| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | NVP-BHG712 perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the NVP-BHG712_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.180192 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.129959 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.126352 |
| ACTG1 | actin gamma 1 | 0.0994104 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0886326 |
| LAMB3 | laminin, beta 3 | 0.0698812 |
| NDRG1 | N-myc downstream regulated 1 | 0.0566088 |
| ARRDC3 | arrestin domain containing 3 | 0.055627 |
| PLEC | plectin | 0.0510761 |
| RPS3 | ribosomal protein S3 | 0.050932 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0472707 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.045604 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0453891 |
| RACK1 | receptor for activated C kinase 1 | 0.041239 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0412078 |
| DSPP | dentin sialophosphoprotein | 0.0404455 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0391662 |
| ANXA2 | annexin A2 | 0.0367767 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0362132 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0356733 |
| TMSB4X | thymosin beta 4, X-linked | 0.0321835 |
| CANX | calnexin | 0.0314567 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.031405 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0307966 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0295328 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0293408 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0286971 |
| AHNAK | AHNAK nucleoprotein | 0.0285114 |
| LAMC2 | laminin, gamma 2 | 0.0277633 |
| HLA-C | major histocompatibility complex, class I, C | 0.0270956 |
| RPS17 | ribosomal protein S17 | 0.0267615 |
| EGR1 | early growth response 1 | 0.0258327 |
| MT2A | metallothionein 2A | 0.0255885 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0252422 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0248166 |
| RPL19 | ribosomal protein L19 | 0.0248153 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0241602 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0241552 |
| RPS12 | ribosomal protein S12 | 0.0241157 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.023939 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.0227291 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0225738 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0223419 |
| RPL7 | ribosomal protein L7 | 0.0222386 |
| RPL18 | ribosomal protein L18 | 0.0214454 |
| ENO1 | enolase 1, (alpha) | 0.0213779 |
| YBX1 | Y box binding protein 1 | 0.0210785 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0208666 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0207799 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0206099 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.0202459 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0202377 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0199828 |
| TPM3 | tropomyosin 3 | 0.0198926 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0198356 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0198338 |
| HSPA1A | heat shock 70kDa protein 1A | 0.019782 |
| TXNRD1 | thioredoxin reductase 1 | 0.0196719 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0195999 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | 0.019381 |
| HMGB2 | high mobility group box 2 | 0.0186275 |
| FN1 | fibronectin 1 | 0.018175 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0181409 |
| LDHA | lactate dehydrogenase A | 0.0180915 |
| RPL36 | ribosomal protein L36 | 0.0178058 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0174653 |
| FAM13A | family with sequence similarity 13, member A | 0.0169624 |
| JUN | jun proto-oncogene | 0.0168885 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0168835 |
| MX1 | MX dynamin-like GTPase 1 | 0.0168607 |
| BRD2 | bromodomain containing 2 | 0.0167014 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0164094 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0163044 |
| SQSTM1 | sequestosome 1 | 0.0163005 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0162753 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0160191 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0160165 |
| GOLGB1 | golgin B1 | 0.0156694 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | 0.0153547 |
| INTS6 | integrator complex subunit 6 | 0.0150499 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 0.0149003 |
| HDAC9 | histone deacetylase 9 | 0.0148239 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.014709 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0145926 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0142651 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0141496 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0141199 |
| MKI67 | marker of proliferation Ki-67 | 0.0139522 |
| SGMS2 | sphingomyelin synthase 2 | 0.0139192 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0138644 |
| AP2M1 | adaptor-related protein complex 2, mu 1 subunit | 0.013705 |
| KLF10 | Kruppel-like factor 10 | 0.0134565 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.013419 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0133204 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.013264 |
| PLAU | plasminogen activator, urokinase | 0.0131189 |
| RPL5 | ribosomal protein L5 | 0.0130414 |
| RPS4X | ribosomal protein S4, X-linked | 0.0130066 |
| RPL4 | ribosomal protein L4 | 0.0128995 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0128117 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.183786 |
