| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | NVP-BHG712 perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the NVP-BHG712_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LOC112694756 | uncharaterized LOC112694756 | 0.126911 |
| TXNRD1 | thioredoxin reductase 1 | 0.113233 |
| FAM13A | family with sequence similarity 13, member A | 0.088135 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0866936 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0845228 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0803341 |
| MT2A | metallothionein 2A | 0.0798019 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.074628 |
| SMAD3 | SMAD family member 3 | 0.0666364 |
| ENO1 | enolase 1, (alpha) | 0.0558447 |
| GRAMD1B | GRAM domain containing 1B | 0.0533637 |
| RNF213 | ring finger protein 213 | 0.0494401 |
| LDHA | lactate dehydrogenase A | 0.0475082 |
| ANKRD11 | ankyrin repeat domain 11 | 0.046172 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0445739 |
| ARRDC3 | arrestin domain containing 3 | 0.0439768 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.042444 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0419377 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0406901 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | 0.0406299 |
| MKI67 | marker of proliferation Ki-67 | 0.0403547 |
| PLEC | plectin | 0.0403202 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0402103 |
| RPS3 | ribosomal protein S3 | 0.0398611 |
| ANXA2 | annexin A2 | 0.0393107 |
| PRRC2C | proline-rich coiled-coil 2C | 0.039236 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0362459 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0362162 |
| SMYD3 | SET and MYND domain containing 3 | 0.0359274 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0355915 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0354028 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0346677 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0341328 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0340967 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0336219 |
| SON | SON DNA binding protein | 0.0335044 |
| MYOF | myoferlin | 0.0331117 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | 0.0318113 |
| DSPP | dentin sialophosphoprotein | 0.0314657 |
| TES | testin LIM domain protein | 0.0312097 |
| HDLBP | high density lipoprotein binding protein | 0.030153 |
| YBX3 | Y box binding protein 3 | 0.0296916 |
| ZNF292 | zinc finger protein 292 | 0.0292264 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.029186 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0290697 |
| ATP11A | ATPase, class VI, type 11A | 0.0290681 |
| NTSR1 | neurotensin receptor 1 (high affinity) | 0.0283281 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0275538 |
| TPI1 | triosephosphate isomerase 1 | 0.0270936 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0270539 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0267436 |
| PGK1 | phosphoglycerate kinase 1 | 0.0264087 |
| EFNA5 | ephrin-A5 | 0.0256829 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0252785 |
| ASPH | aspartate beta-hydroxylase | 0.0252463 |
| TPM3 | tropomyosin 3 | 0.0248463 |
| BDP1 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | 0.0248147 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0242358 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0234605 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0234541 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | 0.0233462 |
| KRT18 | keratin 18, type I | 0.0232663 |
| LANCL2 | LanC lantibiotic synthetase component C-like 2 (bacterial) | 0.0231626 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0226585 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0223934 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0220504 |
| FAT1 | FAT atypical cadherin 1 | 0.0220454 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0216285 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0215496 |
| CAV2 | caveolin 2 | 0.0213876 |
| FOXP1 | forkhead box P1 | 0.0213753 |
| MT1X | metallothionein 1X | 0.0213433 |
| LAMA4 | laminin, alpha 4 | 0.0210674 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0209751 |
| AHNAK | AHNAK nucleoprotein | 0.0207987 |
| KRT7 | keratin 7, type II | 0.0207584 |
| RBM25 | RNA binding motif protein 25 | 0.0201362 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0198958 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0198328 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0198163 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0196065 |
| DST | dystonin | 0.0194965 |
| GSTP1 | glutathione S-transferase pi 1 | 0.0193287 |
| DOCK5 | dedicator of cytokinesis 5 | 0.019315 |
| IRS2 | insulin receptor substrate 2 | 0.0190684 |
| SEC61G | Sec61 gamma subunit | 0.0189959 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0189664 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0189563 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0188668 |
| TPD52 | tumor protein D52 | 0.0185334 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0182808 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0181169 |
| LAMB3 | laminin, beta 3 | 0.0180431 |
| FAM107B | family with sequence similarity 107, member B | 0.0177259 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0176201 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0174787 |
| REL | v-rel avian reticuloendotheliosis viral oncogene homolog | 0.017157 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.017131 |
