| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | NVP-BHG712 perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the NVP-BHG712_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GRAMD1B | GRAM domain containing 1B | 0.106494 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.100569 |
| MCL1 | myeloid cell leukemia 1 | 0.093371 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0799297 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0747906 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0747079 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0738659 |
| TXNRD1 | thioredoxin reductase 1 | 0.0597945 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0593781 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0563631 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0555338 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0536743 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0531634 |
| PLEC | plectin | 0.0527408 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0522799 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0483679 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0477939 |
| TPM3 | tropomyosin 3 | 0.0475661 |
| LOC112694756 | uncharaterized LOC112694756 | 0.04595 |
| ATP11A | ATPase, class VI, type 11A | 0.0435998 |
| RPL3 | ribosomal protein L3 | 0.0433201 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0430503 |
| PRRC2A | proline-rich coiled-coil 2A | 0.0410258 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0396792 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0389281 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0381357 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0378881 |
| TPI1 | triosephosphate isomerase 1 | 0.037522 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0372608 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0352675 |
| RPS4X | ribosomal protein S4, X-linked | 0.0350473 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0343143 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0338413 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0335952 |
| INTS6 | integrator complex subunit 6 | 0.0326787 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0321013 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0316967 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0316696 |
| FLNA | filamin A, alpha | 0.0315831 |
| IGF1R | insulin-like growth factor 1 receptor | 0.031457 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0314295 |
| HOMER1 | homer scaffolding protein 1 | 0.031361 |
| ACTN1 | actinin, alpha 1 | 0.0302664 |
| IPO7 | importin 7 | 0.0287433 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0287241 |
| CLTC | clathrin, heavy chain (Hc) | 0.0283258 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0280223 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0276884 |
| SMAD3 | SMAD family member 3 | 0.0276385 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0276211 |
| RPS3 | ribosomal protein S3 | 0.0275746 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0267433 |
| VCL | vinculin | 0.0263347 |
| DCAF8 | DDB1 and CUL4 associated factor 8 | 0.0262013 |
| CDK17 | cyclin-dependent kinase 17 | 0.0260361 |
| RTN4 | reticulon 4 | 0.0247074 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.0245996 |
| RRM2 | ribonucleotide reductase M2 | 0.024327 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0242879 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0242669 |
| FMNL2 | formin-like 2 | 0.0239615 |
| YAP1 | Yes-associated protein 1 | 0.0239358 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0236109 |
| BRD2 | bromodomain containing 2 | 0.0234956 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0233776 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0227703 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0220804 |
| UBAP2L | ubiquitin associated protein 2-like | 0.021837 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0217602 |
| PPM1L | protein phosphatase, Mg2+/Mn2+ dependent, 1L | 0.0217254 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0216795 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0216289 |
| DST | dystonin | 0.0214739 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0214205 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0209908 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0208171 |
| CTTN | cortactin | 0.0207561 |
| CUL3 | cullin 3 | 0.020742 |
| RPL37 | ribosomal protein L37 | 0.0206547 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0206101 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0205069 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0204856 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0204602 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0204382 |
| KRT18 | keratin 18, type I | 0.0202183 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0200781 |
| HLA-C | major histocompatibility complex, class I, C | 0.0199556 |
| FBXO11 | F-box protein 11 | 0.0197611 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0195847 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0194609 |
| RCOR1 | REST corepressor 1 | 0.0194594 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.019224 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0189838 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0189487 |
| ETV3 | ets variant 3 | 0.018842 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0187825 |
| FERMT2 | fermitin family member 2 | 0.0187561 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0187122 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0186964 |
