NVP-BHG712_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description NVP-BHG712 perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the NVP-BHG712_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.0770828
IGFBP3 insulin-like growth factor binding protein 3 0.0545646
RPL35A ribosomal protein L35a 0.0513164
RPS3 ribosomal protein S3 0.0413383
RACK1 receptor for activated C kinase 1 0.0406987
RPS12 ribosomal protein S12 0.0386463
RPS19 ribosomal protein S19 0.0383773
RPL31 ribosomal protein L31 0.0374244
RPL37A ribosomal protein L37a 0.0361763
RPS17 ribosomal protein S17 0.0329426
LOC112694756 uncharaterized LOC112694756 0.0323948
RPS27 ribosomal protein S27 0.0309292
RPS6 ribosomal protein S6 0.0303127
RPL34 ribosomal protein L34 0.0294655
RPL37 ribosomal protein L37 0.0290778
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 0.0275288
RPS13 ribosomal protein S13 0.0270459
RPS4X ribosomal protein S4, X-linked 0.0256953
RPLP0 ribosomal protein, large, P0 0.0256079
RPS8 ribosomal protein S8 0.0244778
RPLP1 ribosomal protein, large, P1 0.0242184
EIF4H eukaryotic translation initiation factor 4H 0.0240111
RPS14 ribosomal protein S14 0.0237409
RPL36 ribosomal protein L36 0.0231772
RPL12 ribosomal protein L12 0.0228881
CTSL cathepsin L 0.0222702
RPL11 ribosomal protein L11 0.0222662
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0217864
HLA-A major histocompatibility complex, class I, A 0.0214698
B2M beta-2-microglobulin 0.0213897
RPL19 ribosomal protein L19 0.0211729
NDRG1 N-myc downstream regulated 1 0.0206139
FTL ferritin, light polypeptide 0.0206057
RPL27 ribosomal protein L27 0.0194234
VIM vimentin 0.0189609
STC1 stanniocalcin 1 0.018792
MT2A metallothionein 2A 0.0186852
HLA-C major histocompatibility complex, class I, C 0.0184983
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0172902
RPL7 ribosomal protein L7 0.0170913
FTH1 ferritin, heavy polypeptide 1 0.0167849
SMOC1 SPARC related modular calcium binding 1 0.0167068
RPL3 ribosomal protein L3 0.0165036
RPL26 ribosomal protein L26 0.0164341
ESM1 endothelial cell-specific molecule 1 0.0163203
RPL9 ribosomal protein L9 0.0162615
EEF2 eukaryotic translation elongation factor 2 0.0161925
HLA-B major histocompatibility complex, class I, B 0.0160113
RPL13A ribosomal protein L13a 0.0152627
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0152322
RPL30 ribosomal protein L30 0.015163
TBXT T-box transcription factor T 0.0146623
IGFBP6 insulin-like growth factor binding protein 6 0.0144278
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.014173
TPT1 tumor protein, translationally-controlled 1 0.0139374
TPI1 triosephosphate isomerase 1 0.0138012
AKAP12 A kinase (PRKA) anchor protein 12 0.0137234
NACA nascent polypeptide-associated complex alpha subunit 0.0135998
EIF1 eukaryotic translation initiation factor 1 0.0135782
RPS2 ribosomal protein S2 0.0135322
ENO2 enolase 2 (gamma, neuronal) 0.0133257
SRRM2 serine/arginine repetitive matrix 2 0.0130615
ANXA2 annexin A2 0.0130194
ISG15 ISG15 ubiquitin-like modifier 0.0129955
BMP6 bone morphogenetic protein 6 0.0129932
SFTPA2 surfactant protein A2 0.0127221
RPL35 ribosomal protein L35 0.0126909
EGR1 early growth response 1 0.0125345
STC2 stanniocalcin 2 0.0122703
HSPA8 heat shock 70kDa protein 8 0.0120869
NTN4 netrin 4 0.0117698
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0113976
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0112703
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0111934
PLEC plectin 0.0110116
RPL41 ribosomal protein L41 0.0109494
LOC102724023 ES1 protein homolog, mitochondrial 0.0107169
RPL18 ribosomal protein L18 0.0104308
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0103958
RPL29 ribosomal protein L29 0.0101259
SEPTIN9 septin 9 0.00986916
KRT19 keratin 19, type I 0.00960129
RPS20 ribosomal protein S20 0.00939367
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) 0.0093651
ASTN2 astrotactin 2 0.00932349
EEF1B2 eukaryotic translation elongation factor 1 beta 2 0.00928053
AHNAK2 AHNAK nucleoprotein 2 0.00903908
OLFML2A olfactomedin-like 2A 0.00896327
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.00882383
CLMP CXADR-like membrane protein 0.00879435
KRT18 keratin 18, type I 0.00869835
ITGB8 integrin, beta 8 0.0086946
CD44 CD44 molecule (Indian blood group) 0.00866677
SH3KBP1 SH3-domain kinase binding protein 1 0.00866165
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial) 0.00861576
RPL21 ribosomal protein L21 0.00856677
KLF10 Kruppel-like factor 10 0.00847956
SLK STE20-like kinase 0.00843413
RPS25 ribosomal protein S25 0.00839943
AP2M1 adaptor-related protein complex 2, mu 1 subunit 0.00827952

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.389834
ASPH aspartate beta-hydroxylase -0.170883
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.154381
