NVP-BHG712_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description NVP-BHG712 perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the NVP-BHG712_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 0.125094
KYNU kynureninase 0.041964
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0351981
LOC112694756 uncharaterized LOC112694756 0.0337407
PDE4D phosphodiesterase 4D, cAMP-specific 0.033371
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0328434
BACE2 beta-site APP-cleaving enzyme 2 0.0322937
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0312201
TXNRD1 thioredoxin reductase 1 0.0305441
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0294749
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0257613
ERRFI1 ERBB receptor feedback inhibitor 1 0.0257231
SLC38A2 solute carrier family 38, member 2 0.0250768
ATXN1 ataxin 1 0.0246005
NKD1 naked cuticle homolog 1 (Drosophila) 0.0243676
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.023321
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 0.0232532
LIMCH1 LIM and calponin homology domains 1 0.0231328
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.022935
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0226525
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0224607
SAMD4A sterile alpha motif domain containing 4A 0.0223156
PSD3 pleckstrin and Sec7 domain containing 3 0.0221004
DOCK4 dedicator of cytokinesis 4 0.021996
MYOF myoferlin 0.0219542
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0217727
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0213509
CMIP c-Maf inducing protein 0.0210646
MAML3 mastermind-like 3 (Drosophila) 0.0209063
RNF213 ring finger protein 213 0.0208301
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.020127
LMO7 LIM domain 7 0.0201242
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.019252
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0191863
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 0.019085
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.018935
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.0187371
IFITM1 interferon induced transmembrane protein 1 0.0182712
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0179126
ABHD17C abhydrolase domain containing 17C 0.0177058
OSMR oncostatin M receptor 0.0176733
FN1 fibronectin 1 0.0171377
ARHGAP5 Rho GTPase activating protein 5 0.017111
EGFR epidermal growth factor receptor 0.0169107
PRRC2C proline-rich coiled-coil 2C 0.0169089
GPC6 glypican 6 0.0166804
SBNO1 strawberry notch homolog 1 (Drosophila) 0.0166788
VCL vinculin 0.0166702
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 0.0166316
AKAP13 A kinase (PRKA) anchor protein 13 0.0162309
RPS12 ribosomal protein S12 0.0160715
ITPRID2 ITPR interacting domain containing 2 0.0160124
TUSC3 tumor suppressor candidate 3 0.015997
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.015819
CDK13 cyclin-dependent kinase 13 0.0158061
SMYD3 SET and MYND domain containing 3 0.015805
BCAR3 breast cancer anti-estrogen resistance 3 0.0155976
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0155884
BRD2 bromodomain containing 2 0.015456
CDYL chromodomain protein, Y-like 0.0152502
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0151704
SMAD3 SMAD family member 3 0.0151235
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0150989
NRF1 nuclear respiratory factor 1 0.0150389
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0149553
IGF1R insulin-like growth factor 1 receptor 0.0148631
PRKCA protein kinase C, alpha 0.0147444
STK4 serine/threonine kinase 4 0.0147347
RUNX1 runt-related transcription factor 1 0.0144683
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0143911
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0143541
SQSTM1 sequestosome 1 0.014327
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.0142928
SIK3 SIK family kinase 3 0.0142916
YTHDC1 YTH domain containing 1 0.0142889
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0142635
PARD3 par-3 family cell polarity regulator 0.0141839
AGO2 argonaute RISC catalytic component 2 0.013912
SMOC1 SPARC related modular calcium binding 1 0.0139063
DST dystonin 0.0138419
ENO1 enolase 1, (alpha) 0.0136925
MAPK8 mitogen-activated protein kinase 8 0.0136508
RPS16 ribosomal protein S16 0.0135537
TOP1 topoisomerase (DNA) I 0.0132298
ANO6 anoctamin 6 0.0131992
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0131045
METTL15 methyltransferase like 15 0.0130225
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0130204
GOLGA3 golgin A3 0.0128794
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0127383
GLS2 glutaminase 2 (liver, mitochondrial) 0.0127008
ARHGAP21 Rho GTPase activating protein 21 0.0126981
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0125828
EMP1 epithelial membrane protein 1 0.0124157
IRAK2 interleukin-1 receptor-associated kinase 2 0.0123522
LMNA lamin A/C 0.0123181
PTPRK protein tyrosine phosphatase, receptor type, K 0.0122088
NHSL1 NHS-like 1 0.0119537
CAPN2 calpain 2, (m/II) large subunit 0.0119262
DSPP dentin sialophosphoprotein 0.0118468

decreased expression

Symbol Name Standardized Value
