| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | NVP-BHG712 perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the NVP-BHG712_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HDAC9 | histone deacetylase 9 | 0.126283 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | 0.124045 |
| COL5A2 | collagen, type V, alpha 2 | 0.0996877 |
| NTM | neurotrimin | 0.0955738 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.094908 |
| COL11A1 | collagen, type XI, alpha 1 | 0.0906038 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0890463 |
| ZNF292 | zinc finger protein 292 | 0.0832183 |
| TENM3 | teneurin transmembrane protein 3 | 0.0722513 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | 0.0676814 |
| ENAH | enabled homolog (Drosophila) | 0.0661492 |
| PRTG | protogenin | 0.0628271 |
| RBM20 | RNA binding motif protein 20 | 0.0623626 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | 0.0599748 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0570081 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0550693 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0543261 |
| STAG2 | stromal antigen 2 | 0.0505186 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | 0.0493453 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0489115 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0478569 |
| ANK2 | ankyrin 2, neuronal | 0.0475805 |
| DST | dystonin | 0.0467387 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | 0.0465118 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0462021 |
| PEG10 | paternally expressed 10 | 0.045934 |
| RASAL2 | RAS protein activator like 2 | 0.0458636 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0456415 |
| TRPS1 | trichorhinophalangeal syndrome I | 0.0453394 |
| MED13L | mediator complex subunit 13-like | 0.0447286 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0446659 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0442756 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0441904 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0432656 |
| PPP4R1 | protein phosphatase 4, regulatory subunit 1 | 0.0431731 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0430681 |
| PARD3B | par-3 family cell polarity regulator beta | 0.0425744 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0424245 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0422385 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0417493 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0417207 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0415419 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0415124 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.0414906 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0409689 |
| RPS4X | ribosomal protein S4, X-linked | 0.0397838 |
| PHIP | pleckstrin homology domain interacting protein | 0.0397578 |
| FAT1 | FAT atypical cadherin 1 | 0.0386335 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0382398 |
| YBX1 | Y box binding protein 1 | 0.0374325 |
| PDGFC | platelet derived growth factor C | 0.0370473 |
| RPL3 | ribosomal protein L3 | 0.0360244 |
| NHSL1 | NHS-like 1 | 0.0355659 |
| PHLPP1 | PH domain and leucine rich repeat protein phosphatase 1 | 0.0347236 |
| SHROOM3 | shroom family member 3 | 0.0343765 |
| GPC4 | glypican 4 | 0.0343563 |
| CDH19 | cadherin 19, type 2 | 0.0338765 |
| TJP1 | tight junction protein 1 | 0.0335242 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0334391 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.0333104 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | 0.033298 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0327854 |
| USP25 | ubiquitin specific peptidase 25 | 0.0324512 |
| PGAP1 | post-GPI attachment to proteins 1 | 0.0324036 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0319329 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0317875 |
| ENO1 | enolase 1, (alpha) | 0.0317184 |
| PCDH18 | protocadherin 18 | 0.031436 |
| RPS3 | ribosomal protein S3 | 0.0313127 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.0312097 |
| HS3ST5 | heparan sulfate (glucosamine) 3-O-sulfotransferase 5 | 0.0310591 |
| ID3 | inhibitor of DNA binding 3, dominant negative helix-loop-helix protein | 0.0308865 |
| SFPQ | splicing factor proline/glutamine-rich | 0.030796 |
| ZNF608 | zinc finger protein 608 | 0.0307358 |
| MEF2C | myocyte enhancer factor 2C | 0.0306725 |
| SERTAD2 | SERTA domain containing 2 | 0.0304896 |
| ACTG1 | actin gamma 1 | 0.0303868 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0302026 |
| RPL30 | ribosomal protein L30 | 0.0301265 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0300287 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.029833 |
| ITSN2 | intersectin 2 | 0.0295583 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0295239 |
| MTF2 | metal response element binding transcription factor 2 | 0.0294242 |
| XPO1 | exportin 1 | 0.0292527 |
| TENM2 | teneurin transmembrane protein 2 | 0.0291597 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0290937 |
| HECTD4 | HECT domain containing E3 ubiquitin protein ligase 4 | 0.0289323 |
| PLPP1 | phospholipid phosphatase 1 | 0.0287856 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.0287246 |
| PFN1 | profilin 1 | 0.0286298 |
| ADGRL3 | adhesion G protein-coupled receptor L3 | 0.0285694 |
| POTEF | POTE ankyrin domain family, member F | 0.0284566 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.0279658 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0277305 |
| NCOA2 | nuclear receptor coactivator 2 | 0.0275597 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0273477 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0273451 |
