NVP-BHG712_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description NVP-BHG712 perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

126 genes differentially expressed following the NVP-BHG712_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 0.371289
FN1 fibronectin 1 0.172153
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.115037
LOC112694756 uncharaterized LOC112694756 0.112067
TPR translocated promoter region, nuclear basket protein 0.107009
PDE4D phosphodiesterase 4D, cAMP-specific 0.106806
SPIDR scaffolding protein involved in DNA repair 0.0983387
EXT1 exostosin glycosyltransferase 1 0.0932129
SMYD3 SET and MYND domain containing 3 0.0891887
IGFBP3 insulin-like growth factor binding protein 3 0.0891091
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0832807
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.080466
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0785421
RPS19 ribosomal protein S19 0.0765683
MAML3 mastermind-like 3 (Drosophila) 0.075591
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0722849
KTN1 kinectin 1 (kinesin receptor) 0.0715912
SLC38A2 solute carrier family 38, member 2 0.0701177
CD109 CD109 molecule 0.0688749
FLNA filamin A, alpha 0.0655576
SEPTIN9 septin 9 0.0571254
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0563417
TENM3 teneurin transmembrane protein 3 0.0549896
RAD51B RAD51 paralog B 0.0547831
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0547792
CXCL8 chemokine (C-X-C motif) ligand 8 0.0544173
FMNL2 formin-like 2 0.052352
CTBP2 C-terminal binding protein 2 0.050519
RPS8 ribosomal protein S8 0.0490869
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0483965
EEF2 eukaryotic translation elongation factor 2 0.0480017
FTL ferritin, light polypeptide 0.0468285
ACTG1 actin gamma 1 0.0458214
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0416874
APP amyloid beta (A4) precursor protein 0.0413304
TRIO trio Rho guanine nucleotide exchange factor 0.0397901
B2M beta-2-microglobulin 0.0385802
LAMA4 laminin, alpha 4 0.0360262
RPS3 ribosomal protein S3 0.0321745
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0291209
LPP LIM domain containing preferred translocation partner in lipoma 0.0291123
PDE10A phosphodiesterase 10A 0.0288004
ASPH aspartate beta-hydroxylase 0.0213491
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0187984
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0180398
AKAP12 A kinase (PRKA) anchor protein 12 0.0139014
AHR aryl hydrocarbon receptor 0.0117333
LMO7 LIM domain 7 0.0108844
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.00989717
RPS6 ribosomal protein S6 0.00988106
PGK1 phosphoglycerate kinase 1 5.28757E-4

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.340382
PTMA prothymosin, alpha -0.143278
ALCAM activated leukocyte cell adhesion molecule -0.107444
TMSB10 thymosin beta 10 -0.101905
EIF1 eukaryotic translation initiation factor 1 -0.100261
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0948605
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.094013
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0854107
PTK2 protein tyrosine kinase 2 -0.0762222
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0741521
FNDC3B fibronectin type III domain containing 3B -0.0738021
CANX calnexin -0.073266
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0727625
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0708818
RTN4 reticulon 4 -0.0688071
RLF rearranged L-myc fusion -0.0680267
LDHA lactate dehydrogenase A -0.067293
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0667993
EGFR epidermal growth factor receptor -0.0664415
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0657145
UBC ubiquitin C -0.0653374
PARD3 par-3 family cell polarity regulator -0.060562
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0604684
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0551424
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0532528
WAC WW domain containing adaptor with coiled-coil -0.0518755
RPL31 ribosomal protein L31 -0.0509944
TPT1 tumor protein, translationally-controlled 1 -0.048582
NAMPT nicotinamide phosphoribosyltransferase -0.0476065
NDRG1 N-myc downstream regulated 1 -0.0475399
MYO1E myosin IE -0.0461
MCL1 myeloid cell leukemia 1 -0.044525
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0433235
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.042169
ACTN4 actinin, alpha 4 -0.0417648
ADAM10 ADAM metallopeptidase domain 10 -0.0415741
SRPK2 SRSF protein kinase 2 -0.0403233
NUP58 nucleoporin 58 -0.039585
MYOF myoferlin -0.0377757
FLNB filamin B, beta -0.0363085
VIM vimentin -0.0359094
RPS27A ribosomal protein S27a -0.0344186
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0340903
LRP1B low density lipoprotein receptor-related protein 1B -0.0320887
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0319699
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.031757
PRKCA protein kinase C, alpha -0.0302322
TTC3 tetratricopeptide repeat domain 3 -0.0295373
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0290076
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0273187
RPL23 ribosomal protein L23 -0.0264152
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0261608
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0252212
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.023659
DSCAM Down syndrome cell adhesion molecule -0.0236419
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0203573
CCNI cyclin I -0.0186148
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0175027
ZNF292 zinc finger protein 292 -0.0172731
ANXA2 annexin A2 -0.0163014
EFNA5 ephrin-A5 -0.0157218
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0146092
RPL37 ribosomal protein L37 -0.0141598
MYH9 myosin, heavy chain 9, non-muscle -0.0124617
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0109943
SETD5 SET domain containing 5 -0.00919899
ZBTB20 zinc finger and BTB domain containing 20 -0.00689719
PKM pyruvate kinase, muscle -0.00670718
RAB1A RAB1A, member RAS oncogene family -0.00585296
RPL34 ribosomal protein L34 -0.00583762
DST dystonin -0.00411186
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0029296
HMGA2 high mobility group AT-hook 2 -0.00284892
GPC6 glypican 6 -0.0023157
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -4.05832E-4