| POTEF | POTE ankyrin domain family, member F | -0.0842686 |
| PTMA | prothymosin, alpha | -0.0668796 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0521183 |
| MYO6 | myosin VI | -0.0514381 |
| RPS23 | ribosomal protein S23 | -0.0463057 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0451215 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0438008 |
| S100A10 | S100 calcium binding protein A10 | -0.0430761 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.0383051 |
| ERBIN | erbb2 interacting protein | -0.0366774 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0337945 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.031709 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0316237 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0313124 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0302866 |
| FAM3C | family with sequence similarity 3, member C | -0.0301056 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0292067 |
| CD2AP | CD2-associated protein | -0.0281983 |
| RPS24 | ribosomal protein S24 | -0.027365 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0273338 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0265997 |
| RPL35A | ribosomal protein L35a | -0.0260706 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0257857 |
| TMSB10 | thymosin beta 10 | -0.0252275 |
| GOLGA4 | golgin A4 | -0.024943 |
| GNAS | GNAS complex locus | -0.0248751 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0243716 |
| HLA-B | major histocompatibility complex, class I, B | -0.0243063 |
| TMEM165 | transmembrane protein 165 | -0.023676 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0233239 |
| WASF2 | WAS protein family, member 2 | -0.0231588 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0229905 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0229094 |
| RPL36A | ribosomal protein L36a | -0.0227417 |
| SETD5 | SET domain containing 5 | -0.0224276 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0222842 |
| SRPK2 | SRSF protein kinase 2 | -0.0222067 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.021953 |
| RPL15 | ribosomal protein L15 | -0.0217561 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0217222 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0215874 |
| RPS25 | ribosomal protein S25 | -0.0215102 |
| FBXO34 | F-box protein 34 | -0.0214204 |
| UBE2E1 | ubiquitin-conjugating enzyme E2E 1 | -0.0212973 |
| PTK2 | protein tyrosine kinase 2 | -0.0212609 |
| RPL8 | ribosomal protein L8 | -0.0212123 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -0.0211934 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.021065 |
| S100A6 | S100 calcium binding protein A6 | -0.0209825 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0209693 |
| RCOR1 | REST corepressor 1 | -0.0206446 |
| ZFAND6 | zinc finger, AN1-type domain 6 | -0.0206051 |
| UBC | ubiquitin C | -0.0196043 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0195506 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0193007 |
| MAP3K13 | mitogen-activated protein kinase kinase kinase 13 | -0.0192693 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0192197 |
| KRT8 | keratin 8, type II | -0.0192002 |
| RPS15 | ribosomal protein S15 | -0.0188446 |
| CCNL1 | cyclin L1 | -0.0188032 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.018803 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.0187591 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0187474 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0187177 |
| MCU | mitochondrial calcium uniporter | -0.018663 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0186083 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0185191 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0184289 |
| RNF145 | ring finger protein 145 | -0.018296 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | -0.0182814 |
| BCL2L1 | BCL2-like 1 | -0.0182236 |
| ARHGAP20 | Rho GTPase activating protein 20 | -0.0181834 |
| H3-3B | H3.3 histone B | -0.018148 |
| RBM25 | RNA binding motif protein 25 | -0.0179392 |
| RPS29 | ribosomal protein S29 | -0.0178143 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0177813 |
| CTSD | cathepsin D | -0.0177324 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0177047 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | -0.0176935 |
| ZNF148 | zinc finger protein 148 | -0.0176404 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0175771 |
| RPL28 | ribosomal protein L28 | -0.0175555 |
| MICAL3 | microtubule associated monooxygenase, calponin and LIM domain containing 3 | -0.0174681 |
| PALS1 | protein associated with LIN7 1, MAGUK p55 family member | -0.0173365 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0172564 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | -0.0170576 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0168936 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.016874 |
| PGBD5 | piggyBac transposable element derived 5 | -0.0166324 |
| CYRIB | CYFIP related Rac1 interactor B | -0.0166189 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0165527 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0164635 |
| TMEM263 | transmembrane protein 263 | -0.0164532 |
| RPLP2 | ribosomal protein, large, P2 | -0.0164293 |
| FBXO32 | F-box protein 32 | -0.0163253 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | -0.0161738 |
| FRMD5 | FERM domain containing 5 | -0.0160912 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0160752 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0160389 |