| AFDN | afadin, adherens junction formation factor | 0.0169575 |
| EGFR | epidermal growth factor receptor | 0.0168913 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.44282 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0879548 |
| INTS6 | integrator complex subunit 6 | -0.0834255 |
| MCL1 | myeloid cell leukemia 1 | -0.0776342 |
| PTMA | prothymosin, alpha | -0.0750845 |
| TMSB10 | thymosin beta 10 | -0.0676321 |
| S100A10 | S100 calcium binding protein A10 | -0.0648132 |
| RPS25 | ribosomal protein S25 | -0.0625164 |
| WASF2 | WAS protein family, member 2 | -0.0557799 |
| RPS23 | ribosomal protein S23 | -0.0549467 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0534418 |
| NABP1 | nucleic acid binding protein 1 | -0.0500424 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | -0.0496948 |
| FTL | ferritin, light polypeptide | -0.0451664 |
| RPS24 | ribosomal protein S24 | -0.0435011 |
| EGR1 | early growth response 1 | -0.0400068 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.038989 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0377426 |
| RAB7A | RAB7A, member RAS oncogene family | -0.034672 |
| FBXO11 | F-box protein 11 | -0.0343233 |
| VCL | vinculin | -0.0343177 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0331164 |
| MYO1D | myosin ID | -0.0322095 |
| RPS29 | ribosomal protein S29 | -0.0321572 |
| MAP3K13 | mitogen-activated protein kinase kinase kinase 13 | -0.031212 |
| RPS6 | ribosomal protein S6 | -0.0311687 |
| FUS | FUS RNA binding protein | -0.0307755 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0303379 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0299441 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0298737 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0293268 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0291014 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0286057 |
| UBC | ubiquitin C | -0.028089 |
| KDM3B | lysine (K)-specific demethylase 3B | -0.0268634 |
| NSUN6 | NOP2/Sun domain family, member 6 | -0.0267562 |
| VMP1 | vacuole membrane protein 1 | -0.0266802 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0264285 |
| HOMER1 | homer scaffolding protein 1 | -0.0263514 |
| RPS8 | ribosomal protein S8 | -0.0261555 |
| ATG7 | autophagy related 7 | -0.0260442 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.024973 |
| SPIRE1 | spire-type actin nucleation factor 1 | -0.024635 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0245258 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0243872 |
| USP34 | ubiquitin specific peptidase 34 | -0.0243773 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0240029 |
| RPLP2 | ribosomal protein, large, P2 | -0.02392 |
| RPS11 | ribosomal protein S11 | -0.0238473 |
| RCOR1 | REST corepressor 1 | -0.0235668 |
| IER3 | immediate early response 3 | -0.0234717 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0233535 |
| RPS15 | ribosomal protein S15 | -0.0231645 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0227639 |
| MYO1E | myosin IE | -0.0224724 |
| CYSTM1 | cysteine-rich transmembrane module containing 1 | -0.0223659 |
| TRAF3 | TNF receptor-associated factor 3 | -0.0220367 |
| RPL31 | ribosomal protein L31 | -0.0219 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0216994 |
| RPS16 | ribosomal protein S16 | -0.0215679 |
| FAM193A | family with sequence similarity 193, member A | -0.0214986 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0213982 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | -0.0209107 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0205546 |
| RPL8 | ribosomal protein L8 | -0.0205051 |
| CCNI | cyclin I | -0.0204972 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | -0.0203484 |
| ZNF609 | zinc finger protein 609 | -0.020169 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0199898 |
| TMEM184B | transmembrane protein 184B | -0.0196915 |
| UBE2B | ubiquitin-conjugating enzyme E2B | -0.0196778 |
| MAGT1 | magnesium transporter 1 | -0.0196222 |
| TUFT1 | tuftelin 1 | -0.0195959 |
| ENSA | endosulfine alpha | -0.019391 |
| SETD5 | SET domain containing 5 | -0.0192823 |
| RPLP1 | ribosomal protein, large, P1 | -0.0190898 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0188707 |
| COG5 | component of oligomeric golgi complex 5 | -0.0188253 |
| AGO3 | argonaute RISC catalytic component 3 | -0.0186271 |
| UPP1 | uridine phosphorylase 1 | -0.0185095 |
| MCU | mitochondrial calcium uniporter | -0.0184916 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0183967 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0183285 |
| HMGA1 | high mobility group AT-hook 1 | -0.0182964 |
| ATP5MG | ATP synthase membrane subunit g | -0.0182686 |
| GOSR2 | golgi SNAP receptor complex member 2 | -0.0182521 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | -0.0181497 |
| KRT8 | keratin 8, type II | -0.0180269 |
| AGR2 | anterior gradient 2 | -0.0178185 |
| ADAM32 | ADAM metallopeptidase domain 32 | -0.0178029 |
| SETX | senataxin | -0.0174309 |
| RPL36A | ribosomal protein L36a | -0.0173746 |
| CD163L1 | CD163 molecule-like 1 | -0.0173457 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0173277 |
| CUX1 | cut-like homeobox 1 | -0.0173161 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0169488 |
| KIAA1217 | KIAA1217 | -0.0169032 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0165412 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | -0.016457 |
| TMBIM1 | transmembrane BAX inhibitor motif containing 1 | -0.0163985 |
