NVP-BHG712_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description NVP-BHG712 perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the NVP-BHG712_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.313659
IGFBP3 insulin-like growth factor binding protein 3 0.0693224
EEF2 eukaryotic translation elongation factor 2 0.0527461
SMOC1 SPARC related modular calcium binding 1 0.0482222
FTH1 ferritin, heavy polypeptide 1 0.0467051
RPL37A ribosomal protein L37a 0.0464943
MCL1 myeloid cell leukemia 1 0.0460101
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0422362
NDRG1 N-myc downstream regulated 1 0.0418981
RPS12 ribosomal protein S12 0.0408547
RPS17 ribosomal protein S17 0.0374709
RPS3 ribosomal protein S3 0.0323727
POTEF POTE ankyrin domain family, member F 0.0320623
FLNB filamin B, beta 0.0320127
LOC112694756 uncharaterized LOC112694756 0.0317877
TIMP1 TIMP metallopeptidase inhibitor 1 0.0303441
HLA-A major histocompatibility complex, class I, A 0.0292757
B2M beta-2-microglobulin 0.028755
HLA-B major histocompatibility complex, class I, B 0.0281556
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0281184
RPL3 ribosomal protein L3 0.0280104
TPM3 tropomyosin 3 0.0277215
APLP2 amyloid beta (A4) precursor-like protein 2 0.026946
HLA-C major histocompatibility complex, class I, C 0.0262074
RPL31 ribosomal protein L31 0.0258461
RPL36 ribosomal protein L36 0.0256122
KTN1 kinectin 1 (kinesin receptor) 0.0252996
PLEC plectin 0.0249494
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0245737
TMSB10 thymosin beta 10 0.0239403
ANGPTL4 angiopoietin-like 4 0.0235105
SRRM2 serine/arginine repetitive matrix 2 0.0231731
RPL37 ribosomal protein L37 0.0227635
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0227318
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0223255
TPI1 triosephosphate isomerase 1 0.0223143
IGF2 insulin-like growth factor 2 0.0215516
MYH9 myosin, heavy chain 9, non-muscle 0.0213567
AP2M1 adaptor-related protein complex 2, mu 1 subunit 0.0213315
RPS19 ribosomal protein S19 0.0209567
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0205163
RPS8 ribosomal protein S8 0.0202791
LOC102724023 ES1 protein homolog, mitochondrial 0.0201964
FLNA filamin A, alpha 0.0201774
HYOU1 hypoxia up-regulated 1 0.0195888
BRD2 bromodomain containing 2 0.0193905
RPS13 ribosomal protein S13 0.0193752
EPAS1 endothelial PAS domain protein 1 0.0193574
RPS27 ribosomal protein S27 0.0193565
DDIT4 DNA-damage-inducible transcript 4 0.0191986
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0188465
PRRC2A proline-rich coiled-coil 2A 0.0187912
ZSWIM6 zinc finger, SWIM-type containing 6 0.0186817
ACTN1 actinin, alpha 1 0.018329
MAP7 microtubule-associated protein 7 0.0173185
PFN1 profilin 1 0.0172614
RPL19 ribosomal protein L19 0.0171607
ACTG1 actin gamma 1 0.0169768
JUP junction plakoglobin 0.016933
EIF4H eukaryotic translation initiation factor 4H 0.0167673
MSN moesin 0.0167243
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein 0.016578
MT1F metallothionein 1F 0.0162
AKAP12 A kinase (PRKA) anchor protein 12 0.0161984
IDS iduronate 2-sulfatase 0.0158424
CTSL cathepsin L 0.0150757
LAMA5 laminin, alpha 5 0.014904
HSPA8 heat shock 70kDa protein 8 0.0148097
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0145374
TLN1 talin 1 0.0144758
LAMC2 laminin, gamma 2 0.0144255
RCC1 regulator of chromosome condensation 1 0.0144212
PCBP2 poly(rC) binding protein 2 0.0143777
MT1X metallothionein 1X 0.014345
VEGFA vascular endothelial growth factor A 0.0142131
PYGL phosphorylase, glycogen, liver 0.0140636
LGALS1 lectin, galactoside-binding, soluble, 1 0.0139724
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0137957
SH3KBP1 SH3-domain kinase binding protein 1 0.0136403
RPS4X ribosomal protein S4, X-linked 0.013616
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0132755
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.013244
WAC WW domain containing adaptor with coiled-coil 0.0132013
COX4I1 cytochrome c oxidase subunit IV isoform 1 0.0131981
BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2 0.0131214
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0129541
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0128907
DOCK5 dedicator of cytokinesis 5 0.012772
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0126148
LDHA lactate dehydrogenase A 0.0126063
SFPQ splicing factor proline/glutamine-rich 0.0125835
CCL5 chemokine (C-C motif) ligand 5 0.0125531
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0125489
HEBP2 heme binding protein 2 0.012448
HMOX1 heme oxygenase 1 0.012411
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0123659
MIDEAS mitotic deacetylase associated SANT domain protein 0.012306
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 0.0122971
GABARAPL1 GABA(A) receptor-associated protein like 1 0.0122884
YTHDC1 YTH domain containing 1 0.0120845

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.27638
GRAMD1B GRAM domain containing 1B -0.196848
TXNRD1 thioredoxin reductase 1 -0.187647