PDE10A phosphodiesterase 10A -0.152628
EFNA5 ephrin-A5 -0.126623
MYOF myoferlin -0.0960241
LIMCH1 LIM and calponin homology domains 1 -0.0938353
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0931434
NAMPT nicotinamide phosphoribosyltransferase -0.0930223
NALF1 NALCN channel auxiliary factor 1 -0.0928972
UBC ubiquitin C -0.0902271
COL5A2 collagen, type V, alpha 2 -0.0831168
TXNRD1 thioredoxin reductase 1 -0.0771125
FNDC3B fibronectin type III domain containing 3B -0.0716086
PSD3 pleckstrin and Sec7 domain containing 3 -0.0699013
PCBP3 poly(rC) binding protein 3 -0.0691983
NRCAM neuronal cell adhesion molecule -0.0654928
TRIO trio Rho guanine nucleotide exchange factor -0.0629111
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.061966
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0579793
TM4SF1 transmembrane 4 L six family member 1 -0.056927
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0546927
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0542857
RPS27A ribosomal protein S27a -0.0533399
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0527368
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0522017
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0516522
COL4A5 collagen, type IV, alpha 5 -0.0515894
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0510074
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0503771
SMYD3 SET and MYND domain containing 3 -0.0465492
OGA O-GlcNAcase -0.0453928
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0446399
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0438316
PRKN parkin RBR E3 ubiquitin protein ligase -0.0437173
PTPRM protein tyrosine phosphatase, receptor type, M -0.0436734
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0429317
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0427976
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0425919
GRAMD1B GRAM domain containing 1B -0.0423357
BASP1 brain abundant, membrane attached signal protein 1 -0.0420513
PCBP2 poly(rC) binding protein 2 -0.0420054
USP34 ubiquitin specific peptidase 34 -0.0417926
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -0.0414167
RBM39 RNA binding motif protein 39 -0.0413492
TMSB10 thymosin beta 10 -0.0411142
CXCL8 chemokine (C-X-C motif) ligand 8 -0.041106
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0409875
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0408032
LSAMP limbic system-associated membrane protein -0.0407064
PRELID2 PRELI domain containing 2 -0.0403669
NAP1L1 nucleosome assembly protein 1-like 1 -0.0401912
TGFBR1 transforming growth factor, beta receptor 1 -0.0392146
ELL2 elongation factor, RNA polymerase II, 2 -0.0390082
DST dystonin -0.0380736
PTMA prothymosin, alpha -0.037745
GDA guanine deaminase -0.0375571
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0374789
P3H2 prolyl 3-hydroxylase 2 -0.0371565
NT5C2 5'-nucleotidase, cytosolic II -0.0356886
PDLIM5 PDZ and LIM domain 5 -0.0351022
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0345456
PM20D1 peptidase M20 domain containing 1 -0.0337559
CANX calnexin -0.0330853
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0329581
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0322643
EPB41L3 erythrocyte membrane protein band 4.1-like 3 -0.03177
AHNAK AHNAK nucleoprotein -0.0311457
TNPO1 transportin 1 -0.0308073
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0307653
SPAG9 sperm associated antigen 9 -0.0307102
NEK7 NIMA-related kinase 7 -0.0302236
SFPQ splicing factor proline/glutamine-rich -0.0299463
FLNB filamin B, beta -0.0298536
PTGR1 prostaglandin reductase 1 -0.029498
MBD5 methyl-CpG binding domain protein 5 -0.0283996
ENO1 enolase 1, (alpha) -0.0281871
ZNF638 zinc finger protein 638 -0.0281125
VCL vinculin -0.0278261
AGFG1 ArfGAP with FG repeats 1 -0.0277593
FUS FUS RNA binding protein -0.0276342
BIRC6 baculoviral IAP repeat containing 6 -0.0273798
SRPK2 SRSF protein kinase 2 -0.0273655
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 -0.0273176
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0272088
ARID4B AT rich interactive domain 4B (RBP1-like) -0.027094
VMP1 vacuole membrane protein 1 -0.0267994
USP9X ubiquitin specific peptidase 9, X-linked -0.0267653
TFPI2 tissue factor pathway inhibitor 2 -0.0267164
RGS2 regulator of G-protein signaling 2 -0.0266805
MAML3 mastermind-like 3 (Drosophila) -0.0265603
KMT2C lysine (K)-specific methyltransferase 2C -0.0261108
DGKD diacylglycerol kinase, delta 130kDa -0.0260817
NPAS2 neuronal PAS domain protein 2 -0.0254106
KYNU kynureninase -0.0253985
PCDH15 protocadherin-related 15 -0.0253682
PRKD3 protein kinase D3 -0.0253178
DOCK4 dedicator of cytokinesis 4 -0.0251982
PDIA4 protein disulfide isomerase family A, member 4 -0.0246727
SRGN serglycin -0.0246063