| MYPN | myopalladin | 0.0184551 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.451972 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.126556 |
| PTMA | prothymosin, alpha | -0.12599 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0951528 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0816071 |
| VIM | vimentin | -0.065639 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0642603 |
| TMSB10 | thymosin beta 10 | -0.0594684 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0516077 |
| RSF1 | remodeling and spacing factor 1 | -0.0396292 |
| BBX | bobby sox homolog (Drosophila) | -0.039479 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0374414 |
| HLA-B | major histocompatibility complex, class I, B | -0.0366856 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0349923 |
| PFN1 | profilin 1 | -0.0315748 |
| CANX | calnexin | -0.0315492 |
| EGR1 | early growth response 1 | -0.0315183 |
| POTEF | POTE ankyrin domain family, member F | -0.031496 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0314245 |
| H1-0 | H1.0 linker histone | -0.0314195 |
| COPA | coatomer protein complex, subunit alpha | -0.0311782 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.0310753 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0303285 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0299206 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.029489 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0293212 |
| GNAS | GNAS complex locus | -0.0288596 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0286228 |
| RAD51B | RAD51 paralog B | -0.0286159 |
| MT2A | metallothionein 2A | -0.0280659 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0279876 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0278149 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0277232 |
| RPS15 | ribosomal protein S15 | -0.0274763 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0271744 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0263643 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0262065 |
| WASF2 | WAS protein family, member 2 | -0.0261226 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0257003 |
| RYR3 | ryanodine receptor 3 | -0.0243957 |
| RPL35A | ribosomal protein L35a | -0.0241342 |
| FMN1 | formin 1 | -0.0238678 |
| USP34 | ubiquitin specific peptidase 34 | -0.0238442 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0236659 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0236219 |
| S100A10 | S100 calcium binding protein A10 | -0.0235832 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0235438 |
| MAP4 | microtubule-associated protein 4 | -0.0231999 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0230496 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0228799 |
| FTL | ferritin, light polypeptide | -0.0222992 |
| KMT2A | lysine (K)-specific methyltransferase 2A | -0.0222486 |
| SBF2 | SET binding factor 2 | -0.0220531 |
| RPL8 | ribosomal protein L8 | -0.0219301 |
| EHBP1 | EH domain binding protein 1 | -0.0213697 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0208117 |
| THOC2 | THO complex 2 | -0.0204007 |
| RPL36A | ribosomal protein L36a | -0.0203411 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0201934 |
| HMGA2 | high mobility group AT-hook 2 | -0.0200045 |
| GOLGA4 | golgin A4 | -0.0199738 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0199387 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0198379 |
| SCAF11 | SR-related CTD-associated factor 11 | -0.0197293 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0197172 |
| ZNF292 | zinc finger protein 292 | -0.0196358 |
| TUBA1B | tubulin, alpha 1b | -0.0195683 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0193742 |
| RPS6 | ribosomal protein S6 | -0.0192626 |
| DEK | DEK proto-oncogene | -0.0191978 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0191077 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0190552 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0190434 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0189153 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0187479 |
| GOSR1 | golgi SNAP receptor complex member 1 | -0.0183456 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | -0.0183012 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0181873 |
| PHF20 | PHD finger protein 20 | -0.0181321 |
| RPLP2 | ribosomal protein, large, P2 | -0.0180558 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0178835 |
| ZFR | zinc finger RNA binding protein | -0.0178001 |
| CALR | calreticulin | -0.0177203 |
| RBM25 | RNA binding motif protein 25 | -0.017657 |
| RPS8 | ribosomal protein S8 | -0.0176039 |
| TMEM263 | transmembrane protein 263 | -0.0175619 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0174921 |
| PHF21A | PHD finger protein 21A | -0.0174733 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0174682 |
| SRP72 | signal recognition particle 72kDa | -0.0174453 |
| GORASP2 | golgi reassembly stacking protein 2, 55kDa | -0.0173639 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0173634 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -0.0170788 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0170716 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0169839 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0166976 |
| RPS24 | ribosomal protein S24 | -0.0166015 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0165207 |
| TNRC6B | trinucleotide repeat containing 6B | -0.0164701 |
| CD2AP | CD2-associated protein | -0.0163832 |