| CLTC | clathrin, heavy chain (Hc) | 0.0273039 |
| ANXA1 | annexin A1 | 0.027252 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | -0.218306 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.154971 |
| VIM | vimentin | -0.0970597 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0925583 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0871364 |
| RPS16 | ribosomal protein S16 | -0.0817213 |
| SPAG9 | sperm associated antigen 9 | -0.0791796 |
| RPL35A | ribosomal protein L35a | -0.0606485 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.0601195 |
| RPS24 | ribosomal protein S24 | -0.0512158 |
| B2M | beta-2-microglobulin | -0.0498593 |
| H1-0 | H1.0 linker histone | -0.0494947 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0458426 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0453062 |
| RPS21 | ribosomal protein S21 | -0.0442044 |
| AHNAK | AHNAK nucleoprotein | -0.0433232 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0410982 |
| COL3A1 | collagen, type III, alpha 1 | -0.0408273 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0394505 |
| RPS25 | ribosomal protein S25 | -0.0387073 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0384162 |
| S100A10 | S100 calcium binding protein A10 | -0.0382625 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0373296 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0367 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0363321 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0355264 |
| RPL11 | ribosomal protein L11 | -0.0346797 |
| RPL19 | ribosomal protein L19 | -0.0343564 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0332576 |
| GALNTL6 | polypeptide N-acetylgalactosaminyltransferase-like 6 | -0.0329555 |
| MORF4L2 | mortality factor 4 like 2 | -0.0321475 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0319584 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0319157 |
| RPL34 | ribosomal protein L34 | -0.0314253 |
| RPL31 | ribosomal protein L31 | -0.0314173 |
| SRP72 | signal recognition particle 72kDa | -0.0304118 |
| HMGB1 | high mobility group box 1 | -0.0303926 |
| CCDC138 | coiled-coil domain containing 138 | -0.0300604 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0299438 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0297033 |
| RPL28 | ribosomal protein L28 | -0.0291355 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0289833 |
| RPL38 | ribosomal protein L38 | -0.0284917 |
| UBE2B | ubiquitin-conjugating enzyme E2B | -0.0284484 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0282705 |
| EMP1 | epithelial membrane protein 1 | -0.0281027 |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | -0.027928 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | -0.0278738 |
| CERT1 | ceramide transporter 1 | -0.0274487 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0274486 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.027407 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | -0.0274024 |
| ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) | -0.0272816 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0272293 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0269577 |
| KIAA1958 | KIAA1958 | -0.0267285 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0263692 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0257072 |
| PKM | pyruvate kinase, muscle | -0.0256832 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.025468 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.0254269 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0254194 |
| THBS1 | thrombospondin 1 | -0.0254149 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.0254134 |
| TPM4 | tropomyosin 4 | -0.025276 |
| CENPE | centromere protein E, 312kDa | -0.0250739 |
| CADM2 | cell adhesion molecule 2 | -0.0249775 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.024843 |
| RPS8 | ribosomal protein S8 | -0.0247438 |
| PCDH17 | protocadherin 17 | -0.0244462 |
| PHF3 | PHD finger protein 3 | -0.0244451 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0244118 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0243983 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0242532 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0239942 |
| PCDH9 | protocadherin 9 | -0.0237725 |
| RPS27A | ribosomal protein S27a | -0.0237162 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0235011 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0232425 |
| SGO2 | shugoshin 2 | -0.0230889 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.0229403 |
| RHEB | Ras homolog enriched in brain | -0.022798 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0225057 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | -0.0223315 |
| KHSRP | KH-type splicing regulatory protein | -0.0222537 |
| MPG | N-methylpurine-DNA glycosylase | -0.0221015 |
| DEK | DEK proto-oncogene | -0.0220848 |
| FTL | ferritin, light polypeptide | -0.0220156 |
| PRR11 | proline rich 11 | -0.0219832 |
| KANK2 | KN motif and ankyrin repeat domains 2 | -0.0218963 |
| VPS13D | vacuolar protein sorting 13 homolog D (S. cerevisiae) | -0.0218933 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0218621 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0218437 |
| PPHLN1 | periphilin 1 | -0.0217394 |
| IGF2 | insulin-like growth factor 2 | -0.0217338 |
| HLA-B | major histocompatibility complex, class I, B | -0.0217182 |
| SEPTIN10 | septin 10 | -0.0217096 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.0216981 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.0216511 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0216393 |
