growth differentiation factor 15 -0.0356587
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0356395
XAF1 XIAP associated factor 1 -0.035213
RNF213 ring finger protein 213 -0.0350963
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0350102
SERINC5 serine incorporator 5 -0.0346682
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.0345767
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0338013
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0336814
PALLD palladin, cytoskeletal associated protein -0.0335188
IFRD1 interferon-related developmental regulator 1 -0.0329532
WARS1 tryptophanyl-tRNA synthetase 1 -0.0325583
NAP1L1 nucleosome assembly protein 1-like 1 -0.0323002
MCU mitochondrial calcium uniporter -0.0319964
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0319793
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.031469
IFIH1 interferon induced with helicase C domain 1 -0.031143
ADIPOR2 adiponectin receptor 2 -0.0310621
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0310613
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0310157
EIF1 eukaryotic translation initiation factor 1 -0.0309685
COBL cordon-bleu WH2 repeat protein -0.0303525
RRBP1 ribosome binding protein 1 -0.0303519
TRIM2 tripartite motif containing 2 -0.0299475
KLF5 Kruppel-like factor 5 (intestinal) -0.0291444
RBBP6 retinoblastoma binding protein 6 -0.0291429
PELI1 pellino E3 ubiquitin protein ligase 1 -0.028931
AHCYL2 adenosylhomocysteinase-like 2 -0.0288936
USP15 ubiquitin specific peptidase 15 -0.0288898
GPBP1 GC-rich promoter binding protein 1 -0.0288748
RPL19 ribosomal protein L19 -0.0288393
CUX1 cut-like homeobox 1 -0.028397
VCL vinculin -0.0282607
PHF14 PHD finger protein 14 -0.0280892