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0582521
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0481753
TMSB10 thymosin beta 10 -0.0420542
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0416347
FTL ferritin, light polypeptide -0.0405854
SRPK2 SRSF protein kinase 2 -0.0392656
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0364917
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0359924
DICER1 dicer 1, ribonuclease type III -0.033302
NAMPT nicotinamide phosphoribosyltransferase -0.0324167
TRA2A transformer 2 alpha homolog (Drosophila) -0.0318568
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0315066
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0310663
TPT1 tumor protein, translationally-controlled 1 -0.0294751
GOLGA4 golgin A4 -0.0290146
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0287065
NPTN neuroplastin -0.0276079
LAMB3 laminin, beta 3 -0.0266512
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0261488
PTK2 protein tyrosine kinase 2 -0.0260884
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0258357
OGA O-GlcNAcase -0.025688
H3-3B H3.3 histone B -0.0255316
ACVR1 activin A receptor, type I -0.0252661
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0250779
MARCHF6 membrane associated ring-CH-type finger 6 -0.0249082
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0247661
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0234714
S100A10 S100 calcium binding protein A10 -0.0234157
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0232246
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0224846
PTMA prothymosin, alpha -0.0222204
RAB1A RAB1A, member RAS oncogene family -0.021429
UBC ubiquitin C -0.0208227
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0207256
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.020666
KTN1 kinectin 1 (kinesin receptor) -0.0205421
S100A6 S100 calcium binding protein A6 -0.0204589
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0204573
KDM6A lysine (K)-specific demethylase 6A -0.020457
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0202394
RPS19 ribosomal protein S19 -0.020096
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0200753
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0200402
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0197716
KMT2C lysine (K)-specific methyltransferase 2C -0.0196567
RPS24 ribosomal protein S24 -0.0193305
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0193121
DLG1 discs, large homolog 1 (Drosophila) -0.0192493
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0185643
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0184492
RAB8B RAB8B, member RAS oncogene family -0.0182118
RPL12 ribosomal protein L12 -0.0178109
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0174077
KMT2E lysine (K)-specific methyltransferase 2E -0.0171609
SPAG9 sperm associated antigen 9 -0.0169718
STAU1 staufen double-stranded RNA binding protein 1 -0.0167924
RNF24 ring finger protein 24 -0.0167758
RB1CC1 RB1-inducible coiled-coil 1 -0.0166753
KDM5B lysine (K)-specific demethylase 5B -0.0165495
RNF149 ring finger protein 149 -0.0165471
TMSB4X thymosin beta 4, X-linked -0.0165392
MEF2A myocyte enhancer factor 2A -0.0164708
IFIH1 interferon induced with helicase C domain 1 -0.0164702
CD2AP CD2-associated protein -0.0163567
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 -0.016005
NEK7 NIMA-related kinase 7 -0.0157608
NKTR natural killer cell triggering receptor -0.0156587
RAP1B RAP1B, member of RAS oncogene family -0.0155922
SSH2 slingshot protein phosphatase 2 -0.0155
SLC38A1 solute carrier family 38, member 1 -0.0154247
DENND4C DENN/MADD domain containing 4C -0.0152701
USP9X ubiquitin specific peptidase 9, X-linked -0.0152512
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0151672
NPEPPS aminopeptidase puromycin sensitive -0.0150291
VIM vimentin -0.0148306
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0146329
MTDH metadherin -0.0145411
KRT17 keratin 17, type I -0.0143814
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0143608
GCLC glutamate-cysteine ligase, catalytic subunit -0.0143576
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0142819
FNDC3A fibronectin type III domain containing 3A -0.0142745
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0139882
TXNIP thioredoxin interacting protein -0.0138999
TNIP1 TNFAIP3 interacting protein 1 -0.0138674
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0137643
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0137103
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0135524
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0134449
SOD2 superoxide dismutase 2, mitochondrial -0.0131736
PICALM phosphatidylinositol binding clathrin assembly protein -0.013102
PKM pyruvate kinase, muscle -0.0129308
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0129288
RBM39 RNA binding motif protein 39 -0.0129261
RAB10 RAB10, member RAS oncogene family -0.0127491
GPBP1L1 GC-rich promoter binding protein 1-like 1 -0.0127069
ADAM17 ADAM metallopeptidase domain 17 -0.0124856
BIRC6 baculoviral IAP repeat containing 6 -0.0123449
FNDC3B fibronectin type III domain containing 3B -0.012313