PDE4D phosphodiesterase 4D, cAMP-specific -0.127627
TFPI2 tissue factor pathway inhibitor 2 -0.109341
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.103322
TM4SF1 transmembrane 4 L six family member 1 -0.0857491
BICC1 BicC family RNA binding protein 1 -0.0667654
RAD21 RAD21 homolog (S. pombe) -0.0628809
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0621776
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0618786
RBM39 RNA binding motif protein 39 -0.0545657
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0542937
ASPH aspartate beta-hydroxylase -0.0540433
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0540023
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0534584
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0527265
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0518426
ZFAND3 zinc finger, AN1-type domain 3 -0.0517937
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0513945
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0499746
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0486753
PM20D1 peptidase M20 domain containing 1 -0.0481227
PTMA prothymosin, alpha -0.0477265
NAMPT nicotinamide phosphoribosyltransferase -0.0473483
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0473044
THSD4 thrombospondin, type I, domain containing 4 -0.0465982
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.045296
HDAC9 histone deacetylase 9 -0.0450086
WWOX WW domain containing oxidoreductase -0.0449696
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0440698
ECT2 epithelial cell transforming 2 -0.0435861
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0425022
NEGR1 neuronal growth regulator 1 -0.0422811
RTN4 reticulon 4 -0.0420445
TPT1 tumor protein, translationally-controlled 1 -0.0405855
FUS FUS RNA binding protein -0.0403966
ZNF292 zinc finger protein 292 -0.0398363
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0387517
DENND4A DENN/MADD domain containing 4A -0.0383017
BIRC3 baculoviral IAP repeat containing 3 -0.0377884
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.037638
ADGRG6 adhesion G protein-coupled receptor G6 -0.0374
MORF4L1 mortality factor 4 like 1 -0.0370811
DST dystonin -0.0368957
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0363732
USP34 ubiquitin specific peptidase 34 -0.0361997
OSMR oncostatin M receptor -0.0361494
PDLIM5 PDZ and LIM domain 5 -0.0358303
FNDC3B fibronectin type III domain containing 3B -0.0356557
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0354175
CYRIB CYFIP related Rac1 interactor B -0.0350443
YBX3 Y box binding protein 3 -0.0345337
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0344335
RPL4 ribosomal protein L4 -0.0344079
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0339859
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0338547
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0337961
MIS18BP1 MIS18 binding protein 1 -0.0336331
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0336072
ANKRD28 ankyrin repeat domain 28 -0.0335421
WDR43 WD repeat domain 43 -0.0335174
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0329307
QKI QKI, KH domain containing, RNA binding -0.0327217
ERBIN erbb2 interacting protein -0.0319359
BABAM2 BRISC and BRCA1 A complex member 2 -0.0318613
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.03167
EIF3H eukaryotic translation initiation factor 3, subunit H -0.0316625
ANLN anillin, actin binding protein -0.0316026
EFNA5 ephrin-A5 -0.0314659
RPS24 ribosomal protein S24 -0.0310288
IER3 immediate early response 3 -0.0309943
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0308926
FGB fibrinogen beta chain -0.0308482
TTC28 tetratricopeptide repeat domain 28 -0.0306154
PTK2 protein tyrosine kinase 2 -0.0304086
RFWD3 ring finger and WD repeat domain 3 -0.0303762
NRG1 neuregulin 1 -0.0300993
TPX2 TPX2, microtubule-associated -0.0295738
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) -0.0295639
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0295574
MYL12B myosin, light chain 12B, regulatory -0.0293532
NNMT nicotinamide N-methyltransferase -0.0291087
SRGN serglycin -0.0290765
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0289688
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.028961
IGF1R insulin-like growth factor 1 receptor -0.0289198
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0288585
AHR aryl hydrocarbon receptor -0.0285879
CENPF centromere protein F, 350/400kDa -0.0283249
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.028132
KDM3A lysine (K)-specific demethylase 3A -0.0281239
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0281237
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.0278237
MARCHF6 membrane associated ring-CH-type finger 6 -0.0277629
AK1 adenylate kinase 1 -0.0276435
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0274114
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0273739
LAMB1 laminin, beta 1 -0.0272278
FBXO11 F-box protein 11 -0.0271739